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Protein

Casein kinase I homolog 1

Gene

cki1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATP1
Active sitei131Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATP9

GO - Molecular functioni

  • ATP binding Source: PomBase
  • magnesium ion binding Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase
  • protein tyrosine kinase activity Source: PomBase

GO - Biological processi

  • peptidyl-serine phosphorylation Source: GO_Central
  • peptidyl-tyrosine autophosphorylation Source: PomBase
  • protein phosphorylation Source: PomBase
  • regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: PomBase
  • regulation of cell shape Source: GO_Central
  • regulation of endocytosis Source: PomBase
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 1 (EC:2.7.11.1)
Gene namesi
Name:cki1
ORF Names:SPBC1347.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1347.06c.
PomBaseiSPBC1347.06c. cki1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GO_Central
  • plasma membrane Source: PomBase
  • vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928611 – 446Casein kinase I homolog 1Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40233.
PRIDEiP40233.

PTM databases

iPTMnetiP40233.

Interactioni

Protein-protein interaction databases

BioGridi276168. 2 interactors.
IntActiP40233. 1 interactor.
MINTiMINT-4689462.

Structurei

Secondary structure

1446
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 11Combined sources3
Beta strandi12 – 20Combined sources9
Beta strandi25 – 31Combined sources7
Turni32 – 35Combined sources4
Beta strandi36 – 44Combined sources9
Helixi52 – 61Combined sources10
Turni62 – 64Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi71 – 77Combined sources7
Beta strandi80 – 86Combined sources7
Helixi92 – 98Combined sources7
Turni99 – 101Combined sources3
Helixi105 – 123Combined sources19
Turni124 – 126Combined sources3
Helixi134 – 136Combined sources3
Beta strandi137 – 139Combined sources3
Beta strandi142 – 144Combined sources3
Turni145 – 148Combined sources4
Beta strandi150 – 152Combined sources3
Beta strandi159 – 162Combined sources4
Turni164 – 166Combined sources3
Turni182 – 184Combined sources3
Helixi187 – 190Combined sources4
Helixi197 – 213Combined sources17
Helixi226 – 239Combined sources14
Helixi242 – 245Combined sources4
Turni246 – 248Combined sources3
Helixi251 – 262Combined sources12
Helixi271 – 284Combined sources14
Helixi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSNX-ray2.00A1-298[»]
1EH4X-ray2.80A/B1-298[»]
2CSNX-ray2.50A2-298[»]
ProteinModelPortaliP40233.
SMRiP40233.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 274Protein kinasePROSITE-ProRule annotationAdd BLAST263

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000182055.
InParanoidiP40233.
KOiK02218.
OMAiPSQMELH.
OrthoDBiEOG092C30PR.
PhylomeDBiP40233.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQNNVVGV HYKVGRRIGE GSFGVIFEGT NLLNNQQVAI KFEPRRSDAP
60 70 80 90 100
QLRDEYRTYK LLAGCTGIPN VYYFGQEGLH NILVIDLLGP SLEDLLDLCG
110 120 130 140 150
RKFSVKTVAM AAKQMLARVQ SIHEKSLVYR DIKPDNFLIG RPNSKNANMI
160 170 180 190 200
YVVDFGMVKF YRDPVTKQHI PYREKKNLSG TARYMSINTH LGREQSRRDD
210 220 230 240 250
LEALGHVFMY FLRGSLPWQG LKAATNKQKY ERIGEKKQST PLRELCAGFP
260 270 280 290 300
EEFYKYMHYA RNLAFDATPD YDYLQGLFSK VLERLNTTED ENFDWNLLNN
310 320 330 340 350
GKGWQSLKSR NAETENQRSS KPPAPKLESK SPALQNHAST QNVVSKRSDY
360 370 380 390 400
EKPFAEPHLN SASDSAEPNQ NSLPNPPTET KATTTVPDRS GLATNQPAPV
410 420 430 440
DVHDSSEERV TREQVQNATK ETEAPKKKKS FWASILSCCS GSNEDT
Length:446
Mass (Da):50,425
Last modified:December 1, 2000 - v2
Checksum:iD813483056CD8FD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82I → V in AAA19019 (PubMed:8163505).Curated1
Sequence conflicti310R → Q in AAA19019 (PubMed:8163505).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06929 mRNA. Translation: AAA19019.1.
CU329671 Genomic DNA. Translation: CAB37437.1.
PIRiA53581.
RefSeqiNP_596698.1. NM_001022622.2.

Genome annotation databases

EnsemblFungiiSPBC1347.06c.1; SPBC1347.06c.1:pep; SPBC1347.06c.
GeneIDi2539610.
KEGGispo:SPBC1347.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06929 mRNA. Translation: AAA19019.1.
CU329671 Genomic DNA. Translation: CAB37437.1.
PIRiA53581.
RefSeqiNP_596698.1. NM_001022622.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSNX-ray2.00A1-298[»]
1EH4X-ray2.80A/B1-298[»]
2CSNX-ray2.50A2-298[»]
ProteinModelPortaliP40233.
SMRiP40233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276168. 2 interactors.
IntActiP40233. 1 interactor.
MINTiMINT-4689462.

PTM databases

iPTMnetiP40233.

Proteomic databases

MaxQBiP40233.
PRIDEiP40233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1347.06c.1; SPBC1347.06c.1:pep; SPBC1347.06c.
GeneIDi2539610.
KEGGispo:SPBC1347.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1347.06c.
PomBaseiSPBC1347.06c. cki1.

Phylogenomic databases

HOGENOMiHOG000182055.
InParanoidiP40233.
KOiK02218.
OMAiPSQMELH.
OrthoDBiEOG092C30PR.
PhylomeDBiP40233.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Miscellaneous databases

EvolutionaryTraceiP40233.
PROiP40233.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKI1_SCHPO
AccessioniPrimary (citable) accession number: P40233
Secondary accession number(s): Q9UUL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.