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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

LTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Miscellaneous

Present with 3500 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophileBy similarity1
Active sitei20By similarity1
Active sitei133Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: UniProtKB-EC
  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-34220-MONOMER
BRENDAi3.1.3.48 984

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
PTPase
Gene namesi
Name:LTP1
Ordered Locus Names:YPR073C
ORF Names:YP9499.28C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YPR073C
SGDiS000006277 LTP1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5397

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465651 – 161Low molecular weight phosphotyrosine protein phosphataseAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40347
PaxDbiP40347
PRIDEiP40347

PTM databases

iPTMnetiP40347

Interactioni

Protein-protein interaction databases

BioGridi36246, 74 interactors
DIPiDIP-6559N
IntActiP40347, 1 interactor
STRINGi4932.YPR073C

Chemistry databases

BindingDBiP40347

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 19Combined sources12
Helixi20 – 34Combined sources15
Helixi38 – 40Combined sources3
Beta strandi41 – 50Combined sources10
Turni52 – 55Combined sources4
Helixi60 – 68Combined sources9
Helixi82 – 86Combined sources5
Beta strandi89 – 95Combined sources7
Helixi96 – 105Combined sources10
Beta strandi113 – 116Combined sources4
Helixi117 – 120Combined sources4
Beta strandi124 – 127Combined sources4
Helixi139 – 160Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D1PX-ray2.20A/B2-161[»]
1D1QX-ray1.70A/B1-161[»]
1D2AX-ray1.90A/B2-161[»]
ProteinModelPortaliP40347
SMRiP40347
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40347

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00500000044891
HOGENOMiHOG000273094
InParanoidiP40347
KOiK14394
OMAiAGTGSWH
OrthoDBiEOG092C5FEA

Family and domain databases

InterProiView protein in InterPro
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
IPR017867 Tyr_phospatase_low_mol_wt
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
PRINTSiPR00719 LMWPTPASE
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit

Sequencei

Sequence statusi: Complete.

P40347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEKPKISV AFICLGNFCR SPMAEAIFKH EVEKANLENR FNKIDSFGTS
60 70 80 90 100
NYHVGESPDH RTVSICKQHG VKINHKGKQI KTKHFDEYDY IIGMDESNIN
110 120 130 140 150
NLKKIQPEGS KAKVCLFGDW NTNDGTVQTI IEDPWYGDIQ DFEYNFKQIT
160
YFSKQFLKKE L
Length:161
Mass (Da):18,675
Last modified:February 1, 1995 - v1
Checksum:i0911F4B85C050AB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11057 mRNA Translation: AAA99546.1
L48604 Genomic DNA Translation: AAA80146.1
Z49219 Genomic DNA Translation: CAA89190.1
Z71255 Genomic DNA Translation: CAA94981.1
U51033 Genomic DNA Translation: AAB68124.1
AY692891 Genomic DNA Translation: AAT92910.1
BK006949 Genomic DNA Translation: DAA11493.1
PIRiA57390
RefSeqiNP_015398.1, NM_001184170.1

Genome annotation databases

EnsemblFungiiYPR073C; YPR073C; YPR073C
GeneIDi856187
KEGGisce:YPR073C

Similar proteinsi

Entry informationi

Entry nameiPPAL_YEAST
AccessioniPrimary (citable) accession number: P40347
Secondary accession number(s): D6W477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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