Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P40293

- CD79A_BOVIN

UniProt

P40293 - CD79A_BOVIN

Protein

B-cell antigen receptor complex-associated protein alpha chain

Gene

CD79A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei207 – 2071Required for binding to BLNKBy similarity

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. B cell activation Source: UniProtKB
    2. B cell differentiation Source: UniProtKB
    3. B cell proliferation Source: UniProtKB
    4. B cell receptor signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_214174. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell antigen receptor complex-associated protein alpha chain
    Alternative name(s):
    Ig-alpha
    MB-1 membrane glycoprotein
    Membrane-bound immunoglobulin-associated protein
    Surface IgM-associated protein
    CD_antigen: CD79a
    Gene namesi
    Name:CD79A
    Synonyms:IGA, MB-1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein
    Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.By similarity

    GO - Cellular componenti

    1. B cell receptor complex Source: UniProtKB
    2. external side of plasma membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: UniProtKB
    5. multivesicular body Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 223192B-cell antigen receptor complex-associated protein alpha chainPRO_0000014557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 104PROSITE-ProRule annotation
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 – 116Interchain (with beta chain)PROSITE-ProRule annotation
    Modified residuei185 – 1851Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotation
    Modified residuei196 – 1961PhosphotyrosinePROSITE-ProRule annotation
    Modified residuei201 – 2011Asymmetric dimethylarginine; by PRMT1By similarity
    Modified residuei207 – 2071Phosphotyrosine; by Tyr-kinasesPROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation By similarity.By similarity
    Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

    Proteomic databases

    PRIDEiP40293.

    Expressioni

    Tissue specificityi

    B-cells.

    Interactioni

    Subunit structurei

    Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP40293.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 140109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 22362CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12089Ig-like C2-typeAdd
    BLAST
    Domaini174 – 20229ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41728.
    GeneTreeiENSGT00510000049127.
    HOGENOMiHOG000074307.
    HOVERGENiHBG050854.
    InParanoidiP40293.
    KOiK06506.
    OMAiRKRWQNE.
    OrthoDBiEOG7J70GM.
    TreeFamiTF336032.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF02189. ITAM. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P40293-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEGPQALQS PPATIFLLLI SAAGLGPGCQ ALWVEWGPPS VTVSVGEEVR    50
    LQCTHNGSNT NVTWWHVLQS NSSWPPVMYR GDVGAGGELI IKPVNKTHRG 100
    MYRCQVSDGK KIQRSCGTYL RVRDPLPRPF LDMGEGTKNN IITAEGIILL 150
    ICAVVPGTLL LFRKRWQNMK FGADIQDDYE DENLYEGLNL DDCSMYEDIS 200
    RGLQGTYQDV GSLHIGDAQL EKP 223
    Length:223
    Mass (Da):24,630
    Last modified:February 1, 1995 - v1
    Checksum:iCE2F0AF175748304
    GO
    Isoform 2 (identifier: P40293-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-133: DPLPRPFLDM → ETMAEHEIRG
         134-223: Missing.

    Show »
    Length:133
    Mass (Da):14,569
    Checksum:i2138247082818E68
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei124 – 13310DPLPRPFLDM → ETMAEHEIRG in isoform 2. 1 PublicationVSP_027221
    Alternative sequencei134 – 22390Missing in isoform 2. 1 PublicationVSP_027222Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16412 mRNA. Translation: BAA03899.1.
    D16459 mRNA. Translation: BAA03926.1.
    BC120260 mRNA. Translation: AAI20261.1.
    PIRiI45927.
    RefSeqiNP_776691.2. NM_174266.4. [P40293-1]
    UniGeneiBt.4436.

    Genome annotation databases

    EnsembliENSBTAT00000002451; ENSBTAP00000002451; ENSBTAG00000001882. [P40293-1]
    ENSBTAT00000031989; ENSBTAP00000031933; ENSBTAG00000001882. [P40293-2]
    GeneIDi281674.
    KEGGibta:281674.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16412 mRNA. Translation: BAA03899.1 .
    D16459 mRNA. Translation: BAA03926.1 .
    BC120260 mRNA. Translation: AAI20261.1 .
    PIRi I45927.
    RefSeqi NP_776691.2. NM_174266.4. [P40293-1 ]
    UniGenei Bt.4436.

    3D structure databases

    ProteinModelPortali P40293.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P40293.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002451 ; ENSBTAP00000002451 ; ENSBTAG00000001882 . [P40293-1 ]
    ENSBTAT00000031989 ; ENSBTAP00000031933 ; ENSBTAG00000001882 . [P40293-2 ]
    GeneIDi 281674.
    KEGGi bta:281674.

    Organism-specific databases

    CTDi 973.

    Phylogenomic databases

    eggNOGi NOG41728.
    GeneTreei ENSGT00510000049127.
    HOGENOMi HOG000074307.
    HOVERGENi HBG050854.
    InParanoidi P40293.
    KOi K06506.
    OMAi RKRWQNE.
    OrthoDBi EOG7J70GM.
    TreeFami TF336032.

    Enzyme and pathway databases

    Reactomei REACT_214174. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

    Miscellaneous databases

    NextBioi 20805602.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF02189. ITAM. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two forms of the mb-1 gene transcript in cattle."
      Youn H.-Y., Goitsuka R., Okuda M., Watari T., Tsujimoto H., Hasegawa A.
      J. Immunol. 153:5127-5132(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Leukocyte and Lymphoblast.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCD79A_BOVIN
    AccessioniPrimary (citable) accession number: P40293
    Secondary accession number(s): Q0P5B8, Q28134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3