P40237 (CD82_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD82 antigen

Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1 homolog
CD_antigen=CD82

Gene names

Name:	Cd82
Synonyms:	Kai1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Subunit structure	Interacts directly with IGSF8 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	CD82 antigen		PRO_0000219227
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Helical; Potential
	Topological domain	33 – 53	21	Extracellular Potential
	Transmembrane	54 – 72	19	Helical; Potential
	Topological domain	73 – 83	11	Cytoplasmic Potential
	Transmembrane	84 – 110	27	Helical; Potential
	Topological domain	111 – 227	117	Extracellular Potential
	Transmembrane	228 – 249	22	Helical; Potential
	Topological domain	250 – 266	17	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	131	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	157	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	161	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	197	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P40237 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: CB4BE669E7C52D57	FASTA	266	29,629
	10 20 30 40 50 60 MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS SLQVGAYVFI 70 80 90 100 110 120 GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV TVGVLFYFNA DKLKKEMGNT 130 140 150 160 170 180 VMDIIRNYTA NATSSREEAW DYVQAQVKCC GWVSHYNWTE NEELMGFTKT TYPCSCEKIK 190 200 210 220 230 240 EEDNQLIVKK GFCEADNSTV SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI 250 260 ELLGLFLSIC LCRYIHSEDY SKVPKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression." Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O. Cell. Immunol. 157:144-157(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131; ASN-157 AND ASN-161, MASS SPECTROMETRY. Tissue: Myoblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14883 mRNA. Translation: BAA03602.1.
IPI	IPI00108098.
PIR	I49561.
RefSeq	NP_001129527.1. NM_001136055.2. NP_001258359.1. NM_001271430.1. NP_001258360.1. NM_001271431.1. NP_001258361.1. NM_001271432.1. NP_001258390.1. NM_001271461.1. NP_001258391.1. NM_001271462.1. NP_031682.1. NM_007656.5.
UniGene	Mm.4261.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	P40237.
Proteomic databases
PaxDb	P40237.
PRIDE	P40237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215. ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215. ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215. ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneID	12521.
KEGG	mmu:12521.
Organism-specific databases
CTD	3732.
MGI	MGI:104651. Cd82.
Phylogenomic databases
eggNOG	NOG259116.
HOGENOM	HOG000230651.
HOVERGEN	HBG002324.
InParanoid	P40237.
KO	K06509.
OMA	CGWVSFY.
OrthoDB	EOG444KMB.
Gene expression databases
ArrayExpress	P40237.
Bgee	P40237.
CleanEx	MM_CD82.
Genevestigator	P40237.
GermOnline	ENSMUSG00000027215. Mus musculus.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CD82. mouse.
NextBio	281530.
SOURCE	Search...

Entry information

Entry name

CD82_MOUSE

Accession

Primary (citable) accession number: P40237

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program