Reviewed, UniProtKB/Swiss-Prot P40205 (NCYM_HUMAN)

Names and origin

Protein names

Recommended name:
    N-cym protein
Alternative name(s):
    N-myc opposite strand

Gene names

Name:	MYCNOS
Synonyms:	CYMN, NCYM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May have a functional role during normal fetal development.
Tissue specificity	Expressed in the fetal brain, lung, liver and kidney at varying low levels.
Developmental stage	Expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels.

Ontologies

Gene Ontology (GO)
Biological process	multicellular organismal development Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	N-cym protein		PRO_0000096769
Regions
	Compositional bias	68 – 109	42	Arg/Lys-rich (basic)
Experimental info
	Sequence conflict	70	1	V → L in AAB24206. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40205-1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 1F6A1628CF07F6F3	FASTA	109	11,733
	10 20 30 40 50 60 MQHPPCEPGN CLSLKEKKIT EGSGGVCWGG ETDASNPAPA LTACCAAERE ANVEQGLAGR 70 80 90 100 LLLCNYERRV VRRCKIAGRG RAPLGTRPLD VSSFKLKEEG RPPCLKINK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc." Armstrong B.C., Krystal G.W. Cell Growth Differ. 3:385-390(1992) [PubMed: 1419902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	S49953 mRNA. Translation: AAB24206.1. AC010145 Genomic DNA. Translation: AAY14951.1.
PIR	A49009.
UniGene	Hs.651453
3D structure databases
ModBase	Search...
Organism-specific databases
HGNC	HGNC:16911. MYCNOS.
MIM	605374. gene.
PharmGKB	PA134938338.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P40205.
HOVERGEN	P40205.
Gene expression databases
ArrayExpress	P40205.
CleanEx	HS_MYCNOS.
GermOnline	ENSG00000169050. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

NCYM_HUMAN

Accession

Primary (citable) accession number: P40205
Secondary accession number(s): Q53TD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 25, 2008
Last modified:	November 25, 2008
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)