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Protein

T-complex protein 1 subunit zeta

Gene

CCT6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • unfolded protein binding Source: GO_Central
  • WD40-repeat domain binding Source: BHF-UCL

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • positive regulation of establishment of protein localization to telomere Source: BHF-UCL
  • positive regulation of protein localization to Cajal body Source: BHF-UCL
  • positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • protein folding Source: Reactome
  • protein stabilization Source: BHF-UCL

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-HSA-389960. Formation of tubulin folding intermediates by CCT/TriC.
R-HSA-390450. Folding of actin by CCT/TriC.
R-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
Acute morphine dependence-related protein 2
CCT-zeta-1
HTR3
Tcp20
Gene namesi
Name:CCT6A
Synonyms:CCT6, CCTZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146731.10.
HGNCiHGNC:1620. CCT6A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi908.
OpenTargetsiENSG00000146731.
PharmGKBiPA26183.

Polymorphism and mutation databases

BioMutaiCCT6A.
DMDMi730922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001283552 – 531T-complex protein 1 subunit zetaAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei287N6-acetyllysineBy similarity1
Modified residuei365N6-acetyllysineCombined sources1
Modified residuei377N6-acetyllysineCombined sources1
Modified residuei388N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP40227.
MaxQBiP40227.
PaxDbiP40227.
PeptideAtlasiP40227.
PRIDEiP40227.

2D gel databases

DOSAC-COBS-2DPAGEiP40227.
REPRODUCTION-2DPAGEiIPI00027626.
P40227.
SWISS-2DPAGEiP40227.
UCD-2DPAGEiP40227.

PTM databases

iPTMnetiP40227.
PhosphoSitePlusiP40227.
SwissPalmiP40227.

Expressioni

Gene expression databases

BgeeiENSG00000146731.
CleanExiHS_CCT6A.
ExpressionAtlasiP40227. baseline and differential.
GenevisibleiP40227. HS.

Organism-specific databases

HPAiHPA042996.
HPA045576.
HPA049949.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.1 Publication

GO - Molecular functioni

  • protein binding involved in protein folding Source: BHF-UCL
  • unfolded protein binding Source: GO_Central
  • WD40-repeat domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107346. 236 interactors.
CORUMiP40227.
DIPiDIP-33558N.
IntActiP40227. 137 interactors.
MINTiMINT-1156875.
STRINGi9606.ENSP00000275603.

Structurei

3D structure databases

ProteinModelPortaliP40227.
SMRiP40227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiP40227.
KOiK09498.
OMAiMQHKTDT.
OrthoDBiEOG091G07CE.
PhylomeDBiP40227.
TreeFamiTF106333.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQFLEEVKVS REMDRETLID
160 170 180 190 200
VARTSLRTKV HAELADVLTE AVVDSILAIK KQDEPIDLFM IEIMEMKHKS
210 220 230 240 250
ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE KTEVNSGFFY
260 270 280 290 300
KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF
310 320 330 340 350
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN
410 420 430 440 450
AIDDGCVVPG AGAVEVAMAE ALIKHKPSVK GRAQLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD LNTGEPMVAA EVGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK G
Length:531
Mass (Da):58,024
Last modified:January 23, 2007 - v3
Checksum:i43ABCF548CC82B81
GO
Isoform 2 (identifier: P40227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):53,289
Checksum:i2B0A27299B03A08A
GO

Sequence cautioni

The sequence AAA58676 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BU540578 differs from that shown. Several sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301 – 303SLD → PLS in BAB61032 (Ref. 3) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052268229Y → C. Corresponds to variant dbSNP:rs33922584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04491868 – 112Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27706 mRNA. Translation: AAA61061.1.
AF385084 mRNA. Translation: AAK61354.1.
AB063318 mRNA. Translation: BAB61032.1.
AC092101 Genomic DNA. Translation: AAS07451.1.
AC092579 Genomic DNA. No translation available.
BC106942 mRNA. Translation: AAI06943.1.
BU540578 mRNA. No translation available.
M94083 mRNA. Translation: AAA58676.1. Different initiation.
CCDSiCCDS34640.1. [P40227-2]
CCDS5523.1. [P40227-1]
PIRiS48087.
RefSeqiNP_001009186.1. NM_001009186.1. [P40227-2]
NP_001753.1. NM_001762.3. [P40227-1]
UniGeneiHs.82916.

Genome annotation databases

EnsembliENST00000275603; ENSP00000275603; ENSG00000146731. [P40227-1]
ENST00000335503; ENSP00000352019; ENSG00000146731. [P40227-2]
GeneIDi908.
KEGGihsa:908.
UCSCiuc003trl.2. human. [P40227-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPZ_HUMAN
AccessioniPrimary (citable) accession number: P40227
Secondary accession number(s): A6NCD2
, Q3KP28, Q75LP4, Q96S46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families