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P40319

- ELO3_YEAST

UniProt

P40319 - ELO3_YEAST

Protein

Elongation of fatty acids protein 3

Gene

SUR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Affects plasma membrane H+-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Is essential for the conversion of 24-carbon fatty acids to 26 carbon species.

    Catalytic activityi

    A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

    GO - Molecular functioni

    1. fatty acid elongase activity Source: SGD

    GO - Biological processi

    1. fatty acid biosynthetic process Source: SGD
    2. fatty acid elongation Source: SGD
    3. post-Golgi vesicle-mediated transport Source: SGD
    4. sphingolipid biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17331.
    YEAST:G3O-32441-MONOMER.
    YEAST:MONOMER3O-70.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation of fatty acids protein 3 (EC:2.3.1.199)
    Alternative name(s):
    3-keto acyl-CoA synthase ELO3
    Protein SRE1
    Protein SUR4
    Very-long-chain 3-oxoacyl-CoA synthase 3
    v-SNARE bypass mutant gene 1 protein
    Gene namesi
    Name:SUR4
    Synonyms:APA1, ELO3, SRE1, VBM1
    Ordered Locus Names:YLR372W
    ORF Names:L8039.2
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR372w.
    SGDiS000004364. SUR4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Elongation of fatty acids protein 3PRO_0000207550Add
    BLAST

    Proteomic databases

    MaxQBiP40319.
    PaxDbiP40319.
    PeptideAtlasiP40319.

    Expressioni

    Gene expression databases

    GenevestigatoriP40319.

    Interactioni

    Protein-protein interaction databases

    BioGridi31632. 436 interactions.
    DIPiDIP-4024N.
    IntActiP40319. 55 interactions.
    MINTiMINT-505805.
    STRINGi4932.YLR372W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40319.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7373ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini95 – 10511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini127 – 20781ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 24214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 28320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 34541CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ELO family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305096.
    GeneTreeiENSGT00740000115027.
    HOGENOMiHOG000160635.
    KOiK10246.
    OMAiLIVLYYM.
    OrthoDBiEOG7F51CG.

    Family and domain databases

    InterProiIPR002076. GNS1_SUR4.
    [Graphical view]
    PANTHERiPTHR11157. PTHR11157. 1 hit.
    PfamiPF01151. ELO. 1 hit.
    [Graphical view]
    PROSITEiPS01188. ELO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF    50
    EYFSGYPAEQ FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS 100
    PLKFKLLFEI HNLFLTSISL VLWLLMLEQL VPMVYHNGLF WSICSKEAFA 150
    PKLVTLYYLN YLTKFVELID TVFLVLRRKK LLFLHTYHHG ATALLCYTQL 200
    IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV TRFQIIQFLI 250
    DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI 300
    SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA 345
    Length:345
    Mass (Da):39,465
    Last modified:February 1, 1995 - v1
    Checksum:i1303A9AC54BFFCC5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351E → D in CAA55129. (PubMed:8027068)Curated
    Sequence conflicti208 – 2081W → R in CAA55129. (PubMed:8027068)Curated
    Sequence conflicti330 – 3312ST → FY in CAA55129. (PubMed:8027068)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28723 Genomic DNA. Translation: AAA35134.1.
    X82033 Genomic DNA. Translation: CAA57553.1.
    X78326 Genomic DNA. Translation: CAA55129.1.
    U19103 Genomic DNA. Translation: AAB67563.1.
    AF011409 Genomic DNA. Translation: AAC28398.1.
    BK006945 Genomic DNA. Translation: DAA09675.1.
    PIRiS48517.
    RefSeqiNP_013476.3. NM_001182261.3.

    Genome annotation databases

    EnsemblFungiiYLR372W; YLR372W; YLR372W.
    GeneIDi851087.
    KEGGisce:YLR372W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28723 Genomic DNA. Translation: AAA35134.1 .
    X82033 Genomic DNA. Translation: CAA57553.1 .
    X78326 Genomic DNA. Translation: CAA55129.1 .
    U19103 Genomic DNA. Translation: AAB67563.1 .
    AF011409 Genomic DNA. Translation: AAC28398.1 .
    BK006945 Genomic DNA. Translation: DAA09675.1 .
    PIRi S48517.
    RefSeqi NP_013476.3. NM_001182261.3.

    3D structure databases

    ProteinModelPortali P40319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31632. 436 interactions.
    DIPi DIP-4024N.
    IntActi P40319. 55 interactions.
    MINTi MINT-505805.
    STRINGi 4932.YLR372W.

    Proteomic databases

    MaxQBi P40319.
    PaxDbi P40319.
    PeptideAtlasi P40319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR372W ; YLR372W ; YLR372W .
    GeneIDi 851087.
    KEGGi sce:YLR372W.

    Organism-specific databases

    CYGDi YLR372w.
    SGDi S000004364. SUR4.

    Phylogenomic databases

    eggNOGi NOG305096.
    GeneTreei ENSGT00740000115027.
    HOGENOMi HOG000160635.
    KOi K10246.
    OMAi LIVLYYM.
    OrthoDBi EOG7F51CG.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17331.
    YEAST:G3O-32441-MONOMER.
    YEAST:MONOMER3O-70.

    Miscellaneous databases

    NextBioi 967756.
    PROi P40319.

    Gene expression databases

    Genevestigatori P40319.

    Family and domain databases

    InterProi IPR002076. GNS1_SUR4.
    [Graphical view ]
    PANTHERi PTHR11157. PTHR11157. 1 hit.
    Pfami PF01151. ELO. 1 hit.
    [Graphical view ]
    PROSITEi PS01188. ELO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Revardel E.
      Thesis (1994), University of Bordeaux II, France
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 44827 / SKQ2N.
    2. "The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae."
      Silve S., Leplatois P., Josse A., Dupuy P.-H., Lanau C., Kaghad M., Dhers C., Picard C., Rahier A., Taton M., Le Fur G., Caput D., Ferrara P., Loison G.
      Mol. Cell. Biol. 16:2719-2727(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation."
      Garcia-Arranz M., Maldonado A.M., Mazon M.J., Portillo F.
      J. Biol. Chem. 269:18076-18082(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. "Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast."
      David D., Sundarababu S., Gerst J.E.
      J. Cell Biol. 143:1167-1182(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation."
      Oh C.-S., Toke D.A., Mandala S., Martin C.E.
      J. Biol. Chem. 272:17376-17384(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiELO3_YEAST
    AccessioniPrimary (citable) accession number: P40319
    Secondary accession number(s): D6VZ09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3