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Protein

K(+)/H(+) antiporter 1

Gene

KHA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potassium-proton antiport.

GO - Molecular functioni

  • potassium:proton antiporter activity Source: SGD

GO - Biological processi

  • monovalent inorganic cation transport Source: SGD
  • regulation of pH Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31549-MONOMER.

Protein family/group databases

TCDBi2.A.37.4.1. the monovalent cation:proton antiporter-2 (cpa2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)/H(+) antiporter 1
Gene namesi
Name:KHA1
Ordered Locus Names:YJL094C
ORF Names:J0909
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL094C.
SGDiS000003630. KHA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 51CytoplasmicSequence analysis7
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 82ExtracellularSequence analysis10
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 116CytoplasmicSequence analysisAdd BLAST13
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 154ExtracellularSequence analysisAdd BLAST17
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 188CytoplasmicSequence analysisAdd BLAST13
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 220ExtracellularSequence analysisAdd BLAST11
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 267CytoplasmicSequence analysisAdd BLAST26
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 316ExtracellularSequence analysisAdd BLAST28
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 341CytoplasmicSequence analysis4
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 375ExtracellularSequence analysisAdd BLAST13
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 404CytoplasmicSequence analysis8
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 726ExtracellularSequence analysisAdd BLAST301
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Topological domaini748 – 873CytoplasmicSequence analysisAdd BLAST126

GO - Cellular componenti

  • Golgi apparatus Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001966181 – 873K(+)/H(+) antiporter 1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei557PhosphoserineCombined sources1
Cross-linki562Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP40309.
PRIDEiP40309.

PTM databases

iPTMnetiP40309.

Interactioni

Protein-protein interaction databases

BioGridi33663. 26 interactors.
DIPiDIP-4799N.
IntActiP40309. 1 interactor.
MINTiMINT-494478.

Structurei

3D structure databases

ProteinModelPortaliP40309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000247916.
InParanoidiP40309.
OMAiMEDIPNI.
OrthoDBiEOG092C0I99.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00932. 2a37. 1 hit.

Sequencei

Sequence statusi: Complete.

P40309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTVGGILS GVNPFHYNSS SPLTLFLFQA CLILLVCNLI HIPFSMMRQP
60 70 80 90 100
KVISEVISGV ILGPTIFGQI PNYTNTIFPT SSIPGLNLVA NLGIILFMFF
110 120 130 140 150
LGLEVDIAFI KKHLKKALVI GIVTLAVPFG FGCLLAIPLF HTYANKTEGE
160 170 180 190 200
RHIKFSVFMV FIAVSISVTA FPVLCRILNE LRLIKDRAGI VVLAAGIIND
210 220 230 240 250
IMGWILLALS IILSSAEGSP VNTVYILLIT FAWFLIYFFP LKYLLRWVLI
260 270 280 290 300
RTHELDRSKP SPLATMCILF IMFISAYFTD IIGVHPIFGA FIAGLVVPRD
310 320 330 340 350
DHYVVKLTER MEDIPNIVFI PIYFAVAGLN VDLTLLNEGR DWGYVFATIG
360 370 380 390 400
IAIFTKIISG TLTAKLTGLF WREATAAGVL MSCKGIVEIV VLTVGLNAGI
410 420 430 440 450
ISRKIFGMFV LMALVSTFVT TPLTQLVYPD SYRDGVRKSL STPAEDDGAA
460 470 480 490 500
DGLDSEGVDK TEINTQLNSL ADVSKYRIGE LTTVINTTEA ISPSLKLLNY
510 520 530 540 550
LSLGVSPKPK NNKHKNETSL SRMTTATDST LKSNTFKIKK MVHIWSKSVD
560 570 580 590 600
DVDTNLSVID EKLTPFEGVG ALRAIHLRLL TERTTDLLQS SSLYNDDPHF
610 620 630 640 650
TANTDSLLQI FDIFSNLSKI PFSSEVIFST MREKAANIAT MKMDSTDLIL
660 670 680 690 700
LPLKGASYEY RGSPVFIDEK YANFDHIYSH LLGLNELSST FFKSIFQSLK
710 720 730 740 750
ANFAVQISNT YGRLNADRFK RKRFNLLLPK PYLTQSDYLG LYLLLLICYR
760 770 780 790 800
DGYNNDNASC SIFINSKNID FAKDLSTAFA EHDWLNESTI KIVDIPFETK
810 820 830 840 850
VPEEAIEKPS FIETVLDVGL SDTALADIEE TTFIIGEDLP DESEPFSEEV
860 870
RTVIFEGSNR RFDTLIVHHF SSE
Length:873
Mass (Da):97,111
Last modified:February 1, 1995 - v1
Checksum:i881E55A1F59C8CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77087 Genomic DNA. Translation: CAA54359.1.
Z49369 Genomic DNA. Translation: CAA89387.1.
BK006943 Genomic DNA. Translation: DAA08706.1.
PIRiS46584.
RefSeqiNP_012441.1. NM_001181527.1.

Genome annotation databases

EnsemblFungiiYJL094C; YJL094C; YJL094C.
GeneIDi853351.
KEGGisce:YJL094C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77087 Genomic DNA. Translation: CAA54359.1.
Z49369 Genomic DNA. Translation: CAA89387.1.
BK006943 Genomic DNA. Translation: DAA08706.1.
PIRiS46584.
RefSeqiNP_012441.1. NM_001181527.1.

3D structure databases

ProteinModelPortaliP40309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33663. 26 interactors.
DIPiDIP-4799N.
IntActiP40309. 1 interactor.
MINTiMINT-494478.

Protein family/group databases

TCDBi2.A.37.4.1. the monovalent cation:proton antiporter-2 (cpa2) family.

PTM databases

iPTMnetiP40309.

Proteomic databases

MaxQBiP40309.
PRIDEiP40309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL094C; YJL094C; YJL094C.
GeneIDi853351.
KEGGisce:YJL094C.

Organism-specific databases

EuPathDBiFungiDB:YJL094C.
SGDiS000003630. KHA1.

Phylogenomic databases

HOGENOMiHOG000247916.
InParanoidiP40309.
OMAiMEDIPNI.
OrthoDBiEOG092C0I99.

Enzyme and pathway databases

BioCyciYEAST:G3O-31549-MONOMER.

Miscellaneous databases

PROiP40309.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR004771. K/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00932. 2a37. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKHA1_YEAST
AccessioniPrimary (citable) accession number: P40309
Secondary accession number(s): D6VW90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.