Reviewed, UniProtKB/Swiss-Prot P40340 (TBP7_YEAST)

Names and origin

Protein names

Recommended name:
    TAT-binding homolog 7

Gene names

Name:	YTA7
Ordered Locus Names:	YGR270W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	1379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	Present with 172 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the AAA ATPase family. Contains 1 bromo domain.

Ontologies

Keywords
Domain	Bromodomain
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular protein localization Inferred from mutant phenotype. Source: SGD positive regulation of gene-specific transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: SGD positive regulation of isoprenoid metabolic process Inferred from direct assay. Source: SGD
Cellular component	extrinsic to endoplasmic reticulum membrane Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DOC1	P53068	1	EBI-19030,EBI-2603

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1379	1379	TAT-binding homolog 7		PRO_0000084771
Regions
	Domain	1044 – 1086	43	Bromo; divergent
	Nucleotide binding	454 – 461	8	ATP Potential
	Compositional bias	135 – 139	5	Poly-Glu
	Compositional bias	157 – 160	4	Poly-Arg
	Compositional bias	358 – 361	4	Poly-Asn
	Compositional bias	390 – 395	6	Poly-Lys
	Compositional bias	737 – 740	4	Poly-Glu
Amino acid modifications
	Modified residue	11	1	Phosphoserine Ref.7 Ref.8 Ref.9
	Modified residue	17	1	Phosphoserine Ref.7
	Modified residue	94	1	Phosphoserine Ref.6
	Modified residue	212	1	Phosphothreonine Ref.8 Ref.9
	Modified residue	241	1	Phosphoserine Ref.8 Ref.9
	Modified residue	259	1	Phosphoserine Ref.8 Ref.9 Ref.6
	Modified residue	285	1	Phosphoserine Ref.9
	Modified residue	304	1	Phosphoserine Ref.9
	Modified residue	316	1	Phosphoserine Ref.9
	Modified residue	941	1	Phosphoserine Ref.9
	Modified residue	1142	1	Phosphoserine Ref.8 Ref.9
	Modified residue	1256	1	Phosphoserine Ref.9
	Modified residue	1259	1	Phosphothreonine Ref.9
Experimental info
	Sequence conflict	70	1	D → E in CAA56963. Ref.1
	Sequence conflict	241	1	S → N in CAA56963. Ref.1
	Sequence conflict	1016	1	S → N in CAA56963. Ref.1
	Sequence conflict	1142	1	S → N in CAA56963. Ref.1
	Sequence conflict	1153	1	K → E in CAA56963. Ref.1
	Sequence conflict	1250	1	P → L in CAA56963. Ref.1
	Sequence conflict	1276	1	I → R in CAA56963. Ref.1
	Sequence conflict	1283	1	Q → P in CAA56963. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40340-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 31D1F6F87E62E04F	FASTA	1,379	157,407
	10 20 30 40 50 60 MARNLRNRRG SDVEDASNAK VGYETQIKDE NGIIHTTTRS LRKINYAEIE KVFDFLEDDQ 70 80 90 100 110 120 VMDKDETPVD VTSDEHHNNN QKGDDEDDDV DLVSPHENAR TNEELTNERN LRKRKAHDPE 130 140 150 160 170 180 EDDESFHEED VDDDEEEEEA DEFEDEYLDE DSKDNNRRRR AADRKFVVPD PDDDEEYDED 190 200 210 220 230 240 DEEGDRISHS ASSKRLKRAN SRRTRSSRHP ETPPPVRRAL RSRTRHSRTS NEENDDENDN 250 260 270 280 290 300 SRNEALTLAD EIRELQEDSP IREKRFLRER TKPVNYKLPP PLTASNAEEF IDKNNNALSF 310 320 330 340 350 360 HNPSPARRGR GGWNASQNSG PTRRLFPTGG PFGGNDVTTI FGKNTNFYNQ VPSAFSDNNN 370 380 390 400 410 420 NKLILDSDSS DDEILPLGVT PKTKKENTQK KKKKKPEIAD LDPLGVDMNV NFDDIGGLDN 430 440 450 460 470 480 YIDQLKEMVA LPLLYPELYQ NFNITPPRGV LFHGPPGTGK TLMARALAAS CSSDERKITF 490 500 510 520 530 540 FMRKGADILS KWVGEAERQL RLLFEEAKKH QPSIIFFDEI DGLAPVRSSK QEQIHASIVS 550 560 570 580 590 600 TLLALMDGMD NRGQVIVIGA TNRPDAVDPA LRRPGRFDRE FYFPLPDVKA RFKILQIQTR 610 620 630 640 650 660 KWSSPLSTNF IDKLAFLTKG YGGADLRSLC TEAALISIQR SFPQIYRSND KLLVDPSKIK 670 680 690 700 710 720 VKVSDFMLAL KKIVPSSARS TGSSPQPLPE LIKPLLADQL NNLKNKLDYM LNIKDTTFQR 730 740 750 760 770 780 NTSLLQNFID YEEYSGEEEE HDKYGGNEDT SSFRSYEFFE SMAESQICKP RLLINGPKGN 790 800 810 820 830 840 GQQYVGAAIL NYLEEFNVQN LDLASLVSES SRTIEAAVVQ SFMEAKKRQP SVVFIPNLDI 850 860 870 880 890 900 WINTIPENVI LVLSGLFRSL QSNEKILLLC LAENLDISEV KNGILSDFAF DKNIFQLHKP 910 920 930 940 950 960 SKENITRYFS NLIELLKTKP SDIPMKKRRV KPLPELQKVT SNAAPTNFDE NGEPLSEKVV 970 980 990 1000 1010 1020 LRRKLKSFQH QDMRLKNVLK IKLSGLMDLF KNRYKRFRKP PIDDAFLVHL FEPETSNDPN 1030 1040 1050 1060 1070 1080 WQPAYIKDEN MILEVSTGRK FFNMDLDIVE ERLWNGYYSE PKQFLKDIEL IYRDANTIGD 1090 1100 1110 1120 1130 1140 RERVIKASEM FANAQMGIEE ISTPDFIQEC KATRQRDLER QELFLEDEEK RAAMELEAKE 1150 1160 1170 1180 1190 1200 QSQENILQEP DLKDNKANEF GVAAGNQLQA QLQTTINTAS IVNNSEVPQP IDTNLYKKEI 1210 1220 1230 1240 1250 1260 PAAIPSAVDK EKAVIPEDSG ANEEYTTELI QATCTSEITT DDDERARKEP KENEDSLQTQ 1270 1280 1290 1300 1310 1320 VTEENFSKID ANTNNINHVK EIQSVNKPNS LHETVEKRER SPIPKEVVEP EQGKKSDKEL 1330 1340 1350 1360 1370 ILTPEQIKKV SACLIEHCQN FTVSQLEDVH SSVAKIIWKS KSAWDKTGTV DEIIKFLSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex." Schnall R., Mannhaupt G., Stucka R., Tauer R., Ehnle S., Schwarzlose C., Vetter I., Feldmann H. Yeast 10:1141-1155(1994) [PubMed: 7754704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C836.
[2]	Feldmann H. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames." Agostoni Carbone M.L., Lucchini G., Melchioretto P., Nardese V., Vanoni M., Panzeri L. Yeast 14:587-591(1998) [PubMed: 9605509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-259, MASS SPECTROMETRY.
[7]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-17, MASS SPECTROMETRY.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; THR-212; SER-241; SER-259 AND SER-1142, MASS SPECTROMETRY.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; THR-212; SER-241; SER-259; SER-285; SER-304; SER-316; SER-941; SER-1142; SER-1256 AND THR-1259, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81072 Genomic DNA. Translation: CAA56963.1. Y07893 Genomic DNA. Translation: CAA69201.1. Z73055 Genomic DNA. Translation: CAA97300.1.
PIR	S64603.
RefSeq	NP_011786.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6557N.
IntAct	P40340. 6 interactions.
STRING	P40340.
Genome annotation databases
Ensembl	YGR270W; YGR270W; YGR270W; Saccharomyces cerevisiae. [Genome view]
GeneID	853186.
KEGG	sce:YGR270W.
NMPDR	fig|4932.3.peg.2915.
Organism-specific databases
CYGD	YGR270w.
SGD	S000003502. YTA7.
Phylogenomic databases
HOGENOM	HBG756787.
OMA	PELYQNF.
OrthoDB	EOG9QRJM9.
Gene expression databases
ArrayExpress	P40340.
Genevestigator	P40340.
GermOnline	YGR270W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR001487. Bromodomain. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00674. AAA. 1 hit. PS00633. BROMODOMAIN_1. False negative. PS50014. BROMODOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	973329.

Entry information

Entry name

TBP7_YEAST

Accession

Primary (citable) accession number: P40340

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 1, 1996
Last modified:	December 15, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)