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P40305

- IFI27_HUMAN

UniProt

P40305 - IFI27_HUMAN

Protein

Interferon alpha-inducible protein 27, mitochondrial

Gene

IFI27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.1 Publication

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. apoptotic signaling pathway Source: UniProtKB
    3. cytokine-mediated signaling pathway Source: Reactome
    4. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-inducible protein 27, mitochondrial
    Short name:
    p27
    Alternative name(s):
    Interferon alpha-induced 11.5 kDa protein
    Interferon-stimulated gene 12a protein
    Short name:
    ISG12(a)
    Gene namesi
    Name:IFI27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:5397. IFI27.

    Subcellular locationi

    Mitochondrion 1 Publication. Membrane Curated; Multi-pass membrane protein Curated

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: Reactome
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 11986Interferon alpha-inducible protein 27, mitochondrialPRO_0000147372Add
    BLAST

    Proteomic databases

    MaxQBiP40305.
    PaxDbiP40305.
    PRIDEiP40305.

    PTM databases

    PhosphoSiteiP40305.

    Expressioni

    Inductioni

    Up-regulated by interferons.1 Publication

    Gene expression databases

    ArrayExpressiP40305.
    BgeeiP40305.
    CleanExiHS_IFI27.
    GenevestigatoriP40305.

    Organism-specific databases

    HPAiHPA028875.

    Interactioni

    Protein-protein interaction databases

    BioGridi109655. 2 interactions.
    IntActiP40305. 12 interactions.
    MINTiMINT-4726676.
    STRINGi9606.ENSP00000298902.

    Structurei

    3D structure databases

    ProteinModelPortaliP40305.
    SMRiP40305. Positions 48-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IFI6/IFI27 family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245779.
    HOGENOMiHOG000112988.
    HOVERGENiHBG099821.
    InParanoidiP40305.
    PhylomeDBiP40305.
    TreeFamiTF340510.

    Family and domain databases

    InterProiIPR009311. IFI6/IFI27.
    [Graphical view]
    PANTHERiPTHR16932. PTHR16932. 1 hit.
    PfamiPF06140. Ifi-6-16. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA    50
    MGFTAAGIAS SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT 100
    KFILGSIGSA IAAVIARFY 119
    Length:119
    Mass (Da):11,268
    Last modified:October 17, 2006 - v3
    Checksum:i242C9388FEF8FF9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421V → VAMA in CAA47739. (PubMed:8358738)Curated
    Sequence conflicti86 – 861A → G in CAA47739. (PubMed:8358738)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061S → F.
    Corresponds to variant rs2227974 [ dbSNP | Ensembl ].
    VAR_028066

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67325 mRNA. Translation: CAA47739.1.
    BT006781 mRNA. Translation: AAP35427.1.
    AM393107 mRNA. Translation: CAL37985.1.
    BC015492 mRNA. Translation: AAH15492.1.
    BN000227 mRNA. Translation: CAE00394.1.
    CCDSiCCDS32148.1.
    PIRiI38081.
    RefSeqiNP_001123552.1. NM_001130080.2.
    NP_001275881.1. NM_001288952.1.
    NP_001275883.1. NM_001288954.1.
    NP_001275885.1. NM_001288956.1.
    NP_001275886.1. NM_001288957.1.
    NP_001275887.1. NM_001288958.1.
    NP_001275924.1. NM_001288995.1.
    NP_005523.3. NM_005532.4.
    UniGeneiHs.532634.

    Genome annotation databases

    EnsembliENST00000298902; ENSP00000298902; ENSG00000165949.
    ENST00000555744; ENSP00000451956; ENSG00000165949.
    GeneIDi3429.
    KEGGihsa:3429.

    Polymorphism databases

    DMDMi116242590.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67325 mRNA. Translation: CAA47739.1 .
    BT006781 mRNA. Translation: AAP35427.1 .
    AM393107 mRNA. Translation: CAL37985.1 .
    BC015492 mRNA. Translation: AAH15492.1 .
    BN000227 mRNA. Translation: CAE00394.1 .
    CCDSi CCDS32148.1.
    PIRi I38081.
    RefSeqi NP_001123552.1. NM_001130080.2.
    NP_001275881.1. NM_001288952.1.
    NP_001275883.1. NM_001288954.1.
    NP_001275885.1. NM_001288956.1.
    NP_001275886.1. NM_001288957.1.
    NP_001275887.1. NM_001288958.1.
    NP_001275924.1. NM_001288995.1.
    NP_005523.3. NM_005532.4.
    UniGenei Hs.532634.

    3D structure databases

    ProteinModelPortali P40305.
    SMRi P40305. Positions 48-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109655. 2 interactions.
    IntActi P40305. 12 interactions.
    MINTi MINT-4726676.
    STRINGi 9606.ENSP00000298902.

    PTM databases

    PhosphoSitei P40305.

    Polymorphism databases

    DMDMi 116242590.

    Proteomic databases

    MaxQBi P40305.
    PaxDbi P40305.
    PRIDEi P40305.

    Protocols and materials databases

    DNASUi 3429.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298902 ; ENSP00000298902 ; ENSG00000165949 .
    ENST00000555744 ; ENSP00000451956 ; ENSG00000165949 .
    GeneIDi 3429.
    KEGGi hsa:3429.

    Organism-specific databases

    CTDi 3429.
    GeneCardsi GC14P094577.
    HGNCi HGNC:5397. IFI27.
    HPAi HPA028875.
    MIMi 600009. gene.
    neXtProti NX_P40305.
    PharmGKBi PA29643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245779.
    HOGENOMi HOG000112988.
    HOVERGENi HBG099821.
    InParanoidi P40305.
    PhylomeDBi P40305.
    TreeFami TF340510.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    ChiTaRSi IFI27. human.
    GeneWikii IFI27.
    GenomeRNAii 3429.
    NextBioi 13520.
    PROi P40305.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40305.
    Bgeei P40305.
    CleanExi HS_IFI27.
    Genevestigatori P40305.

    Family and domain databases

    InterProi IPR009311. IFI6/IFI27.
    [Graphical view ]
    PANTHERi PTHR16932. PTHR16932. 1 hit.
    Pfami PF06140. Ifi-6-16. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma."
      Rasmussen U.B., Wolf C., Mattei M.-G., Chenard M.P., Bellocq J.-P., Chambon P., Rio M.C., Basset P.
      Cancer Res. 53:4096-4101(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12."
      Parker N., Porter A.C.G.
      BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a."
      Rosebeck S., Leaman D.W.
      Apoptosis 13:562-572(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.

    Entry informationi

    Entry nameiIFI27_HUMAN
    AccessioniPrimary (citable) accession number: P40305
    Secondary accession number(s): Q53YA6, Q6IEC1, Q96BK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3