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Protein

Probable 26S protease subunit YTA6

Gene

YTA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi511 – 5188ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33981-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S protease subunit YTA6
Alternative name(s):
Tat-binding homolog 6
Gene namesi
Name:YTA6
Ordered Locus Names:YPL074W
ORF Names:LPF11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL074W.
SGDiS000005995. YTA6.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Probable 26S protease subunit YTA6PRO_0000084759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei255 – 2551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40328.
PRIDEiP40328.
TopDownProteomicsiP40328.

PTM databases

iPTMnetiP40328.

Interactioni

Protein-protein interaction databases

BioGridi36106. 58 interactions.
DIPiDIP-4025N.
IntActiP40328. 6 interactions.
MINTiMINT-546593.

Structurei

3D structure databases

ProteinModelPortaliP40328.
SMRiP40328. Positions 455-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

GeneTreeiENSGT00570000078874.
HOGENOMiHOG000066024.
InParanoidiP40328.
OMAiRYMNERI.
OrthoDBiEOG72JWRT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHEKFSIPE NFTLAQSLQL LYSVVKNQYK NLADLIINSK GNKDTVTYGK
60 70 80 90 100
IHKNLDTLLV YVNEGLRKIE KTYTLKKGLG NLVVDHPELR SIIEDFQILG
110 120 130 140 150
QDIRIARRKA ETLMAEGNGS PSLSSSSSVL GLGTGNGLRF PKLWRMGSKR
160 170 180 190 200
DKLKEADEKE AKINKQADNI RRARKLEEEK KLGAKLQYER DLELQREKLI
210 220 230 240 250
ELKVKEKVEF EVAQKLEEER VKREEEERKH REQAEKKRIS TLKHERKTNY
260 270 280 290 300
KSRASLDNFS SSSKSSGKID NSLIKRRSLD VVRTSGERVR TPVRKSMEAA
310 320 330 340 350
EIGMAAQLAW SQYQNGANHS KVSNNGSHSN ELQIRYKPTP PLKKRYDYKK
360 370 380 390 400
PTVNRPIIKS PTLNRQNSKS SRNIPTNSKL KASKSNTNKV SRRNEQNLEP
410 420 430 440 450
SSPVLVSATA VPAESKPMRS KSGTPDKESS ASSSLDSRKE DILKSVQGVD
460 470 480 490 500
RNACEQILNE ILVTDEKVYW EDIAGLRNAK NSLKEAVVYP FLRPDLFKGL
510 520 530 540 550
REPVRGMLLF GPPGTGKTMI AKAVATESNS TFFSVSASSL LSKYLGESEK
560 570 580 590 600
LVRALFYMAK KLSPSIIFID EIDSMLTARS DNENESSRRI KTELLIQWSS
610 620 630 640 650
LSSATAQSED RNNTLDSRVL VLGATNLPWA IDDAARRRFS RKLYIPLPDY
660 670 680 690 700
ETRLYHLKRL MAKQKNSLQD LDYELITEMT EGFSGSDLTS LAKEAAMEPI
710 720 730 740 750
RDLGDKLMFA DFDKIRGIEI KDFQNALLTI KKSVSSESLQ KYEEWSSKFG

SNGS
Length:754
Mass (Da):85,300
Last modified:September 26, 2001 - v2
Checksum:i709F33D563382356
GO

Sequence cautioni

The sequence CAA56959.1 differs from that shown.Rearrangements.Curated
The sequence CAA56959.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence CAA56960.1 differs from that shown.Rearrangements.Curated
The sequence CAA56960.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201L → LQL in AAA66912 (PubMed:3025612).Curated
Sequence conflicti85 – 851D → I in AAA66912 (PubMed:3025612).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81071 Genomic DNA. Translation: CAA56960.1. Sequence problems.
X81071 Genomic DNA. Translation: CAA56959.1. Sequence problems.
U41849 Genomic DNA. Translation: AAB68264.1.
M14145 Genomic DNA. Translation: AAA66912.1.
BK006949 Genomic DNA. Translation: DAA11358.1.
PIRiS61113.
RefSeqiNP_015251.1. NM_001183888.1.

Genome annotation databases

EnsemblFungiiYPL074W; YPL074W; YPL074W.
GeneIDi856031.
KEGGisce:YPL074W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81071 Genomic DNA. Translation: CAA56960.1. Sequence problems.
X81071 Genomic DNA. Translation: CAA56959.1. Sequence problems.
U41849 Genomic DNA. Translation: AAB68264.1.
M14145 Genomic DNA. Translation: AAA66912.1.
BK006949 Genomic DNA. Translation: DAA11358.1.
PIRiS61113.
RefSeqiNP_015251.1. NM_001183888.1.

3D structure databases

ProteinModelPortaliP40328.
SMRiP40328. Positions 455-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36106. 58 interactions.
DIPiDIP-4025N.
IntActiP40328. 6 interactions.
MINTiMINT-546593.

PTM databases

iPTMnetiP40328.

Proteomic databases

MaxQBiP40328.
PRIDEiP40328.
TopDownProteomicsiP40328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL074W; YPL074W; YPL074W.
GeneIDi856031.
KEGGisce:YPL074W.

Organism-specific databases

EuPathDBiFungiDB:YPL074W.
SGDiS000005995. YTA6.

Phylogenomic databases

GeneTreeiENSGT00570000078874.
HOGENOMiHOG000066024.
InParanoidiP40328.
OMAiRYMNERI.
OrthoDBiEOG72JWRT.

Enzyme and pathway databases

BioCyciYEAST:G3O-33981-MONOMER.

Miscellaneous databases

NextBioi980956.
PROiP40328.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex."
    Schnall R., Mannhaupt G., Stucka R., Tauer R., Ehnle S., Schwarzlose C., Vetter I., Feldmann H.
    Yeast 10:1141-1155(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Glycolytic gene expression in Saccharomyces cerevisiae: nucleotide sequence of GCR1, null mutants, and evidence for expression."
    Baker H.V.
    Mol. Cell. Biol. 6:3774-3784(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTBP6_YEAST
AccessioniPrimary (citable) accession number: P40328
Secondary accession number(s): D6W3U2
, P40324, Q02845, Q05773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 26, 2001
Last modified: May 11, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.