Virulence sensor protein BvgS precursor - Bordetella parapertussis

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P40330 (BVGS_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Virulence sensor protein BvgS
EC=2.7.13.3

Gene names

Name:	bvgS
Ordered Locus Names:	BPP3029

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	1238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Post-translational modification	Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain By similarity.
Sequence similarities	Contains 1 histidine kinase domain. Contains 1 HPt domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain. Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Two-component regulatory system Virulence
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro two-component response regulator activity Inferred from electronic annotation. Source: InterPro two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 32

Potential

Chain

33 – 1238

1206

Virulence sensor protein BvgS

PRO_0000032369

Regions

Topological domain

33 – 307

275

Cytoplasmic Potential

Transmembrane

308 – 331

Helical; Potential

Topological domain

332 – 541

210

Periplasmic Potential

Transmembrane

542 – 563

Helical; Potential

Topological domain

564 – 1238

675

Cytoplasmic Potential

Domain

580 – 651

PAS

Domain

652 – 708

PAC

Domain

726 – 948

223

Histidine kinase

Domain

974 – 1095

122

Response regulatory

Domain

1133 – 1228

HPt

Amino acid modifications

Modified residue

729

Phosphohistidine; by autocatalysis By similarity

Modified residue

1023

4-aspartylphosphate By similarity

Modified residue

1172

Phosphohistidine By similarity

Experimental info

Sequence conflict

1067 – 1068

QR → HA in CAA37124. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P40330 [UniParc].

Last modified October 3, 2003. Version 2.
Checksum: 3A0FBF9C5EC17246
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FASTA

1,238

134,819

        10         20         30         40         50         60 
MPAPHRLYPR SLICLAQALL VWALLAWAPA QASQELTLVG KAAVPDVEIA LDGDDWRWLA 

        70         80         90        100        110        120 
RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL GVQAKVLRYP TREQAVGALE 

       130        140        150        160        170        180 
SGQIDLIGTV NGIEGRLQSL RLSVPYAADH PVLVMPIGAR RAPPADLAGQ RLAVDANYLP 

       190        200        210        220        230        240 
RETLQQAYPQ ATLHYFPSSE QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ 

       250        260        270        280        290        300 
IVTGGESFGV RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 

       310        320        330        340        350        360 
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI IGVDTVEELI 

       370        380        390        400        410        420 
AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR QDPAAPADAD HLDGRTIAMV 

       430        440        450        460        470        480 
RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL VADGQADAVV QTQISASYYV NRYFAGKLRI 

       490        500        510        520        530        540 
ASALDLPPAE IALATARGQT ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN 

       550        560        570        580        590        600 
EIYLLIGLGL LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 

       610        620        630        640        650        660 
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM AAEREPRFED 

       670        680        690        700        710        720 
RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA ELLRELHDAK ESADAANRAK 

       730        740        750        760        770        780 
TTFLATMSHE IRTPMNAIIG MLELALLRPA DQEPDRQSIQ VAYDSARSLL ELIGDILDIA 

       790        800        810        820        830        840 
KIEAGKFDLA PVRTALRALP EGAIRLFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV 

       850        860        870        880        890        900 
LSNLVGNAIK FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 

       910        920        930        940        950        960 
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMIE KSAQATPPAA 

       970        980        990       1000       1010       1020 
AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV AADSGEAALA LWHEHAFDVV 

      1030       1040       1050       1060       1070       1080 
ITDCNMPGIN GYELARRIRA AEAAPGYGRT RCILFGFTAS AQMDEAQRCR AAGMDDCLFK 

      1090       1100       1110       1120       1130       1140 
PIGVDALRQR LNEAAARAAL PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL 

      1150       1160       1170       1180       1190       1200 
LEEVIRTNRA DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 

      1210       1220       1230 
AGPSPEIDGL VRTLAAQSAA LETQLRAWLE QRPHQGQP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural and genetic analysis of the bvg locus in Bordetella species." Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R. Mol. Microbiol. 5:2481-2491(1991) [PubMed: 1791760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9305.
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52948 Genomic DNA. Translation: CAA37124.1. BX640432 Genomic DNA. Translation: CAE38319.1.
PIR	S17946.
RefSeq	NP_885214.1. NC_002928.3.
3D structure databases
ProteinModelPortal	P40330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1667276.
GenomeReviews	Gene locus BPP3029 in contig BX470249_GR.
KEGG	bpa:BPP3029.
NMPDR	fig\|257311.1.peg.2848.
PATRIC	21150017. VBIBorPar43418_3184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG640045.
OMA	SFAEAFI.
PhylomeDB	P40330.
ProtClustDB	CLSK920529.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP3029-MONOMER.
BRENDA	2.7.13.3. 898.
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR011006. CheY-like_superfamily. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR013767. PAS_fold. IPR001638. SBP_bac_3. IPR004358. Sig_transdc_His_kin-like_C. IPR008207. Sig_transdc_His_kin_Hpt_dom. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. IPR001789. Sig_transdc_resp-reg_receiver. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:1.20.120.160. Sig_transdc_His_kin_Hpt_dom. 1 hit.
KO	K07679.
Pfam	PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. PF01627. Hpt. 1 hit. PF00989. PAS. 1 hit. PF00072. Response_reg. 1 hit. PF00497. SBP_bac_3. 2 hits. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. SM00073. HPT. 1 hit. SM00091. PAS. 1 hit. SM00062. PBPb. 2 hits. SM00448. REC. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF52172. CheY_like. 1 hit. SSF47384. His_kin_homodim. 1 hit. SSF47226. Hpt. 1 hit.
TIGRFAMs	TIGR00229. Sensory_box. 1 hit.
PROSITE	PS50109. HIS_KIN. 1 hit. PS50894. HPT. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BVGS_BORPA

Accession

Primary (citable) accession number: P40330

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 3, 2003
Last modified:	January 25, 2012
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents