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P40325

- HUA1_YEAST

UniProt

P40325 - HUA1_YEAST

Protein

Proline-rich protein HUA1

Gene

HUA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May be involved in assembly and disassembly of the actin cytoskeleton.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30935-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich protein HUA1
    Gene namesi
    Name:HUA1
    Ordered Locus Names:YGR268C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR268c.
    SGDiS000003500. HUA1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 198197Proline-rich protein HUA1PRO_0000202865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Cross-linki3 – 3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki18 – 18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP40325.
    PaxDbiP40325.
    PeptideAtlasiP40325.

    Expressioni

    Gene expression databases

    GenevestigatoriP40325.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSB3P436035EBI-23614,EBI-22980
    YSC84P327933EBI-23614,EBI-24460

    Protein-protein interaction databases

    BioGridi33518. 23 interactions.
    DIPiDIP-1987N.
    IntActiP40325. 12 interactions.
    MINTiMINT-411559.
    STRINGi4932.YGR268C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 9266Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HUA1 family.Curated

    Phylogenomic databases

    eggNOGiNOG87920.
    HOGENOMiHOG000000943.
    OMAiMILINTR.
    OrthoDBiEOG75QRG4.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40325-1 [UniParc]FASTAAdd to Basket

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    MSKDTHDDEL PSYEDVIKEE ERLQSQPPRP PRPAANLAQG HQSRPHQRPS    50
    TMPATSSSQT YAHSHSYTPT SSQPRPPPRP QQNPSLPWTY PPRFYCSKCG 100
    NTGYKLKNGR SCKSCWRRFA PQNNVVSAPT YYTNYTMPVY TNAWQGNRPL 150
    YVQPGDPRLG GVLCGECRGS GRTRFLLDED ICPLCHGVGR IITQPQRY 198
    Length:198
    Mass (Da):22,435
    Last modified:October 1, 1996 - v2
    Checksum:i78029FD484168793
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07893 Genomic DNA. Translation: CAA69199.1.
    Z73053 Genomic DNA. Translation: CAA97298.1.
    AY558512 Genomic DNA. Translation: AAS56838.1.
    X81072 Genomic DNA. Translation: CAA56961.1.
    BK006941 Genomic DNA. Translation: DAA08357.1.
    PIRiS64601.
    RefSeqiNP_011784.3. NM_001181397.3.

    Genome annotation databases

    EnsemblFungiiYGR268C; YGR268C; YGR268C.
    GeneIDi853185.
    KEGGisce:YGR268C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07893 Genomic DNA. Translation: CAA69199.1 .
    Z73053 Genomic DNA. Translation: CAA97298.1 .
    AY558512 Genomic DNA. Translation: AAS56838.1 .
    X81072 Genomic DNA. Translation: CAA56961.1 .
    BK006941 Genomic DNA. Translation: DAA08357.1 .
    PIRi S64601.
    RefSeqi NP_011784.3. NM_001181397.3.

    3D structure databases

    ProteinModelPortali P40325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33518. 23 interactions.
    DIPi DIP-1987N.
    IntActi P40325. 12 interactions.
    MINTi MINT-411559.
    STRINGi 4932.YGR268C.

    Proteomic databases

    MaxQBi P40325.
    PaxDbi P40325.
    PeptideAtlasi P40325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR268C ; YGR268C ; YGR268C .
    GeneIDi 853185.
    KEGGi sce:YGR268C.

    Organism-specific databases

    CYGDi YGR268c.
    SGDi S000003500. HUA1.

    Phylogenomic databases

    eggNOGi NOG87920.
    HOGENOMi HOG000000943.
    OMAi MILINTR.
    OrthoDBi EOG75QRG4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30935-MONOMER.

    Miscellaneous databases

    NextBioi 973326.

    Gene expression databases

    Genevestigatori P40325.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames."
      Agostoni Carbone M.L., Lucchini G., Melchioretto P., Nardese V., Vanoni M., Panzeri L.
      Yeast 14:587-591(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex."
      Schnall R., Mannhaupt G., Stucka R., Tauer R., Ehnle S., Schwarzlose C., Vetter I., Feldmann H.
      Yeast 10:1141-1155(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-156.
      Strain: C836.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-3 AND LYS-18.
      Strain: SUB592.
    8. "Predicting protein functions from redundancies in large-scale protein interaction networks."
      Samanta M.P., Liang S.
      Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHUA1_YEAST
    AccessioniPrimary (citable) accession number: P40325
    Secondary accession number(s): D6VV46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3