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P40309

- KHA1_YEAST

UniProt

P40309 - KHA1_YEAST

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Protein
K(+)/H(+) antiporter 1
Gene
KHA1, YJL094C, J0909
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Potassium-proton antiport.

GO - Molecular functioni

  1. potassium:proton antiporter activity Source: SGD

GO - Biological processi

  1. monovalent inorganic cation transport Source: SGD
  2. potassium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31549-MONOMER.

Protein family/group databases

TCDBi2.A.37.4.1. the monovalent cation:proton antiporter-2 (cpa2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)/H(+) antiporter 1
Gene namesi
Name:KHA1
Ordered Locus Names:YJL094C
ORF Names:J0909
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL094c.
SGDiS000003630. KHA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4421Helical; Reviewed prediction
Add
BLAST
Topological domaini45 – 517Cytoplasmic Reviewed prediction
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Topological domaini73 – 8210Extracellular Reviewed prediction
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 11613Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 15417Extracellular Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Reviewed prediction
Add
BLAST
Topological domaini176 – 18813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 22011Extracellular Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Topological domaini242 – 26726Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Topological domaini289 – 31628Extracellular Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Topological domaini338 – 3414Cytoplasmic Reviewed prediction
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 37513Extracellular Reviewed prediction
Add
BLAST
Transmembranei376 – 39621Helical; Reviewed prediction
Add
BLAST
Topological domaini397 – 4048Cytoplasmic Reviewed prediction
Transmembranei405 – 42521Helical; Reviewed prediction
Add
BLAST
Topological domaini426 – 726301Extracellular Reviewed prediction
Add
BLAST
Transmembranei727 – 74721Helical; Reviewed prediction
Add
BLAST
Topological domaini748 – 873126Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873K(+)/H(+) antiporter 1
PRO_0000196618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei557 – 5571Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40309.
PaxDbiP40309.

Expressioni

Gene expression databases

GenevestigatoriP40309.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADH1P003301EBI-25993,EBI-2218

Protein-protein interaction databases

BioGridi33663. 26 interactions.
DIPiDIP-4799N.
IntActiP40309. 1 interaction.
MINTiMINT-494478.
STRINGi4932.YJL094C.

Structurei

3D structure databases

ProteinModelPortaliP40309.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0475.
HOGENOMiHOG000247916.
OMAiTERMEDI.
OrthoDBiEOG7GBG5B.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00932. 2a37. 1 hit.

Sequencei

Sequence statusi: Complete.

P40309-1 [UniParc]FASTAAdd to Basket

« Hide

MANTVGGILS GVNPFHYNSS SPLTLFLFQA CLILLVCNLI HIPFSMMRQP    50
KVISEVISGV ILGPTIFGQI PNYTNTIFPT SSIPGLNLVA NLGIILFMFF 100
LGLEVDIAFI KKHLKKALVI GIVTLAVPFG FGCLLAIPLF HTYANKTEGE 150
RHIKFSVFMV FIAVSISVTA FPVLCRILNE LRLIKDRAGI VVLAAGIIND 200
IMGWILLALS IILSSAEGSP VNTVYILLIT FAWFLIYFFP LKYLLRWVLI 250
RTHELDRSKP SPLATMCILF IMFISAYFTD IIGVHPIFGA FIAGLVVPRD 300
DHYVVKLTER MEDIPNIVFI PIYFAVAGLN VDLTLLNEGR DWGYVFATIG 350
IAIFTKIISG TLTAKLTGLF WREATAAGVL MSCKGIVEIV VLTVGLNAGI 400
ISRKIFGMFV LMALVSTFVT TPLTQLVYPD SYRDGVRKSL STPAEDDGAA 450
DGLDSEGVDK TEINTQLNSL ADVSKYRIGE LTTVINTTEA ISPSLKLLNY 500
LSLGVSPKPK NNKHKNETSL SRMTTATDST LKSNTFKIKK MVHIWSKSVD 550
DVDTNLSVID EKLTPFEGVG ALRAIHLRLL TERTTDLLQS SSLYNDDPHF 600
TANTDSLLQI FDIFSNLSKI PFSSEVIFST MREKAANIAT MKMDSTDLIL 650
LPLKGASYEY RGSPVFIDEK YANFDHIYSH LLGLNELSST FFKSIFQSLK 700
ANFAVQISNT YGRLNADRFK RKRFNLLLPK PYLTQSDYLG LYLLLLICYR 750
DGYNNDNASC SIFINSKNID FAKDLSTAFA EHDWLNESTI KIVDIPFETK 800
VPEEAIEKPS FIETVLDVGL SDTALADIEE TTFIIGEDLP DESEPFSEEV 850
RTVIFEGSNR RFDTLIVHHF SSE 873
Length:873
Mass (Da):97,111
Last modified:February 1, 1995 - v1
Checksum:i881E55A1F59C8CE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77087 Genomic DNA. Translation: CAA54359.1.
Z49369 Genomic DNA. Translation: CAA89387.1.
BK006943 Genomic DNA. Translation: DAA08706.1.
PIRiS46584.
RefSeqiNP_012441.1. NM_001181527.1.

Genome annotation databases

EnsemblFungiiYJL094C; YJL094C; YJL094C.
GeneIDi853351.
KEGGisce:YJL094C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77087 Genomic DNA. Translation: CAA54359.1 .
Z49369 Genomic DNA. Translation: CAA89387.1 .
BK006943 Genomic DNA. Translation: DAA08706.1 .
PIRi S46584.
RefSeqi NP_012441.1. NM_001181527.1.

3D structure databases

ProteinModelPortali P40309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33663. 26 interactions.
DIPi DIP-4799N.
IntActi P40309. 1 interaction.
MINTi MINT-494478.
STRINGi 4932.YJL094C.

Protein family/group databases

TCDBi 2.A.37.4.1. the monovalent cation:proton antiporter-2 (cpa2) family.

Proteomic databases

MaxQBi P40309.
PaxDbi P40309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL094C ; YJL094C ; YJL094C .
GeneIDi 853351.
KEGGi sce:YJL094C.

Organism-specific databases

CYGDi YJL094c.
SGDi S000003630. KHA1.

Phylogenomic databases

eggNOGi COG0475.
HOGENOMi HOG000247916.
OMAi TERMEDI.
OrthoDBi EOG7GBG5B.

Enzyme and pathway databases

BioCyci YEAST:G3O-31549-MONOMER.

Miscellaneous databases

NextBioi 973756.

Gene expression databases

Genevestigatori P40309.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
[Graphical view ]
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00932. 2a37. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and function analysis of a 9.46 kb fragment of Saccharomyces cerevisiae chromosome X."
    Miosga T., Witzel A., Zimmermann F.K.
    Yeast 10:965-973(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKHA1_YEAST
AccessioniPrimary (citable) accession number: P40309
Secondary accession number(s): D6VW90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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