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Protein

Casein kinase II subunit alpha

Gene

cka1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Plays a role in the translation of cell polarity into polarized growth. The alpha and alpha' chains contain the catalytic site.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotation
Active sitei160 – 1601Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • establishment or maintenance of bipolar cell polarity regulating cell shape Source: PomBase
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.
ReactomeiR-SPO-2514853. Condensation of Prometaphase Chromosomes.
R-SPO-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit alpha (EC:2.7.11.1)
Short name:
CK II subunit alpha
Gene namesi
Name:cka1
Synonyms:orb5
ORF Names:SPAC23C11.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23C11.11.
PomBaseiSPAC23C11.11. cka1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • protein kinase CK2 complex Source: PomBase
  • TORC1 complex Source: PomBase
  • TORC2 complex Source: PomBase
  • UTP-C complex Source: PomBase
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Casein kinase II subunit alphaPRO_0000085903Add
BLAST

Proteomic databases

MaxQBiP40231.

Interactioni

Subunit structurei

Tetramer composed of an alpha chain, an alpha' and two beta chains.

Protein-protein interaction databases

BioGridi278457. 42 interactions.
IntActiP40231. 2 interactions.
MINTiMINT-4689433.

Chemistry

BindingDBiP40231.

Structurei

3D structure databases

ProteinModelPortaliP40231.
SMRiP40231. Positions 8-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 327285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233021.
InParanoidiP40231.
KOiK03097.
OMAiWHSFVTS.
OrthoDBiEOG092C3L63.
PhylomeDBiP40231.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTEAAPVV SVSRVYAHVN EEMPREYWDY ENMQEVFGYQ DNYEIIRKVG
60 70 80 90 100
RGKYSEVFEG LNVLNNSKCI IKVLKPVKYK KIKREIKILQ NLAGGPNIIS
110 120 130 140 150
LLDIVRDPES KTPSLIFEFV DNIDFRTLYP TLSDYDIRYY SYELLKALDF
160 170 180 190 200
CHSRGIMHRD VKPHNVMIDH KKRKLRLIDW GLAEFYHAGM EYNVRVASRY
210 220 230 240 250
FKGPELLVDF REYDYSLDIW SFGVMFAALI FKKDTFFRGR DNYDQLVKIA
260 270 280 290 300
KVLGTDELFA YVQKYQIVLD RQYDNILGQY PKRDWYSFVN RDNRSLANDE
310 320 330
AIDLLNRLLR YDHQERLTCQ EAMAHPYFQV LK
Length:332
Mass (Da):39,527
Last modified:July 15, 1998 - v2
Checksum:iBE20AA4405456B72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → R in CAA52331 (PubMed:8264625).Curated
Sequence conflicti141 – 1411S → L in CAA52331 (PubMed:8264625).Curated
Sequence conflicti167 – 1693MID → IIV in CAA52331 (PubMed:8264625).Curated
Sequence conflicti234 – 2352DT → EP in CAA52331 (PubMed:8264625).Curated
Sequence conflicti287 – 2871Missing in CAA52331 (PubMed:8264625).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74275 mRNA. Translation: CAA52331.1.
L29508 mRNA. Translation: AAA19875.1.
CU329670 Genomic DNA. Translation: CAB11164.1.
PIRiS44355.
RefSeqiNP_593642.1. NM_001019073.2.

Genome annotation databases

EnsemblFungiiSPAC23C11.11.1; SPAC23C11.11.1:pep; SPAC23C11.11.
GeneIDi2541972.
KEGGispo:SPAC23C11.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74275 mRNA. Translation: CAA52331.1.
L29508 mRNA. Translation: AAA19875.1.
CU329670 Genomic DNA. Translation: CAB11164.1.
PIRiS44355.
RefSeqiNP_593642.1. NM_001019073.2.

3D structure databases

ProteinModelPortaliP40231.
SMRiP40231. Positions 8-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278457. 42 interactions.
IntActiP40231. 2 interactions.
MINTiMINT-4689433.

Chemistry

BindingDBiP40231.
ChEMBLiCHEMBL1075255.

Proteomic databases

MaxQBiP40231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23C11.11.1; SPAC23C11.11.1:pep; SPAC23C11.11.
GeneIDi2541972.
KEGGispo:SPAC23C11.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC23C11.11.
PomBaseiSPAC23C11.11. cka1.

Phylogenomic databases

HOGENOMiHOG000233021.
InParanoidiP40231.
KOiK03097.
OMAiWHSFVTS.
OrthoDBiEOG092C3L63.
PhylomeDBiP40231.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.
ReactomeiR-SPO-2514853. Condensation of Prometaphase Chromosomes.
R-SPO-6804756. Regulation of TP53 Activity through Phosphorylation.

Miscellaneous databases

PROiP40231.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2A_SCHPO
AccessioniPrimary (citable) accession number: P40231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.