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Protein

Granulocyte colony-stimulating factor receptor

Gene

Csf3r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.

GO - Molecular functioni

  • cytokine receptor activity Source: InterPro
  • granulocyte colony-stimulating factor binding Source: MGI

GO - Biological processi

  • amelogenesis Source: Ensembl
  • cell adhesion Source: UniProtKB-KW
  • neutrophil chemotaxis Source: MGI
  • regulation of myeloid cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor receptor
Short name:
G-CSF receptor
Short name:
G-CSF-R
Alternative name(s):
CD_antigen: CD114
Gene namesi
Name:Csf3r
Synonyms:Csfgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1339755. Csf3r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 626ExtracellularSequence analysisAdd BLAST601
Transmembranei627 – 650HelicalSequence analysisAdd BLAST24
Topological domaini651 – 837CytoplasmicSequence analysisAdd BLAST187

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001087526 – 837Granulocyte colony-stimulating factor receptorAdd BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 52By similarity
Disulfide bondi46 ↔ 102By similarity
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)1 Publication1
Disulfide bondi132 ↔ 1431 Publication
Disulfide bondi168 ↔ 2191 Publication
Disulfide bondi178 ↔ 1871 Publication
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 2961 Publication
Disulfide bondi267 ↔ 3101 Publication
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1
Glycosylationi582N-linked (GlcNAc...)Sequence analysis1
Glycosylationi613N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP40223.
PRIDEiP40223.

PTM databases

iPTMnetiP40223.
PhosphoSitePlusiP40223.

Expressioni

Tissue specificityi

Found in bone marrow.

Gene expression databases

BgeeiENSMUSG00000028859.
GenevisibleiP40223. MM.

Interactioni

Subunit structurei

Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969).2 Publications

GO - Molecular functioni

  • granulocyte colony-stimulating factor binding Source: MGI

Protein-protein interaction databases

BioGridi198935. 3 interactors.
DIPiDIP-61167N.
STRINGi10090.ENSMUSP00000030673.

Structurei

Secondary structure

1837
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi128 – 135Combined sources8
Turni136 – 139Combined sources4
Beta strandi140 – 146Combined sources7
Beta strandi156 – 163Combined sources8
Helixi166 – 168Combined sources3
Beta strandi174 – 179Combined sources6
Beta strandi186 – 190Combined sources5
Helixi191 – 193Combined sources3
Beta strandi200 – 208Combined sources9
Beta strandi211 – 214Combined sources4
Beta strandi218 – 220Combined sources3
Helixi222 – 225Combined sources4
Beta strandi232 – 235Combined sources4
Beta strandi242 – 244Combined sources3
Beta strandi250 – 255Combined sources6
Helixi258 – 260Combined sources3
Beta strandi265 – 275Combined sources11
Beta strandi281 – 288Combined sources8
Beta strandi290 – 295Combined sources6
Beta strandi304 – 315Combined sources12
Beta strandi326 – 328Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CD9X-ray2.80B/D120-334[»]
1CTONMR-A228-333[»]
1GCFNMR-A228-333[»]
1PGRX-ray3.50B/D/F/H120-334[»]
ProteinModelPortaliP40223.
SMRiP40223.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40223.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 118Ig-like C2-typeAdd BLAST93
Domaini126 – 231Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST106
Domaini236 – 331Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini334 – 433Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini434 – 529Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini530 – 624Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi319 – 323WSXWS motif5
Motifi658 – 666Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHT. Eukaryota.
ENOG410XVIU. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000231142.
HOVERGENiHBG051130.
InParanoidiP40223.
KOiK05061.
OMAiYLRCDST.
OrthoDBiEOG091G01XM.
TreeFamiTF338122.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLGACTLT GVTLIFLLLP RSLESCGHIE ISPPVVRLGD PVLASCTISP
60 70 80 90 100
NCSKLDQQAK ILWRLQDEPI QPGDRQHHLP DGTQESLITL PHLNYTQAFL
110 120 130 140 150
FCLVPWEDSV QLLDQAELHA GYPPASPSNL SCLMHLTTNS LVCQWEPGPE
160 170 180 190 200
THLPTSFILK SFRSRADCQY QGDTIPDCVA KKRQNNCSIP RKNLLLYQYM
210 220 230 240 250
AIWVQAENML GSSESPKLCL DPMDVVKLEP PMLQALDIGP DVVSHQPGCL
260 270 280 290 300
WLSWKPWKPS EYMEQECELR YQPQLKGANW TLVFHLPSSK DQFELCGLHQ
310 320 330 340 350
APVYTLQMRC IRSSLPGFWS PWSPGLQLRP TMKAPTIRLD TWCQKKQLDP
360 370 380 390 400
GTVSVQLFWK PTPLQEDSGQ IQGYLLSWSS PDHQGQDIHL CNTTQLSCIF
410 420 430 440 450
LLPSEAQNVT LVAYNKAGTS SPTTVVFLEN EGPAVTGLHA MAQDLNTIWV
460 470 480 490 500
DWEAPSLLPQ GYLIEWEMSS PSYNNSYKSW MIEPNGNITG ILLKDNINPF
510 520 530 540 550
QLYRITVAPL YPGIVGPPVN VYTFAGERAP PHAPALHLKH VGTTWAQLEW
560 570 580 590 600
VPEAPRLGMI PLTHYTIFWA DAGDHSFSVT LNISLHDFVL KHLEPASLYH
610 620 630 640 650
VYLMATSRAG STNSTGLTLR TLDPSDLNIF LGILCLVLLS TTCVVTWLCC
660 670 680 690 700
KRRGKTSFWS DVPDPAHSSL SSWLPTIMTE ETFQLPSFWD SSVPSITKIT
710 720 730 740 750
ELEEDKKPTH WDSESSGNGS LPALVQAYVL QGDPREISNQ SQPPSRTGDQ
760 770 780 790 800
VLYGQVLESP TSPGVMQYIR SDSTQPLLGG PTPSPKSYEN IWFHSRPQET
810 820 830
FVPQPPNQED DCVFGPPFDF PLFQGLQVHG VEEQGGF
Length:837
Mass (Da):93,379
Last modified:July 27, 2011 - v2
Checksum:iF46E9D62A3DC4C3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379S → N in AAA37673 (PubMed:2158861).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58288 mRNA. Translation: AAA37673.1.
AL627101 Genomic DNA. Translation: CAM15033.1.
CCDSiCCDS18640.1.
PIRiA34898.
RefSeqiNP_031808.2. NM_007782.3.
XP_006502771.1. XM_006502708.3.
XP_006502772.1. XM_006502709.2.
XP_006502773.1. XM_006502710.3.
XP_006502774.1. XM_006502711.3.
XP_006502775.1. XM_006502712.3.
XP_006502776.1. XM_006502713.2.
XP_006502777.1. XM_006502714.2.
XP_011238723.1. XM_011240421.2.
XP_011238724.1. XM_011240422.2.
XP_017175433.1. XM_017319944.1.
UniGeneiMm.271701.

Genome annotation databases

EnsembliENSMUST00000030673; ENSMUSP00000030673; ENSMUSG00000028859.
ENSMUST00000106162; ENSMUSP00000101768; ENSMUSG00000028859.
GeneIDi12986.
KEGGimmu:12986.
UCSCiuc008usd.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58288 mRNA. Translation: AAA37673.1.
AL627101 Genomic DNA. Translation: CAM15033.1.
CCDSiCCDS18640.1.
PIRiA34898.
RefSeqiNP_031808.2. NM_007782.3.
XP_006502771.1. XM_006502708.3.
XP_006502772.1. XM_006502709.2.
XP_006502773.1. XM_006502710.3.
XP_006502774.1. XM_006502711.3.
XP_006502775.1. XM_006502712.3.
XP_006502776.1. XM_006502713.2.
XP_006502777.1. XM_006502714.2.
XP_011238723.1. XM_011240421.2.
XP_011238724.1. XM_011240422.2.
XP_017175433.1. XM_017319944.1.
UniGeneiMm.271701.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CD9X-ray2.80B/D120-334[»]
1CTONMR-A228-333[»]
1GCFNMR-A228-333[»]
1PGRX-ray3.50B/D/F/H120-334[»]
ProteinModelPortaliP40223.
SMRiP40223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198935. 3 interactors.
DIPiDIP-61167N.
STRINGi10090.ENSMUSP00000030673.

PTM databases

iPTMnetiP40223.
PhosphoSitePlusiP40223.

Proteomic databases

PaxDbiP40223.
PRIDEiP40223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030673; ENSMUSP00000030673; ENSMUSG00000028859.
ENSMUST00000106162; ENSMUSP00000101768; ENSMUSG00000028859.
GeneIDi12986.
KEGGimmu:12986.
UCSCiuc008usd.3. mouse.

Organism-specific databases

CTDi1441.
MGIiMGI:1339755. Csf3r.

Phylogenomic databases

eggNOGiENOG410IGHT. Eukaryota.
ENOG410XVIU. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000231142.
HOVERGENiHBG051130.
InParanoidiP40223.
KOiK05061.
OMAiYLRCDST.
OrthoDBiEOG091G01XM.
TreeFamiTF338122.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

EvolutionaryTraceiP40223.
PROiP40223.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028859.
GenevisibleiP40223. MM.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSF3R_MOUSE
AccessioniPrimary (citable) accession number: P40223
Secondary accession number(s): A2A8Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.