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Protein

Chymotrypsin-like protease CTRL-1

Gene

CTRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemBy similarity
Active sitei121 – 1211Charge relay systemBy similarity
Active sitei214 – 2141Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

  • digestion Source: ProtInc
  • proteolysis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.256.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like protease CTRL-1 (EC:3.4.21.-)
Gene namesi
Name:CTRL
Synonyms:CTRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2524. CTRL.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27025.

Chemistry

ChEMBLiCHEMBL4873.

Polymorphism and mutation databases

BioMutaiCTRL.
DMDMi729224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 3315Activation peptideSequence analysisPRO_0000027660Add
BLAST
Chaini34 – 264231Chymotrypsin-like protease CTRL-1PRO_0000027661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 141PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 220PROSITE-ProRule annotation
Disulfide bondi187 ↔ 201PROSITE-ProRule annotation
Disulfide bondi210 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP40313.
PeptideAtlasiP40313.
PRIDEiP40313.

PTM databases

iPTMnetiP40313.
PhosphoSiteiP40313.

Expressioni

Gene expression databases

CleanExiHS_CTRL.
ExpressionAtlasiP40313. baseline and differential.
GenevisibleiP40313. HS.

Organism-specific databases

HPAiHPA034504.
HPA034505.

Interactioni

Protein-protein interaction databases

BioGridi107886. 4 interactions.
IntActiP40313. 1 interaction.
MINTiMINT-6616091.
STRINGi9606.ENSP00000458537.

Chemistry

BindingDBiP40313.

Structurei

3D structure databases

ProteinModelPortaliP40313.
SMRiP40313. Positions 19-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 262229Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOVERGENiHBG013304.
InParanoidiP40313.
KOiK09632.
OMAiFNTWINQ.
OrthoDBiEOG091G0AH5.
PhylomeDBiP40313.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS
60 70 80 90 100
LQDSSGFHFC GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ
110 120 130 140 150
VLSVSRAITH PSWNSTTMNN DVTLLKLASP AQYTTRISPV CLASSNEALT
160 170 180 190 200
EGLTCVTTGW GRLSGVGNVT PAHLQQVALP LVTVNQCRQY WGSSITDSMI
210 220 230 240 250
CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN VRAPAVYTRV
260
SKFSTWINQV IAYN
Length:264
Mass (Da):28,002
Last modified:February 1, 1995 - v1
Checksum:i3F629F02FA6DDFB4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501T → I.
Corresponds to variant rs11552953 [ dbSNP | Ensembl ].
VAR_051834
Natural varianti173 – 1731H → R.
Corresponds to variant rs1134760 [ dbSNP | Ensembl ].
VAR_021939

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71874 Genomic DNA. Translation: CAA50710.1.
X71877 mRNA. Translation: CAA50711.1.
BC063475 mRNA. Translation: AAH63475.1.
CCDSiCCDS10852.1.
PIRiI38136.
RefSeqiNP_001898.1. NM_001907.2.
UniGeneiHs.654546.

Genome annotation databases

EnsembliENST00000574481; ENSP00000458537; ENSG00000141086.
GeneIDi1506.
KEGGihsa:1506.
UCSCiuc002euw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71874 Genomic DNA. Translation: CAA50710.1.
X71877 mRNA. Translation: CAA50711.1.
BC063475 mRNA. Translation: AAH63475.1.
CCDSiCCDS10852.1.
PIRiI38136.
RefSeqiNP_001898.1. NM_001907.2.
UniGeneiHs.654546.

3D structure databases

ProteinModelPortaliP40313.
SMRiP40313. Positions 19-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107886. 4 interactions.
IntActiP40313. 1 interaction.
MINTiMINT-6616091.
STRINGi9606.ENSP00000458537.

Chemistry

BindingDBiP40313.
ChEMBLiCHEMBL4873.

Protein family/group databases

MEROPSiS01.256.

PTM databases

iPTMnetiP40313.
PhosphoSiteiP40313.

Polymorphism and mutation databases

BioMutaiCTRL.
DMDMi729224.

Proteomic databases

PaxDbiP40313.
PeptideAtlasiP40313.
PRIDEiP40313.

Protocols and materials databases

DNASUi1506.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000574481; ENSP00000458537; ENSG00000141086.
GeneIDi1506.
KEGGihsa:1506.
UCSCiuc002euw.4. human.

Organism-specific databases

CTDi1506.
GeneCardsiCTRL.
H-InvDBHIX0079830.
HGNCiHGNC:2524. CTRL.
HPAiHPA034504.
HPA034505.
MIMi118888. gene.
neXtProtiNX_P40313.
PharmGKBiPA27025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOVERGENiHBG013304.
InParanoidiP40313.
KOiK09632.
OMAiFNTWINQ.
OrthoDBiEOG091G0AH5.
PhylomeDBiP40313.

Miscellaneous databases

ChiTaRSiCTRL. human.
GeneWikiiCTRL_(gene).
GenomeRNAii1506.
PROiP40313.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CTRL.
ExpressionAtlasiP40313. baseline and differential.
GenevisibleiP40313. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRL_HUMAN
AccessioniPrimary (citable) accession number: P40313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.