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P40319 (ELO3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation of fatty acids protein 3

EC=2.3.1.199
Alternative name(s):
3-keto acyl-CoA synthase ELO3
Protein SRE1
Protein SUR4
Very-long-chain 3-oxoacyl-CoA synthase 3
v-SNARE bypass mutant gene 1 protein
Gene names
Name:SUR4
Synonyms:APA1, ELO3, SRE1, VBM1
Ordered Locus Names:YLR372W
ORF Names:L8039.2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Affects plasma membrane H+-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Is essential for the conversion of 24-carbon fatty acids to 26 carbon species.

Catalytic activity

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the ELO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Elongation of fatty acids protein 3
PRO_0000207550

Regions

Topological domain1 – 7373Extracellular Potential
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 10511Cytoplasmic Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 20781Extracellular Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 24214Cytoplasmic Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 28320Extracellular Potential
Transmembrane284 – 30421Helical; Potential
Topological domain305 – 34541Cytoplasmic Potential

Experimental info

Sequence conflict351E → D in CAA55129. Ref.3
Sequence conflict2081W → R in CAA55129. Ref.3
Sequence conflict330 – 3312ST → FY in CAA55129. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P40319 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1303A9AC54BFFCC5

FASTA34539,465
        10         20         30         40         50         60 
MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF EYFSGYPAEQ 

        70         80         90        100        110        120 
FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS PLKFKLLFEI HNLFLTSISL 

       130        140        150        160        170        180 
VLWLLMLEQL VPMVYHNGLF WSICSKEAFA PKLVTLYYLN YLTKFVELID TVFLVLRRKK 

       190        200        210        220        230        240 
LLFLHTYHHG ATALLCYTQL IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV 

       250        260        270        280        290        300 
TRFQIIQFLI DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI 

       310        320        330        340 
SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA 

« Hide

References

« Hide 'large scale' references
[1]Revardel E.
Thesis (1994), University of Bordeaux II, France
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 44827 / SKQ2N.
[2]"The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae."
Silve S., Leplatois P., Josse A., Dupuy P.-H., Lanau C., Kaghad M., Dhers C., Picard C., Rahier A., Taton M., Le Fur G., Caput D., Ferrara P., Loison G.
Mol. Cell. Biol. 16:2719-2727(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation."
Garcia-Arranz M., Maldonado A.M., Mazon M.J., Portillo F.
J. Biol. Chem. 269:18076-18082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast."
David D., Sundarababu S., Gerst J.E.
J. Cell Biol. 143:1167-1182(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation."
Oh C.-S., Toke D.A., Mandala S., Martin C.E.
J. Biol. Chem. 272:17376-17384(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28723 Genomic DNA. Translation: AAA35134.1.
X82033 Genomic DNA. Translation: CAA57553.1.
X78326 Genomic DNA. Translation: CAA55129.1.
U19103 Genomic DNA. Translation: AAB67563.1.
AF011409 Genomic DNA. Translation: AAC28398.1.
BK006945 Genomic DNA. Translation: DAA09675.1.
PIRS48517.
RefSeqNP_013476.3. NM_001182261.3.

3D structure databases

ProteinModelPortalP40319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31632. 433 interactions.
DIPDIP-4024N.
IntActP40319. 55 interactions.
MINTMINT-505805.
STRING4932.YLR372W.

Proteomic databases

MaxQBP40319.
PaxDbP40319.
PeptideAtlasP40319.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR372W; YLR372W; YLR372W.
GeneID851087.
KEGGsce:YLR372W.

Organism-specific databases

CYGDYLR372w.
SGDS000004364. SUR4.

Phylogenomic databases

eggNOGNOG305096.
GeneTreeENSGT00740000115027.
HOGENOMHOG000160635.
KOK10246.
OMALIVLYYM.
OrthoDBEOG7F51CG.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-17331.
YEAST:G3O-32441-MONOMER.
YEAST:MONOMER3O-70.

Gene expression databases

GenevestigatorP40319.

Family and domain databases

InterProIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERPTHR11157. PTHR11157. 1 hit.
PfamPF01151. ELO. 1 hit.
[Graphical view]
PROSITEPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967756.
PROP40319.

Entry information

Entry nameELO3_YEAST
AccessionPrimary (citable) accession number: P40319
Secondary accession number(s): D6VZ09
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families