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P40199

- CEAM6_HUMAN

UniProt

P40199 - CEAM6_HUMAN

Protein

Carcinoembryonic antigen-related cell adhesion molecule 6

Gene

CEACAM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. signal transduction Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 6
    Alternative name(s):
    Non-specific crossreacting antigen
    Normal cross-reacting antigen
    CD_antigen: CD66c
    Gene namesi
    Name:CEACAM6
    Synonyms:NCA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1818. CEACAM6.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 34341 PublicationAdd
    BLAST
    Chaini35 – 320286Carcinoembryonic antigen-related cell adhesion molecule 6PRO_0000014568Add
    BLAST
    Propeptidei321 – 34424Removed in mature formBy similarityPRO_0000014569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi167 ↔ 215Curated
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)1 Publication
    Glycosylationi224 – 2241N-linked (GlcNAc...)1 Publication
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi259 ↔ 299Curated
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Lipidationi320 – 3201GPI-anchor amidated glycineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiP40199.
    PaxDbiP40199.
    PRIDEiP40199.

    PTM databases

    PhosphoSiteiP40199.

    Expressioni

    Gene expression databases

    ArrayExpressiP40199.
    BgeeiP40199.
    CleanExiHS_CEACAM6.
    GenevestigatoriP40199.

    Organism-specific databases

    HPAiCAB008370.
    HPA011041.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CARTPTQ165683EBI-4314501,EBI-4314526
    CEACAM1P136882EBI-4314501,EBI-4314481

    Protein-protein interaction databases

    BioGridi110760. 7 interactions.
    IntActiP40199. 5 interactions.
    MINTiMINT-5002810.
    STRINGi9606.ENSP00000199764.

    Structurei

    3D structure databases

    ProteinModelPortaliP40199.
    SMRiP40199. Positions 34-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 142108Ig-like V-typeAdd
    BLAST
    Domaini145 – 23288Ig-like C2-type 1Add
    BLAST
    Domaini237 – 31478Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG151357.
    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    InParanoidiP40199.
    KOiK06499.
    OMAiPWKEVLL.
    OrthoDBiEOG74BJS7.
    PhylomeDBiP40199.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE    50
    VLLLAHNLPQ NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET 100
    IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS 150
    SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV NGQSLPVSPR LQLSNGNMTL 200
    TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP TISPSKANYR 250
    PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ 300
    AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI 344
    Length:344
    Mass (Da):37,195
    Last modified:May 18, 2010 - v3
    Checksum:i28469487A74C18A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381F → L in AAA59915. (PubMed:3220478)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti239 – 2391G → V.5 Publications
    Corresponds to variant rs11548735 [ dbSNP | Ensembl ].
    VAR_034680

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29541 mRNA. Translation: AAA59915.1.
    M18728 mRNA. Translation: AAA59907.1.
    M18216 mRNA. Translation: AAA51739.1.
    BT009774 mRNA. Translation: AAP88776.1.
    AK312542 mRNA. Translation: BAG35441.1.
    AC011513 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57061.1.
    BC005008 mRNA. Translation: AAH05008.1.
    CCDSiCCDS12585.1.
    RefSeqiNP_002474.4. NM_002483.6.
    UniGeneiHs.466814.

    Genome annotation databases

    EnsembliENST00000199764; ENSP00000199764; ENSG00000086548.
    GeneIDi4680.
    KEGGihsa:4680.
    UCSCiuc002orm.2. human.

    Polymorphism databases

    DMDMi296439410.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29541 mRNA. Translation: AAA59915.1 .
    M18728 mRNA. Translation: AAA59907.1 .
    M18216 mRNA. Translation: AAA51739.1 .
    BT009774 mRNA. Translation: AAP88776.1 .
    AK312542 mRNA. Translation: BAG35441.1 .
    AC011513 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57061.1 .
    BC005008 mRNA. Translation: AAH05008.1 .
    CCDSi CCDS12585.1.
    RefSeqi NP_002474.4. NM_002483.6.
    UniGenei Hs.466814.

    3D structure databases

    ProteinModelPortali P40199.
    SMRi P40199. Positions 34-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110760. 7 interactions.
    IntActi P40199. 5 interactions.
    MINTi MINT-5002810.
    STRINGi 9606.ENSP00000199764.

    PTM databases

    PhosphoSitei P40199.

    Polymorphism databases

    DMDMi 296439410.

    Proteomic databases

    MaxQBi P40199.
    PaxDbi P40199.
    PRIDEi P40199.

    Protocols and materials databases

    DNASUi 4680.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000199764 ; ENSP00000199764 ; ENSG00000086548 .
    GeneIDi 4680.
    KEGGi hsa:4680.
    UCSCi uc002orm.2. human.

    Organism-specific databases

    CTDi 4680.
    GeneCardsi GC19P042260.
    HGNCi HGNC:1818. CEACAM6.
    HPAi CAB008370.
    HPA011041.
    MIMi 163980. gene.
    neXtProti NX_P40199.
    PharmGKBi PA26362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151357.
    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    InParanoidi P40199.
    KOi K06499.
    OMAi PWKEVLL.
    OrthoDBi EOG74BJS7.
    PhylomeDBi P40199.
    TreeFami TF336859.

    Miscellaneous databases

    ChiTaRSi CEACAM6. human.
    GeneWikii CEACAM6.
    GenomeRNAii 4680.
    NextBioi 18040.
    PROi P40199.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40199.
    Bgeei P40199.
    CleanExi HS_CEACAM6.
    Genevestigatori P40199.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."
      Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.
      Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence."
      Tawaragi Y., Oikawa S., Matsuoka Y., Kosaki G., Nakazato H.
      Biochem. Biophys. Res. Commun. 150:89-96(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-239.
      Tissue: Lung carcinoma.
    3. "Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen."
      Neumaier M., Zimmermann W., Shively L., Hinoda Y., Riggs A.D., Shively J.E.
      J. Biol. Chem. 263:3202-3207(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
      Tissue: Tongue.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
      Tissue: Pancreas.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 35-49.
    10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197.
      Tissue: Saliva.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-224.
      Tissue: Liver.
    12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCEAM6_HUMAN
    AccessioniPrimary (citable) accession number: P40199
    Secondary accession number(s): Q13774, Q14920, Q53XP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3