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Protein

Proline-rich protein HUA1

Gene

HUA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in assembly and disassembly of the actin cytoskeleton.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-30935-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein HUA1
Gene namesi
Name:HUA1
Ordered Locus Names:YGR268C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR268c.
SGDiS000003500. HUA1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 198197Proline-rich protein HUA1PRO_0000202865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Cross-linki3 – 3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki18 – 18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP40325.
PaxDbiP40325.
PeptideAtlasiP40325.

Expressioni

Gene expression databases

GenevestigatoriP40325.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSB3P436035EBI-23614,EBI-22980
YSC84P327933EBI-23614,EBI-24460

Protein-protein interaction databases

BioGridi33518. 24 interactions.
DIPiDIP-1987N.
IntActiP40325. 12 interactions.
MINTiMINT-411559.
STRINGi4932.YGR268C.

Structurei

3D structure databases

ProteinModelPortaliP40325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 9266Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the HUA1 family.Curated

Phylogenomic databases

eggNOGiNOG87920.
HOGENOMiHOG000000943.
InParanoidiP40325.
OrthoDBiEOG75QRG4.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40325-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKDTHDDEL PSYEDVIKEE ERLQSQPPRP PRPAANLAQG HQSRPHQRPS
60 70 80 90 100
TMPATSSSQT YAHSHSYTPT SSQPRPPPRP QQNPSLPWTY PPRFYCSKCG
110 120 130 140 150
NTGYKLKNGR SCKSCWRRFA PQNNVVSAPT YYTNYTMPVY TNAWQGNRPL
160 170 180 190
YVQPGDPRLG GVLCGECRGS GRTRFLLDED ICPLCHGVGR IITQPQRY
Length:198
Mass (Da):22,435
Last modified:October 1, 1996 - v2
Checksum:i78029FD484168793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07893 Genomic DNA. Translation: CAA69199.1.
Z73053 Genomic DNA. Translation: CAA97298.1.
AY558512 Genomic DNA. Translation: AAS56838.1.
X81072 Genomic DNA. Translation: CAA56961.1.
BK006941 Genomic DNA. Translation: DAA08357.1.
PIRiS64601.
RefSeqiNP_011784.3. NM_001181397.3.

Genome annotation databases

EnsemblFungiiYGR268C; YGR268C; YGR268C.
GeneIDi853185.
KEGGisce:YGR268C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07893 Genomic DNA. Translation: CAA69199.1.
Z73053 Genomic DNA. Translation: CAA97298.1.
AY558512 Genomic DNA. Translation: AAS56838.1.
X81072 Genomic DNA. Translation: CAA56961.1.
BK006941 Genomic DNA. Translation: DAA08357.1.
PIRiS64601.
RefSeqiNP_011784.3. NM_001181397.3.

3D structure databases

ProteinModelPortaliP40325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33518. 24 interactions.
DIPiDIP-1987N.
IntActiP40325. 12 interactions.
MINTiMINT-411559.
STRINGi4932.YGR268C.

Proteomic databases

MaxQBiP40325.
PaxDbiP40325.
PeptideAtlasiP40325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR268C; YGR268C; YGR268C.
GeneIDi853185.
KEGGisce:YGR268C.

Organism-specific databases

CYGDiYGR268c.
SGDiS000003500. HUA1.

Phylogenomic databases

eggNOGiNOG87920.
HOGENOMiHOG000000943.
InParanoidiP40325.
OrthoDBiEOG75QRG4.

Enzyme and pathway databases

BioCyciYEAST:G3O-30935-MONOMER.

Miscellaneous databases

NextBioi973326.

Gene expression databases

GenevestigatoriP40325.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames."
    Agostoni Carbone M.L., Lucchini G., Melchioretto P., Nardese V., Vanoni M., Panzeri L.
    Yeast 14:587-591(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex."
    Schnall R., Mannhaupt G., Stucka R., Tauer R., Ehnle S., Schwarzlose C., Vetter I., Feldmann H.
    Yeast 10:1141-1155(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-156.
    Strain: C836.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-3 AND LYS-18.
    Strain: SUB592.
  8. "Predicting protein functions from redundancies in large-scale protein interaction networks."
    Samanta M.P., Liang S.
    Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHUA1_YEAST
AccessioniPrimary (citable) accession number: P40325
Secondary accession number(s): D6VV46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.