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Protein

Small nuclear ribonucleoprotein G

Gene

SMX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30503-MONOMER.
ReactomeiR-SCE-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein G
Short name:
snRNP-G
Alternative name(s):
Sm protein G
Short name:
Sm-G
Short name:
SmG
Gene namesi
Name:SMX2
Synonyms:SNP2
Ordered Locus Names:YFL017W-A
ORF Names:YFL017Bw
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL017W-A.
SGDiS000002965. SMX2.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • P granule Source: GO_Central
  • precatalytic spliceosome Source: GO_Central
  • SMN-Sm protein complex Source: GO_Central
  • U12-type spliceosomal complex Source: GO_Central
  • U1 snRNP Source: SGD
  • U2 snRNP Source: GO_Central
  • U2-type prespliceosome Source: SGD
  • U4/U6 x U5 tri-snRNP complex Source: SGD
  • U4 snRNP Source: GO_Central
  • U5 snRNP Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7777Small nuclear ribonucleoprotein GPRO_0000125552Add
BLAST

Proteomic databases

MaxQBiP40204.
TopDownProteomicsiP40204.

Interactioni

Subunit structurei

Component of the Sm core complex, present in spliceosomal snRNP U1, U2, U4/U6 and U5. The core complex contains SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively), and is probably a heptameric ring structure. SMX2 specifically interacts with SME1. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.4 Publications

Protein-protein interaction databases

BioGridi31129. 49 interactions.
DIPiDIP-6683N.
IntActiP40204. 57 interactions.
MINTiMINT-613464.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCMelectron microscopy3.80X/a1-77[»]
5GAMelectron microscopy3.70g1-77[»]
5GANelectron microscopy3.60g/r1-77[»]
5GAOelectron microscopy3.60r1-77[»]
ProteinModelPortaliP40204.
SMRiP40204. Positions 5-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000046985.
HOGENOMiHOG000223546.
InParanoidiP40204.
KOiK11099.
OMAiDDAMEIN.
OrthoDBiEOG092C5VL3.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P40204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTPELKKY MDKKILLNIN GSRKVAGILR GYDIFLNVVL DDAMEINGED
60 70
PANNHQLGLQ TVIRGNSIIS LEALDAI
Length:77
Mass (Da):8,482
Last modified:February 1, 1995 - v1
Checksum:i5C6208B8C5A9AB33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20880 Genomic DNA. No translation available.
L31794 Genomic DNA. Translation: AAB63977.1.
D50617 Genomic DNA. No translation available.
Z46255 Genomic DNA. Translation: CAA86353.1.
AY558463 Genomic DNA. Translation: AAS56789.1.
BK006940 Genomic DNA. Translation: DAA12422.1.
PIRiS48322.
RefSeqiNP_116636.1. NM_001180864.1.

Genome annotation databases

EnsemblFungiiYFL017W-A; YFL017W-A; YFL017W-A.
GeneIDi850528.
KEGGisce:YFL017W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20880 Genomic DNA. No translation available.
L31794 Genomic DNA. Translation: AAB63977.1.
D50617 Genomic DNA. No translation available.
Z46255 Genomic DNA. Translation: CAA86353.1.
AY558463 Genomic DNA. Translation: AAS56789.1.
BK006940 Genomic DNA. Translation: DAA12422.1.
PIRiS48322.
RefSeqiNP_116636.1. NM_001180864.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCMelectron microscopy3.80X/a1-77[»]
5GAMelectron microscopy3.70g1-77[»]
5GANelectron microscopy3.60g/r1-77[»]
5GAOelectron microscopy3.60r1-77[»]
ProteinModelPortaliP40204.
SMRiP40204. Positions 5-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31129. 49 interactions.
DIPiDIP-6683N.
IntActiP40204. 57 interactions.
MINTiMINT-613464.

Proteomic databases

MaxQBiP40204.
TopDownProteomicsiP40204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL017W-A; YFL017W-A; YFL017W-A.
GeneIDi850528.
KEGGisce:YFL017W-A.

Organism-specific databases

EuPathDBiFungiDB:YFL017W-A.
SGDiS000002965. SMX2.

Phylogenomic databases

GeneTreeiENSGT00510000046985.
HOGENOMiHOG000223546.
InParanoidiP40204.
KOiK11099.
OMAiDDAMEIN.
OrthoDBiEOG092C5VL3.

Enzyme and pathway databases

BioCyciYEAST:G3O-30503-MONOMER.
ReactomeiR-SCE-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiP40204.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRUXG_YEAST
AccessioniPrimary (citable) accession number: P40204
Secondary accession number(s): D6VTL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.