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Protein

Probable 26S proteasome subunit YTA6

Gene

YTA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi511 – 518ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33981-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome subunit YTA6
Alternative name(s):
Tat-binding homolog 6
Gene namesi
Name:YTA6
Ordered Locus Names:YPL074W
ORF Names:LPF11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL074W.
SGDiS000005995. YTA6.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: SGD
  • nucleus Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847591 – 754Probable 26S proteasome subunit YTA6Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40328.
PRIDEiP40328.
TopDownProteomicsiP40328.

PTM databases

iPTMnetiP40328.

Interactioni

Protein-protein interaction databases

BioGridi36106. 174 interactors.
DIPiDIP-4025N.
IntActiP40328. 6 interactors.
MINTiMINT-546593.
STRINGi4932.YPL074W.

Structurei

3D structure databases

ProteinModelPortaliP40328.
SMRiP40328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

GeneTreeiENSGT00570000078874.
HOGENOMiHOG000066024.
InParanoidiP40328.
OMAiALFYMAK.
OrthoDBiEOG092C2QJ3.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

P40328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHEKFSIPE NFTLAQSLQL LYSVVKNQYK NLADLIINSK GNKDTVTYGK
60 70 80 90 100
IHKNLDTLLV YVNEGLRKIE KTYTLKKGLG NLVVDHPELR SIIEDFQILG
110 120 130 140 150
QDIRIARRKA ETLMAEGNGS PSLSSSSSVL GLGTGNGLRF PKLWRMGSKR
160 170 180 190 200
DKLKEADEKE AKINKQADNI RRARKLEEEK KLGAKLQYER DLELQREKLI
210 220 230 240 250
ELKVKEKVEF EVAQKLEEER VKREEEERKH REQAEKKRIS TLKHERKTNY
260 270 280 290 300
KSRASLDNFS SSSKSSGKID NSLIKRRSLD VVRTSGERVR TPVRKSMEAA
310 320 330 340 350
EIGMAAQLAW SQYQNGANHS KVSNNGSHSN ELQIRYKPTP PLKKRYDYKK
360 370 380 390 400
PTVNRPIIKS PTLNRQNSKS SRNIPTNSKL KASKSNTNKV SRRNEQNLEP
410 420 430 440 450
SSPVLVSATA VPAESKPMRS KSGTPDKESS ASSSLDSRKE DILKSVQGVD
460 470 480 490 500
RNACEQILNE ILVTDEKVYW EDIAGLRNAK NSLKEAVVYP FLRPDLFKGL
510 520 530 540 550
REPVRGMLLF GPPGTGKTMI AKAVATESNS TFFSVSASSL LSKYLGESEK
560 570 580 590 600
LVRALFYMAK KLSPSIIFID EIDSMLTARS DNENESSRRI KTELLIQWSS
610 620 630 640 650
LSSATAQSED RNNTLDSRVL VLGATNLPWA IDDAARRRFS RKLYIPLPDY
660 670 680 690 700
ETRLYHLKRL MAKQKNSLQD LDYELITEMT EGFSGSDLTS LAKEAAMEPI
710 720 730 740 750
RDLGDKLMFA DFDKIRGIEI KDFQNALLTI KKSVSSESLQ KYEEWSSKFG

SNGS
Length:754
Mass (Da):85,300
Last modified:September 26, 2001 - v2
Checksum:i709F33D563382356
GO

Sequence cautioni

The sequence CAA56959 differs from that shown. Rearrangements.Curated
The sequence CAA56959 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAA56960 differs from that shown. Rearrangements.Curated
The sequence CAA56960 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20L → LQL in AAA66912 (PubMed:3025612).Curated1
Sequence conflicti85D → I in AAA66912 (PubMed:3025612).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81071 Genomic DNA. Translation: CAA56960.1. Sequence problems.
X81071 Genomic DNA. Translation: CAA56959.1. Sequence problems.
U41849 Genomic DNA. Translation: AAB68264.1.
M14145 Genomic DNA. Translation: AAA66912.1.
BK006949 Genomic DNA. Translation: DAA11358.1.
PIRiS61113.
RefSeqiNP_015251.1. NM_001183888.1.

Genome annotation databases

EnsemblFungiiYPL074W; YPL074W; YPL074W.
GeneIDi856031.
KEGGisce:YPL074W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTBP6_YEAST
AccessioniPrimary (citable) accession number: P40328
Secondary accession number(s): D6W3U2
, P40324, Q02845, Q05773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 26, 2001
Last modified: July 5, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names