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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

LTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophileBy similarity1
Active sitei20By similarity1
Active sitei133Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: UniProtKB-EC
  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-34220-MONOMER.
BRENDAi3.1.3.48. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
PTPase
Gene namesi
Name:LTP1
Ordered Locus Names:YPR073C
ORF Names:YP9499.28C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR073C.
SGDiS000006277. LTP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465651 – 161Low molecular weight phosphotyrosine protein phosphataseAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40347.
PRIDEiP40347.

PTM databases

iPTMnetiP40347.

Interactioni

Protein-protein interaction databases

BioGridi36246. 22 interactors.
DIPiDIP-6559N.
MINTiMINT-689803.

Chemistry databases

BindingDBiP40347.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 19Combined sources12
Helixi20 – 34Combined sources15
Helixi38 – 40Combined sources3
Beta strandi41 – 50Combined sources10
Turni52 – 55Combined sources4
Helixi60 – 68Combined sources9
Helixi82 – 86Combined sources5
Beta strandi89 – 95Combined sources7
Helixi96 – 105Combined sources10
Beta strandi113 – 116Combined sources4
Helixi117 – 120Combined sources4
Beta strandi124 – 127Combined sources4
Helixi139 – 160Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D1PX-ray2.20A/B2-161[»]
1D1QX-ray1.70A/B1-161[»]
1D2AX-ray1.90A/B2-161[»]
ProteinModelPortaliP40347.
SMRiP40347.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40347.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
InParanoidiP40347.
KOiK14394.
OMAiENKWRID.
OrthoDBiEOG092C5FEA.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P40347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEKPKISV AFICLGNFCR SPMAEAIFKH EVEKANLENR FNKIDSFGTS
60 70 80 90 100
NYHVGESPDH RTVSICKQHG VKINHKGKQI KTKHFDEYDY IIGMDESNIN
110 120 130 140 150
NLKKIQPEGS KAKVCLFGDW NTNDGTVQTI IEDPWYGDIQ DFEYNFKQIT
160
YFSKQFLKKE L
Length:161
Mass (Da):18,675
Last modified:February 1, 1995 - v1
Checksum:i0911F4B85C050AB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11057 mRNA. Translation: AAA99546.1.
L48604 Genomic DNA. Translation: AAA80146.1.
Z49219 Genomic DNA. Translation: CAA89190.1.
Z71255 Genomic DNA. Translation: CAA94981.1.
U51033 Genomic DNA. Translation: AAB68124.1.
AY692891 Genomic DNA. Translation: AAT92910.1.
BK006949 Genomic DNA. Translation: DAA11493.1.
PIRiA57390.
RefSeqiNP_015398.1. NM_001184170.1.

Genome annotation databases

EnsemblFungiiYPR073C; YPR073C; YPR073C.
GeneIDi856187.
KEGGisce:YPR073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11057 mRNA. Translation: AAA99546.1.
L48604 Genomic DNA. Translation: AAA80146.1.
Z49219 Genomic DNA. Translation: CAA89190.1.
Z71255 Genomic DNA. Translation: CAA94981.1.
U51033 Genomic DNA. Translation: AAB68124.1.
AY692891 Genomic DNA. Translation: AAT92910.1.
BK006949 Genomic DNA. Translation: DAA11493.1.
PIRiA57390.
RefSeqiNP_015398.1. NM_001184170.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D1PX-ray2.20A/B2-161[»]
1D1QX-ray1.70A/B1-161[»]
1D2AX-ray1.90A/B2-161[»]
ProteinModelPortaliP40347.
SMRiP40347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36246. 22 interactors.
DIPiDIP-6559N.
MINTiMINT-689803.

Chemistry databases

BindingDBiP40347.
ChEMBLiCHEMBL5397.

PTM databases

iPTMnetiP40347.

Proteomic databases

MaxQBiP40347.
PRIDEiP40347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR073C; YPR073C; YPR073C.
GeneIDi856187.
KEGGisce:YPR073C.

Organism-specific databases

EuPathDBiFungiDB:YPR073C.
SGDiS000006277. LTP1.

Phylogenomic databases

GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
InParanoidiP40347.
KOiK14394.
OMAiENKWRID.
OrthoDBiEOG092C5FEA.

Enzyme and pathway databases

BioCyciYEAST:G3O-34220-MONOMER.
BRENDAi3.1.3.48. 984.

Miscellaneous databases

EvolutionaryTraceiP40347.
PROiP40347.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPAL_YEAST
AccessioniPrimary (citable) accession number: P40347
Secondary accession number(s): D6W477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.