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P40237

- CD82_MOUSE

UniProt

P40237 - CD82_MOUSE

Protein

CD82 antigen

Gene

Cd82

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD82 antigen
    Alternative name(s):
    C33 antigen
    IA4
    Inducible membrane protein R2
    Metastasis suppressor Kangai-1 homolog
    CD_antigen: CD82
    Gene namesi
    Name:Cd82
    Synonyms:Kai1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:104651. Cd82.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266CD82 antigenPRO_0000219227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
    Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
    Glycosylationi161 – 1611N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP40237.
    PaxDbiP40237.
    PRIDEiP40237.

    PTM databases

    PhosphoSiteiP40237.

    Expressioni

    Tissue specificityi

    Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

    Gene expression databases

    ArrayExpressiP40237.
    BgeeiP40237.
    CleanExiMM_CD82.
    GenevestigatoriP40237.

    Interactioni

    Subunit structurei

    Interacts directly with IGSF8.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP40237.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 5321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 227117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini250 – 26617CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 11027HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259116.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiP40237.
    KOiK06509.
    OMAiVTYPCSC.
    OrthoDBiEOG7FV3R2.
    PhylomeDBiP40237.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 2 hits.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40237-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS    50
    SLQVGAYVFI GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV 100
    TVGVLFYFNA DKLKKEMGNT VMDIIRNYTA NATSSREEAW DYVQAQVKCC 150
    GWVSHYNWTE NEELMGFTKT TYPCSCEKIK EEDNQLIVKK GFCEADNSTV 200
    SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC 250
    LCRYIHSEDY SKVPKY 266
    Length:266
    Mass (Da):29,629
    Last modified:February 1, 1995 - v1
    Checksum:iCB4BE669E7C52D57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14883 mRNA. Translation: BAA03602.1.
    CCDSiCCDS16454.1.
    PIRiI49561.
    RefSeqiNP_001129527.1. NM_001136055.2.
    NP_001258359.1. NM_001271430.1.
    NP_001258360.1. NM_001271431.1.
    NP_001258361.1. NM_001271432.1.
    NP_001258390.1. NM_001271461.1.
    NP_001258391.1. NM_001271462.1.
    NP_031682.1. NM_007656.5.
    XP_006498715.1. XM_006498652.1.
    UniGeneiMm.4261.

    Genome annotation databases

    EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
    ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
    ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
    ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
    GeneIDi12521.
    KEGGimmu:12521.
    UCSCiuc008lfx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14883 mRNA. Translation: BAA03602.1 .
    CCDSi CCDS16454.1.
    PIRi I49561.
    RefSeqi NP_001129527.1. NM_001136055.2.
    NP_001258359.1. NM_001271430.1.
    NP_001258360.1. NM_001271431.1.
    NP_001258361.1. NM_001271432.1.
    NP_001258390.1. NM_001271461.1.
    NP_001258391.1. NM_001271462.1.
    NP_031682.1. NM_007656.5.
    XP_006498715.1. XM_006498652.1.
    UniGenei Mm.4261.

    3D structure databases

    ProteinModelPortali P40237.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P40237.

    Proteomic databases

    MaxQBi P40237.
    PaxDbi P40237.
    PRIDEi P40237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028644 ; ENSMUSP00000028644 ; ENSMUSG00000027215 .
    ENSMUST00000099696 ; ENSMUSP00000097287 ; ENSMUSG00000027215 .
    ENSMUST00000111257 ; ENSMUSP00000106888 ; ENSMUSG00000027215 .
    ENSMUST00000116457 ; ENSMUSP00000112158 ; ENSMUSG00000027215 .
    GeneIDi 12521.
    KEGGi mmu:12521.
    UCSCi uc008lfx.1. mouse.

    Organism-specific databases

    CTDi 3732.
    MGIi MGI:104651. Cd82.

    Phylogenomic databases

    eggNOGi NOG259116.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi P40237.
    KOi K06509.
    OMAi VTYPCSC.
    OrthoDBi EOG7FV3R2.
    PhylomeDBi P40237.
    TreeFami TF352892.

    Miscellaneous databases

    ChiTaRSi CD82. mouse.
    NextBioi 281530.
    PROi P40237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40237.
    Bgeei P40237.
    CleanExi MM_CD82.
    Genevestigatori P40237.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 2 hits.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression."
      Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O.
      Cell. Immunol. 157:144-157(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131; ASN-157 AND ASN-161.
      Tissue: Myoblast.

    Entry informationi

    Entry nameiCD82_MOUSE
    AccessioniPrimary (citable) accession number: P40237
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3