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Protein

Casein kinase I homolog 2

Gene

cki2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 2 (EC:2.7.11.1)
Gene namesi
Name:cki2
ORF Names:SPBP35G2.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP35G2.05c
PomBaseiSPBP35G2.05c cki2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928621 – 435Casein kinase I homolog 2Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei361Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40234
PaxDbiP40234
PRIDEiP40234

PTM databases

iPTMnetiP40234

Interactioni

Protein-protein interaction databases

BioGridi277852, 2 interactors
STRINGi4896.SPBP35G2.05c.1

Structurei

3D structure databases

ProteinModelPortaliP40234
SMRiP40234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 282Protein kinasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000182055
InParanoidiP40234
KOiK02218
OMAiNAPITAN
OrthoDBiEOG092C30PR
PhylomeDBiP40234

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P40234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQTSVVGV HYRVGRKIGE GSFGVIFDGM NLLNNQLIAI KFEPKKSEAP
60 70 80 90 100
QLRDEYRTYK LLVGNAGIPN VYYFGQEGLH NILVIDLLGP SLEDLFEWCG
110 120 130 140 150
RRFSVKTVAM TAKQMLSRVQ TIHEKNLVYR DIKPDNFLIG RPSSRNANMV
160 170 180 190 200
YMVDFGMAKY YRDPKTKQHI PYSERKSLSG TARYMSINTH LGREQSRRDD
210 220 230 240 250
LESLGHVFMY FLRGSLPWQG LKAANNKHKY EKISEKKQST SISELCAGFP
260 270 280 290 300
NEFSKYMTYV RSLEFDEEPD YAFLQELFDD VLRANGDTND GVYDWMLLND
310 320 330 340 350
GKGWESSSSH FSVVAMKRRK NYLGLNVVQN DDSRKKNSTL QTQNMRFKSS
360 370 380 390 400
YGVRGPRNYS SFDALPSKNA PLVRQEQSAS KKTIYAHSSR GYDRVRPMYV
410 420 430
SQPSNNAVGV NHPNDNSDSE AKGGFFDMIC CRCFS
Length:435
Mass (Da):49,746
Last modified:August 14, 2001 - v2
Checksum:i74CA7F1001B31F34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169H → Y in AAA19020 (PubMed:8163505).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06930 Genomic DNA Translation: AAA19020.1
CU329671 Genomic DNA Translation: CAB87367.1
PIRiB53581
RefSeqiNP_595380.1, NM_001021287.2

Genome annotation databases

EnsemblFungiiSPBP35G2.05c.1; SPBP35G2.05c.1:pep; SPBP35G2.05c
GeneIDi2541341
KEGGispo:SPBP35G2.05c

Similar proteinsi

Entry informationi

Entry nameiCKI2_SCHPO
AccessioniPrimary (citable) accession number: P40234
Secondary accession number(s): Q9P798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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