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Protein

Alpha-taxilin

Gene

TXLNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Caution

Was originally thought to be a high molecular weight interleukin (IL-14 or IL14).1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • high molecular weight B cell growth factor receptor binding Source: UniProtKB
  • syntaxin binding Source: InterPro

GO - Biological processi

  • B cell activation Source: Ensembl
  • cell proliferation Source: UniProtKB
  • cytokine-mediated signaling pathway Source: Reactome
  • exocytosis Source: UniProtKB-KW

Keywordsi

Biological processExocytosis

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-taxilin
Gene namesi
Name:TXLNA
Synonyms:TXLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000084652.15
HGNCiHGNC:30685 TXLNA
MIMi608676 gene
neXtProtiNX_P40222

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi200081
OpenTargetsiENSG00000084652
PharmGKBiPA142670668

Polymorphism and mutation databases

BioMutaiTXLNA
DMDMi55584162

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894211 – 546Alpha-taxilinAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP40222
MaxQBiP40222
PaxDbiP40222
PeptideAtlasiP40222
PRIDEiP40222

PTM databases

iPTMnetiP40222
PhosphoSitePlusiP40222
SwissPalmiP40222

Expressioni

Tissue specificityi

Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000084652
GenevisibleiP40222 HS

Organism-specific databases

HPAiHPA045383
HPA072477

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • high molecular weight B cell growth factor receptor binding Source: UniProtKB
  • syntaxin binding Source: InterPro

Protein-protein interaction databases

BioGridi128297, 119 interactors
CORUMiP40222
DIPiDIP-27612N
IntActiP40222, 108 interactors
STRINGi9606.ENSP00000362711

Structurei

3D structure databases

ProteinModelPortaliP40222
SMRiP40222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 491Sequence analysisAdd BLAST306

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOVERGENiHBG104385
InParanoidiP40222
OMAiSTYCVDN
OrthoDBiEOG091G0GVB
PhylomeDBiP40222
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequencei

Sequence statusi: Complete.

P40222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQDKKNGA AKQSNPKSSP GQPEAGPEGA QERPSQAAPA VEAEGPGSSQ
60 70 80 90 100
APRKPEGAQA RTAQSGALRD VSEELSRQLE DILSTYCVDN NQGGPGEDGA
110 120 130 140 150
QGEPAEPEDA EKSRTYVARN GEPEPTPVVN GEKEPSKGDP NTEEIRQSDE
160 170 180 190 200
VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL
210 220 230 240 250
EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR
260 270 280 290 300
HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ
310 320 330 340 350
ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE
360 370 380 390 400
AEERHQREKD FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT
410 420 430 440 450
LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK
460 470 480 490 500
TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLSA GGQGSLTDSG
510 520 530 540
PERRPEGPGA QAPSSPRVTE APCYPGAPST EASGQTGPQE PTSARA
Length:546
Mass (Da):61,891
Last modified:November 9, 2004 - v3
Checksum:i698CD74F78897DF6
GO

Sequence cautioni

The sequence AAH46565 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → Q in CAD89951 (PubMed:17974005).Curated1
Sequence conflicti194K → R in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti228R → C in AAH80578 (PubMed:15489334).Curated1
Sequence conflicti249 – 250QR → HG (PubMed:8327514).Curated2
Sequence conflicti278Q → L in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti368E → A in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti412K → E in CAD89951 (PubMed:17974005).Curated1
Sequence conflicti530T → A in CAD91138 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516206 mRNA Translation: AAO42465.1
AL832636 mRNA Translation: CAD89951.1
AL832637 mRNA Translation: CAD89952.1
AL832338 mRNA Translation: CAD91138.1
AL049795 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07565.1
CH471059 Genomic DNA Translation: EAX07566.1
BC029686 mRNA Translation: AAH29686.1
BC046565 mRNA Translation: AAH46565.1 Different initiation.
BC080578 mRNA Translation: AAH80578.1
BC103823 mRNA Translation: AAI03824.1
BC103824 mRNA Translation: AAI03825.1
L15344 mRNA No translation available.
CCDSiCCDS353.1
PIRiA48203
RefSeqiNP_787048.1, NM_175852.3
XP_016856051.1, XM_017000562.1
UniGeneiHs.17987

Genome annotation databases

EnsembliENST00000373609; ENSP00000362711; ENSG00000084652
ENST00000373610; ENSP00000362712; ENSG00000084652
GeneIDi200081
KEGGihsa:200081
UCSCiuc001bui.4 human

Similar proteinsi

Entry informationi

Entry nameiTXLNA_HUMAN
AccessioniPrimary (citable) accession number: P40222
Secondary accession number(s): D3DPP6
, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 9, 2004
Last modified: May 23, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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