Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

B-cell antigen receptor complex-associated protein beta chain

Gene

CD79B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.3 Publications

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • B cell differentiation Source: GO_Central
  • B cell receptor signaling pathway Source: GO_Central
  • immune response Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007312-MONOMER.
ReactomeiR-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP40259.
SIGNORiP40259.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein beta chain
Alternative name(s):
B-cell-specific glycoprotein B29
Ig-beta
Immunoglobulin-associated B29 protein
CD_antigen: CD79b
Gene namesi
Name:CD79B
Synonyms:B29, IGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1699. CD79B.

Subcellular locationi

  • Cell membrane; Single-pass type I membrane protein

  • Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 159ExtracellularSequence analysisAdd BLAST131
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 229CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • B cell receptor complex Source: GO_Central
  • cytoplasm Source: HPA
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: HPA
  • integral component of plasma membrane Source: ProtInc
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Agammaglobulinemia 6, autosomal recessive (AGM6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
See also OMIM:612692
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057833137G → S in AGM6. 1 PublicationCorresponds to variant rs121912424dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi974.
MalaCardsiCD79B.
MIMi612692. phenotype.
OpenTargetsiENSG00000007312.
Orphaneti33110. Autosomal agammaglobulinemia.
PharmGKBiPA26238.

Polymorphism and mutation databases

BioMutaiCD79B.
DMDMi728994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001456029 – 229B-cell antigen receptor complex-associated protein beta chainAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 126PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 122PROSITE-ProRule annotation1 Publication
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi136Interchain (with C-119 in alpha chain)PROSITE-ProRule annotation1 Publication
Modified residuei196Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei207Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP40259.
MaxQBiP40259.
PaxDbiP40259.
PeptideAtlasiP40259.
PRIDEiP40259.
TopDownProteomicsiP40259-2. [P40259-2]

PTM databases

iPTMnetiP40259.
PhosphoSitePlusiP40259.

Expressioni

Tissue specificityi

B-cells.

Gene expression databases

BgeeiENSG00000007312.
CleanExiHS_CD79B.
GenevisibleiP40259. HS.

Organism-specific databases

HPAiCAB009751.
HPA009178.

Interactioni

Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-2873732,EBI-347996

Protein-protein interaction databases

BioGridi107412. 100 interactors.
DIPiDIP-59497N.
IntActiP40259. 2 interactors.
STRINGi9606.ENSP00000376544.

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi61 – 66Combined sources6
Beta strandi75 – 84Combined sources10
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi102 – 109Combined sources8
Turni114 – 116Combined sources3
Beta strandi118 – 125Combined sources8
Turni127 – 129Combined sources3
Beta strandi132 – 134Combined sources3
Beta strandi138 – 143Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KG5X-ray3.20A/B26-159[»]
DisProtiDP00503.
ProteinModelPortaliP40259.
SMRiP40259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 138Ig-like V-typeAdd BLAST101
Domaini185 – 213ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J02H. Eukaryota.
ENOG410Z4S5. LUCA.
GeneTreeiENSGT00510000048811.
HOGENOMiHOG000049137.
HOVERGENiHBG050855.
InParanoidiP40259.
KOiK06507.
OMAiDQTATYE.
OrthoDBiEOG091G0O8L.
PhylomeDBiP40259.
TreeFamiTF336032.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P40259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP
60 70 80 90 100
RFIARKRGFT VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ
110 120 130 140 150
NESLATLTIQ GIRFEDNGIY FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ
160 170 180 190 200
LKQRNTLKDG IIMIQTLLII LFIIVPIFLL LDKDDSKAGM EEDHTYEGLD
210 220
IDQTATYEDI VTLRTGEVKW SVGEHPGQE
Length:229
Mass (Da):26,048
Last modified:February 1, 1995 - v1
Checksum:iC467175567D10883
GO
Isoform Short (identifier: P40259-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-144: Missing.

Show »
Length:125
Mass (Da):14,030
Checksum:i6CEE8C7A4F0AB1C0
GO
Isoform 3 (identifier: P40259-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: A → AA

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,119
Checksum:iFE9E79CA0CE5BBC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58G → A in AAB24822 (PubMed:8419481).Curated1
Sequence conflicti58G → R in AAA58387 (PubMed:1534761).Curated1
Sequence conflicti84E → A in AAB24822 (PubMed:8419481).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057833137G → S in AGM6. 1 PublicationCorresponds to variant rs121912424dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04722223A → AA in isoform 3. 1 Publication1
Alternative sequenceiVSP_00247741 – 144Missing in isoform Short. 2 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80461 mRNA. Translation: AAA58387.1.
M89957 mRNA. Translation: AAA64459.1.
S52229 mRNA. Translation: AAB24822.2.
L27587 Genomic DNA. Translation: AAA72424.1.
S79249 mRNA. Translation: AAC60654.1.
X83539 mRNA. Translation: CAA58522.1.
AK222954 mRNA. Translation: BAD96674.1.
AK223210 mRNA. Translation: BAD96930.1.
BC002975 mRNA. Translation: AAH02975.2.
BC032651 mRNA. Translation: AAH32651.1.
CCDSiCCDS11655.1. [P40259-1]
CCDS11656.1. [P40259-2]
CCDS42372.1. [P40259-3]
PIRiI54534. A46527.
RefSeqiNP_000617.1. NM_000626.3. [P40259-1]
NP_001035022.1. NM_001039933.2. [P40259-3]
NP_067613.1. NM_021602.3. [P40259-2]
UniGeneiHs.89575.

Genome annotation databases

EnsembliENST00000006750; ENSP00000006750; ENSG00000007312. [P40259-1]
ENST00000349817; ENSP00000245862; ENSG00000007312. [P40259-2]
ENST00000392795; ENSP00000376544; ENSG00000007312. [P40259-3]
GeneIDi974.
KEGGihsa:974.
UCSCiuc002jdp.2. human. [P40259-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

CD79Bbase

CD79B mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80461 mRNA. Translation: AAA58387.1.
M89957 mRNA. Translation: AAA64459.1.
S52229 mRNA. Translation: AAB24822.2.
L27587 Genomic DNA. Translation: AAA72424.1.
S79249 mRNA. Translation: AAC60654.1.
X83539 mRNA. Translation: CAA58522.1.
AK222954 mRNA. Translation: BAD96674.1.
AK223210 mRNA. Translation: BAD96930.1.
BC002975 mRNA. Translation: AAH02975.2.
BC032651 mRNA. Translation: AAH32651.1.
CCDSiCCDS11655.1. [P40259-1]
CCDS11656.1. [P40259-2]
CCDS42372.1. [P40259-3]
PIRiI54534. A46527.
RefSeqiNP_000617.1. NM_000626.3. [P40259-1]
NP_001035022.1. NM_001039933.2. [P40259-3]
NP_067613.1. NM_021602.3. [P40259-2]
UniGeneiHs.89575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KG5X-ray3.20A/B26-159[»]
DisProtiDP00503.
ProteinModelPortaliP40259.
SMRiP40259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107412. 100 interactors.
DIPiDIP-59497N.
IntActiP40259. 2 interactors.
STRINGi9606.ENSP00000376544.

PTM databases

iPTMnetiP40259.
PhosphoSitePlusiP40259.

Polymorphism and mutation databases

BioMutaiCD79B.
DMDMi728994.

Proteomic databases

EPDiP40259.
MaxQBiP40259.
PaxDbiP40259.
PeptideAtlasiP40259.
PRIDEiP40259.
TopDownProteomicsiP40259-2. [P40259-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006750; ENSP00000006750; ENSG00000007312. [P40259-1]
ENST00000349817; ENSP00000245862; ENSG00000007312. [P40259-2]
ENST00000392795; ENSP00000376544; ENSG00000007312. [P40259-3]
GeneIDi974.
KEGGihsa:974.
UCSCiuc002jdp.2. human. [P40259-1]

Organism-specific databases

CTDi974.
DisGeNETi974.
GeneCardsiCD79B.
HGNCiHGNC:1699. CD79B.
HPAiCAB009751.
HPA009178.
MalaCardsiCD79B.
MIMi147245. gene.
612692. phenotype.
neXtProtiNX_P40259.
OpenTargetsiENSG00000007312.
Orphaneti33110. Autosomal agammaglobulinemia.
PharmGKBiPA26238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J02H. Eukaryota.
ENOG410Z4S5. LUCA.
GeneTreeiENSGT00510000048811.
HOGENOMiHOG000049137.
HOVERGENiHBG050855.
InParanoidiP40259.
KOiK06507.
OMAiDQTATYE.
OrthoDBiEOG091G0O8L.
PhylomeDBiP40259.
TreeFamiTF336032.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007312-MONOMER.
ReactomeiR-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP40259.
SIGNORiP40259.

Miscellaneous databases

GeneWikiiCD79B.
GenomeRNAii974.
PROiP40259.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007312.
CleanExiHS_CD79B.
GenevisibleiP40259. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD79B_HUMAN
AccessioniPrimary (citable) accession number: P40259
Secondary accession number(s): Q53FS2, Q9BU06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.