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Protein

Tat-binding homolog 7

Gene

YTA7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi454 – 4618ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: SGD
  • histone binding Source: SGD

GO - Biological processi

  • negative regulation of chromatin silencing Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of invasive growth in response to glucose limitation Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30936-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tat-binding homolog 7
Gene namesi
Name:YTA7
Ordered Locus Names:YGR270W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR270W.
SGDiS000003502. YTA7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • extrinsic component of endoplasmic reticulum membrane Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 13791378Tat-binding homolog 7PRO_0000084771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei11 – 111PhosphoserineCombined sources
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei212 – 2121PhosphothreonineCombined sources
Modified residuei229 – 2291PhosphothreonineCombined sources
Modified residuei241 – 2411PhosphoserineCombined sources
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei285 – 2851PhosphoserineCombined sources
Modified residuei367 – 3671PhosphoserineCombined sources
Modified residuei369 – 3691PhosphoserineCombined sources
Modified residuei370 – 3701PhosphoserineCombined sources
Modified residuei735 – 7351PhosphoserineCombined sources
Modified residuei1142 – 11421PhosphoserineCombined sources
Modified residuei1256 – 12561PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40340.

PTM databases

iPTMnetiP40340.

Interactioni

GO - Molecular functioni

  • histone binding Source: SGD

Protein-protein interaction databases

BioGridi33519. 302 interactions.
DIPiDIP-6557N.
IntActiP40340. 85 interactions.
MINTiMINT-629064.

Structurei

3D structure databases

ProteinModelPortaliP40340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1044 – 108643Bromo; divergentPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1395Poly-Glu
Compositional biasi157 – 1604Poly-Arg
Compositional biasi358 – 3614Poly-Asn
Compositional biasi390 – 3956Poly-Lys
Compositional biasi737 – 7404Poly-Glu

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

GeneTreeiENSGT00550000074694.
HOGENOMiHOG000157282.
InParanoidiP40340.
OMAiNGYYSEP.
OrthoDBiEOG092C06QF.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNLRNRRG SDVEDASNAK VGYETQIKDE NGIIHTTTRS LRKINYAEIE
60 70 80 90 100
KVFDFLEDDQ VMDKDETPVD VTSDEHHNNN QKGDDEDDDV DLVSPHENAR
110 120 130 140 150
TNEELTNERN LRKRKAHDPE EDDESFHEED VDDDEEEEEA DEFEDEYLDE
160 170 180 190 200
DSKDNNRRRR AADRKFVVPD PDDDEEYDED DEEGDRISHS ASSKRLKRAN
210 220 230 240 250
SRRTRSSRHP ETPPPVRRAL RSRTRHSRTS NEENDDENDN SRNEALTLAD
260 270 280 290 300
EIRELQEDSP IREKRFLRER TKPVNYKLPP PLTASNAEEF IDKNNNALSF
310 320 330 340 350
HNPSPARRGR GGWNASQNSG PTRRLFPTGG PFGGNDVTTI FGKNTNFYNQ
360 370 380 390 400
VPSAFSDNNN NKLILDSDSS DDEILPLGVT PKTKKENTQK KKKKKPEIAD
410 420 430 440 450
LDPLGVDMNV NFDDIGGLDN YIDQLKEMVA LPLLYPELYQ NFNITPPRGV
460 470 480 490 500
LFHGPPGTGK TLMARALAAS CSSDERKITF FMRKGADILS KWVGEAERQL
510 520 530 540 550
RLLFEEAKKH QPSIIFFDEI DGLAPVRSSK QEQIHASIVS TLLALMDGMD
560 570 580 590 600
NRGQVIVIGA TNRPDAVDPA LRRPGRFDRE FYFPLPDVKA RFKILQIQTR
610 620 630 640 650
KWSSPLSTNF IDKLAFLTKG YGGADLRSLC TEAALISIQR SFPQIYRSND
660 670 680 690 700
KLLVDPSKIK VKVSDFMLAL KKIVPSSARS TGSSPQPLPE LIKPLLADQL
710 720 730 740 750
NNLKNKLDYM LNIKDTTFQR NTSLLQNFID YEEYSGEEEE HDKYGGNEDT
760 770 780 790 800
SSFRSYEFFE SMAESQICKP RLLINGPKGN GQQYVGAAIL NYLEEFNVQN
810 820 830 840 850
LDLASLVSES SRTIEAAVVQ SFMEAKKRQP SVVFIPNLDI WINTIPENVI
860 870 880 890 900
LVLSGLFRSL QSNEKILLLC LAENLDISEV KNGILSDFAF DKNIFQLHKP
910 920 930 940 950
SKENITRYFS NLIELLKTKP SDIPMKKRRV KPLPELQKVT SNAAPTNFDE
960 970 980 990 1000
NGEPLSEKVV LRRKLKSFQH QDMRLKNVLK IKLSGLMDLF KNRYKRFRKP
1010 1020 1030 1040 1050
PIDDAFLVHL FEPETSNDPN WQPAYIKDEN MILEVSTGRK FFNMDLDIVE
1060 1070 1080 1090 1100
ERLWNGYYSE PKQFLKDIEL IYRDANTIGD RERVIKASEM FANAQMGIEE
1110 1120 1130 1140 1150
ISTPDFIQEC KATRQRDLER QELFLEDEEK RAAMELEAKE QSQENILQEP
1160 1170 1180 1190 1200
DLKDNKANEF GVAAGNQLQA QLQTTINTAS IVNNSEVPQP IDTNLYKKEI
1210 1220 1230 1240 1250
PAAIPSAVDK EKAVIPEDSG ANEEYTTELI QATCTSEITT DDDERARKEP
1260 1270 1280 1290 1300
KENEDSLQTQ VTEENFSKID ANTNNINHVK EIQSVNKPNS LHETVEKRER
1310 1320 1330 1340 1350
SPIPKEVVEP EQGKKSDKEL ILTPEQIKKV SACLIEHCQN FTVSQLEDVH
1360 1370
SSVAKIIWKS KSAWDKTGTV DEIIKFLSE
Length:1,379
Mass (Da):157,407
Last modified:October 1, 1996 - v2
Checksum:i31D1F6F87E62E04F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701D → E in CAA56963 (PubMed:7754704).Curated
Sequence conflicti241 – 2411S → N in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1016 – 10161S → N in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1142 – 11421S → N in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1153 – 11531K → E in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1250 – 12501P → L in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1276 – 12761I → R in CAA56963 (PubMed:7754704).Curated
Sequence conflicti1283 – 12831Q → P in CAA56963 (PubMed:7754704).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81072 Genomic DNA. Translation: CAA56963.1.
Y07893 Genomic DNA. Translation: CAA69201.1.
Z73055 Genomic DNA. Translation: CAA97300.1.
BK006941 Genomic DNA. Translation: DAA08358.1.
PIRiS64603.
RefSeqiNP_011786.1. NM_001181399.1.

Genome annotation databases

EnsemblFungiiYGR270W; YGR270W; YGR270W.
GeneIDi853186.
KEGGisce:YGR270W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81072 Genomic DNA. Translation: CAA56963.1.
Y07893 Genomic DNA. Translation: CAA69201.1.
Z73055 Genomic DNA. Translation: CAA97300.1.
BK006941 Genomic DNA. Translation: DAA08358.1.
PIRiS64603.
RefSeqiNP_011786.1. NM_001181399.1.

3D structure databases

ProteinModelPortaliP40340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33519. 302 interactions.
DIPiDIP-6557N.
IntActiP40340. 85 interactions.
MINTiMINT-629064.

PTM databases

iPTMnetiP40340.

Proteomic databases

MaxQBiP40340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR270W; YGR270W; YGR270W.
GeneIDi853186.
KEGGisce:YGR270W.

Organism-specific databases

EuPathDBiFungiDB:YGR270W.
SGDiS000003502. YTA7.

Phylogenomic databases

GeneTreeiENSGT00550000074694.
HOGENOMiHOG000157282.
InParanoidiP40340.
OMAiNGYYSEP.
OrthoDBiEOG092C06QF.

Enzyme and pathway databases

BioCyciYEAST:G3O-30936-MONOMER.

Miscellaneous databases

PROiP40340.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP7_YEAST
AccessioniPrimary (citable) accession number: P40340
Secondary accession number(s): D6VV47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.