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Protein

Glucose 1-dehydrogenase

Gene
N/A
Organism
Bacillus megaterium
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145SubstrateBy similarity1
Active sitei158Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 35NADP1 PublicationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.47. 656.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose 1-dehydrogenase (EC:1.1.1.47)
OrganismiBacillus megaterium
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi96E → A, G or K: Heat stable. 1 Publication1
Mutagenesisi108D → N: Heat stable. 1 Publication1
Mutagenesisi112V → A: Heat stable. 1 Publication1
Mutagenesisi133E → K: Heat stable. 1 Publication1
Mutagenesisi183V → I: Heat stable. 1 Publication1
Mutagenesisi194P → Q: Heat stable. 1 Publication1
Mutagenesisi210E → K: Heat stable. 1 Publication1
Mutagenesisi217Y → H: Heat stable. 1 Publication1
Mutagenesisi252Q → L: Heat stable. 1 Publication1
Mutagenesisi253Y → C: Heat stable. 1 Publication1
Mutagenesisi258A → G: Heat stable. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546151 – 261Glucose 1-dehydrogenaseAdd BLAST261

Expressioni

Developmental stagei

Expressed during sporulation.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi545693.BMQ_0838.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi9 – 12Combined sources4
Helixi18 – 29Combined sources12
Beta strandi33 – 40Combined sources8
Helixi42 – 54Combined sources13
Beta strandi58 – 63Combined sources6
Helixi69 – 83Combined sources15
Beta strandi88 – 91Combined sources4
Helixi101 – 103Combined sources3
Helixi106 – 116Combined sources11
Helixi118 – 133Combined sources16
Beta strandi139 – 143Combined sources5
Helixi146 – 148Combined sources3
Helixi156 – 176Combined sources21
Helixi177 – 179Combined sources3
Beta strandi182 – 188Combined sources7
Helixi194 – 196Combined sources3
Helixi197 – 201Combined sources5
Helixi203 – 210Combined sources8
Helixi221 – 232Combined sources12
Helixi234 – 236Combined sources3
Beta strandi243 – 247Combined sources5
Helixi250 – 252Combined sources3
Helixi254 – 259Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G6KX-ray2.00A/B/E/F1-261[»]
1GCOX-ray1.70A/B/E/F1-261[»]
1GEEX-ray1.60A/B/E/F1-261[»]
1RWBX-ray2.00A/B/E/F1-261[»]
ProteinModelPortaliP40288.
SMRiP40288.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40288.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EXU. Bacteria.
COG1028. LUCA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKDLEGKVV VITGSSTGLG KSMAIRFATE KAKVVVNYRS KEDEANSVLE
60 70 80 90 100
EIKKVGGEAI AVKGDVTVES DVINLVQSAI KEFGKLDVMI NNAGLENPVS
110 120 130 140 150
SHEMSLSDWN KVIDTNLTGA FLGSREAIKY FVENDIKGTV INMSSVHEKI
160 170 180 190 200
PWPLFVHYAA SKGGMKLMTE TLALEYAPKG IRVNNIGPGA INTPINAEKF
210 220 230 240 250
ADPEQRADVE SMIPMGYIGE PEEIAAVAAW LASSEASYVT GITLFADGGM
260
TQYPSFQAGR G
Length:261
Mass (Da):28,085
Last modified:February 1, 1995 - v1
Checksum:iC23AC98D304EEB2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04805 Genomic DNA. Translation: AAA22475.1.
PIRiA33528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04805 Genomic DNA. Translation: AAA22475.1.
PIRiA33528.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G6KX-ray2.00A/B/E/F1-261[»]
1GCOX-ray1.70A/B/E/F1-261[»]
1GEEX-ray1.60A/B/E/F1-261[»]
1RWBX-ray2.00A/B/E/F1-261[»]
ProteinModelPortaliP40288.
SMRiP40288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi545693.BMQ_0838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107EXU. Bacteria.
COG1028. LUCA.

Enzyme and pathway databases

BRENDAi1.1.1.47. 656.

Miscellaneous databases

EvolutionaryTraceiP40288.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHG_BACME
AccessioniPrimary (citable) accession number: P40288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.