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Protein

Casein kinase II subunit beta-1

Gene

CKB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor GBFl, resulting in stimulation of its DNA binding activity (PubMed:7696877). CK2 phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376). CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (PubMed:19509278, PubMed:19509420). Stimulates the binding of CCA1 to promoters (Probable).1 Publication4 Publications

GO - Molecular functioni

  • protein kinase regulator activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-ATH-2514853. Condensation of Prometaphase Chromosomes.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta-1Curated
Short name:
CK II beta-1Curated
Gene namesi
Name:CKB1
Ordered Locus Names:At5g47080
ORF Names:K14A3.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G47080.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: GO_Central
  • protein kinase CK2 complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000682481 – 287Casein kinase II subunit beta-1Add BLAST287

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP40228.

Expressioni

Gene expression databases

ExpressionAtlasiP40228. baseline and differential.
GenevisibleiP40228. AT.

Interactioni

Subunit structurei

Heterotetramer of two catalytic alpha subunits and two regulatory beta subunits (PubMed:7696877, PubMed:19509278). Interacts with CCA1 (PubMed:9724822). Interacts with LHY (PubMed:10535927).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCA1P929733EBI-1644917,EBI-1644880

Protein-protein interaction databases

BioGridi20002. 2 interactors.
IntActiP40228. 2 interactors.
STRINGi3702.AT5G47080.1.

Structurei

3D structure databases

ProteinModelPortaliP40228.
SMRiP40228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
HOGENOMiHOG000039270.
InParanoidiP40228.
KOiK03115.
OMAiMSEYMED.
OrthoDBiEOG09360IGI.
PhylomeDBiP40228.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P40228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRDRGTVNS RPEVVDRKRI NDALERPSPS TSRQVNGKGK GTVTAATTTA
60 70 80 90 100
NLIGKQQSNN INHRDSRSAS LSKNNTVSDD ESDTDSEESD VSGSDGEDTS
110 120 130 140 150
WISWFCNLRG NEFFCEVDDD YIQDDFNLCG LSSLVPYYEY ALDLILDVES
160 170 180 190 200
SQGEMFTEEQ NELIESAAEM LYGLIHARYI LTSKGLAAML DKYKNYDFGR
210 220 230 240 250
CPRVYCCGQP CLPVGQSDLP RSSTVKIYCP KCEDIYYPRS KYQGNIDGAY
260 270 280
FGTTFPHLFL MTYGHLKPAK ATQNYVQRVF GFKLHKP
Length:287
Mass (Da):32,355
Last modified:February 1, 1995 - v1
Checksum:i43C811727B0985EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22563 mRNA. Translation: AAA53233.1.
AB025609 Genomic DNA. Translation: BAA98103.1.
CP002688 Genomic DNA. Translation: AED95466.1.
PIRiS47967.
RefSeqiNP_199519.1. NM_124079.4. [P40228-1]
UniGeneiAt.23955.

Genome annotation databases

EnsemblPlantsiAT5G47080.1; AT5G47080.1; AT5G47080. [P40228-1]
GeneIDi834754.
GrameneiAT5G47080.1; AT5G47080.1; AT5G47080.
KEGGiath:AT5G47080.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22563 mRNA. Translation: AAA53233.1.
AB025609 Genomic DNA. Translation: BAA98103.1.
CP002688 Genomic DNA. Translation: AED95466.1.
PIRiS47967.
RefSeqiNP_199519.1. NM_124079.4. [P40228-1]
UniGeneiAt.23955.

3D structure databases

ProteinModelPortaliP40228.
SMRiP40228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20002. 2 interactors.
IntActiP40228. 2 interactors.
STRINGi3702.AT5G47080.1.

Proteomic databases

PaxDbiP40228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G47080.1; AT5G47080.1; AT5G47080. [P40228-1]
GeneIDi834754.
GrameneiAT5G47080.1; AT5G47080.1; AT5G47080.
KEGGiath:AT5G47080.

Organism-specific databases

TAIRiAT5G47080.

Phylogenomic databases

eggNOGiKOG3092. Eukaryota.
COG5041. LUCA.
HOGENOMiHOG000039270.
InParanoidiP40228.
KOiK03115.
OMAiMSEYMED.
OrthoDBiEOG09360IGI.
PhylomeDBiP40228.

Enzyme and pathway databases

ReactomeiR-ATH-2514853. Condensation of Prometaphase Chromosomes.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-6804756. Regulation of TP53 Activity through Phosphorylation.

Miscellaneous databases

PROiP40228.

Gene expression databases

ExpressionAtlasiP40228. baseline and differential.
GenevisibleiP40228. AT.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_ARATH
AccessioniPrimary (citable) accession number: P40228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.