P40205 (NCYM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-cym protein

Alternative name(s):
N-myc opposite strand

Gene names

Name:	MYCNOS
Synonyms:	CYMN, NCYM

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a functional role during normal fetal development.
Tissue specificity	Expressed in the fetal brain, lung, liver and kidney at varying low levels.
Developmental stage	Expressed during fetal development, as well as in tumor cell lines containing amplified MYCN loci, where it is expressed at very high levels.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	N-cym protein		PRO_0000096769
Regions
	Compositional bias	68 – 109	42	Arg/Lys-rich (basic)
Experimental info
	Sequence conflict	70	1	V → L in AAB24206. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40205 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 1F6A1628CF07F6F3	FASTA	109	11,733
	10 20 30 40 50 60 MQHPPCEPGN CLSLKEKKIT EGSGGVCWGG ETDASNPAPA LTACCAAERE ANVEQGLAGR 70 80 90 100 LLLCNYERRV VRRCKIAGRG RAPLGTRPLD VSSFKLKEEG RPPCLKINK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc." Armstrong B.C., Krystal G.W. Cell Growth Differ. 3:385-390(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	S49953 mRNA. Translation: AAB24206.1. AC010145 Genomic DNA. Translation: AAY14951.1.
IPI	IPI00027605.
PIR	A49009.
UniGene	Hs.651453.
3D structure databases
ModBase	Search...
Polymorphism databases
DMDM	215274037.
Proteomic databases
PRIDE	P40205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC02M015998.
H-InvDB	HIX0029915.
HGNC	HGNC:16911. MYCNOS.
MIM	605374. gene.
neXtProt	NX_P40205.
GenAtlas	Search...
Gene expression databases
CleanEx	HS_MYCNOS.
Genevestigator	P40205.
GermOnline	ENSG00000169050. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NCYM_HUMAN

Accession

Primary (citable) accession number: P40205
Secondary accession number(s): Q53TD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 25, 2008
Last modified:	April 3, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.