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P40189

- IL6RB_HUMAN

UniProt

P40189 - IL6RB_HUMAN

Protein

Interleukin-6 receptor subunit beta

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 172 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development By similarity. The type I OSM receptor is capable of transducing OSM-specific signaling events.By similarity

    GO - Molecular functioni

    1. ciliary neurotrophic factor receptor activity Source: BHF-UCL
    2. ciliary neurotrophic factor receptor binding Source: BHF-UCL
    3. growth factor binding Source: BHF-UCL
    4. interleukin-11 receptor activity Source: Ensembl
    5. interleukin-27 receptor activity Source: BHF-UCL
    6. protein binding Source: IntAct
    7. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
    2. cytokine-mediated signaling pathway Source: BHF-UCL
    3. glycogen metabolic process Source: Ensembl
    4. interleukin-27-mediated signaling pathway Source: BHF-UCL
    5. interleukin-6-mediated signaling pathway Source: BHF-UCL
    6. leukemia inhibitory factor signaling pathway Source: BHF-UCL
    7. negative regulation of apoptotic process Source: BHF-UCL
    8. negative regulation of interleukin-6-mediated signaling pathway Source: BHF-UCL
    9. oncostatin-M-mediated signaling pathway Source: BHF-UCL
    10. positive regulation of acute inflammatory response Source: BHF-UCL
    11. positive regulation of adaptive immune response Source: BHF-UCL
    12. positive regulation of astrocyte differentiation Source: Ensembl
    13. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
    14. positive regulation of cell proliferation Source: BHF-UCL
    15. positive regulation of osteoblast differentiation Source: BHF-UCL
    16. positive regulation of T cell proliferation Source: BHF-UCL
    17. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
    18. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
    19. positive regulation vascular endothelial growth factor production Source: BHF-UCL
    20. regulation of Notch signaling pathway Source: Ensembl
    21. response to cytokine Source: BHF-UCL
    22. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_27307. Interleukin-6 signaling.
    SignaLinkiP40189.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-6 receptor subunit beta
    Short name:
    IL-6 receptor subunit beta
    Short name:
    IL-6R subunit beta
    Short name:
    IL-6R-beta
    Short name:
    IL-6RB
    Alternative name(s):
    CDw130
    Interleukin-6 signal transducer
    Membrane glycoprotein 130
    Short name:
    gp130
    Oncostatin-M receptor subunit alpha
    CD_antigen: CD130
    Gene namesi
    Name:IL6ST
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6021. IL6ST.

    Subcellular locationi

    GO - Cellular componenti

    1. ciliary neurotrophic factor receptor complex Source: BHF-UCL
    2. dendrite Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. extracellular region Source: Reactome
    5. extracellular space Source: BHF-UCL
    6. extracellular vesicular exosome Source: UniProt
    7. interleukin-6 receptor complex Source: BHF-UCL
    8. membrane Source: UniProtKB
    9. neuronal cell body Source: Ensembl
    10. oncostatin-M receptor complex Source: BHF-UCL
    11. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi782 – 7821S → A: Increases cell surface expression. 1 Publication

    Organism-specific databases

    PharmGKBiPA29837.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Add
    BLAST
    Chaini23 – 918896Interleukin-6 receptor subunit betaPRO_0000010899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 541 Publication
    Glycosylationi43 – 431N-linked (GlcNAc...)2 Publications
    Disulfide bondi48 ↔ 1031 Publication
    Glycosylationi83 – 831N-linked (GlcNAc...)2 Publications
    Glycosylationi131 – 1311N-linked (GlcNAc...)2 Publications
    Disulfide bondi134 ↔ 1441 Publication
    Glycosylationi157 – 1571N-linked (GlcNAc...)2 Publications
    Disulfide bondi172 ↔ 1821 Publication
    Glycosylationi227 – 2271N-linked (GlcNAc...)3 Publications
    Glycosylationi379 – 3791N-linked (GlcNAc...)3 Publications
    Glycosylationi383 – 3831N-linked (GlcNAc...)3 Publications
    Glycosylationi390 – 3901N-linked (GlcNAc...) (complex)3 Publications
    Disulfide bondi458 ↔ 4661 Publication
    Glycosylationi553 – 5531N-linked (GlcNAc...)2 Publications
    Glycosylationi564 – 5641N-linked (GlcNAc...)2 Publications
    Modified residuei667 – 6671Phosphoserine2 Publications
    Modified residuei782 – 7821Phosphoserine1 Publication
    Modified residuei829 – 8291Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation of Ser-782 down-regulates cell surface expression.4 Publications
    Heavily N-glycosylated.5 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP40189.
    PaxDbiP40189.
    PRIDEiP40189.

    PTM databases

    PhosphoSiteiP40189.

    Expressioni

    Tissue specificityi

    Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

    Inductioni

    LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.1 Publication

    Gene expression databases

    ArrayExpressiP40189.
    BgeeiP40189.
    CleanExiHS_IL6ST.
    GenevestigatoriP40189.

    Organism-specific databases

    HPAiCAB025784.
    HPA010558.

    Interactioni

    Subunit structurei

    Interacts with INPP5D/SHIP1 By similarity. Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.By similarity6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    K2Q2HRC72EBI-1030834,EBI-9007403From a different organism.
    Stat3P422276EBI-1030834,EBI-602878From a different organism.

    Protein-protein interaction databases

    BioGridi109786. 23 interactions.
    DIPiDIP-95N.
    IntActiP40189. 9 interactions.
    MINTiMINT-130473.
    STRINGi9606.ENSP00000338799.

    Structurei

    Secondary structure

    1
    918
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 358
    Beta strandi37 – 393
    Beta strandi44 – 507
    Helixi52 – 587
    Helixi62 – 643
    Beta strandi65 – 695
    Helixi76 – 783
    Beta strandi80 – 834
    Beta strandi86 – 916
    Beta strandi97 – 10711
    Turni108 – 1103
    Beta strandi111 – 12313
    Beta strandi130 – 1378
    Beta strandi143 – 1475
    Beta strandi157 – 1648
    Beta strandi176 – 1783
    Beta strandi181 – 1833
    Beta strandi194 – 2029
    Beta strandi205 – 2084
    Beta strandi212 – 2143
    Helixi216 – 2183
    Beta strandi219 – 2213
    Beta strandi226 – 2316
    Beta strandi234 – 2385
    Beta strandi240 – 2456
    Helixi248 – 2514
    Beta strandi255 – 2639
    Helixi274 – 2774
    Beta strandi282 – 2865
    Beta strandi291 – 30313
    Beta strandi317 – 3215
    Helixi325 – 3317
    Beta strandi332 – 3387
    Beta strandi345 – 3517
    Helixi356 – 3594
    Beta strandi363 – 37210
    Beta strandi378 – 39114
    Beta strandi396 – 40611
    Beta strandi412 – 4165
    Beta strandi428 – 4358
    Beta strandi438 – 4447
    Beta strandi452 – 4609
    Beta strandi462 – 4643
    Beta strandi469 – 4746
    Beta strandi478 – 4814
    Beta strandi491 – 50010
    Beta strandi508 – 5158
    Beta strandi525 – 5306
    Beta strandi535 – 5395
    Helixi544 – 5474
    Beta strandi553 – 5608
    Beta strandi566 – 5716
    Beta strandi575 – 5795
    Beta strandi587 – 59610
    Beta strandi599 – 6024
    Beta strandi606 – 6094

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BJ8NMR-A219-325[»]
    1BQUX-ray2.00A/B122-333[»]
    1I1RX-ray2.40A23-325[»]
    1N2Qmodel-A/B23-324[»]
    1P9MX-ray3.65A23-321[»]
    1PVHX-ray2.50A/C123-323[»]
    3L5HX-ray3.60A24-612[»]
    3L5IX-ray1.90A323-612[»]
    3L5JX-ray3.04A/B323-610[»]
    ProteinModelPortaliP40189.
    SMRiP40189. Positions 24-612.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP40189.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 619597ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini642 – 918277CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei620 – 64122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 12095Ig-like C2-typeAdd
    BLAST
    Domaini125 – 21692Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 324101Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini329 – 42496Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini426 – 51792Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 61396Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi310 – 3145WSXWS motif
    Motifi651 – 6599Box 1 motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi725 – 75531Ser-richAdd
    BLAST

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145009.
    HOGENOMiHOG000015771.
    HOVERGENiHBG052119.
    InParanoidiP40189.
    KOiK05060.
    OMAiFKQNCSQ.
    OrthoDBiEOG7FXZXN.
    PhylomeDBiP40189.
    TreeFamiTF338122.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 5 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 5 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P40189-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL    50
    KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ 100
    LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR 150
    ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA 200
    ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK 250
    SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR 300
    CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV 350
    WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL 400
    TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV 450
    KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY 500
    ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF 550
    IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG 600
    KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH 650
    IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND 700
    KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS 750
    QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD 800
    HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ 850
    QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG 900
    MPKSYLPQTV RQGGYMPQ 918
    Length:918
    Mass (Da):103,537
    Last modified:November 25, 2008 - v2
    Checksum:i6510A4409FFCF08C
    GO
    Isoform 2 (identifier: P40189-2) [UniParc]FASTAAdd to Basket

    Also known as: GP130-RAPS

    The sequence of this isoform differs from the canonical sequence as follows:
         325-329: RPSKA → NIASF
         330-918: Missing.

    Show »
    Length:329
    Mass (Da):37,499
    Checksum:iD556124C867984E4
    GO
    Isoform 3 (identifier: P40189-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         423-483: Missing.

    Show »
    Length:857
    Mass (Da):96,276
    Checksum:i726208A5073B5451
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81L → V.2 Publications
    Corresponds to variant rs1063560 [ dbSNP | Ensembl ].
    VAR_047782
    Natural varianti148 – 1481G → R.
    Corresponds to variant rs2228044 [ dbSNP | Ensembl ].
    VAR_047783
    Natural varianti397 – 3971L → V.
    Corresponds to variant rs2228043 [ dbSNP | Ensembl ].
    VAR_047784
    Natural varianti415 – 4151T → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036165
    Natural varianti454 – 4541I → T.
    Corresponds to variant rs2228046 [ dbSNP | Ensembl ].
    VAR_047785
    Natural varianti499 – 4991V → I.
    Corresponds to variant rs34417936 [ dbSNP | Ensembl ].
    VAR_047786

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei325 – 3295RPSKA → NIASF in isoform 2. 1 PublicationVSP_001684
    Alternative sequencei330 – 918589Missing in isoform 2. 1 PublicationVSP_001685Add
    BLAST
    Alternative sequencei423 – 48361Missing in isoform 3. 1 PublicationVSP_043716Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57230 mRNA. Translation: AAA59155.1.
    AB015706 mRNA. Translation: BAA78112.1.
    AB102802 mRNA. Translation: BAD89393.1.
    EF064722 Genomic DNA. Translation: ABK41905.1.
    AC008914 Genomic DNA. No translation available.
    AC016596 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54936.1.
    CCDSiCCDS3971.1. [P40189-1]
    CCDS47209.1. [P40189-2]
    CCDS54856.1. [P40189-3]
    PIRiA36337.
    RefSeqiNP_001177910.1. NM_001190981.1. [P40189-3]
    NP_002175.2. NM_002184.3. [P40189-1]
    NP_786943.1. NM_175767.2. [P40189-2]
    UniGeneiHs.532082.
    Hs.706627.

    Genome annotation databases

    EnsembliENST00000336909; ENSP00000338799; ENSG00000134352. [P40189-1]
    ENST00000381287; ENSP00000370687; ENSG00000134352. [P40189-2]
    ENST00000381294; ENSP00000370694; ENSG00000134352. [P40189-3]
    ENST00000381298; ENSP00000370698; ENSG00000134352. [P40189-1]
    ENST00000502326; ENSP00000462158; ENSG00000134352. [P40189-1]
    ENST00000522633; ENSP00000435399; ENSG00000134352. [P40189-2]
    GeneIDi3572.
    KEGGihsa:3572.
    UCSCiuc003jqq.3. human. [P40189-1]
    uc003jqr.3. human. [P40189-2]
    uc010iwb.3. human. [P40189-3]

    Polymorphism databases

    DMDMi215273999.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57230 mRNA. Translation: AAA59155.1 .
    AB015706 mRNA. Translation: BAA78112.1 .
    AB102802 mRNA. Translation: BAD89393.1 .
    EF064722 Genomic DNA. Translation: ABK41905.1 .
    AC008914 Genomic DNA. No translation available.
    AC016596 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54936.1 .
    CCDSi CCDS3971.1. [P40189-1 ]
    CCDS47209.1. [P40189-2 ]
    CCDS54856.1. [P40189-3 ]
    PIRi A36337.
    RefSeqi NP_001177910.1. NM_001190981.1. [P40189-3 ]
    NP_002175.2. NM_002184.3. [P40189-1 ]
    NP_786943.1. NM_175767.2. [P40189-2 ]
    UniGenei Hs.532082.
    Hs.706627.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BJ8 NMR - A 219-325 [» ]
    1BQU X-ray 2.00 A/B 122-333 [» ]
    1I1R X-ray 2.40 A 23-325 [» ]
    1N2Q model - A/B 23-324 [» ]
    1P9M X-ray 3.65 A 23-321 [» ]
    1PVH X-ray 2.50 A/C 123-323 [» ]
    3L5H X-ray 3.60 A 24-612 [» ]
    3L5I X-ray 1.90 A 323-612 [» ]
    3L5J X-ray 3.04 A/B 323-610 [» ]
    ProteinModelPortali P40189.
    SMRi P40189. Positions 24-612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109786. 23 interactions.
    DIPi DIP-95N.
    IntActi P40189. 9 interactions.
    MINTi MINT-130473.
    STRINGi 9606.ENSP00000338799.

    PTM databases

    PhosphoSitei P40189.

    Polymorphism databases

    DMDMi 215273999.

    Proteomic databases

    MaxQBi P40189.
    PaxDbi P40189.
    PRIDEi P40189.

    Protocols and materials databases

    DNASUi 3572.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336909 ; ENSP00000338799 ; ENSG00000134352 . [P40189-1 ]
    ENST00000381287 ; ENSP00000370687 ; ENSG00000134352 . [P40189-2 ]
    ENST00000381294 ; ENSP00000370694 ; ENSG00000134352 . [P40189-3 ]
    ENST00000381298 ; ENSP00000370698 ; ENSG00000134352 . [P40189-1 ]
    ENST00000502326 ; ENSP00000462158 ; ENSG00000134352 . [P40189-1 ]
    ENST00000522633 ; ENSP00000435399 ; ENSG00000134352 . [P40189-2 ]
    GeneIDi 3572.
    KEGGi hsa:3572.
    UCSCi uc003jqq.3. human. [P40189-1 ]
    uc003jqr.3. human. [P40189-2 ]
    uc010iwb.3. human. [P40189-3 ]

    Organism-specific databases

    CTDi 3572.
    GeneCardsi GC05M055230.
    HGNCi HGNC:6021. IL6ST.
    HPAi CAB025784.
    HPA010558.
    MIMi 600694. gene.
    neXtProti NX_P40189.
    PharmGKBi PA29837.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145009.
    HOGENOMi HOG000015771.
    HOVERGENi HBG052119.
    InParanoidi P40189.
    KOi K05060.
    OMAi FKQNCSQ.
    OrthoDBi EOG7FXZXN.
    PhylomeDBi P40189.
    TreeFami TF338122.

    Enzyme and pathway databases

    Reactomei REACT_27307. Interleukin-6 signaling.
    SignaLinki P40189.

    Miscellaneous databases

    ChiTaRSi IL6ST. human.
    EvolutionaryTracei P40189.
    GeneWikii Glycoprotein_130.
    GenomeRNAii 3572.
    NextBioi 13960.
    PROi P40189.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P40189.
    Bgeei P40189.
    CleanExi HS_IL6ST.
    Genevestigatori P40189.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 5 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of an IL-6 signal transducer, gp130."
      Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T.
      Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-8.
      Tissue: Myeloma and Placenta.
    2. "Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis."
      Tanaka M., Kishimura M., Ozaki S., Osakada F., Hashimoto H., Okubo M., Murakami M., Nakao K.
      J. Clin. Invest. 106:137-144(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-8.
      Tissue: Synovium.
    3. "IL6ST mRNA, nirs splice variant 4."
      Hayashi A., Sameshima E., Tabata Y., Iida K., Mitsuyama M., Kanai S., Furuya T., Saito T.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130."
      Moritz R.L., Hall N.E., Connolly L.M., Simpson R.J.
      J. Biol. Chem. 276:8244-8253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS, GLYCOSYLATION AT ASN-43; ASN-83; ASN-131; ASN-157; ASN-227; ASN-379; ASN-383; ASN-553 AND ASN-564.
    8. "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
      Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
      J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, INDUCTION.
    9. "Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."
      Hallek M., Neumann C., Schaffer M., Danhauser-Riedl S., von Bubnoff N., de Vos G., Druker B.J., Yasukawa K., Griffin J.D., Emmerich B.
      Exp. Hematol. 25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCK.
    10. "Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling."
      Gibson R.M., Schiemann W.P., Prichard L.B., Reno J.M., Ericsson L.H., Nathanson N.M.
      J. Biol. Chem. 275:22574-22582(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-782, MUTAGENESIS OF SER-782, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling."
      Li H., Wang H., Nicholas J.
      J. Virol. 75:3325-3334(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HHV-8 PROTEIN VIL6.
    12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-379 AND ASN-383.
      Tissue: Plasma.
    13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227 AND ASN-390.
      Tissue: Liver.
    17. Cited for: GLYCOSYLATION AT ASN-390.
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "Crystal structure of a cytokine-binding region of gp130."
      Bravo J., Staunton D., Heath J.K., Jones E.Y.
      EMBO J. 17:1665-1674(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 122-325.
    20. "Structure of an extracellular gp130 cytokine receptor signaling complex."
      Chow D.-C., He X.-L., Snow A.L., Rose-John S., Garcia K.C.
      Science 291:2150-2155(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 23-325 IN COMPLEX WITH HERPES VIRUS IL6, SUBUNIT, GLYCOSYLATION.
    21. "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."
      Boulanger M.J., Bankovich A.J., Kortemme T., Baker D., Garcia K.C.
      Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 123-323 IN COMPLEX WITH LIF.
    22. "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
      Boulanger M.J., Chow D.-C., Brevnova E.E., Garcia K.C.
      Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 23-321 IN COMPLEX WITH IL6 AND IL6R, SUBUNIT.
    23. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-415.

    Entry informationi

    Entry nameiIL6RB_HUMAN
    AccessioniPrimary (citable) accession number: P40189
    Secondary accession number(s): A0N0L4, Q5FC04, Q9UQ41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 172 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3