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P40205

- NCYM_HUMAN

UniProt

P40205 - NCYM_HUMAN

Protein

N-cym protein

Gene

MYCNOS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May have a functional role during normal fetal development.

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-cym protein
    Alternative name(s):
    N-myc opposite strand
    Gene namesi
    Name:MYCNOS
    Synonyms:CYMN, NCYM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:16911. MYCNOS.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 109109N-cym proteinPRO_0000096769Add
    BLAST

    Proteomic databases

    PRIDEiP40205.

    Expressioni

    Tissue specificityi

    Expressed in the fetal brain, lung, liver and kidney at varying low levels.

    Developmental stagei

    Expressed during fetal development, as well as in tumor cell lines containing amplified MYCN loci, where it is expressed at very high levels.

    Gene expression databases

    CleanExiHS_MYCNOS.
    GenevestigatoriP40205.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 10942Arg/Lys-rich (basic)Add
    BLAST

    Sequencei

    Sequence statusi: Complete.

    P40205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHPPCEPGN CLSLKEKKIT EGSGGVCWGG ETDASNPAPA LTACCAAERE    50
    ANVEQGLAGR LLLCNYERRV VRRCKIAGRG RAPLGTRPLD VSSFKLKEEG 100
    RPPCLKINK 109
    Length:109
    Mass (Da):11,733
    Last modified:November 25, 2008 - v2
    Checksum:i1F6A1628CF07F6F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701V → L in AAB24206. (PubMed:1419902)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S49953 mRNA. Translation: AAB24206.1.
    AC010145 Genomic DNA. Translation: AAY14951.1.
    PIRiA49009.
    UniGeneiHs.651453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S49953 mRNA. Translation: AAB24206.1 .
    AC010145 Genomic DNA. Translation: AAY14951.1 .
    PIRi A49009.
    UniGenei Hs.651453.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P40205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC02M016061.
    H-InvDB HIX0029915.
    HGNCi HGNC:16911. MYCNOS.
    MIMi 605374. gene.
    neXtProti NX_P40205.
    GenAtlasi Search...

    Miscellaneous databases

    PROi P40205.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_MYCNOS.
    Genevestigatori P40205.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc."
      Armstrong B.C., Krystal G.W.
      Cell Growth Differ. 3:385-390(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNCYM_HUMAN
    AccessioniPrimary (citable) accession number: P40205
    Secondary accession number(s): Q53TD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3