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Protein

Alpha-taxilin

Gene

TXLNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • high molecular weight B cell growth factor receptor binding Source: UniProtKB

GO - Biological processi

  • B cell activation Source: Ensembl
  • cell proliferation Source: UniProtKB
  • exocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084652-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-taxilin
Gene namesi
Name:TXLNA
Synonyms:TXLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30685. TXLNA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: LIFEdb
  • extracellular region Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi200081.
OpenTargetsiENSG00000084652.
PharmGKBiPA142670668.

Polymorphism and mutation databases

BioMutaiTXLNA.
DMDMi55584162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894211 – 546Alpha-taxilinAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP40222.
MaxQBiP40222.
PaxDbiP40222.
PeptideAtlasiP40222.
PRIDEiP40222.

PTM databases

iPTMnetiP40222.
PhosphoSitePlusiP40222.
SwissPalmiP40222.

Expressioni

Tissue specificityi

Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000084652.
GenevisibleiP40222. HS.

Organism-specific databases

HPAiHPA045383.

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Azi2Q9QYP62EBI-359793,EBI-6115874From a different organism.
BTF3P202903EBI-359793,EBI-1054687
BTF3L4Q96K175EBI-359793,EBI-6137496
CCDC136Q96JN2-25EBI-359793,EBI-10171416
CCDC53Q9Y3C03EBI-359793,EBI-712969
CCDC67E9PJR55EBI-359793,EBI-10177066
CCDC67Q05D603EBI-359793,EBI-748597
CCHCR1Q8TD31-33EBI-359793,EBI-10175300
CDR2Q018505EBI-359793,EBI-1181367
CEP44Q9C0F13EBI-359793,EBI-744115
CEP57L1Q8IYX8-23EBI-359793,EBI-10181988
CEP63Q96MT84EBI-359793,EBI-741977
DKFZp451B226Q5HYH75EBI-359793,EBI-10173842
DTNBO609414EBI-359793,EBI-740402
EIF4ENIF1Q9NRA83EBI-359793,EBI-301024
GOLGA2Q083793EBI-359793,EBI-618309
GORASP2Q9H8Y85EBI-359793,EBI-739467
HAUS3Q68CZ63EBI-359793,EBI-2558217
HYPKQ9NX555EBI-359793,EBI-1048743
KANK2Q63ZY35EBI-359793,EBI-2556193
KRT13A1A4E93EBI-359793,EBI-10171552
KRT15P190123EBI-359793,EBI-739566
KRT20P359005EBI-359793,EBI-742094
KRT31Q153235EBI-359793,EBI-948001
KRT38O760153EBI-359793,EBI-1047263
KRT40Q6A1623EBI-359793,EBI-10171697
LCA5Q86VQ03EBI-359793,EBI-6658186
MBIPQ9NS73-53EBI-359793,EBI-10182361
MED4Q9NPJ65EBI-359793,EBI-394607
MEOX1P502213EBI-359793,EBI-2864512
MEOX2A4D1273EBI-359793,EBI-10172134
NACAQ137652EBI-359793,EBI-712216
NDC80O147773EBI-359793,EBI-715849
NMIQ132875EBI-359793,EBI-372942
NMIQ8WTW23EBI-359793,EBI-10174268
NSMCE2Q96MF75EBI-359793,EBI-2557388
NUP62P371985EBI-359793,EBI-347978
PPFIA1Q131363EBI-359793,EBI-745426
RCOR3Q9P2K33EBI-359793,EBI-743428
RINT1Q6NUQ15EBI-359793,EBI-726876
SMARCE1Q969G33EBI-359793,EBI-455078
SPERTQ8NA613EBI-359793,EBI-741724
STMN2Q930453EBI-359793,EBI-714194
TBK1Q9UHD24EBI-359793,EBI-356402
TCL1AP562793EBI-359793,EBI-749995
TFIP11Q9UBB95EBI-359793,EBI-1105213
TNIP1Q150255EBI-359793,EBI-357849
TP53BP2Q13625-33EBI-359793,EBI-10175039
TXLNBQ8N3L34EBI-359793,EBI-6116822
USHBP1Q8N6Y05EBI-359793,EBI-739895
VPS52Q8N1B45EBI-359793,EBI-2799833

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • high molecular weight B cell growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128297. 115 interactors.
DIPiDIP-27612N.
IntActiP40222. 92 interactors.
MINTiMINT-1150979.
STRINGi9606.ENSP00000362711.

Structurei

3D structure databases

ProteinModelPortaliP40222.
SMRiP40222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 491Sequence analysisAdd BLAST306

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOVERGENiHBG104385.
InParanoidiP40222.
OMAiDILNTYC.
OrthoDBiEOG091G0GVB.
PhylomeDBiP40222.
TreeFamiTF318595.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQDKKNGA AKQSNPKSSP GQPEAGPEGA QERPSQAAPA VEAEGPGSSQ
60 70 80 90 100
APRKPEGAQA RTAQSGALRD VSEELSRQLE DILSTYCVDN NQGGPGEDGA
110 120 130 140 150
QGEPAEPEDA EKSRTYVARN GEPEPTPVVN GEKEPSKGDP NTEEIRQSDE
160 170 180 190 200
VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL
210 220 230 240 250
EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR
260 270 280 290 300
HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ
310 320 330 340 350
ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE
360 370 380 390 400
AEERHQREKD FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT
410 420 430 440 450
LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK
460 470 480 490 500
TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLSA GGQGSLTDSG
510 520 530 540
PERRPEGPGA QAPSSPRVTE APCYPGAPST EASGQTGPQE PTSARA
Length:546
Mass (Da):61,891
Last modified:November 9, 2004 - v3
Checksum:i698CD74F78897DF6
GO

Sequence cautioni

The sequence AAH46565 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → Q in CAD89951 (PubMed:17974005).Curated1
Sequence conflicti194K → R in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti228R → C in AAH80578 (PubMed:15489334).Curated1
Sequence conflicti249 – 250QR → HG (PubMed:8327514).Curated2
Sequence conflicti278Q → L in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti368E → A in CAD89952 (PubMed:17974005).Curated1
Sequence conflicti412K → E in CAD89951 (PubMed:17974005).Curated1
Sequence conflicti530T → A in CAD91138 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516206 mRNA. Translation: AAO42465.1.
AL832636 mRNA. Translation: CAD89951.1.
AL832637 mRNA. Translation: CAD89952.1.
AL832338 mRNA. Translation: CAD91138.1.
AL049795 Genomic DNA. Translation: CAI22055.1.
CH471059 Genomic DNA. Translation: EAX07565.1.
CH471059 Genomic DNA. Translation: EAX07566.1.
BC029686 mRNA. Translation: AAH29686.1.
BC046565 mRNA. Translation: AAH46565.1. Different initiation.
BC080578 mRNA. Translation: AAH80578.1.
BC103823 mRNA. Translation: AAI03824.1.
BC103824 mRNA. Translation: AAI03825.1.
L15344 mRNA. No translation available.
CCDSiCCDS353.1.
PIRiA48203.
RefSeqiNP_787048.1. NM_175852.3.
XP_016856051.1. XM_017000562.1.
UniGeneiHs.17987.

Genome annotation databases

EnsembliENST00000373609; ENSP00000362711; ENSG00000084652.
ENST00000373610; ENSP00000362712; ENSG00000084652.
GeneIDi200081.
KEGGihsa:200081.
UCSCiuc001bui.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516206 mRNA. Translation: AAO42465.1.
AL832636 mRNA. Translation: CAD89951.1.
AL832637 mRNA. Translation: CAD89952.1.
AL832338 mRNA. Translation: CAD91138.1.
AL049795 Genomic DNA. Translation: CAI22055.1.
CH471059 Genomic DNA. Translation: EAX07565.1.
CH471059 Genomic DNA. Translation: EAX07566.1.
BC029686 mRNA. Translation: AAH29686.1.
BC046565 mRNA. Translation: AAH46565.1. Different initiation.
BC080578 mRNA. Translation: AAH80578.1.
BC103823 mRNA. Translation: AAI03824.1.
BC103824 mRNA. Translation: AAI03825.1.
L15344 mRNA. No translation available.
CCDSiCCDS353.1.
PIRiA48203.
RefSeqiNP_787048.1. NM_175852.3.
XP_016856051.1. XM_017000562.1.
UniGeneiHs.17987.

3D structure databases

ProteinModelPortaliP40222.
SMRiP40222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128297. 115 interactors.
DIPiDIP-27612N.
IntActiP40222. 92 interactors.
MINTiMINT-1150979.
STRINGi9606.ENSP00000362711.

PTM databases

iPTMnetiP40222.
PhosphoSitePlusiP40222.
SwissPalmiP40222.

Polymorphism and mutation databases

BioMutaiTXLNA.
DMDMi55584162.

Proteomic databases

EPDiP40222.
MaxQBiP40222.
PaxDbiP40222.
PeptideAtlasiP40222.
PRIDEiP40222.

Protocols and materials databases

DNASUi200081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373609; ENSP00000362711; ENSG00000084652.
ENST00000373610; ENSP00000362712; ENSG00000084652.
GeneIDi200081.
KEGGihsa:200081.
UCSCiuc001bui.4. human.

Organism-specific databases

CTDi200081.
DisGeNETi200081.
GeneCardsiTXLNA.
HGNCiHGNC:30685. TXLNA.
HPAiHPA045383.
MIMi608676. gene.
neXtProtiNX_P40222.
OpenTargetsiENSG00000084652.
PharmGKBiPA142670668.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOVERGENiHBG104385.
InParanoidiP40222.
OMAiDILNTYC.
OrthoDBiEOG091G0GVB.
PhylomeDBiP40222.
TreeFamiTF318595.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084652-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiTXLNA. human.
GeneWikiiTXLNA.
GenomeRNAii200081.
PROiP40222.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084652.
GenevisibleiP40222. HS.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNA_HUMAN
AccessioniPrimary (citable) accession number: P40222
Secondary accession number(s): D3DPP6
, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 9, 2004
Last modified: November 30, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a high molecular weight interleukin (IL-14 or IL14).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.