P40289 (Y669_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase H16_A0669
EC=3.1.3.48

Gene names

Ordered Locus Names:

H16_A0669

Organism

Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

381666 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › Cupriavidus necator

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 273	258	Putative tyrosine-protein phosphatase H16_A0669		PRO_0000066290
Sites
	Active site	169	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P40289 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 111724C25FF66286	FASTA	273	29,325
	10 20 30 40 50 60 MIKWLQRAGC LSAHAVVPQA PAAASVQGRH DLAFDTISNA RDLGGLAGAG GRRVRQGRLY 70 80 90 100 110 120 RSGNPALASA ADLERLQTLG LDMVVDFRSP GEKSPEEAAF GQRFHWVAAP VLEGSMAMDV 130 140 150 160 170 180 LMPRLRASTP AQMDAFMLEV YGDFPVRYRE AFAGFMRTAQ GGKTLLFHCT AGKDRTGFAA 190 200 210 220 230 240 LLLLAALGVA QDDILANYLE SNQRNAQFNQ TALARMAGLG VAPAVMTPLL EVRASYLDAS 250 260 270 MRAIDAGWGS VDNYLRDALE VDVAQLRGHY LAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16." Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B. Nat. Biotechnol. 24:1257-1262(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.
[2]	"The Alcaligenes eutrophus ldh structural gene encodes a novel type of lactate dehydrogenase." Jendrossek D., Kratzin H.D., Steinbuechel A. FEMS Microbiol. Lett. 112:229-235(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260479 Genomic DNA. Translation: CAJ91817.1. Z22737 Genomic DNA. No translation available.
RefSeq	YP_725185.1. NC_008313.1.
3D structure databases
ProteinModelPortal	P40289.
ModBase	Search...
Protein-protein interaction databases
STRING	381666.H16_A0669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ91817; CAJ91817; H16_A0669.
GeneID	4247616.
KEGG	reh:H16_A0669.
PATRIC	35230739. VBIRalEut6770_1038.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2365.
HOGENOM	HOG000036053.
KO	K01104.
OMA	GLHTIFD.
ProtClustDB	CLSK939295.
Enzyme and pathway databases
BioCyc	CNEC381666:GJUJ-668-MONOMER.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR026893. Tyr/Ser_Pase_IphP-type. IPR016130. Tyr_Pase_AS. IPR025163. Tyr_Phosphatase_C_dom. [Graphical view]
Pfam	PF13350. Y_phosphatase3. 1 hit. PF13348. Y_phosphatase3C. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y669_CUPNH

Accession

Primary (citable) accession number: P40289
Secondary accession number(s): Q0KDV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program