P40305 (IFI27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-inducible protein 27, mitochondrial
Short name=p27

Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein
Short name=ISG12(a)

Gene names

Name:

IFI27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Ref.6
Subcellular location	Mitochondrion. Membrane; Multi-pass membrane protein Potential Ref.6.
Induction	Up-regulated by interferons. Ref.6
Sequence similarities	Belongs to the IFI6/IFI27 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay Ref.6. Source: UniProtKB activation of pro-apoptotic gene products Inferred from direct assay Ref.6. Source: UniProtKB induction of apoptosis by extracellular signals Inferred from direct assay Ref.6. Source: UniProtKB type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB mitochondrial outer membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 33	33	Mitochondrion Potential
	Chain	34 – 119	86	Interferon alpha-inducible protein 27, mitochondrial		PRO_0000147372
Regions
	Transmembrane	34 – 54	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
Amino acid modifications
	Modified residue	7	1	Phosphothreonine Ref.5
Natural variations
	Natural variant	106	1	S → F. Corresponds to variant rs2227974 [ dbSNP | Ensembl ].		VAR_028066
Experimental info
	Sequence conflict	42	1	V → VAMA in CAA47739. Ref.1
	Sequence conflict	86	1	A → G in CAA47739. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40305 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 242C9388FEF8FF9C	FASTA	119	11,268
	10 20 30 40 50 60 MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA MGFTAAGIAS 70 80 90 100 110 SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT KFILGSIGSA IAAVIARFY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma." Rasmussen U.B., Wolf C., Mattei M.-G., Chenard M.P., Bellocq J.-P., Chambon P., Rio M.C., Basset P. Cancer Res. 53:4096-4101(1993) [PubMed: 8358738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12." Parker N., Porter A.C.G. BMC Genomics 5:8-8(2004) [PubMed: 14728724] [Abstract] Cited for: IDENTIFICATION.
[5]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a." Rosebeck S., Leaman D.W. Apoptosis 13:562-572(2008) [PubMed: 18330707] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67325 mRNA. Translation: CAA47739.1. BT006781 mRNA. Translation: AAP35427.1. AM393107 mRNA. Translation: CAL37985.1. BC015492 mRNA. Translation: AAH15492.1. BN000227 mRNA. Translation: CAE00394.1.
IPI	IPI00793404.
PIR	I38081.
RefSeq	NP_001123552.1. NM_001130080.1. NP_005523.3. NM_005532.3.
UniGene	Hs.532634.
3D structure databases
ProteinModelPortal	P40305.
ModBase	Search...
Protein-protein interaction databases
IntAct	P40305. 12 interactions.
STRING	P40305.
PTM databases
PhosphoSite	P40305.
Polymorphism databases
DMDM	116242590.
Proteomic databases
PRIDE	P40305.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298902; ENSP00000298902; ENSG00000165949.
GeneID	3429.
KEGG	hsa:3429.
UCSC	uc001yco.1. human.
Organism-specific databases
CTD	3429.
GeneCards	GC14P094577.
H-InvDB	HIX0011925.
HGNC	HGNC:5397. IFI27.
HPA	HPA028875.
MIM	600009. gene.
neXtProt	NX_P40305.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG099821.
InParanoid	P40305.
OrthoDB	EOG4TTGKP.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P40305.
Bgee	P40305.
CleanEx	HS_IFI27.
Genevestigator	P40305.
GermOnline	ENSG00000165949. Homo sapiens.
Family and domain databases
InterPro	IPR009311. Interferon-induced_6-16. [Graphical view]
PANTHER	PTHR16932. Ifi-6-16. 1 hit.
Pfam	PF06140. Ifi-6-16. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13520.
SOURCE	Search...

Entry information

Entry name

IFI27_HUMAN

Accession

Primary (citable) accession number: P40305
Secondary accession number(s): Q53YA6, Q6IEC1, Q96BK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.