P40197 (GPV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Platelet glycoprotein V
Short name=GPV

Alternative name(s):
Glycoprotein 5
CD_antigen=CD42d

Gene names

Name:

GP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Platelets and megakaryocytes.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Contains 13 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Biological process	Blood coagulation Cell adhesion
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	blood coagulation, intrinsic pathway Traceable author statement. Source: Reactome cell adhesion Non-traceable author statement. Source: ProtInc platelet activation Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 560	544	Platelet glycoprotein V		PRO_0000021361
Regions
	Topological domain	17 – 523	507	Extracellular Potential
	Transmembrane	524 – 544	21	Helical; Potential
	Topological domain	545 – 560	16	Cytoplasmic Potential
	Domain	17 – 50	34	LRRNT
	Repeat	75 – 96	22	LRR 1
	Repeat	99 – 120	22	LRR 2
	Repeat	123 – 144	22	LRR 3
	Repeat	147 – 168	22	LRR 4
	Repeat	171 – 193	23	LRR 5
	Repeat	195 – 216	22	LRR 6
	Repeat	219 – 240	22	LRR 7
	Repeat	243 – 264	22	LRR 8
	Repeat	267 – 288	22	LRR 9
	Repeat	291 – 312	22	LRR 10
	Repeat	340 – 361	22	LRR 11
	Repeat	364 – 385	22	LRR 12
	Repeat	388 – 409	22	LRR 13
	Domain	421 – 474	54	LRRCT
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...)
	Glycosylation	181	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...)
	Glycosylation	312	1	N-linked (GlcNAc...)
	Glycosylation	385	1	N-linked (GlcNAc...)
	Glycosylation	499	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	130	1	D → W AA sequence Ref.3
	Sequence conflict	136 – 138	3	GID → PGG AA sequence Ref.3
	Sequence conflict	267	1	N → H AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P40197 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B1CDB04AF8AF7115	FASTA	560	60,959
	10 20 30 40 50 60 MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM 70 80 90 100 110 120 GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK 130 140 150 160 170 180 MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN 190 200 210 220 230 240 NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR 250 260 270 280 290 300 LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT 310 320 330 340 350 360 QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR 370 380 390 400 410 420 GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH 430 440 450 460 470 480 NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP 490 500 510 520 530 540 RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV 550 560 FAMIKIGQLF RKLIRERALG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins." Hickey M.J., Hagen F.S., Yagi M., Roth G.J. Proc. Natl. Acad. Sci. U.S.A. 90:8327-8331(1993) [PubMed: 7690959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation." Lanza F., Morales M., de la Salle C., Cazenave J.-P., Clemetson K.J., Shimomura T., Phillips D.R. J. Biol. Chem. 268:20801-20807(1993) [PubMed: 8407908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Platelet.
[3]	"Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib." Shimomura T., Fujimura K., Maehama S., Takemoto M., Oda K., Fujimoto T., Oyama R., Suzuki M., Icihara-Tanaka K., Titani K., Kuramoto A. Blood 75:2349-2356(1990) [PubMed: 2350580] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Platelet.
[4]	"Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion." Roth G.J., Church T.A., McMullen B.A., Williams S.A. Biochem. Biophys. Res. Commun. 170:153-161(1990) [PubMed: 2372284] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Platelet.
[5]	"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach." Lewandrowski U., Moebius J., Walter U., Sickmann A. Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-181, MASS SPECTROMETRY. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11238 mRNA. Translation: AAA03069.1. Z23091 Genomic DNA. Translation: CAA80637.1.
IPI	IPI00027410.
PIR	A60164. A48030.
RefSeq	NP_004479.1. NM_004488.2.
UniGene	Hs.73734.
3D structure databases
ProteinModelPortal	P40197.
SMR	P40197. Positions 21-477.
ModBase	Search...
Protein-protein interaction databases
STRING	P40197.
Polymorphism databases
DMDM	729616.
Proteomic databases
PeptideAtlas	P40197.
PRIDE	P40197.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323007; ENSP00000319286; ENSG00000178732. ENST00000401815; ENSP00000383931; ENSG00000178732.
GeneID	2814.
KEGG	hsa:2814.
UCSC	uc003ftv.1. human.
Organism-specific databases
CTD	2814.
GeneCards	GC03M194115.
H-InvDB	HIX0030879.
HGNC	HGNC:4443. GP5.
MIM	173511. gene.
neXtProt	NX_P40197.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19159.
GeneTree	ENSGT00600000084136.
HOGENOM	HBG125496.
HOVERGEN	HBG005906.
InParanoid	P40197.
OMA	AMIKIGQ.
OrthoDB	EOG4JHCFD.
PhylomeDB	P40197.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	P40197.
Bgee	P40197.
CleanEx	HS_GP5.
Genevestigator	P40197.
GermOnline	ENSG00000178732. Homo sapiens.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
KO	K06260.
SMART	SM00369. LRR_TYP. 9 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 12 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	11093.
PMAP-CutDB	P40197.
SOURCE	Search...

Entry information

Entry name

GPV_HUMAN

Accession

Primary (citable) accession number: P40197

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.