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Protein

Tat-binding homolog 7

Gene

YTA7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi454 – 461ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: SGD
  • histone binding Source: SGD

GO - Biological processi

  • negative regulation of chromatin silencing Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of invasive growth in response to glucose limitation Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30936-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tat-binding homolog 7
Gene namesi
Name:YTA7
Ordered Locus Names:YGR270W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR270W.
SGDiS000003502. YTA7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000847712 – 1379Tat-binding homolog 7Add BLAST1378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei212PhosphothreonineCombined sources1
Modified residuei229PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei1142PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP40340.
PRIDEiP40340.

PTM databases

iPTMnetiP40340.

Interactioni

GO - Molecular functioni

  • histone binding Source: SGD

Protein-protein interaction databases

BioGridi33519. 559 interactors.
DIPiDIP-6557N.
IntActiP40340. 88 interactors.
MINTiMINT-629064.
STRINGi4932.YGR270W.

Structurei

3D structure databases

ProteinModelPortaliP40340.
SMRiP40340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1044 – 1086Bromo; divergentPROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 139Poly-Glu5
Compositional biasi157 – 160Poly-Arg4
Compositional biasi358 – 361Poly-Asn4
Compositional biasi390 – 395Poly-Lys6
Compositional biasi737 – 740Poly-Glu4

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Bromodomain

Phylogenomic databases

GeneTreeiENSGT00550000074694.
HOGENOMiHOG000157282.
InParanoidiP40340.
OMAiNGYYSEP.
OrthoDBiEOG092C06QF.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNLRNRRG SDVEDASNAK VGYETQIKDE NGIIHTTTRS LRKINYAEIE
60 70 80 90 100
KVFDFLEDDQ VMDKDETPVD VTSDEHHNNN QKGDDEDDDV DLVSPHENAR
110 120 130 140 150
TNEELTNERN LRKRKAHDPE EDDESFHEED VDDDEEEEEA DEFEDEYLDE
160 170 180 190 200
DSKDNNRRRR AADRKFVVPD PDDDEEYDED DEEGDRISHS ASSKRLKRAN
210 220 230 240 250
SRRTRSSRHP ETPPPVRRAL RSRTRHSRTS NEENDDENDN SRNEALTLAD
260 270 280 290 300
EIRELQEDSP IREKRFLRER TKPVNYKLPP PLTASNAEEF IDKNNNALSF
310 320 330 340 350
HNPSPARRGR GGWNASQNSG PTRRLFPTGG PFGGNDVTTI FGKNTNFYNQ
360 370 380 390 400
VPSAFSDNNN NKLILDSDSS DDEILPLGVT PKTKKENTQK KKKKKPEIAD
410 420 430 440 450
LDPLGVDMNV NFDDIGGLDN YIDQLKEMVA LPLLYPELYQ NFNITPPRGV
460 470 480 490 500
LFHGPPGTGK TLMARALAAS CSSDERKITF FMRKGADILS KWVGEAERQL
510 520 530 540 550
RLLFEEAKKH QPSIIFFDEI DGLAPVRSSK QEQIHASIVS TLLALMDGMD
560 570 580 590 600
NRGQVIVIGA TNRPDAVDPA LRRPGRFDRE FYFPLPDVKA RFKILQIQTR
610 620 630 640 650
KWSSPLSTNF IDKLAFLTKG YGGADLRSLC TEAALISIQR SFPQIYRSND
660 670 680 690 700
KLLVDPSKIK VKVSDFMLAL KKIVPSSARS TGSSPQPLPE LIKPLLADQL
710 720 730 740 750
NNLKNKLDYM LNIKDTTFQR NTSLLQNFID YEEYSGEEEE HDKYGGNEDT
760 770 780 790 800
SSFRSYEFFE SMAESQICKP RLLINGPKGN GQQYVGAAIL NYLEEFNVQN
810 820 830 840 850
LDLASLVSES SRTIEAAVVQ SFMEAKKRQP SVVFIPNLDI WINTIPENVI
860 870 880 890 900
LVLSGLFRSL QSNEKILLLC LAENLDISEV KNGILSDFAF DKNIFQLHKP
910 920 930 940 950
SKENITRYFS NLIELLKTKP SDIPMKKRRV KPLPELQKVT SNAAPTNFDE
960 970 980 990 1000
NGEPLSEKVV LRRKLKSFQH QDMRLKNVLK IKLSGLMDLF KNRYKRFRKP
1010 1020 1030 1040 1050
PIDDAFLVHL FEPETSNDPN WQPAYIKDEN MILEVSTGRK FFNMDLDIVE
1060 1070 1080 1090 1100
ERLWNGYYSE PKQFLKDIEL IYRDANTIGD RERVIKASEM FANAQMGIEE
1110 1120 1130 1140 1150
ISTPDFIQEC KATRQRDLER QELFLEDEEK RAAMELEAKE QSQENILQEP
1160 1170 1180 1190 1200
DLKDNKANEF GVAAGNQLQA QLQTTINTAS IVNNSEVPQP IDTNLYKKEI
1210 1220 1230 1240 1250
PAAIPSAVDK EKAVIPEDSG ANEEYTTELI QATCTSEITT DDDERARKEP
1260 1270 1280 1290 1300
KENEDSLQTQ VTEENFSKID ANTNNINHVK EIQSVNKPNS LHETVEKRER
1310 1320 1330 1340 1350
SPIPKEVVEP EQGKKSDKEL ILTPEQIKKV SACLIEHCQN FTVSQLEDVH
1360 1370
SSVAKIIWKS KSAWDKTGTV DEIIKFLSE
Length:1,379
Mass (Da):157,407
Last modified:October 1, 1996 - v2
Checksum:i31D1F6F87E62E04F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70D → E in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti241S → N in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1016S → N in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1142S → N in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1153K → E in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1250P → L in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1276I → R in CAA56963 (PubMed:7754704).Curated1
Sequence conflicti1283Q → P in CAA56963 (PubMed:7754704).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81072 Genomic DNA. Translation: CAA56963.1.
Y07893 Genomic DNA. Translation: CAA69201.1.
Z73055 Genomic DNA. Translation: CAA97300.1.
BK006941 Genomic DNA. Translation: DAA08358.1.
PIRiS64603.
RefSeqiNP_011786.1. NM_001181399.1.

Genome annotation databases

EnsemblFungiiYGR270W; YGR270W; YGR270W.
GeneIDi853186.
KEGGisce:YGR270W.

Similar proteinsi

Entry informationi

Entry nameiTBP7_YEAST
AccessioniPrimary (citable) accession number: P40340
Secondary accession number(s): D6VV47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names