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Protein

Interleukin-6 receptor subunit beta

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).By similarity3 Publications

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: BHF-UCL
  • ciliary neurotrophic factor receptor binding Source: BHF-UCL
  • growth factor binding Source: BHF-UCL
  • interleukin-11 receptor activity Source: Ensembl
  • interleukin-27 receptor activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
  • cytokine-mediated signaling pathway Source: BHF-UCL
  • glycogen metabolic process Source: Ensembl
  • interleukin-27-mediated signaling pathway Source: BHF-UCL
  • interleukin-6-mediated signaling pathway Source: BHF-UCL
  • leukemia inhibitory factor signaling pathway Source: BHF-UCL
  • negative regulation of apoptotic process Source: BHF-UCL
  • negative regulation of interleukin-6-mediated signaling pathway Source: BHF-UCL
  • oncostatin-M-mediated signaling pathway Source: BHF-UCL
  • positive regulation of acute inflammatory response Source: BHF-UCL
  • positive regulation of adaptive immune response Source: BHF-UCL
  • positive regulation of astrocyte differentiation Source: Ensembl
  • positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • regulation of Notch signaling pathway Source: Ensembl
  • response to cytokine Source: BHF-UCL
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-1059683. Interleukin-6 signaling.
R-HSA-110056. MAPK3 (ERK1) activation.
R-HSA-112411. MAPK1 (ERK2) activation.
R-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiP40189.
SIGNORiP40189.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit beta
Short name:
IL-6 receptor subunit beta
Short name:
IL-6R subunit beta
Short name:
IL-6R-beta
Short name:
IL-6RB
Alternative name(s):
CDw130
Interleukin-6 signal transducer
Membrane glycoprotein 130
Short name:
gp130
Oncostatin-M receptor subunit alpha
CD_antigen: CD130
Gene namesi
Name:IL6ST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6021. IL6ST.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 619597ExtracellularSequence analysisAdd
BLAST
Transmembranei620 – 64122HelicalSequence analysisAdd
BLAST
Topological domaini642 – 918277CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • ciliary neurotrophic factor receptor complex Source: BHF-UCL
  • dendrite Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • interleukin-6 receptor complex Source: BHF-UCL
  • membrane Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • oncostatin-M receptor complex Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi172 – 1721C → S: Induces ligand-independent activation. 1 Publication
Mutagenesisi186 – 1905Missing : Induces ligand-independent activation. 1 Publication
Mutagenesisi189 – 1891V → G: Does not induce ligand-independent activation. 1 Publication
Mutagenesisi190 – 1901Y → G: Does not induce ligand-independent activation. 1 Publication
Mutagenesisi215 – 2151D → G: Induces ligand-independent activation. 1 Publication
Mutagenesisi252 – 2521V → G: Induces ligand-independent activation. 1 Publication
Mutagenesisi782 – 7821S → A: Increases cell surface expression. 1 Publication

Organism-specific databases

PharmGKBiPA29837.

Chemistry

ChEMBLiCHEMBL3137266.

Polymorphism and mutation databases

BioMutaiIL6ST.
DMDMi215273999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 918896Interleukin-6 receptor subunit betaPRO_0000010899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 542 Publications
Glycosylationi43 – 431N-linked (GlcNAc...)2 Publications
Disulfide bondi48 ↔ 1032 Publications
Glycosylationi83 – 831N-linked (GlcNAc...)2 Publications
Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
Disulfide bondi134 ↔ 1442 Publications
Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
Disulfide bondi172 ↔ 1822 Publications
Glycosylationi227 – 2271N-linked (GlcNAc...)3 Publications
Glycosylationi379 – 3791N-linked (GlcNAc...)2 Publications
Glycosylationi383 – 3831N-linked (GlcNAc...)3 Publications
Glycosylationi390 – 3901N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi458 ↔ 4662 Publications
Glycosylationi553 – 5531N-linked (GlcNAc...)2 Publications
Glycosylationi564 – 5641N-linked (GlcNAc...)1 Publication
Modified residuei661 – 6611PhosphoserineCombined sources
Modified residuei667 – 6671PhosphoserineCombined sources
Modified residuei782 – 7821Phosphoserine1 Publication
Modified residuei789 – 7891PhosphoserineBy similarity
Modified residuei829 – 8291PhosphoserineCombined sources
Modified residuei839 – 8391PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation of Ser-782 down-regulates cell surface expression.1 Publication
Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP40189.
MaxQBiP40189.
PaxDbiP40189.
PeptideAtlasiP40189.
PRIDEiP40189.

PTM databases

iPTMnetiP40189.
PhosphoSiteiP40189.
SwissPalmiP40189.
UniCarbKBiP40189.

Expressioni

Tissue specificityi

Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).2 Publications

Inductioni

LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.1 Publication

Gene expression databases

BgeeiENSG00000134352.
CleanExiHS_IL6ST.
ExpressionAtlasiP40189. baseline and differential.
GenevisibleiP40189. HS.

Organism-specific databases

HPAiCAB025784.
HPA010558.

Interactioni

Subunit structurei

Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNTFP2644110EBI-1030834,EBI-1050897
K2Q2HRC72EBI-1030834,EBI-9007403From a different organism.
LIFP150182EBI-1030834,EBI-1037189
Stat3P422274EBI-1030834,EBI-602878From a different organism.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: BHF-UCL
  • growth factor binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi109786. 28 interactions.
DIPiDIP-95N.
IntActiP40189. 14 interactions.
MINTiMINT-130473.
STRINGi9606.ENSP00000338799.

Structurei

Secondary structure

1
918
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 358Combined sources
Beta strandi37 – 393Combined sources
Beta strandi44 – 507Combined sources
Helixi52 – 587Combined sources
Helixi62 – 643Combined sources
Beta strandi65 – 695Combined sources
Helixi76 – 783Combined sources
Beta strandi80 – 834Combined sources
Beta strandi86 – 916Combined sources
Beta strandi97 – 10711Combined sources
Turni108 – 1103Combined sources
Beta strandi111 – 12313Combined sources
Beta strandi130 – 1378Combined sources
Beta strandi143 – 1475Combined sources
Beta strandi157 – 1648Combined sources
Beta strandi176 – 1783Combined sources
Beta strandi181 – 1833Combined sources
Beta strandi194 – 2029Combined sources
Beta strandi205 – 2084Combined sources
Beta strandi212 – 2143Combined sources
Helixi216 – 2183Combined sources
Beta strandi219 – 2213Combined sources
Beta strandi226 – 2316Combined sources
Beta strandi234 – 2385Combined sources
Beta strandi240 – 2456Combined sources
Helixi248 – 2514Combined sources
Beta strandi255 – 2639Combined sources
Helixi274 – 2774Combined sources
Beta strandi282 – 2865Combined sources
Beta strandi291 – 30313Combined sources
Beta strandi317 – 3215Combined sources
Helixi325 – 3317Combined sources
Beta strandi332 – 3387Combined sources
Beta strandi345 – 3517Combined sources
Helixi356 – 3594Combined sources
Beta strandi363 – 37210Combined sources
Beta strandi378 – 39114Combined sources
Beta strandi396 – 40611Combined sources
Beta strandi412 – 4165Combined sources
Beta strandi428 – 4358Combined sources
Beta strandi438 – 4447Combined sources
Beta strandi452 – 4609Combined sources
Beta strandi462 – 4643Combined sources
Beta strandi469 – 4746Combined sources
Beta strandi478 – 4814Combined sources
Beta strandi491 – 50010Combined sources
Beta strandi508 – 5158Combined sources
Beta strandi525 – 5306Combined sources
Beta strandi535 – 5395Combined sources
Helixi544 – 5474Combined sources
Beta strandi553 – 5608Combined sources
Beta strandi566 – 5716Combined sources
Beta strandi575 – 5795Combined sources
Beta strandi587 – 59610Combined sources
Beta strandi599 – 6024Combined sources
Beta strandi606 – 6094Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ8NMR-A219-325[»]
1BQUX-ray2.00A/B122-333[»]
1I1RX-ray2.40A23-325[»]
1N2Qmodel-A/B23-324[»]
1P9MX-ray3.65A23-321[»]
1PVHX-ray2.50A/C123-323[»]
3L5HX-ray3.60A24-612[»]
3L5IX-ray1.90A323-612[»]
3L5JX-ray3.04A/B323-610[»]
ProteinModelPortaliP40189.
SMRiP40189. Positions 24-612.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 12095Ig-like C2-typeAdd
BLAST
Domaini125 – 21692Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 324101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 42496Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini426 – 51792Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 61396Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3145WSXWS motif
Motifi651 – 6599Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi725 – 75531Ser-richAdd
BLAST

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1N. Eukaryota.
ENOG410YNQ4. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000015771.
HOVERGENiHBG052119.
InParanoidiP40189.
KOiK05060.
OMAiFKQNCSQ.
OrthoDBiEOG091G01XM.
PhylomeDBiP40189.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40189-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330 340 350
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
360 370 380 390 400
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL
410 420 430 440 450
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
460 470 480 490 500
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
510 520 530 540 550
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
560 570 580 590 600
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
610 620 630 640 650
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
660 670 680 690 700
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
710 720 730 740 750
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
760 770 780 790 800
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
810 820 830 840 850
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
860 870 880 890 900
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
910
MPKSYLPQTV RQGGYMPQ
Length:918
Mass (Da):103,537
Last modified:November 25, 2008 - v2
Checksum:i6510A4409FFCF08C
GO
Isoform 2 (identifier: P40189-2) [UniParc]FASTAAdd to basket
Also known as: GP130-RAPS

The sequence of this isoform differs from the canonical sequence as follows:
     325-329: RPSKA → NIASF
     330-918: Missing.

Show »
Length:329
Mass (Da):37,499
Checksum:iD556124C867984E4
GO
Isoform 3 (identifier: P40189-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-483: Missing.

Show »
Length:857
Mass (Da):96,276
Checksum:i726208A5073B5451
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81L → V.2 Publications
Corresponds to variant rs1063560 [ dbSNP | Ensembl ].
VAR_047782
Natural varianti148 – 1481G → R Polymorphism; associated with increased levels of soluble IL6RB in blood serum. 1 Publication
Corresponds to variant rs2228044 [ dbSNP | Ensembl ].
VAR_047783
Natural varianti200 – 2001A → G Found in patient with lung cancer; unknown pathological significance. 1 Publication
Corresponds to variant rs199905033 [ dbSNP | Ensembl ].
VAR_074654
Natural varianti397 – 3971L → V.
Corresponds to variant rs2228043 [ dbSNP | Ensembl ].
VAR_047784
Natural varianti415 – 4151T → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036165
Natural varianti454 – 4541I → T.
Corresponds to variant rs2228046 [ dbSNP | Ensembl ].
VAR_047785
Natural varianti499 – 4991V → I.
Corresponds to variant rs34417936 [ dbSNP | Ensembl ].
VAR_047786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 3295RPSKA → NIASF in isoform 2. 1 PublicationVSP_001684
Alternative sequencei330 – 918589Missing in isoform 2. 1 PublicationVSP_001685Add
BLAST
Alternative sequencei423 – 48361Missing in isoform 3. 1 PublicationVSP_043716Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57230 mRNA. Translation: AAA59155.1.
AB015706 mRNA. Translation: BAA78112.1.
AB102802 mRNA. Translation: BAD89393.1.
EF064722 Genomic DNA. Translation: ABK41905.1.
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54936.1.
CCDSiCCDS3971.1. [P40189-1]
CCDS47209.1. [P40189-2]
CCDS54856.1. [P40189-3]
PIRiA36337.
RefSeqiNP_001177910.1. NM_001190981.1. [P40189-3]
NP_002175.2. NM_002184.3. [P40189-1]
NP_786943.1. NM_175767.2. [P40189-2]
UniGeneiHs.532082.
Hs.706627.

Genome annotation databases

EnsembliENST00000336909; ENSP00000338799; ENSG00000134352. [P40189-1]
ENST00000381287; ENSP00000370687; ENSG00000134352. [P40189-2]
ENST00000381294; ENSP00000370694; ENSG00000134352. [P40189-3]
ENST00000381298; ENSP00000370698; ENSG00000134352. [P40189-1]
ENST00000502326; ENSP00000462158; ENSG00000134352. [P40189-1]
ENST00000522633; ENSP00000435399; ENSG00000134352. [P40189-2]
GeneIDi3572.
KEGGihsa:3572.
UCSCiuc003jqq.4. human. [P40189-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57230 mRNA. Translation: AAA59155.1.
AB015706 mRNA. Translation: BAA78112.1.
AB102802 mRNA. Translation: BAD89393.1.
EF064722 Genomic DNA. Translation: ABK41905.1.
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54936.1.
CCDSiCCDS3971.1. [P40189-1]
CCDS47209.1. [P40189-2]
CCDS54856.1. [P40189-3]
PIRiA36337.
RefSeqiNP_001177910.1. NM_001190981.1. [P40189-3]
NP_002175.2. NM_002184.3. [P40189-1]
NP_786943.1. NM_175767.2. [P40189-2]
UniGeneiHs.532082.
Hs.706627.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ8NMR-A219-325[»]
1BQUX-ray2.00A/B122-333[»]
1I1RX-ray2.40A23-325[»]
1N2Qmodel-A/B23-324[»]
1P9MX-ray3.65A23-321[»]
1PVHX-ray2.50A/C123-323[»]
3L5HX-ray3.60A24-612[»]
3L5IX-ray1.90A323-612[»]
3L5JX-ray3.04A/B323-610[»]
ProteinModelPortaliP40189.
SMRiP40189. Positions 24-612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109786. 28 interactions.
DIPiDIP-95N.
IntActiP40189. 14 interactions.
MINTiMINT-130473.
STRINGi9606.ENSP00000338799.

Chemistry

ChEMBLiCHEMBL3137266.

PTM databases

iPTMnetiP40189.
PhosphoSiteiP40189.
SwissPalmiP40189.
UniCarbKBiP40189.

Polymorphism and mutation databases

BioMutaiIL6ST.
DMDMi215273999.

Proteomic databases

EPDiP40189.
MaxQBiP40189.
PaxDbiP40189.
PeptideAtlasiP40189.
PRIDEiP40189.

Protocols and materials databases

DNASUi3572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336909; ENSP00000338799; ENSG00000134352. [P40189-1]
ENST00000381287; ENSP00000370687; ENSG00000134352. [P40189-2]
ENST00000381294; ENSP00000370694; ENSG00000134352. [P40189-3]
ENST00000381298; ENSP00000370698; ENSG00000134352. [P40189-1]
ENST00000502326; ENSP00000462158; ENSG00000134352. [P40189-1]
ENST00000522633; ENSP00000435399; ENSG00000134352. [P40189-2]
GeneIDi3572.
KEGGihsa:3572.
UCSCiuc003jqq.4. human. [P40189-1]

Organism-specific databases

CTDi3572.
GeneCardsiIL6ST.
HGNCiHGNC:6021. IL6ST.
HPAiCAB025784.
HPA010558.
MIMi600694. gene.
neXtProtiNX_P40189.
PharmGKBiPA29837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1N. Eukaryota.
ENOG410YNQ4. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000015771.
HOVERGENiHBG052119.
InParanoidiP40189.
KOiK05060.
OMAiFKQNCSQ.
OrthoDBiEOG091G01XM.
PhylomeDBiP40189.
TreeFamiTF338122.

Enzyme and pathway databases

ReactomeiR-HSA-1059683. Interleukin-6 signaling.
R-HSA-110056. MAPK3 (ERK1) activation.
R-HSA-112411. MAPK1 (ERK2) activation.
R-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiP40189.
SIGNORiP40189.

Miscellaneous databases

ChiTaRSiIL6ST. human.
EvolutionaryTraceiP40189.
GeneWikiiGlycoprotein_130.
GenomeRNAii3572.
PROiP40189.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134352.
CleanExiHS_IL6ST.
ExpressionAtlasiP40189. baseline and differential.
GenevisibleiP40189. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL6RB_HUMAN
AccessioniPrimary (citable) accession number: P40189
Secondary accession number(s): A0N0L4, Q5FC04, Q9UQ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 194 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.