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Protein

Thrombopoietin receptor

Gene

MPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell proliferation Source: ProtInc
  3. cell surface receptor signaling pathway Source: ProtInc
  4. homeostasis of number of cells Source: Ensembl
  5. platelet activation Source: Reactome
  6. regulation of chemokine production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_278. Platelet Aggregation (Plug Formation).
SignaLinkiP40238.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombopoietin receptor
Short name:
TPO-R
Alternative name(s):
Myeloproliferative leukemia protein
Proto-oncogene c-Mpl
CD_antigen: CD110
Gene namesi
Name:MPL
Synonyms:TPOR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7217. MPL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 491466ExtracellularSequence AnalysisAdd
BLAST
Transmembranei492 – 51322HelicalSequence AnalysisAdd
BLAST
Topological domaini514 – 635122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital amegakaryocytic thrombocytopenia

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionDisease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.

See also OMIM:604498
Thrombocythemia 22 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.

See also OMIM:601977
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti505 – 5051S → N in THCYT2; activating mutation; induces MPL autonomous dimerization and signal activation in the absence of the ligand. 2 Publications
Corresponds to variant rs121913614 [ dbSNP | Ensembl ].
VAR_067559
Natural varianti515 – 5151W → L in THCYT2 and MMM; somatic mutation in myelofibrosis with myeloid metaplasia; results in cytokine-independent growth and thrombopoietin hypersensitivity; results in constitutive activation of JAK-STAT signaling pathway. 2 Publications
Corresponds to variant rs121913615 [ dbSNP | Ensembl ].
VAR_067561
Myelofibrosis with myeloid metaplasia2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA chronic myeloproliferative disorder characterized by replacement of the bone marrow by fibrous tissue, extramedullary hematopoiesis, anemia, leukoerythroblastosis and hepatosplenomegaly.

See also OMIM:254450
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti515 – 5151W → K in MMM; somatic mutation; requires 2 nucleotide substitutions. 1 Publication
VAR_067560
Natural varianti515 – 5151W → L in THCYT2 and MMM; somatic mutation in myelofibrosis with myeloid metaplasia; results in cytokine-independent growth and thrombopoietin hypersensitivity; results in constitutive activation of JAK-STAT signaling pathway. 2 Publications
Corresponds to variant rs121913615 [ dbSNP | Ensembl ].
VAR_067561

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi254450. phenotype.
601977. phenotype.
604498. phenotype.
Orphaneti3319. Congenital amegakaryocytic thrombocytopenia.
3318. Essential thrombocythemia.
71493. Familial thrombocytosis.
397692. Hereditary aplastic anemia.
824. Myelofibrosis with myeloid metaplasia.
729. Polycythemia vera.
PharmGKBiPA30923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 635610Thrombopoietin receptorPRO_0000010987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 50By similarity
Disulfide bondi77 ↔ 93By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi291 ↔ 301By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 334By similarity
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence Analysis
Cross-linki553 – 553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki573 – 573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Post-translational modificationi

Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP40238.
PRIDEiP40238.

PTM databases

PhosphoSiteiP40238.

Expressioni

Tissue specificityi

Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.

Gene expression databases

BgeeiP40238.
CleanExiHS_MPL.
ExpressionAtlasiP40238. baseline and differential.
GenevestigatoriP40238.

Organism-specific databases

HPAiCAB002011.
HPA007619.

Interactioni

Subunit structurei

Interacts with ATXN2L.1 Publication

Protein-protein interaction databases

BioGridi110492. 5 interactions.
DIPiDIP-5730N.
IntActiP40238. 1 interaction.
STRINGi9606.ENSP00000361548.

Structurei

3D structure databases

ProteinModelPortaliP40238.
SMRiP40238. Positions 22-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 281110Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 48695Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi474 – 4785WSXWS motif
Motifi528 – 5369Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 3384Poly-Glu
Compositional biasi508 – 5136Poly-Leu

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39882.
GeneTreeiENSGT00730000111277.
HOGENOMiHOG000138191.
HOVERGENiHBG000085.
InParanoidiP40238.
KOiK05082.
OMAiQETCYQL.
PhylomeDBiP40238.
TreeFamiTF336573.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P40238-1) [UniParc]FASTAAdd to Basket

Also known as: C-mpl-P

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC
60 70 80 90 100
FWDEEEAAPS GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE
110 120 130 140 150
VRLFFPLHLW VKNVFLNQTR TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL
160 170 180 190 200
QISWEEPAPE ISDFLRYELR YGPRDPKNST GPTVIQLIAT ETCCPALQRP
210 220 230 240 250
HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS CLISGLQPGN
260 270 280 290 300
SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT
310 320 330 340 350
CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS
360 370 380 390 400
RCHFKSRNDS IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE
410 420 430 440 450
ISSGHLELEW QHPSSWAAQE TCYQLRYTGE GHQDWKVLEP PLGARGGTLE
460 470 480 490 500
LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP TRVETATETA WISLVTALHL
510 520 530 540 550
VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG QYLRDTAALS
560 570 580 590 600
PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG
610 620 630
TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP
Length:635
Mass (Da):71,245
Last modified:February 1, 1995 - v1
Checksum:iD25D8D8959359DDC
GO
Isoform 2 (identifier: P40238-2) [UniParc]FASTAAdd to Basket

Also known as: C-mpl-K

The sequence of this isoform differs from the canonical sequence as follows:
     523-579: RLRHALWPSL...ILPKSSERTP → YRPRQAGDWR...LWDSPRLLTL
     580-635: Missing.

Show »
Length:579
Mass (Da):65,521
Checksum:i7A1431E9F64E21D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391K → N Functional polymorphism associated with thrombocytosis; results in altered MPL expression. 1 Publication
Corresponds to variant rs17292650 [ dbSNP | Ensembl ].
VAR_049173
Natural varianti58 – 581A → V.1 Publication
Corresponds to variant rs6087 [ dbSNP | Ensembl ].
VAR_011988
Natural varianti114 – 1141V → M.
Corresponds to variant rs12731981 [ dbSNP | Ensembl ].
VAR_049174
Natural varianti168 – 1681E → K.1 Publication
Corresponds to variant rs6088 [ dbSNP | Ensembl ].
VAR_011989
Natural varianti505 – 5051S → N in THCYT2; activating mutation; induces MPL autonomous dimerization and signal activation in the absence of the ligand. 2 Publications
Corresponds to variant rs121913614 [ dbSNP | Ensembl ].
VAR_067559
Natural varianti515 – 5151W → K in MMM; somatic mutation; requires 2 nucleotide substitutions. 1 Publication
VAR_067560
Natural varianti515 – 5151W → L in THCYT2 and MMM; somatic mutation in myelofibrosis with myeloid metaplasia; results in cytokine-independent growth and thrombopoietin hypersensitivity; results in constitutive activation of JAK-STAT signaling pathway. 2 Publications
Corresponds to variant rs121913615 [ dbSNP | Ensembl ].
VAR_067561

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei523 – 57957RLRHA…SERTP → YRPRQAGDWRWTRWSRTCKQ AFLVRSVTPDLRPPPVRTYG FALPARHLWDSPRLLTL in isoform 2. 1 PublicationVSP_001734Add
BLAST
Alternative sequencei580 – 63556Missing in isoform 2. 1 PublicationVSP_001735Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90102 mRNA. Translation: AAA69971.1.
M90103 mRNA. Translation: AAA69972.1.
U68162
, U68159, U68160, U68161 Genomic DNA. Translation: AAB08424.1.
U68162
, U68159, U68160, U68161 Genomic DNA. Translation: AAB08425.1.
AL139289 Genomic DNA. Translation: CAI23380.1.
CH471059 Genomic DNA. Translation: EAX07103.1.
CCDSiCCDS483.1. [P40238-1]
PIRiA45266.
B45266.
RefSeqiNP_005364.1. NM_005373.2. [P40238-1]
UniGeneiHs.82906.

Genome annotation databases

EnsembliENST00000372470; ENSP00000361548; ENSG00000117400. [P40238-1]
GeneIDi4352.
KEGGihsa:4352.
UCSCiuc001ciw.3. human. [P40238-1]

Polymorphism databases

DMDMi730980.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90102 mRNA. Translation: AAA69971.1.
M90103 mRNA. Translation: AAA69972.1.
U68162
, U68159, U68160, U68161 Genomic DNA. Translation: AAB08424.1.
U68162
, U68159, U68160, U68161 Genomic DNA. Translation: AAB08425.1.
AL139289 Genomic DNA. Translation: CAI23380.1.
CH471059 Genomic DNA. Translation: EAX07103.1.
CCDSiCCDS483.1. [P40238-1]
PIRiA45266.
B45266.
RefSeqiNP_005364.1. NM_005373.2. [P40238-1]
UniGeneiHs.82906.

3D structure databases

ProteinModelPortaliP40238.
SMRiP40238. Positions 22-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110492. 5 interactions.
DIPiDIP-5730N.
IntActiP40238. 1 interaction.
STRINGi9606.ENSP00000361548.

Chemistry

BindingDBiP40238.
ChEMBLiCHEMBL1864.
DrugBankiDB06210. Eltrombopag.
DB05332. Romiplostim.
GuidetoPHARMACOLOGYi1722.

PTM databases

PhosphoSiteiP40238.

Polymorphism databases

DMDMi730980.

Proteomic databases

PaxDbiP40238.
PRIDEiP40238.

Protocols and materials databases

DNASUi4352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372470; ENSP00000361548; ENSG00000117400. [P40238-1]
GeneIDi4352.
KEGGihsa:4352.
UCSCiuc001ciw.3. human. [P40238-1]

Organism-specific databases

CTDi4352.
GeneCardsiGC01P043803.
HGNCiHGNC:7217. MPL.
HPAiCAB002011.
HPA007619.
MIMi159530. gene.
254450. phenotype.
601977. phenotype.
604498. phenotype.
neXtProtiNX_P40238.
Orphaneti3319. Congenital amegakaryocytic thrombocytopenia.
3318. Essential thrombocythemia.
71493. Familial thrombocytosis.
397692. Hereditary aplastic anemia.
824. Myelofibrosis with myeloid metaplasia.
729. Polycythemia vera.
PharmGKBiPA30923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39882.
GeneTreeiENSGT00730000111277.
HOGENOMiHOG000138191.
HOVERGENiHBG000085.
InParanoidiP40238.
KOiK05082.
OMAiQETCYQL.
PhylomeDBiP40238.
TreeFamiTF336573.

Enzyme and pathway databases

ReactomeiREACT_278. Platelet Aggregation (Plug Formation).
SignaLinkiP40238.

Miscellaneous databases

GeneWikiiThrombopoietin_receptor.
GenomeRNAii4352.
NextBioi17122.
PROiP40238.
SOURCEiSearch...

Gene expression databases

BgeeiP40238.
CleanExiHS_MPL.
ExpressionAtlasiP40238. baseline and differential.
GenevestigatoriP40238.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily."
    Vigon I., Mornon J.-P., Cocault L., Mitjavila M.-T., Tambourin P., Gisselbrecht S., Souyri M.
    Proc. Natl. Acad. Sci. U.S.A. 89:5640-5644(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Ubiquitination and degradation of the thrombopoietin receptor c-Mpl."
    Saur S.J., Sangkhae V., Geddis A.E., Kaushansky K., Hitchcock I.S.
    Blood 115:1254-1263(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-553 AND LYS573.
  6. Cited for: VARIANTS VAL-58 AND LYS-168.
  7. "Cloning and characterization of a family of proteins associated with Mpl."
    Meunier C.F., Bordereaux D., Porteu F., Gisselbrecht S., Chretien S., Courtois G.
    J. Biol. Chem. 277:9139-9147(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATXN2L.
  8. "Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin."
    Ding J., Komatsu H., Wakita A., Kato-Uranishi M., Ito M., Satoh A., Tsuboi K., Nitta M., Miyazaki H., Iida S., Ueda R.
    Blood 103:4198-4200(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THCYT2 ASN-505.
  9. Cited for: VARIANT ASN-39, CHARACTERIZATION OF VARIANT ASN-39.
  10. Cited for: VARIANT MMM LYS-515.
  11. Cited for: VARIANT MMM LEU-515, CHARACTERIZATION OF VARIANT MMM LEU-515.
  12. "The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity."
    Ding J., Komatsu H., Iida S., Yano H., Kusumoto S., Inagaki A., Mori F., Ri M., Ito A., Wakita A., Ishida T., Nitta M., Ueda R.
    Blood 114:3325-3328(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT THCYT2 ASN-505.
  13. Cited for: VARIANT THCYT2 LEU-515.

Entry informationi

Entry nameiTPOR_HUMAN
AccessioniPrimary (citable) accession number: P40238
Secondary accession number(s): Q5JUZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.