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P40289

- Y669_CUPNH

UniProt

P40289 - Y669_CUPNH

Protein

Putative tyrosine-protein phosphatase H16_A0669

Gene

H16_A0669

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-668-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tyrosine-protein phosphatase H16_A0669 (EC:3.1.3.48)
    Gene namesi
    Ordered Locus Names:H16_A0669
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 273258Putative tyrosine-protein phosphatase H16_A0669PRO_0000066290Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_A0669.

    Structurei

    3D structure databases

    ProteinModelPortaliP40289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2365.
    HOGENOMiHOG000036053.
    KOiK01104.
    OMAiANTAGPQ.
    OrthoDBiEOG6ZPSXQ.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR026893. Tyr/Ser_Pase_IphP-type.
    IPR016130. Tyr_Pase_AS.
    IPR025163. Tyr_Phosphatase_C_dom.
    [Graphical view]
    PfamiPF13350. Y_phosphatase3. 1 hit.
    PF13348. Y_phosphatase3C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40289-1 [UniParc]FASTAAdd to Basket

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    MIKWLQRAGC LSAHAVVPQA PAAASVQGRH DLAFDTISNA RDLGGLAGAG    50
    GRRVRQGRLY RSGNPALASA ADLERLQTLG LDMVVDFRSP GEKSPEEAAF 100
    GQRFHWVAAP VLEGSMAMDV LMPRLRASTP AQMDAFMLEV YGDFPVRYRE 150
    AFAGFMRTAQ GGKTLLFHCT AGKDRTGFAA LLLLAALGVA QDDILANYLE 200
    SNQRNAQFNQ TALARMAGLG VAPAVMTPLL EVRASYLDAS MRAIDAGWGS 250
    VDNYLRDALE VDVAQLRGHY LAG 273
    Length:273
    Mass (Da):29,325
    Last modified:January 23, 2007 - v2
    Checksum:i111724C25FF66286
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ91817.1.
    Z22737 Genomic DNA. No translation available.
    RefSeqiYP_725185.1. NC_008313.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ91817; CAJ91817; H16_A0669.
    GeneIDi4247616.
    KEGGireh:H16_A0669.
    PATRICi35230739. VBIRalEut6770_1038.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ91817.1 .
    Z22737 Genomic DNA. No translation available.
    RefSeqi YP_725185.1. NC_008313.1.

    3D structure databases

    ProteinModelPortali P40289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_A0669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ91817 ; CAJ91817 ; H16_A0669 .
    GeneIDi 4247616.
    KEGGi reh:H16_A0669.
    PATRICi 35230739. VBIRalEut6770_1038.

    Phylogenomic databases

    eggNOGi COG2365.
    HOGENOMi HOG000036053.
    KOi K01104.
    OMAi ANTAGPQ.
    OrthoDBi EOG6ZPSXQ.

    Enzyme and pathway databases

    BioCyci CNEC381666:GJUJ-668-MONOMER.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR026893. Tyr/Ser_Pase_IphP-type.
    IPR016130. Tyr_Pase_AS.
    IPR025163. Tyr_Phosphatase_C_dom.
    [Graphical view ]
    Pfami PF13350. Y_phosphatase3. 1 hit.
    PF13348. Y_phosphatase3C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.
    2. "The Alcaligenes eutrophus ldh structural gene encodes a novel type of lactate dehydrogenase."
      Jendrossek D., Kratzin H.D., Steinbuechel A.
      FEMS Microbiol. Lett. 112:229-235(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.

    Entry informationi

    Entry nameiY669_CUPNH
    AccessioniPrimary (citable) accession number: P40289
    Secondary accession number(s): Q0KDV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3