Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD82 antigen

Gene

Cd82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1 homolog
CD_antigen: CD82
Gene namesi
Name:Cd82
Synonyms:Kai1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104651. Cd82.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 53ExtracellularSequence analysisAdd BLAST21
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 110HelicalSequence analysisAdd BLAST27
Topological domaini111 – 227ExtracellularSequence analysisAdd BLAST117
Transmembranei228 – 249HelicalSequence analysisAdd BLAST22
Topological domaini250 – 266CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192271 – 266CD82 antigenAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi131N-linked (GlcNAc...)1 Publication1
Glycosylationi157N-linked (GlcNAc...)1 Publication1
Glycosylationi161N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP40237.
PaxDbiP40237.
PeptideAtlasiP40237.
PRIDEiP40237.

PTM databases

iPTMnetiP40237.
PhosphoSitePlusiP40237.
SwissPalmiP40237.

Expressioni

Tissue specificityi

Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

Gene expression databases

BgeeiENSMUSG00000027215.
CleanExiMM_CD82.
ExpressionAtlasiP40237. baseline and differential.
GenevisibleiP40237. MM.

Interactioni

Subunit structurei

Interacts directly with IGSF8.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028644.

Structurei

3D structure databases

ProteinModelPortaliP40237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP40237.
KOiK06509.
OMAiFYNWTDN.
OrthoDBiEOG091G0G4W.
PhylomeDBiP40237.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS
60 70 80 90 100
SLQVGAYVFI GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV
110 120 130 140 150
TVGVLFYFNA DKLKKEMGNT VMDIIRNYTA NATSSREEAW DYVQAQVKCC
160 170 180 190 200
GWVSHYNWTE NEELMGFTKT TYPCSCEKIK EEDNQLIVKK GFCEADNSTV
210 220 230 240 250
SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC
260
LCRYIHSEDY SKVPKY
Length:266
Mass (Da):29,629
Last modified:February 1, 1995 - v1
Checksum:iCB4BE669E7C52D57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA. Translation: BAA03602.1.
CCDSiCCDS16454.1.
PIRiI49561.
RefSeqiNP_001129527.1. NM_001136055.2.
NP_001258359.1. NM_001271430.1.
NP_001258360.1. NM_001271431.1.
NP_001258361.1. NM_001271432.1.
NP_001258390.1. NM_001271461.1.
NP_001258391.1. NM_001271462.1.
NP_031682.1. NM_007656.5.
UniGeneiMm.4261.

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneIDi12521.
KEGGimmu:12521.
UCSCiuc008lfx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA. Translation: BAA03602.1.
CCDSiCCDS16454.1.
PIRiI49561.
RefSeqiNP_001129527.1. NM_001136055.2.
NP_001258359.1. NM_001271430.1.
NP_001258360.1. NM_001271431.1.
NP_001258361.1. NM_001271432.1.
NP_001258390.1. NM_001271461.1.
NP_001258391.1. NM_001271462.1.
NP_031682.1. NM_007656.5.
UniGeneiMm.4261.

3D structure databases

ProteinModelPortaliP40237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028644.

PTM databases

iPTMnetiP40237.
PhosphoSitePlusiP40237.
SwissPalmiP40237.

Proteomic databases

EPDiP40237.
PaxDbiP40237.
PeptideAtlasiP40237.
PRIDEiP40237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneIDi12521.
KEGGimmu:12521.
UCSCiuc008lfx.2. mouse.

Organism-specific databases

CTDi3732.
MGIiMGI:104651. Cd82.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP40237.
KOiK06509.
OMAiFYNWTDN.
OrthoDBiEOG091G0G4W.
PhylomeDBiP40237.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiCd82. mouse.
PROiP40237.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027215.
CleanExiMM_CD82.
ExpressionAtlasiP40237. baseline and differential.
GenevisibleiP40237. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD82_MOUSE
AccessioniPrimary (citable) accession number: P40237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.