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P40289 (Y669_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative tyrosine-protein phosphatase H16_A0669

EC=3.1.3.48
Gene names
Ordered Locus Names:H16_A0669
OrganismCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 273258Putative tyrosine-protein phosphatase H16_A0669
PRO_0000066290

Sites

Active site1691Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P40289 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 111724C25FF66286

FASTA27329,325
        10         20         30         40         50         60 
MIKWLQRAGC LSAHAVVPQA PAAASVQGRH DLAFDTISNA RDLGGLAGAG GRRVRQGRLY 

        70         80         90        100        110        120 
RSGNPALASA ADLERLQTLG LDMVVDFRSP GEKSPEEAAF GQRFHWVAAP VLEGSMAMDV 

       130        140        150        160        170        180 
LMPRLRASTP AQMDAFMLEV YGDFPVRYRE AFAGFMRTAQ GGKTLLFHCT AGKDRTGFAA 

       190        200        210        220        230        240 
LLLLAALGVA QDDILANYLE SNQRNAQFNQ TALARMAGLG VAPAVMTPLL EVRASYLDAS 

       250        260        270 
MRAIDAGWGS VDNYLRDALE VDVAQLRGHY LAG 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16."
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.
Nat. Biotechnol. 24:1257-1262(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.
[2]"The Alcaligenes eutrophus ldh structural gene encodes a novel type of lactate dehydrogenase."
Jendrossek D., Kratzin H.D., Steinbuechel A.
FEMS Microbiol. Lett. 112:229-235(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260479 Genomic DNA. Translation: CAJ91817.1.
Z22737 Genomic DNA. No translation available.
RefSeqYP_725185.1. NC_008313.1.

3D structure databases

ProteinModelPortalP40289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381666.H16_A0669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ91817; CAJ91817; H16_A0669.
GeneID4247616.
KEGGreh:H16_A0669.
PATRIC35230739. VBIRalEut6770_1038.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2365.
HOGENOMHOG000036053.
KOK01104.
OMAGASNFRD.
OrthoDBEOG6ZPSXQ.
ProtClustDBCLSK939295.

Enzyme and pathway databases

BioCycCNEC381666:GJUJ-668-MONOMER.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view]
PfamPF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY669_CUPNH
AccessionPrimary (citable) accession number: P40289
Secondary accession number(s): Q0KDV4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families