P40313 (CTRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chymotrypsin-like protease CTRL-1
EC=3.4.21.-

Gene names

Name:	CTRL
Synonyms:	CTRL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	digestion Traceable author statement PubMed 9065485. Source: ProtInc proteolysis Traceable author statement PubMed 9065485. Source: ProtInc
Cellular_component	extracellular space Traceable author statement PubMed 9065485. Source: ProtInc
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 33	15	Activation peptide Potential		PRO_0000027660
	Chain	34 – 264	231	Chymotrypsin-like protease CTRL-1		PRO_0000027661
Regions
	Domain	34 – 262	229	Peptidase S1
Sites
	Active site	75	1	Charge relay system By similarity
	Active site	121	1	Charge relay system By similarity
	Active site	214	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Disulfide bond	19 ↔ 141		By similarity
	Disulfide bond	60 ↔ 76		By similarity
	Disulfide bond	155 ↔ 220		By similarity
	Disulfide bond	187 ↔ 201		By similarity
	Disulfide bond	210 ↔ 239		By similarity
Natural variations
	Natural variant	150	1	T → I. Corresponds to variant rs11552953 [ dbSNP | Ensembl ].		VAR_051834
	Natural variant	173	1	H → R. Corresponds to variant rs1134760 [ dbSNP | Ensembl ].		VAR_021939

Sequences

	Sequence		Length	Mass (Da)
	P40313 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3F629F02FA6DDFB4	FASTA	264	28,002
	10 20 30 40 50 60 MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS LQDSSGFHFC 70 80 90 100 110 120 GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ VLSVSRAITH PSWNSTTMNN 130 140 150 160 170 180 DVTLLKLASP AQYTTRISPV CLASSNEALT EGLTCVTTGW GRLSGVGNVT PAHLQQVALP 190 200 210 220 230 240 LVTVNQCRQY WGSSITDSMI CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN 250 260 VRAPAVYTRV SKFSTWINQV IAYN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A tight cluster of five unrelated human genes on chromosome 16q22.1." Larsen F., Solheim J., Kristensen T., Kolstoe A.-B., Prydz H. Hum. Mol. Genet. 2:1589-1595(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71874 Genomic DNA. Translation: CAA50710.1. X71877 mRNA. Translation: CAA50711.1. BC063475 mRNA. Translation: AAH63475.1.
IPI	IPI00643847.
PIR	I38136.
RefSeq	NP_001898.1. NM_001907.2.
UniGene	Hs.654546.
3D structure databases
ProteinModelPortal	P40313.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6616091.
STRING	9606.ENSP00000322629.
Protein family/group databases
MEROPS	S01.256.
Polymorphism databases
DMDM	729224.
Proteomic databases
PaxDb	P40313.
PRIDE	P40313.
Protocols and materials databases
DNASU	1506.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000574481; ENSP00000458537; ENSG00000141086.
GeneID	1506.
KEGG	hsa:1506.
UCSC	uc002euw.3. human.
Organism-specific databases
CTD	1506.
GeneCards	GC16M067963.
H-InvDB	HIX0079830.
HGNC	HGNC:2524. CTRL.
HPA	HPA034505.
MIM	118888. gene.
neXtProt	NX_P40313.
PharmGKB	PA27025.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOVERGEN	HBG013304.
InParanoid	P40313.
KO	K09632.
OMA	CQKGNTW.
OrthoDB	EOG4VMFG1.
Gene expression databases
ArrayExpress	P40313.
Bgee	P40313.
CleanEx	HS_CTRL.
Genevestigator	P40313.
GermOnline	ENSG00000141086. Homo sapiens.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P40313.
ChEMBL	CHEMBL4873.
GenomeRNAi	1506.
NextBio	6229.
SOURCE	Search...

Entry information

Entry name

CTRL_HUMAN

Accession

Primary (citable) accession number: P40313

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.