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Protein

Interferon alpha-inducible protein 27, mitochondrial

Gene

IFI27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.1 Publication

GO - Molecular functioni

  • lamin binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: MGI

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic signaling pathway Source: UniProtKB
  • cytokine-mediated signaling pathway Source: Reactome
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of protein export from nucleus Source: MGI
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-inducible protein 27, mitochondrial
Short name:
p27
Alternative name(s):
Interferon alpha-induced 11.5 kDa protein
Interferon-stimulated gene 12a protein
Short name:
ISG12(a)
Gene namesi
Name:IFI27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5397. IFI27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: Reactome
  • mitochondrion Source: UniProtKB
  • nuclear inner membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29643.

Polymorphism and mutation databases

BioMutaiIFI27.
DMDMi116242590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 11986Interferon alpha-inducible protein 27, mitochondrialPRO_0000147372Add
BLAST

Proteomic databases

MaxQBiP40305.
PaxDbiP40305.
PRIDEiP40305.

PTM databases

PhosphoSiteiP40305.

Expressioni

Inductioni

Up-regulated by interferons.1 Publication

Gene expression databases

BgeeiP40305.
CleanExiHS_IFI27.
GenevisibleiP40305. HS.

Organism-specific databases

HPAiHPA028875.

Interactioni

Protein-protein interaction databases

BioGridi109655. 1 interaction.
IntActiP40305. 14 interactions.
MINTiMINT-4726676.
STRINGi9606.ENSP00000298902.

Structurei

3D structure databases

ProteinModelPortaliP40305.
SMRiP40305. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI6/IFI27 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245779.
HOGENOMiHOG000112988.
HOVERGENiHBG099821.
InParanoidiP40305.
PhylomeDBiP40305.
TreeFamiTF340510.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAVPMVLSA
60 70 80 90 100
MGFTAAGIAS SSIAAKMMSA AAIANGGGVA SGSLVATLQS LGATGLSGLT
110
KFILGSIGSA IAAVIARFY
Length:119
Mass (Da):11,268
Last modified:October 17, 2006 - v3
Checksum:i242C9388FEF8FF9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421V → VAMA in CAA47739 (PubMed:8358738).Curated
Sequence conflicti86 – 861A → G in CAA47739 (PubMed:8358738).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061S → F.
Corresponds to variant rs2227974 [ dbSNP | Ensembl ].
VAR_028066

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA. Translation: CAA47739.1.
BT006781 mRNA. Translation: AAP35427.1.
AM393107 mRNA. Translation: CAL37985.1.
BC015492 mRNA. Translation: AAH15492.1.
BN000227 mRNA. Translation: CAE00394.1.
CCDSiCCDS32148.1.
PIRiI38081.
RefSeqiNP_001123552.1. NM_001130080.2.
NP_001275881.1. NM_001288952.1.
NP_001275883.1. NM_001288954.1.
NP_001275885.1. NM_001288956.1.
NP_001275886.1. NM_001288957.1.
NP_001275887.1. NM_001288958.1.
NP_001275924.1. NM_001288995.1.
NP_005523.3. NM_005532.4.
UniGeneiHs.532634.

Genome annotation databases

EnsembliENST00000298902; ENSP00000298902; ENSG00000165949.
ENST00000555744; ENSP00000451956; ENSG00000165949.
GeneIDi3429.
KEGGihsa:3429.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67325 mRNA. Translation: CAA47739.1.
BT006781 mRNA. Translation: AAP35427.1.
AM393107 mRNA. Translation: CAL37985.1.
BC015492 mRNA. Translation: AAH15492.1.
BN000227 mRNA. Translation: CAE00394.1.
CCDSiCCDS32148.1.
PIRiI38081.
RefSeqiNP_001123552.1. NM_001130080.2.
NP_001275881.1. NM_001288952.1.
NP_001275883.1. NM_001288954.1.
NP_001275885.1. NM_001288956.1.
NP_001275886.1. NM_001288957.1.
NP_001275887.1. NM_001288958.1.
NP_001275924.1. NM_001288995.1.
NP_005523.3. NM_005532.4.
UniGeneiHs.532634.

3D structure databases

ProteinModelPortaliP40305.
SMRiP40305. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109655. 1 interaction.
IntActiP40305. 14 interactions.
MINTiMINT-4726676.
STRINGi9606.ENSP00000298902.

PTM databases

PhosphoSiteiP40305.

Polymorphism and mutation databases

BioMutaiIFI27.
DMDMi116242590.

Proteomic databases

MaxQBiP40305.
PaxDbiP40305.
PRIDEiP40305.

Protocols and materials databases

DNASUi3429.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298902; ENSP00000298902; ENSG00000165949.
ENST00000555744; ENSP00000451956; ENSG00000165949.
GeneIDi3429.
KEGGihsa:3429.

Organism-specific databases

CTDi3429.
GeneCardsiGC14P094577.
HGNCiHGNC:5397. IFI27.
HPAiHPA028875.
MIMi600009. gene.
neXtProtiNX_P40305.
PharmGKBiPA29643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245779.
HOGENOMiHOG000112988.
HOVERGENiHBG099821.
InParanoidiP40305.
PhylomeDBiP40305.
TreeFamiTF340510.

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFI27. human.
GeneWikiiIFI27.
GenomeRNAii3429.
NextBioi13520.
PROiP40305.
SOURCEiSearch...

Gene expression databases

BgeeiP40305.
CleanExiHS_IFI27.
GenevisibleiP40305. HS.

Family and domain databases

InterProiIPR009311. IFI6/IFI27.
[Graphical view]
PANTHERiPTHR16932. PTHR16932. 1 hit.
PfamiPF06140. Ifi-6-16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma."
    Rasmussen U.B., Wolf C., Mattei M.-G., Chenard M.P., Bellocq J.-P., Chambon P., Rio M.C., Basset P.
    Cancer Res. 53:4096-4101(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12."
    Parker N., Porter A.C.G.
    BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a."
    Rosebeck S., Leaman D.W.
    Apoptosis 13:562-572(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiIFI27_HUMAN
AccessioniPrimary (citable) accession number: P40305
Secondary accession number(s): Q53YA6, Q6IEC1, Q96BK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.