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P40225

- TPO_HUMAN

UniProt

P40225 - TPO_HUMAN

Protein

Thrombopoietin

Gene

THPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell proliferation Source: ProtInc
    3. multicellular organismal development Source: ProtInc
    4. myeloid cell differentiation Source: Ensembl
    5. platelet activation Source: Reactome
    6. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    7. positive regulation of megakaryocyte differentiation Source: UniProtKB
    8. positive regulation of protein kinase B signaling Source: UniProtKB
    9. positive regulation of protein phosphorylation Source: UniProtKB
    10. thrombopoietin-mediated signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Hormone

    Enzyme and pathway databases

    ReactomeiREACT_278. Platelet Aggregation (Plug Formation).
    SignaLinkiP40225.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombopoietin
    Alternative name(s):
    C-mpl ligand
    Short name:
    ML
    Megakaryocyte colony-stimulating factor
    Megakaryocyte growth and development factor
    Short name:
    MGDF
    Myeloproliferative leukemia virus oncogene ligand
    Gene namesi
    Name:THPO
    Synonyms:MGDF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11795. THPO.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi187950. phenotype.
    Orphaneti71493. Familial thrombocytosis.
    329319. Hereditary thrombocytosis with transverse limb defect.
    PharmGKBiPA36506.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 353332ThrombopoietinPRO_0000008411Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221O-linked (GalNAc...)1 Publication
    Disulfide bondi28 ↔ 172
    Disulfide bondi50 ↔ 106
    Glycosylationi58 – 581O-linked (GalNAc...)1 Publication
    Glycosylationi131 – 1311O-linked (GalNAc...)1 Publication
    Glycosylationi179 – 1791O-linked (GalNAc...)1 Publication
    Glycosylationi180 – 1801O-linked (GalNAc...)1 Publication
    Glycosylationi184 – 1841O-linked (GalNAc...)1 Publication
    Glycosylationi197 – 1971N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi206 – 2061N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi213 – 2131O-linked (GalNAc...)1 Publication
    Glycosylationi234 – 2341N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi255 – 2551N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi265 – 2651O-linked (GalNAc...)1 Publication
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP40225.
    PRIDEiP40225.

    PTM databases

    PhosphoSiteiP40225.

    Miscellaneous databases

    PMAP-CutDBP40225.

    Expressioni

    Gene expression databases

    ArrayExpressiP40225.
    BgeeiP40225.
    CleanExiHS_THPO.
    GenevestigatoriP40225.

    Interactioni

    Protein-protein interaction databases

    BioGridi112922. 3 interactions.
    DIPiDIP-5729N.
    IntActiP40225. 3 interactions.
    STRINGi9606.ENSP00000204615.

    Structurei

    Secondary structure

    1
    353
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi32 – 4514
    Helixi46 – 483
    Beta strandi49 – 524
    Beta strandi60 – 634
    Helixi70 – 745
    Helixi77 – 9822
    Turni99 – 1013
    Beta strandi104 – 1063
    Helixi107 – 1104
    Helixi113 – 12917
    Beta strandi139 – 1435
    Helixi145 – 1473
    Helixi148 – 15710
    Turni158 – 1603
    Helixi161 – 1633
    Beta strandi165 – 1673

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V7MX-ray2.51V/X22-184[»]
    1V7NX-ray3.30V/X/Y/Z22-184[»]
    ProteinModelPortaliP40225.
    SMRiP40225. Positions 28-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40225.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi285 – 33753Pro-richAdd
    BLAST

    Domaini

    Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

    Sequence similaritiesi

    Belongs to the EPO/TPO family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG84342.
    HOVERGENiHBG002468.
    InParanoidiP40225.
    KOiK06854.
    OMAiEQSKAQD.
    OrthoDBiEOG7PVWPW.
    PhylomeDBiP40225.
    TreeFamiTF338084.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003978. Thrombopoeitin.
    [Graphical view]
    PANTHERiPTHR10560. PTHR10560. 1 hit.
    PfamiPF00758. EPO_TPO. 1 hit.
    [Graphical view]
    PRINTSiPR01485. THROMBOPTN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00817. EPO_TPO. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P40225-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC    50
    PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 100
    QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL 150
    SFQHLLRGKV RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS 200
    GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI 250
    HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP 300
    TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS 350
    QEG 353
    Length:353
    Mass (Da):37,823
    Last modified:February 1, 1995 - v1
    Checksum:iF0AB5449B72E5526
    GO
    Isoform 2 (identifier: P40225-2) [UniParc]FASTAAdd to Basket

    Also known as: TPO-2

    The sequence of this isoform differs from the canonical sequence as follows:
         133-136: Missing.

    Show »
    Length:349
    Mass (Da):37,387
    Checksum:iC7348E1148DAA58C
    GO
    Isoform 3 (identifier: P40225-3) [UniParc]FASTAAdd to Basket

    Also known as: Truncated

    The sequence of this isoform differs from the canonical sequence as follows:
         160-198: Missing.

    Show »
    Length:314
    Mass (Da):33,604
    Checksum:i183A09670C9FAEE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461R → K in AAB03392. 1 PublicationCurated
    Sequence conflicti46 – 461R → K in AAB03393. 1 PublicationCurated
    Sequence conflicti46 – 461R → K in AAB03394. 1 PublicationCurated
    Sequence conflicti76 – 761M → MSQ in AAA74083. (PubMed:7822271)Curated
    Sequence conflicti113 – 1131Q → E in AAA50553. (PubMed:8020099)Curated
    Sequence conflicti131 – 1311T → P in AAA74083. (PubMed:7822271)Curated
    Sequence conflicti277 – 2771G → E in AAB03393. 1 PublicationCurated
    Sequence conflicti277 – 2771G → E in AAB03394. 1 PublicationCurated
    Sequence conflicti346 – 3461S → C in AAB03393. 1 PublicationCurated
    Sequence conflicti346 – 3461S → C in AAB03394. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141L → P.
    Corresponds to variant rs1042346 [ dbSNP | Ensembl ].
    VAR_011795
    Natural varianti116 – 1161G → E.
    Corresponds to variant rs1126665 [ dbSNP | Ensembl ].
    VAR_011796

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei133 – 1364Missing in isoform 2. 1 PublicationVSP_001450
    Alternative sequencei160 – 19839Missing in isoform 3. CuratedVSP_001451Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33410 mRNA. Translation: AAA59857.1.
    U11025 mRNA. Translation: AAA50553.1.
    L36051 Genomic DNA. Translation: AAC37568.1.
    L36052 mRNA. Translation: AAC37566.1.
    D32046 Genomic DNA. Translation: BAA06807.1.
    S76771 Genomic DNA. Translation: AAB33390.1.
    D32047 mRNA. Translation: BAA21930.1.
    U59493 mRNA. Translation: AAB03392.1.
    U59494 mRNA. Translation: AAB03393.1.
    U59495 mRNA. Translation: AAB03394.1.
    U17071 Genomic DNA. Translation: AAA74083.1.
    BC130322 mRNA. Translation: AAI30323.1.
    BC136338 mRNA. Translation: AAI36339.1.
    BC143982 mRNA. Translation: AAI43983.1.
    CCDSiCCDS3265.1. [P40225-1]
    CCDS54693.1. [P40225-2]
    PIRiG02729.
    I59281. I80105.
    RefSeqiNP_000451.1. NM_000460.3. [P40225-1]
    NP_001171068.1. NM_001177597.2. [P40225-2]
    NP_001171069.1. NM_001177598.2.
    NP_001276926.1. NM_001289997.1.
    NP_001276927.1. NM_001289998.1. [P40225-1]
    NP_001276932.1. NM_001290003.1.
    NP_001276951.1. NM_001290022.1. [P40225-2]
    NP_001276955.1. NM_001290026.1.
    NP_001276956.1. NM_001290027.1.
    NP_001276957.1. NM_001290028.1. [P40225-1]
    UniGeneiHs.1166.
    Hs.734657.

    Genome annotation databases

    EnsembliENST00000204615; ENSP00000204615; ENSG00000090534. [P40225-1]
    ENST00000445696; ENSP00000410763; ENSG00000090534. [P40225-2]
    GeneIDi7066.
    KEGGihsa:7066.
    UCSCiuc003fol.1. human. [P40225-1]
    uc003fom.2. human. [P40225-2]

    Polymorphism databases

    DMDMi730982.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    R&D Systems' cytokine source book: Thrombopoietin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33410 mRNA. Translation: AAA59857.1 .
    U11025 mRNA. Translation: AAA50553.1 .
    L36051 Genomic DNA. Translation: AAC37568.1 .
    L36052 mRNA. Translation: AAC37566.1 .
    D32046 Genomic DNA. Translation: BAA06807.1 .
    S76771 Genomic DNA. Translation: AAB33390.1 .
    D32047 mRNA. Translation: BAA21930.1 .
    U59493 mRNA. Translation: AAB03392.1 .
    U59494 mRNA. Translation: AAB03393.1 .
    U59495 mRNA. Translation: AAB03394.1 .
    U17071 Genomic DNA. Translation: AAA74083.1 .
    BC130322 mRNA. Translation: AAI30323.1 .
    BC136338 mRNA. Translation: AAI36339.1 .
    BC143982 mRNA. Translation: AAI43983.1 .
    CCDSi CCDS3265.1. [P40225-1 ]
    CCDS54693.1. [P40225-2 ]
    PIRi G02729.
    I59281. I80105.
    RefSeqi NP_000451.1. NM_000460.3. [P40225-1 ]
    NP_001171068.1. NM_001177597.2. [P40225-2 ]
    NP_001171069.1. NM_001177598.2.
    NP_001276926.1. NM_001289997.1.
    NP_001276927.1. NM_001289998.1. [P40225-1 ]
    NP_001276932.1. NM_001290003.1.
    NP_001276951.1. NM_001290022.1. [P40225-2 ]
    NP_001276955.1. NM_001290026.1.
    NP_001276956.1. NM_001290027.1.
    NP_001276957.1. NM_001290028.1. [P40225-1 ]
    UniGenei Hs.1166.
    Hs.734657.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V7M X-ray 2.51 V/X 22-184 [» ]
    1V7N X-ray 3.30 V/X/Y/Z 22-184 [» ]
    ProteinModelPortali P40225.
    SMRi P40225. Positions 28-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112922. 3 interactions.
    DIPi DIP-5729N.
    IntActi P40225. 3 interactions.
    STRINGi 9606.ENSP00000204615.

    Chemistry

    ChEMBLi CHEMBL1293256.

    PTM databases

    PhosphoSitei P40225.

    Polymorphism databases

    DMDMi 730982.

    Proteomic databases

    PaxDbi P40225.
    PRIDEi P40225.

    Protocols and materials databases

    DNASUi 7066.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000204615 ; ENSP00000204615 ; ENSG00000090534 . [P40225-1 ]
    ENST00000445696 ; ENSP00000410763 ; ENSG00000090534 . [P40225-2 ]
    GeneIDi 7066.
    KEGGi hsa:7066.
    UCSCi uc003fol.1. human. [P40225-1 ]
    uc003fom.2. human. [P40225-2 ]

    Organism-specific databases

    CTDi 7066.
    GeneCardsi GC03M184089.
    HGNCi HGNC:11795. THPO.
    MIMi 187950. phenotype.
    600044. gene.
    neXtProti NX_P40225.
    Orphaneti 71493. Familial thrombocytosis.
    329319. Hereditary thrombocytosis with transverse limb defect.
    PharmGKBi PA36506.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84342.
    HOVERGENi HBG002468.
    InParanoidi P40225.
    KOi K06854.
    OMAi EQSKAQD.
    OrthoDBi EOG7PVWPW.
    PhylomeDBi P40225.
    TreeFami TF338084.

    Enzyme and pathway databases

    Reactomei REACT_278. Platelet Aggregation (Plug Formation).
    SignaLinki P40225.

    Miscellaneous databases

    EvolutionaryTracei P40225.
    GeneWikii Thrombopoietin.
    GenomeRNAii 7066.
    NextBioi 27627.
    PMAP-CutDB P40225.
    PROi P40225.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40225.
    Bgeei P40225.
    CleanExi HS_THPO.
    Genevestigatori P40225.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003978. Thrombopoeitin.
    [Graphical view ]
    PANTHERi PTHR10560. PTHR10560. 1 hit.
    Pfami PF00758. EPO_TPO. 1 hit.
    [Graphical view ]
    PRINTSi PR01485. THROMBOPTN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00817. EPO_TPO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    4. "Molecular cloning and chromosomal localization of the human thrombopoietin gene."
      Sohma Y., Akahori H., Seki N., Hori T.-A., Ogami K., Kawamura K., Miyazaki H.
      FEBS Lett. 353:57-61(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. "Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin."
      Gurney A.L., Kuang W.-J., Xie M.-H., Malloy B.E., Eaton D.L., de Sauvage F.J.
      Blood 85:981-988(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
    6. "Purification and characterization of thrombopoietin."
      Kato T., Ogami K., Shimada Y., Iwamatsu A., Sohma Y., Akahori H., Horie K., Kokubo A., Kudo Y., Maeda E., Kobayashi K., Ohashi H., Ozawa T., Inoue H., Kawamura K., Miyazaki H.
      J. Biochem. 118:229-236(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    7. "Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene."
      Chang M., McNinch J., Basu R., Shutter J., Hsu R., Perkins C., Mar V., Suggs S., Welcher A., Li L., Lu H., Bartley T., Hunt P., Martin F., Samal B., Bogenberger J.
      J. Biol. Chem. 270:511-514(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Placenta.
    8. "Cloning and sequencing of human thrombopoietin."
      Im S.H., Lee W.S., Chung K.H.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3).
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    10. "An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia."
      Wiestner A., Schlemper R.J., van der Maas A.P.C., Skoda R.C.
      Nat. Genet. 18:49-52(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.
    11. "Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246."
      Hoffman R.C., Andersen H., Walker K., Krakover J.D., Patel S., Stamm M.R., Osborn S.G.
      Biochemistry 35:14849-14861(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, GLYCOSYLATION AT SER-22; THR-58; THR-131; THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255 AND SER-265.
    12. "Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment."
      Feese M.D., Tamada T., Kato Y., Maeda Y., Hirose M., Matsukura Y., Shigematsu H., Muto T., Matsumoto A., Watarai H., Ogami K., Tahara T., Kato T., Miyazaki H., Kuroki R.
      Proc. Natl. Acad. Sci. U.S.A. 101:1816-1821(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 22-184 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTPO_HUMAN
    AccessioniPrimary (citable) accession number: P40225
    Secondary accession number(s): A1L3Y0
    , B7ZLR8, B9EGA8, Q13020, Q15790, Q15791, Q15792
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3