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P40293

- CD79A_BOVIN

UniProt

P40293 - CD79A_BOVIN

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Protein

B-cell antigen receptor complex-associated protein alpha chain

Gene
CD79A, IGA, MB-1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei207 – 2071Required for binding to BLNK By similarity

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. B cell activation Source: UniProtKB
  2. B cell differentiation Source: UniProtKB
  3. B cell proliferation Source: UniProtKB
  4. B cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_214174. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein alpha chain
Alternative name(s):
Ig-alpha
MB-1 membrane glycoprotein
Membrane-bound immunoglobulin-associated protein
Surface IgM-associated protein
CD_antigen: CD79a
Gene namesi
Name:CD79A
Synonyms:IGA, MB-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 140109Extracellular Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Reviewed predictionAdd
BLAST
Topological domaini162 – 22362Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. B cell receptor complex Source: UniProtKB
  2. external side of plasma membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: UniProtKB
  5. multivesicular body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 223192B-cell antigen receptor complex-associated protein alpha chainPRO_0000014557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 104 Reviewed prediction
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi116 – 116Interchain (with beta chain) Reviewed prediction
Modified residuei185 – 1851Phosphotyrosine; by SRC-type Tyr-kinases By similarity
Modified residuei196 – 1961Phosphotyrosine By similarity
Modified residuei201 – 2011Asymmetric dimethylarginine; by PRMT1 By similarity
Modified residuei207 – 2071Phosphotyrosine; by Tyr-kinases By similarity

Post-translational modificationi

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation By similarity.
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PRIDEiP40293.

Expressioni

Tissue specificityi

B-cells.

Interactioni

Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity By similarity.

Structurei

3D structure databases

ProteinModelPortaliP40293.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12089Ig-like C2-typeAdd
BLAST
Domaini174 – 20229ITAMAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41728.
GeneTreeiENSGT00510000049127.
HOGENOMiHOG000074307.
HOVERGENiHBG050854.
InParanoidiP40293.
KOiK06506.
OMAiRKRWQNE.
OrthoDBiEOG7J70GM.
TreeFamiTF336032.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P40293-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPEGPQALQS PPATIFLLLI SAAGLGPGCQ ALWVEWGPPS VTVSVGEEVR    50
LQCTHNGSNT NVTWWHVLQS NSSWPPVMYR GDVGAGGELI IKPVNKTHRG 100
MYRCQVSDGK KIQRSCGTYL RVRDPLPRPF LDMGEGTKNN IITAEGIILL 150
ICAVVPGTLL LFRKRWQNMK FGADIQDDYE DENLYEGLNL DDCSMYEDIS 200
RGLQGTYQDV GSLHIGDAQL EKP 223
Length:223
Mass (Da):24,630
Last modified:February 1, 1995 - v1
Checksum:iCE2F0AF175748304
GO
Isoform 2 (identifier: P40293-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: DPLPRPFLDM → ETMAEHEIRG
     134-223: Missing.

Show »
Length:133
Mass (Da):14,569
Checksum:i2138247082818E68
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 13310DPLPRPFLDM → ETMAEHEIRG in isoform 2. VSP_027221
Alternative sequencei134 – 22390Missing in isoform 2. VSP_027222Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16412 mRNA. Translation: BAA03899.1.
D16459 mRNA. Translation: BAA03926.1.
BC120260 mRNA. Translation: AAI20261.1.
PIRiI45927.
RefSeqiNP_776691.2. NM_174266.4. [P40293-1]
UniGeneiBt.4436.

Genome annotation databases

EnsembliENSBTAT00000002451; ENSBTAP00000002451; ENSBTAG00000001882. [P40293-1]
ENSBTAT00000031989; ENSBTAP00000031933; ENSBTAG00000001882. [P40293-2]
GeneIDi281674.
KEGGibta:281674.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16412 mRNA. Translation: BAA03899.1 .
D16459 mRNA. Translation: BAA03926.1 .
BC120260 mRNA. Translation: AAI20261.1 .
PIRi I45927.
RefSeqi NP_776691.2. NM_174266.4. [P40293-1 ]
UniGenei Bt.4436.

3D structure databases

ProteinModelPortali P40293.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P40293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002451 ; ENSBTAP00000002451 ; ENSBTAG00000001882 . [P40293-1 ]
ENSBTAT00000031989 ; ENSBTAP00000031933 ; ENSBTAG00000001882 . [P40293-2 ]
GeneIDi 281674.
KEGGi bta:281674.

Organism-specific databases

CTDi 973.

Phylogenomic databases

eggNOGi NOG41728.
GeneTreei ENSGT00510000049127.
HOGENOMi HOG000074307.
HOVERGENi HBG050854.
InParanoidi P40293.
KOi K06506.
OMAi RKRWQNE.
OrthoDBi EOG7J70GM.
TreeFami TF336032.

Enzyme and pathway databases

Reactomei REACT_214174. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

NextBioi 20805602.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two forms of the mb-1 gene transcript in cattle."
    Youn H.-Y., Goitsuka R., Okuda M., Watari T., Tsujimoto H., Hasegawa A.
    J. Immunol. 153:5127-5132(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Leukocyte and Lymphoblast.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiCD79A_BOVIN
AccessioniPrimary (citable) accession number: P40293
Secondary accession number(s): Q0P5B8, Q28134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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