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P40305 (IFI27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon alpha-inducible protein 27, mitochondrial

Short name=p27
Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein
Short name=ISG12(a)
Gene names
Name:IFI27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Ref.5

Subcellular location

Mitochondrion. Membrane; Multi-pass membrane protein Potential Ref.5.

Induction

Up-regulated by interferons. Ref.5

Sequence similarities

Belongs to the IFI6/IFI27 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion Potential
Chain34 – 11986Interferon alpha-inducible protein 27, mitochondrial
PRO_0000147372

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane96 – 11621Helical; Potential

Natural variations

Natural variant1061S → F.
Corresponds to variant rs2227974 [ dbSNP | Ensembl ].
VAR_028066

Experimental info

Sequence conflict421V → VAMA in CAA47739. Ref.1
Sequence conflict861A → G in CAA47739. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P40305 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 242C9388FEF8FF9C

FASTA11911,268
        10         20         30         40         50         60 
MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA MGFTAAGIAS 

        70         80         90        100        110 
SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT KFILGSIGSA IAAVIARFY 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma."
Rasmussen U.B., Wolf C., Mattei M.-G., Chenard M.P., Bellocq J.-P., Chambon P., Rio M.C., Basset P.
Cancer Res. 53:4096-4101(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12."
Parker N., Porter A.C.G.
BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a."
Rosebeck S., Leaman D.W.
Apoptosis 13:562-572(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67325 mRNA. Translation: CAA47739.1.
BT006781 mRNA. Translation: AAP35427.1.
AM393107 mRNA. Translation: CAL37985.1.
BC015492 mRNA. Translation: AAH15492.1.
BN000227 mRNA. Translation: CAE00394.1.
PIRI38081.
RefSeqNP_001123552.1. NM_001130080.2.
NP_001275881.1. NM_001288952.1.
NP_001275883.1. NM_001288954.1.
NP_001275885.1. NM_001288956.1.
NP_001275886.1. NM_001288957.1.
NP_001275887.1. NM_001288958.1.
NP_001275924.1. NM_001288995.1.
NP_005523.3. NM_005532.4.
UniGeneHs.532634.

3D structure databases

ProteinModelPortalP40305.
SMRP40305. Positions 48-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109655. 2 interactions.
IntActP40305. 12 interactions.
MINTMINT-4726676.
STRING9606.ENSP00000298902.

PTM databases

PhosphoSiteP40305.

Polymorphism databases

DMDM116242590.

Proteomic databases

PaxDbP40305.
PRIDEP40305.

Protocols and materials databases

DNASU3429.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298902; ENSP00000298902; ENSG00000165949.
ENST00000555744; ENSP00000451956; ENSG00000165949.
GeneID3429.
KEGGhsa:3429.

Organism-specific databases

CTD3429.
GeneCardsGC14P094577.
HGNCHGNC:5397. IFI27.
HPAHPA028875.
MIM600009. gene.
neXtProtNX_P40305.
PharmGKBPA29643.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245779.
HOGENOMHOG000112988.
HOVERGENHBG099821.
InParanoidP40305.
PhylomeDBP40305.
TreeFamTF340510.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP40305.
BgeeP40305.
CleanExHS_IFI27.
GenevestigatorP40305.

Family and domain databases

InterProIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERPTHR16932. PTHR16932. 1 hit.
PfamPF06140. Ifi-6-16. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIFI27. human.
GeneWikiIFI27.
GenomeRNAi3429.
NextBio13520.
PROP40305.
SOURCESearch...

Entry information

Entry nameIFI27_HUMAN
AccessionPrimary (citable) accession number: P40305
Secondary accession number(s): Q53YA6, Q6IEC1, Q96BK3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM