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Protein

Casein kinase I homolog 2

Gene

cki2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • peptidyl-serine phosphorylation Source: GO_Central
  • regulation of cell shape Source: PomBase
  • regulation of endocytosis Source: PomBase
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 2 (EC:2.7.11.1)
Gene namesi
Name:cki2
ORF Names:SPBP35G2.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP35G2.05c.
PomBaseiSPBP35G2.05c. cki2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928621 – 435Casein kinase I homolog 2Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei361Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40234.
PRIDEiP40234.

PTM databases

iPTMnetiP40234.

Interactioni

Protein-protein interaction databases

BioGridi277852. 2 interactors.
MINTiMINT-4689478.

Structurei

3D structure databases

ProteinModelPortaliP40234.
SMRiP40234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 282Protein kinasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000182055.
InParanoidiP40234.
KOiK02218.
OMAiFPDEMAT.
OrthoDBiEOG092C30PR.
PhylomeDBiP40234.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQTSVVGV HYRVGRKIGE GSFGVIFDGM NLLNNQLIAI KFEPKKSEAP
60 70 80 90 100
QLRDEYRTYK LLVGNAGIPN VYYFGQEGLH NILVIDLLGP SLEDLFEWCG
110 120 130 140 150
RRFSVKTVAM TAKQMLSRVQ TIHEKNLVYR DIKPDNFLIG RPSSRNANMV
160 170 180 190 200
YMVDFGMAKY YRDPKTKQHI PYSERKSLSG TARYMSINTH LGREQSRRDD
210 220 230 240 250
LESLGHVFMY FLRGSLPWQG LKAANNKHKY EKISEKKQST SISELCAGFP
260 270 280 290 300
NEFSKYMTYV RSLEFDEEPD YAFLQELFDD VLRANGDTND GVYDWMLLND
310 320 330 340 350
GKGWESSSSH FSVVAMKRRK NYLGLNVVQN DDSRKKNSTL QTQNMRFKSS
360 370 380 390 400
YGVRGPRNYS SFDALPSKNA PLVRQEQSAS KKTIYAHSSR GYDRVRPMYV
410 420 430
SQPSNNAVGV NHPNDNSDSE AKGGFFDMIC CRCFS
Length:435
Mass (Da):49,746
Last modified:August 14, 2001 - v2
Checksum:i74CA7F1001B31F34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169H → Y in AAA19020 (PubMed:8163505).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06930 Genomic DNA. Translation: AAA19020.1.
CU329671 Genomic DNA. Translation: CAB87367.1.
PIRiB53581.
RefSeqiNP_595380.1. NM_001021287.2.

Genome annotation databases

EnsemblFungiiSPBP35G2.05c.1; SPBP35G2.05c.1:pep; SPBP35G2.05c.
GeneIDi2541341.
KEGGispo:SPBP35G2.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06930 Genomic DNA. Translation: AAA19020.1.
CU329671 Genomic DNA. Translation: CAB87367.1.
PIRiB53581.
RefSeqiNP_595380.1. NM_001021287.2.

3D structure databases

ProteinModelPortaliP40234.
SMRiP40234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277852. 2 interactors.
MINTiMINT-4689478.

PTM databases

iPTMnetiP40234.

Proteomic databases

MaxQBiP40234.
PRIDEiP40234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP35G2.05c.1; SPBP35G2.05c.1:pep; SPBP35G2.05c.
GeneIDi2541341.
KEGGispo:SPBP35G2.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBP35G2.05c.
PomBaseiSPBP35G2.05c. cki2.

Phylogenomic databases

HOGENOMiHOG000182055.
InParanoidiP40234.
KOiK02218.
OMAiFPDEMAT.
OrthoDBiEOG092C30PR.
PhylomeDBiP40234.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Miscellaneous databases

PROiP40234.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKI2_SCHPO
AccessioniPrimary (citable) accession number: P40234
Secondary accession number(s): Q9P798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 14, 2001
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.