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Protein

Heat shock protein 90

Gene

hsp90

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATPBy similarity
Binding sitei79 – 791ATPBy similarity
Binding sitei124 – 1241ATP; via amide nitrogenBy similarity
Binding sitei377 – 3771ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90
Alternative name(s):
65 kDa IgE-binding protein
Heat shock protein hsp1
Allergen: Asp f 12
Gene namesi
Name:hsp90
Synonyms:hsp1
ORF Names:AFUA_5G04170
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g04170.

Subcellular locationi

GO - Cellular componenti

  • cell septum Source: ASPGD
  • cytosol Source: ASPGD
  • fungal-type cell wall Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3110. Asp f 12.0101.
65. Asp f 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Heat shock protein 90PRO_0000062960Add
BLAST

Proteomic databases

PRIDEiP40292.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP40292.
SMRiP40292. Positions 2-674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi702 – 7065TPR repeat-binding

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

HOGENOMiHOG000031988.
InParanoidiP40292.
KOiK04079.
OMAiWSANFER.
OrthoDBiEOG092C1GW3.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSETFEFQA EISQLLSLII NTVYSNKEIF LRELISNASD ALDKIRYQSL
60 70 80 90 100
SDPTKLDTGK DLRIDIIPDK ENKTLTIRDT GIGMTKADLI NNLGTIARSG
110 120 130 140 150
TKQFMEALSA GADISMIGQF GVGFYSAYLV ADRVTVVSKN NDDEQYIWES
160 170 180 190 200
AAGGTFTLTQ DTEGEQLGRG TKIILHLKDE QTDYLNESRI KEVVRKHSEF
210 220 230 240 250
ISYPIYLHVL KETEKEVPDE EAEETKEEED EEKKAKIEEV DDEEEEEKKK
260 270 280 290 300
KKKTKTVKES KIEEEELNKT KPIWTRNPAD ITQEEYASFY KSLSNDWEDH
310 320 330 340 350
LAVKHFSVEG QLEFRAILYV PKRAPFDLFE TKKTKNNIKL YVRRVFITDD
360 370 380 390 400
ATDLIPEWLG FIKGVVDSED LPLNLSRETL QQNKIMKVIK KNIVKKTLEL
410 420 430 440 450
FNEIAEDREQ FDKFYSAFSK NIKLGIHEDA QNRQTLAKLL RYQSTKSGDE
460 470 480 490 500
ATSLADYVTR MPEHQKQIYY ITGESIKAVA KSPFLDSLKQ KNFEVLFLVD
510 520 530 540 550
PIDEYAFTQL KEFDGKKLVD ITKDFELEET EEEKAEREKE EKEYENLAKS
560 570 580 590 600
LKNILGDKVE KVVVSHKLVG SPCAIRTGQF GWSANMERIM KAQALRDTSM
610 620 630 640 650
SSYMSSKKTF EISPKSSIIK ELKKKVEADG ENDRTVKSIT QLLFETSLLV
660 670 680 690 700
SGFTIEEPAS FAERIHKLVS LGLNIDEEAE TTEEKATEEA APAEATTGES

AMEEVD
Length:706
Mass (Da):80,640
Last modified:December 6, 2005 - v3
Checksum:i8C6389FC933934D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL85888.1.
U92465 mRNA. Translation: AAB51544.1.
RefSeqiXP_747926.1. XM_742833.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002754; CADAFUAP00002754; CADAFUAG00002754.
GeneIDi3505604.
KEGGiafm:AFUA_5G04170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA. Translation: EAL85888.1.
U92465 mRNA. Translation: AAB51544.1.
RefSeqiXP_747926.1. XM_742833.1.

3D structure databases

ProteinModelPortaliP40292.
SMRiP40292. Positions 2-674.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3110. Asp f 12.0101.
65. Asp f 12.

Proteomic databases

PRIDEiP40292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00002754; CADAFUAP00002754; CADAFUAG00002754.
GeneIDi3505604.
KEGGiafm:AFUA_5G04170.

Organism-specific databases

EuPathDBiFungiDB:Afu5g04170.

Phylogenomic databases

HOGENOMiHOG000031988.
InParanoidiP40292.
KOiK04079.
OMAiWSANFER.
OrthoDBiEOG092C1GW3.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP90_ASPFU
AccessioniPrimary (citable) accession number: P40292
Secondary accession number(s): Q4WET9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.