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Protein

Outward-rectifier potassium channel TOK1

Gene

TOK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Outwardly rectifying potassium channel.

GO - Molecular functioni

  • potassium channel activity Source: SGD
  • voltage-gated potassium channel activity Source: SGD

GO - Biological processi

  • cellular potassium ion homeostasis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31548-MONOMER.

Protein family/group databases

TCDBi1.A.1.7.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Outward-rectifier potassium channel TOK1
Alternative name(s):
Two-domain outward rectifier K(+) channel YORK
Gene namesi
Name:TOK1
Synonyms:DUK1
Ordered Locus Names:YJL093C
ORF Names:J0911
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL093C.
SGDiS000003629. TOK1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92Helical; Name=S1Sequence analysisAdd BLAST21
Topological domaini93 – 137ExtracellularSequence analysisAdd BLAST45
Transmembranei138 – 158Helical; Name=S2Sequence analysisAdd BLAST21
Topological domaini159 – 170CytoplasmicSequence analysisAdd BLAST12
Transmembranei171 – 191Helical; Name=S3Sequence analysisAdd BLAST21
Topological domaini192 – 203ExtracellularSequence analysisAdd BLAST12
Transmembranei204 – 224Helical; Name=S4Sequence analysisAdd BLAST21
Topological domaini225 – 246CytoplasmicSequence analysisAdd BLAST22
Transmembranei247 – 266Helical; Name=S5Sequence analysisAdd BLAST20
Topological domaini267 – 301ExtracellularSequence analysisAdd BLAST35
Transmembranei302 – 322Helical; Name=S6Sequence analysisAdd BLAST21
Topological domaini323 – 379CytoplasmicSequence analysisAdd BLAST57
Transmembranei380 – 400Helical; Name=S7Sequence analysisAdd BLAST21
Topological domaini401 – 435ExtracellularSequence analysisAdd BLAST35
Transmembranei436 – 456Helical; Name=S8Sequence analysisAdd BLAST21
Topological domaini457 – 691CytoplasmicSequence analysisAdd BLAST235

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017741 – 691Outward-rectifier potassium channel TOK1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40310.
PRIDEiP40310.

PTM databases

iPTMnetiP40310.

Interactioni

Protein-protein interaction databases

BioGridi33664. 26 interactors.
DIPiDIP-8165N.
IntActiP40310. 1 interactor.
MINTiMINT-1358978.

Structurei

3D structure databases

ProteinModelPortaliP40310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066084.
InParanoidiP40310.
KOiK05389.
OMAiPNERSIM.
OrthoDBiEOG092C0TA1.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

P40310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRFMNSFAK QTLGYGNMAT VEQESSAQAV DSHSNNTPKQ AKGVLAEELK
60 70 80 90 100
DALRFRDERV SIINAEPSST LFVFWFVVSC YFPVITACLG PVANTISIAC
110 120 130 140 150
VVEKWRSLKN NSVVTNPRSN DTDVLMNQVK TVFDPPGIFA VNIISLVLGF
160 170 180 190 200
TSNIILMLHF SKKLTYLKSQ LINITGWTIA GGMLLVDVIV CSLNDMPSIY
210 220 230 240 250
SKTIGFWFAC ISSGLYLVCT IILTIHFIGY KLGKYPPTFN LLPNERSIMA
260 270 280 290 300
YTVLLSLWLI WGAGMFSGLL HITYGNALYF CTVSLLTVGL GDILPKSVGA
310 320 330 340 350
KIMVLIFSLS GVVLMGLIVF MTRSIIQKSS GPIFFFHRVE KGRSKSWKHY
360 370 380 390 400
MDSSKNLSER EAFDLMKCIR QTASRKQHWF SLSVTIAIFM AFWLLGALVF
410 420 430 440 450
KFAENWSYFN CIYFCFLCLL TIGYGDYAPR TGAGRAFFVI WALGAVPLMG
460 470 480 490 500
AILSTVGDLL FDISTSLDIK IGESFNNKVK SIVFNGRQRA LSFMVNTGEI
510 520 530 540 550
FEESDTADGD LEENTTSSQS SQISEFNDNN SEENDSGVTS PPASLQESFS
560 570 580 590 600
SLSKASSPEG ILPLEYVSSA EYALQDSGTC NLRNLQELLK AVKKLHRICL
610 620 630 640 650
ADKDYTLSFS DWSYIHKLHL RNITDIEEYT RGPEFWISPD TPLKFPLNEP
660 670 680 690
HFAFMMLFKN IEELVGNLVE DEELYKVISK RKFLGEHRKT L
Length:691
Mass (Da):77,408
Last modified:February 1, 1995 - v1
Checksum:i507167E487B77AAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti442A → T in CAA64176 (PubMed:8723646).Curated1
Sequence conflicti512E → G in CAA64176 (PubMed:8723646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28005 Genomic DNA. Translation: AAC49070.1.
X94403 Genomic DNA. Translation: CAA64176.1.
U37254 Genomic DNA. Translation: AAC49168.1.
X77087 Genomic DNA. Translation: CAA54360.1.
Z49368 Genomic DNA. Translation: CAA89386.1.
BK006943 Genomic DNA. Translation: DAA08707.1.
PIRiS46585.
RefSeqiNP_012442.1. NM_001181526.1.

Genome annotation databases

EnsemblFungiiYJL093C; YJL093C; YJL093C.
GeneIDi853352.
KEGGisce:YJL093C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28005 Genomic DNA. Translation: AAC49070.1.
X94403 Genomic DNA. Translation: CAA64176.1.
U37254 Genomic DNA. Translation: AAC49168.1.
X77087 Genomic DNA. Translation: CAA54360.1.
Z49368 Genomic DNA. Translation: CAA89386.1.
BK006943 Genomic DNA. Translation: DAA08707.1.
PIRiS46585.
RefSeqiNP_012442.1. NM_001181526.1.

3D structure databases

ProteinModelPortaliP40310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33664. 26 interactors.
DIPiDIP-8165N.
IntActiP40310. 1 interactor.
MINTiMINT-1358978.

Protein family/group databases

TCDBi1.A.1.7.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiP40310.

Proteomic databases

MaxQBiP40310.
PRIDEiP40310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL093C; YJL093C; YJL093C.
GeneIDi853352.
KEGGisce:YJL093C.

Organism-specific databases

EuPathDBiFungiDB:YJL093C.
SGDiS000003629. TOK1.

Phylogenomic databases

HOGENOMiHOG000066084.
InParanoidiP40310.
KOiK05389.
OMAiPNERSIM.
OrthoDBiEOG092C0TA1.

Enzyme and pathway databases

BioCyciYEAST:G3O-31548-MONOMER.

Miscellaneous databases

PROiP40310.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiTOK1_YEAST
AccessioniPrimary (citable) accession number: P40310
Secondary accession number(s): D6VW91, Q05721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.