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Protein

CD82 antigen

Gene

Cd82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1 homolog
CD_antigen: CD82
Gene namesi
Name:Cd82
Synonyms:Kai1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104651. Cd82.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 5321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei54 – 7219HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 11027HelicalSequence AnalysisAdd
BLAST
Topological domaini111 – 227117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei228 – 24922HelicalSequence AnalysisAdd
BLAST
Topological domaini250 – 26617CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266CD82 antigenPRO_0000219227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
Glycosylationi161 – 1611N-linked (GlcNAc...); atypical1 Publication
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP40237.
PaxDbiP40237.
PRIDEiP40237.

PTM databases

PhosphoSiteiP40237.

Expressioni

Tissue specificityi

Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

Gene expression databases

BgeeiP40237.
CleanExiMM_CD82.
ExpressionAtlasiP40237. baseline and differential.
GenevestigatoriP40237.

Interactioni

Subunit structurei

Interacts directly with IGSF8.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259116.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP40237.
KOiK06509.
OMAiVTYPCSC.
OrthoDBiEOG7FV3R2.
PhylomeDBiP40237.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS
60 70 80 90 100
SLQVGAYVFI GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV
110 120 130 140 150
TVGVLFYFNA DKLKKEMGNT VMDIIRNYTA NATSSREEAW DYVQAQVKCC
160 170 180 190 200
GWVSHYNWTE NEELMGFTKT TYPCSCEKIK EEDNQLIVKK GFCEADNSTV
210 220 230 240 250
SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC
260
LCRYIHSEDY SKVPKY
Length:266
Mass (Da):29,629
Last modified:February 1, 1995 - v1
Checksum:iCB4BE669E7C52D57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA. Translation: BAA03602.1.
CCDSiCCDS16454.1.
PIRiI49561.
RefSeqiNP_001129527.1. NM_001136055.2.
NP_001258359.1. NM_001271430.1.
NP_001258360.1. NM_001271431.1.
NP_001258361.1. NM_001271432.1.
NP_001258390.1. NM_001271461.1.
NP_001258391.1. NM_001271462.1.
NP_031682.1. NM_007656.5.
XP_006498715.1. XM_006498652.2.
UniGeneiMm.4261.

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneIDi12521.
KEGGimmu:12521.
UCSCiuc008lfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14883 mRNA. Translation: BAA03602.1.
CCDSiCCDS16454.1.
PIRiI49561.
RefSeqiNP_001129527.1. NM_001136055.2.
NP_001258359.1. NM_001271430.1.
NP_001258360.1. NM_001271431.1.
NP_001258361.1. NM_001271432.1.
NP_001258390.1. NM_001271461.1.
NP_001258391.1. NM_001271462.1.
NP_031682.1. NM_007656.5.
XP_006498715.1. XM_006498652.2.
UniGeneiMm.4261.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP40237.

Proteomic databases

MaxQBiP40237.
PaxDbiP40237.
PRIDEiP40237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneIDi12521.
KEGGimmu:12521.
UCSCiuc008lfx.1. mouse.

Organism-specific databases

CTDi3732.
MGIiMGI:104651. Cd82.

Phylogenomic databases

eggNOGiNOG259116.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP40237.
KOiK06509.
OMAiVTYPCSC.
OrthoDBiEOG7FV3R2.
PhylomeDBiP40237.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiCd82. mouse.
NextBioi281530.
PROiP40237.
SOURCEiSearch...

Gene expression databases

BgeeiP40237.
CleanExiMM_CD82.
ExpressionAtlasiP40237. baseline and differential.
GenevestigatoriP40237.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression."
    Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O.
    Cell. Immunol. 157:144-157(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131; ASN-157 AND ASN-161.
    Tissue: Myoblast.

Entry informationi

Entry nameiCD82_MOUSE
AccessioniPrimary (citable) accession number: P40237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 1, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.