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P40347

- PPAL_YEAST

UniProt

P40347 - PPAL_YEAST

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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene
LTP1, YPR073C, YP9499.28C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141Nucleophile By similarity
Active sitei20 – 201 By similarity
Active sitei133 – 1331Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-34220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
PTPase
Gene namesi
Name:LTP1
Ordered Locus Names:YPR073C
ORF Names:YP9499.28C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR073c.
SGDiS000006277. LTP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Low molecular weight phosphotyrosine protein phosphatasePRO_0000046565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40347.
PaxDbiP40347.
PeptideAtlasiP40347.

Expressioni

Gene expression databases

GenevestigatoriP40347.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MOT1P323331EBI-13757,EBI-11152

Protein-protein interaction databases

BioGridi36246. 23 interactions.
DIPiDIP-6559N.
MINTiMINT-689803.
STRINGi4932.YPR073C.

Structurei

Secondary structure

1
161
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 1912
Helixi20 – 3415
Helixi38 – 403
Beta strandi41 – 5010
Turni52 – 554
Helixi60 – 689
Helixi82 – 865
Beta strandi89 – 957
Helixi96 – 10510
Beta strandi113 – 1164
Helixi117 – 1204
Beta strandi124 – 1274
Helixi139 – 16022

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D1PX-ray2.20A/B2-161[»]
1D1QX-ray1.70A/B1-161[»]
1D2AX-ray1.90A/B2-161[»]
ProteinModelPortaliP40347.
SMRiP40347. Positions 5-161.

Miscellaneous databases

EvolutionaryTraceiP40347.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
KOiK14394.
OMAiEIMSADL.
OrthoDBiEOG7P2Z4K.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P40347-1 [UniParc]FASTAAdd to Basket

« Hide

MTIEKPKISV AFICLGNFCR SPMAEAIFKH EVEKANLENR FNKIDSFGTS    50
NYHVGESPDH RTVSICKQHG VKINHKGKQI KTKHFDEYDY IIGMDESNIN 100
NLKKIQPEGS KAKVCLFGDW NTNDGTVQTI IEDPWYGDIQ DFEYNFKQIT 150
YFSKQFLKKE L 161
Length:161
Mass (Da):18,675
Last modified:February 1, 1995 - v1
Checksum:i0911F4B85C050AB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11057 mRNA. Translation: AAA99546.1.
L48604 Genomic DNA. Translation: AAA80146.1.
Z49219 Genomic DNA. Translation: CAA89190.1.
Z71255 Genomic DNA. Translation: CAA94981.1.
U51033 Genomic DNA. Translation: AAB68124.1.
AY692891 Genomic DNA. Translation: AAT92910.1.
BK006949 Genomic DNA. Translation: DAA11493.1.
PIRiA57390.
RefSeqiNP_015398.1. NM_001184170.1.

Genome annotation databases

EnsemblFungiiYPR073C; YPR073C; YPR073C.
GeneIDi856187.
KEGGisce:YPR073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11057 mRNA. Translation: AAA99546.1 .
L48604 Genomic DNA. Translation: AAA80146.1 .
Z49219 Genomic DNA. Translation: CAA89190.1 .
Z71255 Genomic DNA. Translation: CAA94981.1 .
U51033 Genomic DNA. Translation: AAB68124.1 .
AY692891 Genomic DNA. Translation: AAT92910.1 .
BK006949 Genomic DNA. Translation: DAA11493.1 .
PIRi A57390.
RefSeqi NP_015398.1. NM_001184170.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D1P X-ray 2.20 A/B 2-161 [» ]
1D1Q X-ray 1.70 A/B 1-161 [» ]
1D2A X-ray 1.90 A/B 2-161 [» ]
ProteinModelPortali P40347.
SMRi P40347. Positions 5-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36246. 23 interactions.
DIPi DIP-6559N.
MINTi MINT-689803.
STRINGi 4932.YPR073C.

Chemistry

BindingDBi P40347.
ChEMBLi CHEMBL5397.
DrugBanki DB00173. Adenine.

Proteomic databases

MaxQBi P40347.
PaxDbi P40347.
PeptideAtlasi P40347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR073C ; YPR073C ; YPR073C .
GeneIDi 856187.
KEGGi sce:YPR073C.

Organism-specific databases

CYGDi YPR073c.
SGDi S000006277. LTP1.

Phylogenomic databases

eggNOGi COG0394.
GeneTreei ENSGT00500000044891.
HOGENOMi HOG000273094.
KOi K14394.
OMAi EIMSADL.
OrthoDBi EOG7P2Z4K.

Enzyme and pathway databases

BioCyci YEAST:G3O-34220-MONOMER.

Miscellaneous databases

EvolutionaryTracei P40347.
NextBioi 981369.
PROi P40347.

Gene expression databases

Genevestigatori P40347.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase."
    Ostanin K., Pokalsky C., Wang S., van Etten R.L.
    J. Biol. Chem. 270:18491-18499(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Y133.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPAL_YEAST
AccessioniPrimary (citable) accession number: P40347
Secondary accession number(s): D6W477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3500 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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