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Protein

B-cell antigen receptor complex-associated protein alpha chain

Gene

CD79A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei207Required for binding to BLNKBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-BTA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein alpha chain
Alternative name(s):
Ig-alpha
MB-1 membrane glycoprotein
Membrane-bound immunoglobulin-associated protein
Surface IgM-associated protein
CD_antigen: CD79a
Gene namesi
Name:CD79A
Synonyms:IGA, MB-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Cell membrane; Single-pass type I membrane protein

  • Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 140ExtracellularSequence analysisAdd BLAST109
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 223CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001455732 – 223B-cell antigen receptor complex-associated protein alpha chainAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 104PROSITE-ProRule annotation
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116Interchain (with beta chain)PROSITE-ProRule annotation
Modified residuei185Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei196PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei201Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei207Phosphotyrosine; by Tyr-kinasesPROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation (By similarity).By similarity
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP40293.
PRIDEiP40293.

Expressioni

Tissue specificityi

B-cells.

Gene expression databases

BgeeiENSBTAG00000001882.

Interactioni

Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002451.

Structurei

3D structure databases

ProteinModelPortaliP40293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 120Ig-like C2-typeAdd BLAST89
Domaini174 – 202ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV8X. Eukaryota.
ENOG4111VIC. LUCA.
GeneTreeiENSGT00510000049127.
HOGENOMiHOG000074307.
HOVERGENiHBG050854.
InParanoidiP40293.
KOiK06506.
OMAiRKRWQNE.
OrthoDBiEOG091G10RQ.
TreeFamiTF336032.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEGPQALQS PPATIFLLLI SAAGLGPGCQ ALWVEWGPPS VTVSVGEEVR
60 70 80 90 100
LQCTHNGSNT NVTWWHVLQS NSSWPPVMYR GDVGAGGELI IKPVNKTHRG
110 120 130 140 150
MYRCQVSDGK KIQRSCGTYL RVRDPLPRPF LDMGEGTKNN IITAEGIILL
160 170 180 190 200
ICAVVPGTLL LFRKRWQNMK FGADIQDDYE DENLYEGLNL DDCSMYEDIS
210 220
RGLQGTYQDV GSLHIGDAQL EKP
Length:223
Mass (Da):24,630
Last modified:February 1, 1995 - v1
Checksum:iCE2F0AF175748304
GO
Isoform 2 (identifier: P40293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: DPLPRPFLDM → ETMAEHEIRG
     134-223: Missing.

Show »
Length:133
Mass (Da):14,569
Checksum:i2138247082818E68
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027221124 – 133DPLPRPFLDM → ETMAEHEIRG in isoform 2. 1 Publication10
Alternative sequenceiVSP_027222134 – 223Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16412 mRNA. Translation: BAA03899.1.
D16459 mRNA. Translation: BAA03926.1.
BC120260 mRNA. Translation: AAI20261.1.
PIRiI45927.
RefSeqiNP_776691.2. NM_174266.4. [P40293-1]
UniGeneiBt.4436.

Genome annotation databases

EnsembliENSBTAT00000002451; ENSBTAP00000002451; ENSBTAG00000001882. [P40293-1]
ENSBTAT00000031989; ENSBTAP00000031933; ENSBTAG00000001882. [P40293-2]
GeneIDi281674.
KEGGibta:281674.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16412 mRNA. Translation: BAA03899.1.
D16459 mRNA. Translation: BAA03926.1.
BC120260 mRNA. Translation: AAI20261.1.
PIRiI45927.
RefSeqiNP_776691.2. NM_174266.4. [P40293-1]
UniGeneiBt.4436.

3D structure databases

ProteinModelPortaliP40293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002451.

Proteomic databases

PaxDbiP40293.
PRIDEiP40293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002451; ENSBTAP00000002451; ENSBTAG00000001882. [P40293-1]
ENSBTAT00000031989; ENSBTAP00000031933; ENSBTAG00000001882. [P40293-2]
GeneIDi281674.
KEGGibta:281674.

Organism-specific databases

CTDi973.

Phylogenomic databases

eggNOGiENOG410IV8X. Eukaryota.
ENOG4111VIC. LUCA.
GeneTreeiENSGT00510000049127.
HOGENOMiHOG000074307.
HOVERGENiHBG050854.
InParanoidiP40293.
KOiK06506.
OMAiRKRWQNE.
OrthoDBiEOG091G10RQ.
TreeFamiTF336032.

Enzyme and pathway databases

ReactomeiR-BTA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Gene expression databases

BgeeiENSBTAG00000001882.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD79A_BOVIN
AccessioniPrimary (citable) accession number: P40293
Secondary accession number(s): Q0P5B8, Q28134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.