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P40197

- GPV_HUMAN

UniProt

P40197 - GPV_HUMAN

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Protein

Platelet glycoprotein V

Gene

GP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. blood coagulation, intrinsic pathway Source: Reactome
  3. cell adhesion Source: ProtInc
  4. cell-matrix adhesion Source: Ensembl
  5. negative regulation of platelet activation Source: Ensembl
  6. platelet activation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
REACT_23847. GP1b-IX-V activation signalling.
REACT_278. Platelet Aggregation (Plug Formation).
REACT_326. Intrinsic Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein V
Short name:
GPV
Alternative name(s):
Glycoprotein 5
CD_antigen: CD42d
Gene namesi
Name:GP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:4443. GP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 523507ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 56016CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 560544Platelet glycoprotein VPRO_0000021361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)
Glycosylationi181 – 1811N-linked (GlcNAc...) (complex)2 Publications
Glycosylationi243 – 2431N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)
Glycosylationi312 – 3121N-linked (GlcNAc...)
Glycosylationi385 – 3851N-linked (GlcNAc...)
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP40197.
PeptideAtlasiP40197.
PRIDEiP40197.

PTM databases

PhosphoSiteiP40197.

Miscellaneous databases

PMAP-CutDBP40197.

Expressioni

Tissue specificityi

Platelets and megakaryocytes.

Gene expression databases

BgeeiP40197.
CleanExiHS_GP5.
GenevestigatoriP40197.

Interactioni

Protein-protein interaction databases

BioGridi109076. 1 interaction.
MINTiMINT-1530430.
STRINGi9606.ENSP00000319286.

Structurei

3D structure databases

ProteinModelPortaliP40197.
SMRiP40197. Positions 20-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5034LRRNTAdd
BLAST
Repeati75 – 9622LRR 1Add
BLAST
Repeati99 – 12022LRR 2Add
BLAST
Repeati123 – 14422LRR 3Add
BLAST
Repeati147 – 16822LRR 4Add
BLAST
Repeati171 – 19323LRR 5Add
BLAST
Repeati195 – 21622LRR 6Add
BLAST
Repeati219 – 24022LRR 7Add
BLAST
Repeati243 – 26422LRR 8Add
BLAST
Repeati267 – 28822LRR 9Add
BLAST
Repeati291 – 31222LRR 10Add
BLAST
Repeati340 – 36122LRR 11Add
BLAST
Repeati364 – 38522LRR 12Add
BLAST
Repeati388 – 40922LRR 13Add
BLAST
Domaini421 – 47454LRRCTAdd
BLAST

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiP40197.
KOiK06260.
OMAiCPPACKC.
OrthoDBiEOG712TVW.
PhylomeDBiP40197.
TreeFamiTF351124.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40197-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT
60 70 80 90 100
NLTHILLFGM GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL
110 120 130 140 150
KTLRLSRNKI THLPGALLDK MVLLEQLFLD HNALRGIDQN MFQKLVNLQE
160 170 180 190 200
LALNQNQLDF LPASLFTNLE NLKLLDLSGN NLTHLPKGLL GAQAKLERLL
210 220 230 240 250
LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR LPNLSSLTLS
260 270 280 290 300
RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT
310 320 330 340 350
QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG
360 370 380 390 400
LTALPDGLLR GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE
410 420 430 440 450
TLPGDVFGAL PRLTEVLLGH NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR
460 470 480 490 500
CAGPGAHAGL PLWALPGGDA ECPGPRGPPP RPAADSSSEA PVHPALAPNS
510 520 530 540 550
SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV FAMIKIGQLF
560
RKLIRERALG
Length:560
Mass (Da):60,959
Last modified:February 1, 1995 - v1
Checksum:iB1CDB04AF8AF7115
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301D → W AA sequence (PubMed:2350580)Curated
Sequence conflicti136 – 1383GID → PGG AA sequence (PubMed:2350580)Curated
Sequence conflicti267 – 2671N → H AA sequence (PubMed:2350580)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11238 mRNA. Translation: AAA03069.1.
Z23091 Genomic DNA. Translation: CAA80637.1.
GU138099 Genomic DNA. Translation: ACZ44929.1.
CH471052 Genomic DNA. Translation: EAW78053.1.
CCDSiCCDS3307.1.
PIRiA48030. A60164.
RefSeqiNP_004479.1. NM_004488.2.
UniGeneiHs.73734.

Genome annotation databases

EnsembliENST00000401815; ENSP00000383931; ENSG00000178732.
GeneIDi2814.
KEGGihsa:2814.
UCSCiuc003ftv.1. human.

Polymorphism databases

DMDMi729616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11238 mRNA. Translation: AAA03069.1 .
Z23091 Genomic DNA. Translation: CAA80637.1 .
GU138099 Genomic DNA. Translation: ACZ44929.1 .
CH471052 Genomic DNA. Translation: EAW78053.1 .
CCDSi CCDS3307.1.
PIRi A48030. A60164.
RefSeqi NP_004479.1. NM_004488.2.
UniGenei Hs.73734.

3D structure databases

ProteinModelPortali P40197.
SMRi P40197. Positions 20-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109076. 1 interaction.
MINTi MINT-1530430.
STRINGi 9606.ENSP00000319286.

PTM databases

PhosphoSitei P40197.

Polymorphism databases

DMDMi 729616.

Proteomic databases

PaxDbi P40197.
PeptideAtlasi P40197.
PRIDEi P40197.

Protocols and materials databases

DNASUi 2814.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000401815 ; ENSP00000383931 ; ENSG00000178732 .
GeneIDi 2814.
KEGGi hsa:2814.
UCSCi uc003ftv.1. human.

Organism-specific databases

CTDi 2814.
GeneCardsi GC03M194115.
HGNCi HGNC:4443. GP5.
MIMi 173511. gene.
neXtProti NX_P40197.
PharmGKBi PA28823.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000112798.
HOVERGENi HBG005906.
InParanoidi P40197.
KOi K06260.
OMAi CPPACKC.
OrthoDBi EOG712TVW.
PhylomeDBi P40197.
TreeFami TF351124.

Enzyme and pathway databases

Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
REACT_23847. GP1b-IX-V activation signalling.
REACT_278. Platelet Aggregation (Plug Formation).
REACT_326. Intrinsic Pathway.

Miscellaneous databases

GeneWikii GP5.
GenomeRNAii 2814.
NextBioi 11093.
PMAP-CutDB P40197.
PROi P40197.
SOURCEi Search...

Gene expression databases

Bgeei P40197.
CleanExi HS_GP5.
Genevestigatori P40197.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins."
    Hickey M.J., Hagen F.S., Yagi M., Roth G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:8327-8331(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation."
    Lanza F., Morales M., de la Salle C., Cazenave J.-P., Clemetson K.J., Shimomura T., Phillips D.R.
    J. Biol. Chem. 268:20801-20807(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Platelet.
  3. "Single novel mutation in transmembrane region of glycoprotein IX affects platelet surface expressions of glycoprotein GP-Ib-IX complex and causes Bernard Soulier syndrome."
    Xu L., Liu L., Zhang D., Sun G., Wang P., Sun N., Hu Q., Li X., Cao F., Peng B., Yu S.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib."
    Shimomura T., Fujimura K., Maehama S., Takemoto M., Oda K., Fujimoto T., Oyama R., Suzuki M., Icihara-Tanaka K., Titani K., Kuramoto A.
    Blood 75:2349-2356(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Platelet.
  6. "Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion."
    Roth G.J., Church T.A., McMullen B.A., Williams S.A.
    Biochem. Biophys. Res. Commun. 170:153-161(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Platelet.
  7. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-181.
    Tissue: Platelet.
  8. Cited for: GLYCOSYLATION AT ASN-181 AND ASN-243.

Entry informationi

Entry nameiGPV_HUMAN
AccessioniPrimary (citable) accession number: P40197
Secondary accession number(s): D1MER9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3