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P40199

- CEAM6_HUMAN

UniProt

P40199 - CEAM6_HUMAN

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Protein

Carcinoembryonic antigen-related cell adhesion molecule 6

Gene

CEACAM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_160131. Fibronectin matrix formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 6
Alternative name(s):
Non-specific crossreacting antigen
Normal cross-reacting antigen
CD_antigen: CD66c
Gene namesi
Name:CEACAM6
Synonyms:NCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1818. CEACAM6.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 320286Carcinoembryonic antigen-related cell adhesion molecule 6PRO_0000014568Add
BLAST
Propeptidei321 – 34424Removed in mature formBy similarityPRO_0000014569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi167 ↔ 215Curated
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)1 Publication
Glycosylationi224 – 2241N-linked (GlcNAc...)1 Publication
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi259 ↔ 299Curated
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Lipidationi320 – 3201GPI-anchor amidated glycineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP40199.
PaxDbiP40199.
PRIDEiP40199.

PTM databases

PhosphoSiteiP40199.

Expressioni

Gene expression databases

BgeeiP40199.
CleanExiHS_CEACAM6.
ExpressionAtlasiP40199. baseline and differential.
GenevestigatoriP40199.

Organism-specific databases

HPAiCAB008370.
HPA011041.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CARTPTQ165683EBI-4314501,EBI-4314526
CEACAM1P136882EBI-4314501,EBI-4314481

Protein-protein interaction databases

BioGridi110760. 7 interactions.
IntActiP40199. 5 interactions.
MINTiMINT-5002810.
STRINGi9606.ENSP00000199764.

Structurei

3D structure databases

ProteinModelPortaliP40199.
SMRiP40199. Positions 34-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 142108Ig-like V-typeAdd
BLAST
Domaini145 – 23288Ig-like C2-type 1Add
BLAST
Domaini237 – 31478Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG151357.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP40199.
KOiK06499.
OMAiPWKEVLL.
OrthoDBiEOG74BJS7.
PhylomeDBiP40199.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLAHNLPQ NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET
110 120 130 140 150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV NGQSLPVSPR LQLSNGNMTL
210 220 230 240 250
TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP TISPSKANYR
260 270 280 290 300
PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
310 320 330 340
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
Length:344
Mass (Da):37,195
Last modified:May 18, 2010 - v3
Checksum:i28469487A74C18A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381F → L in AAA59915. (PubMed:3220478)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391G → V.5 Publications
Corresponds to variant rs11548735 [ dbSNP | Ensembl ].
VAR_034680

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA. Translation: AAA59915.1.
M18728 mRNA. Translation: AAA59907.1.
M18216 mRNA. Translation: AAA51739.1.
BT009774 mRNA. Translation: AAP88776.1.
AK312542 mRNA. Translation: BAG35441.1.
AC011513 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57061.1.
BC005008 mRNA. Translation: AAH05008.1.
CCDSiCCDS12585.1.
RefSeqiNP_002474.4. NM_002483.6.
UniGeneiHs.466814.

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548.
GeneIDi4680.
KEGGihsa:4680.
UCSCiuc002orm.2. human.

Polymorphism databases

DMDMi296439410.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA. Translation: AAA59915.1 .
M18728 mRNA. Translation: AAA59907.1 .
M18216 mRNA. Translation: AAA51739.1 .
BT009774 mRNA. Translation: AAP88776.1 .
AK312542 mRNA. Translation: BAG35441.1 .
AC011513 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57061.1 .
BC005008 mRNA. Translation: AAH05008.1 .
CCDSi CCDS12585.1.
RefSeqi NP_002474.4. NM_002483.6.
UniGenei Hs.466814.

3D structure databases

ProteinModelPortali P40199.
SMRi P40199. Positions 34-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110760. 7 interactions.
IntActi P40199. 5 interactions.
MINTi MINT-5002810.
STRINGi 9606.ENSP00000199764.

PTM databases

PhosphoSitei P40199.

Polymorphism databases

DMDMi 296439410.

Proteomic databases

MaxQBi P40199.
PaxDbi P40199.
PRIDEi P40199.

Protocols and materials databases

DNASUi 4680.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000199764 ; ENSP00000199764 ; ENSG00000086548 .
GeneIDi 4680.
KEGGi hsa:4680.
UCSCi uc002orm.2. human.

Organism-specific databases

CTDi 4680.
GeneCardsi GC19P042260.
HGNCi HGNC:1818. CEACAM6.
HPAi CAB008370.
HPA011041.
MIMi 163980. gene.
neXtProti NX_P40199.
PharmGKBi PA26362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151357.
GeneTreei ENSGT00760000119187.
HOGENOMi HOG000233417.
HOVERGENi HBG007922.
InParanoidi P40199.
KOi K06499.
OMAi PWKEVLL.
OrthoDBi EOG74BJS7.
PhylomeDBi P40199.
TreeFami TF336859.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_160131. Fibronectin matrix formation.

Miscellaneous databases

ChiTaRSi CEACAM6. human.
GeneWikii CEACAM6.
GenomeRNAii 4680.
NextBioi 18040.
PROi P40199.
SOURCEi Search...

Gene expression databases

Bgeei P40199.
CleanExi HS_CEACAM6.
ExpressionAtlasi P40199. baseline and differential.
Genevestigatori P40199.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."
    Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.
    Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence."
    Tawaragi Y., Oikawa S., Matsuoka Y., Kosaki G., Nakazato H.
    Biochem. Biophys. Res. Commun. 150:89-96(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-239.
    Tissue: Lung carcinoma.
  3. "Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen."
    Neumaier M., Zimmermann W., Shively L., Hinoda Y., Riggs A.D., Shively J.E.
    J. Biol. Chem. 263:3202-3207(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
    Tissue: Tongue.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-239.
    Tissue: Pancreas.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-49.
  10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197.
    Tissue: Saliva.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-224.
    Tissue: Liver.
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCEAM6_HUMAN
AccessioniPrimary (citable) accession number: P40199
Secondary accession number(s): Q13774, Q14920, Q53XP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3