UniProtKB - P40309 (KHA1_YEAST)
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Protein
K(+)/H(+) antiporter 1
Gene
KHA1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Potassium-proton antiport.
Miscellaneous
Present with 172 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- potassium:proton antiporter activity Source: SGD
GO - Biological processi
- monovalent inorganic cation transport Source: SGD
Keywordsi
Biological process | Antiport, Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
BioCyci | YEAST:G3O-31549-MONOMER |
Protein family/group databases
TCDBi | 2.A.37.4.1 the monovalent cation:proton antiporter-2 (cpa2) family |
Names & Taxonomyi
Protein namesi | Recommended name: K(+)/H(+) antiporter 1 |
Gene namesi | Name:KHA1 Ordered Locus Names:YJL094C ORF Names:J0909 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YJL094C |
SGDi | S000003630 KHA1 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 51 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 82 | ExtracellularSequence analysis | 10 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 116 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 154 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 188 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 189 – 209 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 220 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 221 – 241 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 242 – 267 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 316 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 341 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 375 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 397 – 404 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 726 | ExtracellularSequence analysisAdd BLAST | 301 | |
Transmembranei | 727 – 747 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 748 – 873 | CytoplasmicSequence analysisAdd BLAST | 126 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196618 | 1 – 873 | K(+)/H(+) antiporter 1Add BLAST | 873 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 557 | PhosphoserineCombined sources | 1 | |
Cross-linki | 562 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P40309 |
PaxDbi | P40309 |
PRIDEi | P40309 |
PTM databases
CarbonylDBi | P40309 |
iPTMneti | P40309 |
Interactioni
Protein-protein interaction databases
BioGridi | 3366369 interactors. |
DIPi | DIP-4799N |
IntActi | P40309 3 interactors. |
STRINGi | 4932.YJL094C |
Family & Domainsi
Sequence similaritiesi
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000247916 |
InParanoidi | P40309 |
OMAi | MEDIPNI |
OrthoDBi | EOG092C0I99 |
Family and domain databases
InterProi | View protein in InterPro IPR006153 Cation/H_exchanger IPR004771 K/H_exchanger |
Pfami | View protein in Pfam PF00999 Na_H_Exchanger, 1 hit |
TIGRFAMsi | TIGR00932 2a37, 1 hit |
i Sequence
Sequence statusi: Complete.
P40309-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANTVGGILS GVNPFHYNSS SPLTLFLFQA CLILLVCNLI HIPFSMMRQP
60 70 80 90 100
KVISEVISGV ILGPTIFGQI PNYTNTIFPT SSIPGLNLVA NLGIILFMFF
110 120 130 140 150
LGLEVDIAFI KKHLKKALVI GIVTLAVPFG FGCLLAIPLF HTYANKTEGE
160 170 180 190 200
RHIKFSVFMV FIAVSISVTA FPVLCRILNE LRLIKDRAGI VVLAAGIIND
210 220 230 240 250
IMGWILLALS IILSSAEGSP VNTVYILLIT FAWFLIYFFP LKYLLRWVLI
260 270 280 290 300
RTHELDRSKP SPLATMCILF IMFISAYFTD IIGVHPIFGA FIAGLVVPRD
310 320 330 340 350
DHYVVKLTER MEDIPNIVFI PIYFAVAGLN VDLTLLNEGR DWGYVFATIG
360 370 380 390 400
IAIFTKIISG TLTAKLTGLF WREATAAGVL MSCKGIVEIV VLTVGLNAGI
410 420 430 440 450
ISRKIFGMFV LMALVSTFVT TPLTQLVYPD SYRDGVRKSL STPAEDDGAA
460 470 480 490 500
DGLDSEGVDK TEINTQLNSL ADVSKYRIGE LTTVINTTEA ISPSLKLLNY
510 520 530 540 550
LSLGVSPKPK NNKHKNETSL SRMTTATDST LKSNTFKIKK MVHIWSKSVD
560 570 580 590 600
DVDTNLSVID EKLTPFEGVG ALRAIHLRLL TERTTDLLQS SSLYNDDPHF
610 620 630 640 650
TANTDSLLQI FDIFSNLSKI PFSSEVIFST MREKAANIAT MKMDSTDLIL
660 670 680 690 700
LPLKGASYEY RGSPVFIDEK YANFDHIYSH LLGLNELSST FFKSIFQSLK
710 720 730 740 750
ANFAVQISNT YGRLNADRFK RKRFNLLLPK PYLTQSDYLG LYLLLLICYR
760 770 780 790 800
DGYNNDNASC SIFINSKNID FAKDLSTAFA EHDWLNESTI KIVDIPFETK
810 820 830 840 850
VPEEAIEKPS FIETVLDVGL SDTALADIEE TTFIIGEDLP DESEPFSEEV
860 870
RTVIFEGSNR RFDTLIVHHF SSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77087 Genomic DNA Translation: CAA54359.1 Z49369 Genomic DNA Translation: CAA89387.1 BK006943 Genomic DNA Translation: DAA08706.1 |
PIRi | S46584 |
RefSeqi | NP_012441.1, NM_001181527.1 |
Genome annotation databases
EnsemblFungii | YJL094C; YJL094C; YJL094C |
GeneIDi | 853351 |
KEGGi | sce:YJL094C |
Similar proteinsi
Entry informationi
Entry namei | KHA1_YEAST | |
Accessioni | P40309Primary (citable) accession number: P40309 Secondary accession number(s): D6VW90 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |