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P40237 (CD82_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD82 antigen
Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1 homolog
CD_antigen=CD82
Gene names
Name:Cd82
Synonyms:Kai1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Subunit structure

Interacts directly with IGSF8 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266CD82 antigen
PRO_0000219227

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 5321Extracellular Potential
Transmembrane54 – 7219Helical; Potential
Topological domain73 – 8311Cytoplasmic Potential
Transmembrane84 – 11027Helical; Potential
Topological domain111 – 227117Extracellular Potential
Transmembrane228 – 24922Helical; Potential
Topological domain250 – 26617Cytoplasmic Potential

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1311N-linked (GlcNAc...) Ref.2
Glycosylation1571N-linked (GlcNAc...) Ref.2
Glycosylation1611N-linked (GlcNAc...); atypical Ref.2
Glycosylation1971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P40237 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: CB4BE669E7C52D57

FASTA26629,629
        10         20         30         40         50         60 
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS SLQVGAYVFI 

        70         80         90        100        110        120 
GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV TVGVLFYFNA DKLKKEMGNT 

       130        140        150        160        170        180 
VMDIIRNYTA NATSSREEAW DYVQAQVKCC GWVSHYNWTE NEELMGFTKT TYPCSCEKIK 

       190        200        210        220        230        240 
EEDNQLIVKK GFCEADNSTV SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI 

       250        260 
ELLGLFLSIC LCRYIHSEDY SKVPKY 

« Hide

References

« Hide 'large scale' references
[1]"Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression."
Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O.
Cell. Immunol. 157:144-157(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131; ASN-157 AND ASN-161.
Tissue: Myoblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14883 mRNA. Translation: BAA03602.1.
CCDSCCDS16454.1.
PIRI49561.
RefSeqNP_001129527.1. NM_001136055.2.
NP_001258359.1. NM_001271430.1.
NP_001258360.1. NM_001271431.1.
NP_001258361.1. NM_001271432.1.
NP_001258390.1. NM_001271461.1.
NP_001258391.1. NM_001271462.1.
NP_031682.1. NM_007656.5.
XP_006498715.1. XM_006498652.1.
UniGeneMm.4261.

3D structure databases

ProteinModelPortalP40237.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP40237.

Proteomic databases

MaxQBP40237.
PaxDbP40237.
PRIDEP40237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
GeneID12521.
KEGGmmu:12521.
UCSCuc008lfx.1. mouse.

Organism-specific databases

CTD3732.
MGIMGI:104651. Cd82.

Phylogenomic databases

eggNOGNOG259116.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidP40237.
KOK06509.
OMAVTYPCSC.
OrthoDBEOG7FV3R2.
PhylomeDBP40237.
TreeFamTF352892.

Gene expression databases

ArrayExpressP40237.
BgeeP40237.
CleanExMM_CD82.
GenevestigatorP40237.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 2 hits.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD82. mouse.
NextBio281530.
PROP40237.
SOURCESearch...

Entry information

Entry nameCD82_MOUSE
AccessionPrimary (citable) accession number: P40237
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot