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P40223

- CSF3R_MOUSE

UniProt

P40223 - CSF3R_MOUSE

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Protein

Granulocyte colony-stimulating factor receptor

Gene

Csf3r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. neutrophil chemotaxis Source: MGI
  3. odontogenesis of dentin-containing tooth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor receptor
Short name:
G-CSF receptor
Short name:
G-CSF-R
Alternative name(s):
CD_antigen: CD114
Gene namesi
Name:Csf3r
Synonyms:Csfgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1339755. Csf3r.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 837812Granulocyte colony-stimulating factor receptorPRO_0000010875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 52By similarity
Disulfide bondi46 ↔ 102By similarity
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)1 Publication
Disulfide bondi132 ↔ 1431 Publication
Disulfide bondi168 ↔ 2191 Publication
Disulfide bondi178 ↔ 1871 Publication
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 2961 Publication
Disulfide bondi267 ↔ 3101 Publication
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP40223.

PTM databases

PhosphoSiteiP40223.

Expressioni

Tissue specificityi

Found in bone marrow.

Gene expression databases

BgeeiP40223.
GenevestigatoriP40223.

Interactioni

Subunit structurei

Homodimer. The dimeric receptor binds two CSF3 molecules.1 Publication

Protein-protein interaction databases

BioGridi198935. 3 interactions.
STRINGi10090.ENSMUSP00000101768.

Structurei

Secondary structure

1
837
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi128 – 1358
Turni136 – 1394
Beta strandi140 – 1467
Beta strandi156 – 1638
Helixi166 – 1683
Beta strandi174 – 1796
Beta strandi186 – 1905
Helixi191 – 1933
Beta strandi200 – 2089
Beta strandi211 – 2144
Beta strandi218 – 2203
Helixi222 – 2254
Beta strandi232 – 2354
Beta strandi242 – 2443
Beta strandi250 – 2556
Helixi258 – 2603
Beta strandi265 – 27511
Beta strandi281 – 2888
Beta strandi290 – 2956
Beta strandi304 – 31512
Beta strandi326 – 3283

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CD9X-ray2.80B/D120-334[»]
1CTONMR-A228-333[»]
1GCFNMR-A228-333[»]
1PGRX-ray3.50B/D/F/H120-334[»]
ProteinModelPortaliP40223.
SMRiP40223. Positions 26-621.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40223.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 626601ExtracellularSequence AnalysisAdd
BLAST
Topological domaini651 – 837187CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei627 – 65024HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11893Ig-like C2-typeAdd
BLAST
Domaini126 – 231106Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini236 – 33196Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini334 – 433100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 52996Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini530 – 62495Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi319 – 3235WSXWS motif
Motifi658 – 6669Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29566.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000231142.
HOVERGENiHBG051130.
InParanoidiP40223.
KOiK05061.
OMAiYLRCDST.
OrthoDBiEOG7FXZXN.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40223-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGLGACTLT GVTLIFLLLP RSLESCGHIE ISPPVVRLGD PVLASCTISP
60 70 80 90 100
NCSKLDQQAK ILWRLQDEPI QPGDRQHHLP DGTQESLITL PHLNYTQAFL
110 120 130 140 150
FCLVPWEDSV QLLDQAELHA GYPPASPSNL SCLMHLTTNS LVCQWEPGPE
160 170 180 190 200
THLPTSFILK SFRSRADCQY QGDTIPDCVA KKRQNNCSIP RKNLLLYQYM
210 220 230 240 250
AIWVQAENML GSSESPKLCL DPMDVVKLEP PMLQALDIGP DVVSHQPGCL
260 270 280 290 300
WLSWKPWKPS EYMEQECELR YQPQLKGANW TLVFHLPSSK DQFELCGLHQ
310 320 330 340 350
APVYTLQMRC IRSSLPGFWS PWSPGLQLRP TMKAPTIRLD TWCQKKQLDP
360 370 380 390 400
GTVSVQLFWK PTPLQEDSGQ IQGYLLSWSS PDHQGQDIHL CNTTQLSCIF
410 420 430 440 450
LLPSEAQNVT LVAYNKAGTS SPTTVVFLEN EGPAVTGLHA MAQDLNTIWV
460 470 480 490 500
DWEAPSLLPQ GYLIEWEMSS PSYNNSYKSW MIEPNGNITG ILLKDNINPF
510 520 530 540 550
QLYRITVAPL YPGIVGPPVN VYTFAGERAP PHAPALHLKH VGTTWAQLEW
560 570 580 590 600
VPEAPRLGMI PLTHYTIFWA DAGDHSFSVT LNISLHDFVL KHLEPASLYH
610 620 630 640 650
VYLMATSRAG STNSTGLTLR TLDPSDLNIF LGILCLVLLS TTCVVTWLCC
660 670 680 690 700
KRRGKTSFWS DVPDPAHSSL SSWLPTIMTE ETFQLPSFWD SSVPSITKIT
710 720 730 740 750
ELEEDKKPTH WDSESSGNGS LPALVQAYVL QGDPREISNQ SQPPSRTGDQ
760 770 780 790 800
VLYGQVLESP TSPGVMQYIR SDSTQPLLGG PTPSPKSYEN IWFHSRPQET
810 820 830
FVPQPPNQED DCVFGPPFDF PLFQGLQVHG VEEQGGF
Length:837
Mass (Da):93,379
Last modified:July 27, 2011 - v2
Checksum:iF46E9D62A3DC4C3F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti379 – 3791S → N in AAA37673. (PubMed:2158861)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58288 mRNA. Translation: AAA37673.1.
AL627101 Genomic DNA. Translation: CAM15033.1.
CCDSiCCDS18640.1.
PIRiA34898.
RefSeqiNP_031808.2. NM_007782.3.
XP_006502771.1. XM_006502708.1.
XP_006502772.1. XM_006502709.1.
XP_006502773.1. XM_006502710.1.
XP_006502774.1. XM_006502711.1.
XP_006502775.1. XM_006502712.1.
XP_006502776.1. XM_006502713.1.
XP_006502777.1. XM_006502714.1.
UniGeneiMm.271701.

Genome annotation databases

EnsembliENSMUST00000030673; ENSMUSP00000030673; ENSMUSG00000028859.
ENSMUST00000106162; ENSMUSP00000101768; ENSMUSG00000028859.
GeneIDi12986.
KEGGimmu:12986.
UCSCiuc008usd.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58288 mRNA. Translation: AAA37673.1 .
AL627101 Genomic DNA. Translation: CAM15033.1 .
CCDSi CCDS18640.1.
PIRi A34898.
RefSeqi NP_031808.2. NM_007782.3.
XP_006502771.1. XM_006502708.1.
XP_006502772.1. XM_006502709.1.
XP_006502773.1. XM_006502710.1.
XP_006502774.1. XM_006502711.1.
XP_006502775.1. XM_006502712.1.
XP_006502776.1. XM_006502713.1.
XP_006502777.1. XM_006502714.1.
UniGenei Mm.271701.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CD9 X-ray 2.80 B/D 120-334 [» ]
1CTO NMR - A 228-333 [» ]
1GCF NMR - A 228-333 [» ]
1PGR X-ray 3.50 B/D/F/H 120-334 [» ]
ProteinModelPortali P40223.
SMRi P40223. Positions 26-621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198935. 3 interactions.
STRINGi 10090.ENSMUSP00000101768.

PTM databases

PhosphoSitei P40223.

Proteomic databases

PRIDEi P40223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030673 ; ENSMUSP00000030673 ; ENSMUSG00000028859 .
ENSMUST00000106162 ; ENSMUSP00000101768 ; ENSMUSG00000028859 .
GeneIDi 12986.
KEGGi mmu:12986.
UCSCi uc008usd.3. mouse.

Organism-specific databases

CTDi 1441.
MGIi MGI:1339755. Csf3r.

Phylogenomic databases

eggNOGi NOG29566.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000231142.
HOVERGENi HBG051130.
InParanoidi P40223.
KOi K05061.
OMAi YLRCDST.
OrthoDBi EOG7FXZXN.
TreeFami TF338122.

Miscellaneous databases

EvolutionaryTracei P40223.
NextBioi 282776.
PROi P40223.
SOURCEi Search...

Gene expression databases

Bgeei P40223.
Genevestigatori P40223.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a receptor for murine granulocyte colony-stimulating factor."
    Fukunaga R., Ishizaka-Ikeda E., Seto Y., Nagata S.
    Cell 61:341-350(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand."
    Yamasaki K., Naito S., Anaguchi H., Ohkubo T., Ota Y.
    Nat. Struct. Biol. 4:498-504(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 225-333.
  4. "Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme."
    Aritomi M., Kunishima N., Okamoto T., Kuroki R., Ota Y., Morikawa K.
    Nature 401:713-717(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 120-334 IN COMPLEX WITH CSF3, SUBUNIT, GLYCOSYLATION AT ASN-129, DISULFIDE BONDS.

Entry informationi

Entry nameiCSF3R_MOUSE
AccessioniPrimary (citable) accession number: P40223
Secondary accession number(s): A2A8Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3