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Protein

Carcinoembryonic antigen-related cell adhesion molecule 6

Gene

CEACAM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • leukocyte migration Source: Reactome
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086548-MONOMER.
ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 6
Alternative name(s):
Non-specific crossreacting antigen
Normal cross-reacting antigen
CD_antigen: CD66c
Gene namesi
Name:CEACAM6
Synonyms:NCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1818. CEACAM6.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4680.
PharmGKBiPA26362.

Polymorphism and mutation databases

BioMutaiCEACAM6.
DMDMi296439410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000001456835 – 320Carcinoembryonic antigen-related cell adhesion molecule 6Add BLAST286
PropeptideiPRO_0000014569321 – 344Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi167 ↔ 215Curated
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)1 Publication1
Glycosylationi224N-linked (GlcNAc...)1 Publication1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi259 ↔ 299Curated
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Lipidationi320GPI-anchor amidated glycineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP40199.
PaxDbiP40199.
PeptideAtlasiP40199.
PRIDEiP40199.

PTM databases

iPTMnetiP40199.
PhosphoSitePlusiP40199.

Expressioni

Gene expression databases

BgeeiENSG00000086548.
CleanExiHS_CEACAM6.
ExpressionAtlasiP40199. baseline and differential.
GenevisibleiP40199. HS.

Organism-specific databases

HPAiCAB008370.
HPA011041.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CARTPTQ165683EBI-4314501,EBI-4314526
CEACAM1P136882EBI-4314501,EBI-4314481

Protein-protein interaction databases

BioGridi110760. 7 interactors.
IntActiP40199. 5 interactors.
MINTiMINT-5002810.
STRINGi9606.ENSP00000199764.

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 45Combined sources9
Beta strandi51 – 57Combined sources7
Beta strandi62 – 72Combined sources11
Helixi75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Turni84 – 87Combined sources4
Beta strandi88 – 91Combined sources4
Beta strandi99 – 101Combined sources3
Beta strandi107 – 109Combined sources3
Helixi114 – 116Combined sources3
Beta strandi118 – 126Combined sources9
Beta strandi132 – 140Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHCX-ray2.71A/B34-141[»]
4WTZX-ray2.52A/B/C/D/E/F34-141[»]
4Y8AX-ray1.83A/B34-141[»]
4YIQX-ray1.85B/D34-141[»]
ProteinModelPortaliP40199.
SMRiP40199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 142Ig-like V-typeAdd BLAST108
Domaini145 – 232Ig-like C2-type 1Add BLAST88
Domaini237 – 314Ig-like C2-type 2Add BLAST78

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP40199.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiP40199.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLAHNLPQ NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET
110 120 130 140 150
IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV NGQSLPVSPR LQLSNGNMTL
210 220 230 240 250
TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDGP TISPSKANYR
260 270 280 290 300
PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
310 320 330 340
AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI
Length:344
Mass (Da):37,195
Last modified:May 18, 2010 - v3
Checksum:i28469487A74C18A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138F → L in AAA59915 (PubMed:3220478).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034680239G → V.Combined sources4 PublicationsCorresponds to variant rs11548735dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA. Translation: AAA59915.1.
M18728 mRNA. Translation: AAA59907.1.
M18216 mRNA. Translation: AAA51739.1.
BT009774 mRNA. Translation: AAP88776.1.
AK312542 mRNA. Translation: BAG35441.1.
AC011513 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57061.1.
BC005008 mRNA. Translation: AAH05008.1.
CCDSiCCDS12585.1.
RefSeqiNP_002474.4. NM_002483.6.
UniGeneiHs.466814.

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548.
GeneIDi4680.
KEGGihsa:4680.
UCSCiuc032hyc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29541 mRNA. Translation: AAA59915.1.
M18728 mRNA. Translation: AAA59907.1.
M18216 mRNA. Translation: AAA51739.1.
BT009774 mRNA. Translation: AAP88776.1.
AK312542 mRNA. Translation: BAG35441.1.
AC011513 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57061.1.
BC005008 mRNA. Translation: AAH05008.1.
CCDSiCCDS12585.1.
RefSeqiNP_002474.4. NM_002483.6.
UniGeneiHs.466814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHCX-ray2.71A/B34-141[»]
4WTZX-ray2.52A/B/C/D/E/F34-141[»]
4Y8AX-ray1.83A/B34-141[»]
4YIQX-ray1.85B/D34-141[»]
ProteinModelPortaliP40199.
SMRiP40199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110760. 7 interactors.
IntActiP40199. 5 interactors.
MINTiMINT-5002810.
STRINGi9606.ENSP00000199764.

PTM databases

iPTMnetiP40199.
PhosphoSitePlusiP40199.

Polymorphism and mutation databases

BioMutaiCEACAM6.
DMDMi296439410.

Proteomic databases

MaxQBiP40199.
PaxDbiP40199.
PeptideAtlasiP40199.
PRIDEiP40199.

Protocols and materials databases

DNASUi4680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199764; ENSP00000199764; ENSG00000086548.
GeneIDi4680.
KEGGihsa:4680.
UCSCiuc032hyc.2. human.

Organism-specific databases

CTDi4680.
DisGeNETi4680.
GeneCardsiCEACAM6.
HGNCiHGNC:1818. CEACAM6.
HPAiCAB008370.
HPA011041.
MIMi163980. gene.
neXtProtiNX_P40199.
PharmGKBiPA26362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP40199.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiP40199.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086548-MONOMER.
ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiCEACAM6. human.
GeneWikiiCEACAM6.
GenomeRNAii4680.
PROiP40199.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086548.
CleanExiHS_CEACAM6.
ExpressionAtlasiP40199. baseline and differential.
GenevisibleiP40199. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM6_HUMAN
AccessioniPrimary (citable) accession number: P40199
Secondary accession number(s): Q13774, Q14920, Q53XP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.