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Protein

Platelet glycoprotein V

Gene

GP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178732-MONOMER.
ReactomeiR-HSA-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-HSA-430116. GP1b-IX-V activation signalling.
R-HSA-75892. Platelet Adhesion to exposed collagen.
R-HSA-76009. Platelet Aggregation (Plug Formation).

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein V
Short name:
GPV
Alternative name(s):
Glycoprotein 5
CD_antigen: CD42d
Gene namesi
Name:GP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4443. GP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 523ExtracellularSequence analysisAdd BLAST507
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 560CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2814.
OpenTargetsiENSG00000178732.
PharmGKBiPA28823.

Polymorphism and mutation databases

BioMutaiGP5.
DMDMi729616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002136117 – 560Platelet glycoprotein VAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)1
Glycosylationi181N-linked (GlcNAc...) (complex)2 Publications1
Glycosylationi243N-linked (GlcNAc...) (complex)1 Publication1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)1
Glycosylationi312N-linked (GlcNAc...)1
Glycosylationi385N-linked (GlcNAc...)1
Glycosylationi499N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP40197.
PeptideAtlasiP40197.
PRIDEiP40197.

PTM databases

iPTMnetiP40197.
PhosphoSitePlusiP40197.

Miscellaneous databases

PMAP-CutDBP40197.

Expressioni

Tissue specificityi

Platelets and megakaryocytes.

Gene expression databases

BgeeiENSG00000178732.
CleanExiHS_GP5.
GenevisibleiP40197. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GP9P147702EBI-10891395,EBI-1754109

Protein-protein interaction databases

BioGridi109076. 1 interactor.
IntActiP40197. 1 interactor.
MINTiMINT-1530430.
STRINGi9606.ENSP00000319286.

Structurei

3D structure databases

ProteinModelPortaliP40197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 50LRRNTAdd BLAST34
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati123 – 144LRR 3Add BLAST22
Repeati147 – 168LRR 4Add BLAST22
Repeati171 – 193LRR 5Add BLAST23
Repeati195 – 216LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Repeati291 – 312LRR 10Add BLAST22
Repeati340 – 361LRR 11Add BLAST22
Repeati364 – 385LRR 12Add BLAST22
Repeati388 – 409LRR 13Add BLAST22
Domaini421 – 474LRRCTAdd BLAST54

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiP40197.
KOiK06260.
OMAiAECPGPR.
OrthoDBiEOG091G057B.
PhylomeDBiP40197.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT
60 70 80 90 100
NLTHILLFGM GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL
110 120 130 140 150
KTLRLSRNKI THLPGALLDK MVLLEQLFLD HNALRGIDQN MFQKLVNLQE
160 170 180 190 200
LALNQNQLDF LPASLFTNLE NLKLLDLSGN NLTHLPKGLL GAQAKLERLL
210 220 230 240 250
LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR LPNLSSLTLS
260 270 280 290 300
RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT
310 320 330 340 350
QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG
360 370 380 390 400
LTALPDGLLR GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE
410 420 430 440 450
TLPGDVFGAL PRLTEVLLGH NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR
460 470 480 490 500
CAGPGAHAGL PLWALPGGDA ECPGPRGPPP RPAADSSSEA PVHPALAPNS
510 520 530 540 550
SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV FAMIKIGQLF
560
RKLIRERALG
Length:560
Mass (Da):60,959
Last modified:February 1, 1995 - v1
Checksum:iB1CDB04AF8AF7115
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130D → W AA sequence (PubMed:2350580).Curated1
Sequence conflicti136 – 138GID → PGG AA sequence (PubMed:2350580).Curated3
Sequence conflicti267N → H AA sequence (PubMed:2350580).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11238 mRNA. Translation: AAA03069.1.
Z23091 Genomic DNA. Translation: CAA80637.1.
GU138099 Genomic DNA. Translation: ACZ44929.1.
CH471052 Genomic DNA. Translation: EAW78053.1.
CCDSiCCDS3307.1.
PIRiA48030. A60164.
RefSeqiNP_004479.1. NM_004488.2.
UniGeneiHs.73734.

Genome annotation databases

EnsembliENST00000401815; ENSP00000383931; ENSG00000178732.
GeneIDi2814.
KEGGihsa:2814.
UCSCiuc062rou.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11238 mRNA. Translation: AAA03069.1.
Z23091 Genomic DNA. Translation: CAA80637.1.
GU138099 Genomic DNA. Translation: ACZ44929.1.
CH471052 Genomic DNA. Translation: EAW78053.1.
CCDSiCCDS3307.1.
PIRiA48030. A60164.
RefSeqiNP_004479.1. NM_004488.2.
UniGeneiHs.73734.

3D structure databases

ProteinModelPortaliP40197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109076. 1 interactor.
IntActiP40197. 1 interactor.
MINTiMINT-1530430.
STRINGi9606.ENSP00000319286.

PTM databases

iPTMnetiP40197.
PhosphoSitePlusiP40197.

Polymorphism and mutation databases

BioMutaiGP5.
DMDMi729616.

Proteomic databases

PaxDbiP40197.
PeptideAtlasiP40197.
PRIDEiP40197.

Protocols and materials databases

DNASUi2814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401815; ENSP00000383931; ENSG00000178732.
GeneIDi2814.
KEGGihsa:2814.
UCSCiuc062rou.1. human.

Organism-specific databases

CTDi2814.
DisGeNETi2814.
GeneCardsiGP5.
HGNCiHGNC:4443. GP5.
MIMi173511. gene.
neXtProtiNX_P40197.
OpenTargetsiENSG00000178732.
PharmGKBiPA28823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiP40197.
KOiK06260.
OMAiAECPGPR.
OrthoDBiEOG091G057B.
PhylomeDBiP40197.
TreeFamiTF351124.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178732-MONOMER.
ReactomeiR-HSA-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-HSA-430116. GP1b-IX-V activation signalling.
R-HSA-75892. Platelet Adhesion to exposed collagen.
R-HSA-76009. Platelet Aggregation (Plug Formation).

Miscellaneous databases

GeneWikiiGP5.
GenomeRNAii2814.
PMAP-CutDBP40197.
PROiP40197.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178732.
CleanExiHS_GP5.
GenevisibleiP40197. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPV_HUMAN
AccessioniPrimary (citable) accession number: P40197
Secondary accession number(s): D1MER9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.