Reviewed, UniProtKB/Swiss-Prot P40292 (HSP90_ASPFU)

Names and origin

Protein names

Recommended name:
    Heat shock protein 90
Alternative name(s):
    Heat shock protein hsp1
    65 kDa IgE-binding protein
    Allergen=Asp f 12

Gene names

Name:	hsp90
Synonyms:	hsp1
ORF Names:	AFUA_5G04170

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Disease	Allergen
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Heat shock protein 90		PRO_0000062960

Sequences

	Sequence		Length	Mass (Da)
	P40292-1 [UniParc]. Last modified December 6, 2005. Version 3. Checksum: 8C6389FC933934D8	FASTA	706	80,640
	10 20 30 40 50 60 MSSETFEFQA EISQLLSLII NTVYSNKEIF LRELISNASD ALDKIRYQSL SDPTKLDTGK 70 80 90 100 110 120 DLRIDIIPDK ENKTLTIRDT GIGMTKADLI NNLGTIARSG TKQFMEALSA GADISMIGQF 130 140 150 160 170 180 GVGFYSAYLV ADRVTVVSKN NDDEQYIWES AAGGTFTLTQ DTEGEQLGRG TKIILHLKDE 190 200 210 220 230 240 QTDYLNESRI KEVVRKHSEF ISYPIYLHVL KETEKEVPDE EAEETKEEED EEKKAKIEEV 250 260 270 280 290 300 DDEEEEEKKK KKKTKTVKES KIEEEELNKT KPIWTRNPAD ITQEEYASFY KSLSNDWEDH 310 320 330 340 350 360 LAVKHFSVEG QLEFRAILYV PKRAPFDLFE TKKTKNNIKL YVRRVFITDD ATDLIPEWLG 370 380 390 400 410 420 FIKGVVDSED LPLNLSRETL QQNKIMKVIK KNIVKKTLEL FNEIAEDREQ FDKFYSAFSK 430 440 450 460 470 480 NIKLGIHEDA QNRQTLAKLL RYQSTKSGDE ATSLADYVTR MPEHQKQIYY ITGESIKAVA 490 500 510 520 530 540 KSPFLDSLKQ KNFEVLFLVD PIDEYAFTQL KEFDGKKLVD ITKDFELEET EEEKAEREKE 550 560 570 580 590 600 EKEYENLAKS LKNILGDKVE KVVVSHKLVG SPCAIRTGQF GWSANMERIM KAQALRDTSM 610 620 630 640 650 660 SSYMSSKKTF EISPKSSIIK ELKKKVEADG ENDRTVKSIT QLLFETSLLV SGFTIEEPAS 670 680 690 700 FAERIHKLVS LGLNIDEEAE TTEEKATEEA APAEATTGES AMEEVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.
[2]	Kurup V.P., Banerjee B. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-706.
[3]	"Isolation and characterization of a recombinant heat shock protein of Aspergillus fumigatus." Kumar A., Reddy L.V., Sochanik A., Kurup V.P. J. Allergy Clin. Immunol. 91:1024-1030(1993) [PubMed: 8491935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 430-549. Strain: ATCC 42202 / AF-102 / Ag 507.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000011 Genomic DNA. Translation: EAL85888.1. U92465 mRNA. Translation: AAB51544.1.
RefSeq	XP_747926.1.
3D structure databases
SMR	P40292. Positions 2-674.
ModBase	Search...
Protein-protein interaction databases
STRING	P40292.
Genome annotation databases
GeneID	3505604.
GenomeReviews	Gene locus hsp90 in contig CM000173_GR.
KEGG	afm:AFUA_5G04170.
Phylogenomic databases
HOGENOM	HBG631012.
OMA	TEGYWKV.
OrthoDB	EOG9BRZ2V.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR001404. Chaperone_htpG. IPR019805. Heat_shock_protein_90_CS. IPR020576. Hsp90_C. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PANTHER	PTHR11528. Hsp90. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP90_ASPFU

Accession

Primary (citable) accession number: P40292
Secondary accession number(s): Q4WET9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	December 6, 2005
Last modified:	December 15, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)