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P40189

- IL6RB_HUMAN

UniProt

P40189 - IL6RB_HUMAN

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Protein

Interleukin-6 receptor subunit beta

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.By similarity

GO - Molecular functioni

  1. ciliary neurotrophic factor receptor activity Source: BHF-UCL
  2. ciliary neurotrophic factor receptor binding Source: BHF-UCL
  3. growth factor binding Source: BHF-UCL
  4. interleukin-11 receptor activity Source: Ensembl
  5. interleukin-27 receptor activity Source: BHF-UCL
  6. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
  2. cytokine-mediated signaling pathway Source: BHF-UCL
  3. glycogen metabolic process Source: Ensembl
  4. interleukin-27-mediated signaling pathway Source: BHF-UCL
  5. interleukin-6-mediated signaling pathway Source: BHF-UCL
  6. leukemia inhibitory factor signaling pathway Source: BHF-UCL
  7. negative regulation of apoptotic process Source: BHF-UCL
  8. negative regulation of interleukin-6-mediated signaling pathway Source: BHF-UCL
  9. oncostatin-M-mediated signaling pathway Source: BHF-UCL
  10. positive regulation of acute inflammatory response Source: BHF-UCL
  11. positive regulation of adaptive immune response Source: BHF-UCL
  12. positive regulation of astrocyte differentiation Source: Ensembl
  13. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  14. positive regulation of cell proliferation Source: BHF-UCL
  15. positive regulation of osteoblast differentiation Source: BHF-UCL
  16. positive regulation of T cell proliferation Source: BHF-UCL
  17. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  18. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  19. positive regulation vascular endothelial growth factor production Source: BHF-UCL
  20. regulation of Notch signaling pathway Source: Ensembl
  21. response to cytokine Source: BHF-UCL
  22. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_27307. Interleukin-6 signaling.
SignaLinkiP40189.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6 receptor subunit beta
Short name:
IL-6 receptor subunit beta
Short name:
IL-6R subunit beta
Short name:
IL-6R-beta
Short name:
IL-6RB
Alternative name(s):
CDw130
Interleukin-6 signal transducer
Membrane glycoprotein 130
Short name:
gp130
Oncostatin-M receptor subunit alpha
CD_antigen: CD130
Gene namesi
Name:IL6ST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6021. IL6ST.

Subcellular locationi

GO - Cellular componenti

  1. ciliary neurotrophic factor receptor complex Source: BHF-UCL
  2. dendrite Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular region Source: Reactome
  5. extracellular space Source: BHF-UCL
  6. extracellular vesicular exosome Source: UniProtKB
  7. interleukin-6 receptor complex Source: BHF-UCL
  8. membrane Source: UniProtKB
  9. neuronal cell body Source: Ensembl
  10. oncostatin-M receptor complex Source: BHF-UCL
  11. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi782 – 7821S → A: Increases cell surface expression. 1 Publication

Organism-specific databases

PharmGKBiPA29837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 918896Interleukin-6 receptor subunit betaPRO_0000010899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 541 Publication
Glycosylationi43 – 431N-linked (GlcNAc...)1 Publication
Disulfide bondi48 ↔ 1031 Publication
Glycosylationi83 – 831N-linked (GlcNAc...)1 Publication
Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
Disulfide bondi134 ↔ 1441 Publication
Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
Disulfide bondi172 ↔ 1821 Publication
Glycosylationi227 – 2271N-linked (GlcNAc...)2 Publications
Glycosylationi379 – 3791N-linked (GlcNAc...)2 Publications
Glycosylationi383 – 3831N-linked (GlcNAc...)2 Publications
Glycosylationi390 – 3901N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi458 ↔ 4661 Publication
Glycosylationi553 – 5531N-linked (GlcNAc...)1 Publication
Glycosylationi564 – 5641N-linked (GlcNAc...)1 Publication
Modified residuei667 – 6671Phosphoserine2 Publications
Modified residuei782 – 7821Phosphoserine1 Publication
Modified residuei829 – 8291Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation of Ser-782 down-regulates cell surface expression.4 Publications
Heavily N-glycosylated.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP40189.
PaxDbiP40189.
PRIDEiP40189.

PTM databases

PhosphoSiteiP40189.

Expressioni

Tissue specificityi

Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

Inductioni

LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.1 Publication

Gene expression databases

BgeeiP40189.
CleanExiHS_IL6ST.
ExpressionAtlasiP40189. baseline and differential.
GenevestigatoriP40189.

Organism-specific databases

HPAiCAB025784.
HPA010558.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
K2Q2HRC72EBI-1030834,EBI-9007403From a different organism.
Stat3P422276EBI-1030834,EBI-602878From a different organism.

Protein-protein interaction databases

BioGridi109786. 24 interactions.
DIPiDIP-95N.
IntActiP40189. 9 interactions.
MINTiMINT-130473.
STRINGi9606.ENSP00000338799.

Structurei

Secondary structure

1
918
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 358
Beta strandi37 – 393
Beta strandi44 – 507
Helixi52 – 587
Helixi62 – 643
Beta strandi65 – 695
Helixi76 – 783
Beta strandi80 – 834
Beta strandi86 – 916
Beta strandi97 – 10711
Turni108 – 1103
Beta strandi111 – 12313
Beta strandi130 – 1378
Beta strandi143 – 1475
Beta strandi157 – 1648
Beta strandi176 – 1783
Beta strandi181 – 1833
Beta strandi194 – 2029
Beta strandi205 – 2084
Beta strandi212 – 2143
Helixi216 – 2183
Beta strandi219 – 2213
Beta strandi226 – 2316
Beta strandi234 – 2385
Beta strandi240 – 2456
Helixi248 – 2514
Beta strandi255 – 2639
Helixi274 – 2774
Beta strandi282 – 2865
Beta strandi291 – 30313
Beta strandi317 – 3215
Helixi325 – 3317
Beta strandi332 – 3387
Beta strandi345 – 3517
Helixi356 – 3594
Beta strandi363 – 37210
Beta strandi378 – 39114
Beta strandi396 – 40611
Beta strandi412 – 4165
Beta strandi428 – 4358
Beta strandi438 – 4447
Beta strandi452 – 4609
Beta strandi462 – 4643
Beta strandi469 – 4746
Beta strandi478 – 4814
Beta strandi491 – 50010
Beta strandi508 – 5158
Beta strandi525 – 5306
Beta strandi535 – 5395
Helixi544 – 5474
Beta strandi553 – 5608
Beta strandi566 – 5716
Beta strandi575 – 5795
Beta strandi587 – 59610
Beta strandi599 – 6024
Beta strandi606 – 6094

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ8NMR-A219-325[»]
1BQUX-ray2.00A/B122-333[»]
1I1RX-ray2.40A23-325[»]
1N2Qmodel-A/B23-324[»]
1P9MX-ray3.65A23-321[»]
1PVHX-ray2.50A/C123-323[»]
3L5HX-ray3.60A24-612[»]
3L5IX-ray1.90A323-612[»]
3L5JX-ray3.04A/B323-610[»]
ProteinModelPortaliP40189.
SMRiP40189. Positions 24-612.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40189.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 619597ExtracellularSequence AnalysisAdd
BLAST
Topological domaini642 – 918277CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei620 – 64122HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 12095Ig-like C2-typeAdd
BLAST
Domaini125 – 21692Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 324101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 42496Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini426 – 51792Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 61396Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3145WSXWS motif
Motifi651 – 6599Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi725 – 75531Ser-richAdd
BLAST

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145009.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000015771.
HOVERGENiHBG052119.
InParanoidiP40189.
KOiK05060.
OMAiFKQNCSQ.
OrthoDBiEOG7FXZXN.
PhylomeDBiP40189.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P40189-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330 340 350
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
360 370 380 390 400
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL
410 420 430 440 450
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
460 470 480 490 500
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
510 520 530 540 550
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
560 570 580 590 600
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
610 620 630 640 650
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
660 670 680 690 700
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
710 720 730 740 750
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
760 770 780 790 800
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
810 820 830 840 850
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
860 870 880 890 900
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
910
MPKSYLPQTV RQGGYMPQ
Length:918
Mass (Da):103,537
Last modified:November 25, 2008 - v2
Checksum:i6510A4409FFCF08C
GO
Isoform 2 (identifier: P40189-2) [UniParc]FASTAAdd to Basket

Also known as: GP130-RAPS

The sequence of this isoform differs from the canonical sequence as follows:
     325-329: RPSKA → NIASF
     330-918: Missing.

Show »
Length:329
Mass (Da):37,499
Checksum:iD556124C867984E4
GO
Isoform 3 (identifier: P40189-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-483: Missing.

Show »
Length:857
Mass (Da):96,276
Checksum:i726208A5073B5451
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81L → V.2 Publications
Corresponds to variant rs1063560 [ dbSNP | Ensembl ].
VAR_047782
Natural varianti148 – 1481G → R.
Corresponds to variant rs2228044 [ dbSNP | Ensembl ].
VAR_047783
Natural varianti397 – 3971L → V.
Corresponds to variant rs2228043 [ dbSNP | Ensembl ].
VAR_047784
Natural varianti415 – 4151T → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036165
Natural varianti454 – 4541I → T.
Corresponds to variant rs2228046 [ dbSNP | Ensembl ].
VAR_047785
Natural varianti499 – 4991V → I.
Corresponds to variant rs34417936 [ dbSNP | Ensembl ].
VAR_047786

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 3295RPSKA → NIASF in isoform 2. 1 PublicationVSP_001684
Alternative sequencei330 – 918589Missing in isoform 2. 1 PublicationVSP_001685Add
BLAST
Alternative sequencei423 – 48361Missing in isoform 3. 1 PublicationVSP_043716Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57230 mRNA. Translation: AAA59155.1.
AB015706 mRNA. Translation: BAA78112.1.
AB102802 mRNA. Translation: BAD89393.1.
EF064722 Genomic DNA. Translation: ABK41905.1.
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54936.1.
CCDSiCCDS3971.1. [P40189-1]
CCDS47209.1. [P40189-2]
CCDS54856.1. [P40189-3]
PIRiA36337.
RefSeqiNP_001177910.1. NM_001190981.1. [P40189-3]
NP_002175.2. NM_002184.3. [P40189-1]
NP_786943.1. NM_175767.2. [P40189-2]
UniGeneiHs.532082.
Hs.706627.

Genome annotation databases

EnsembliENST00000336909; ENSP00000338799; ENSG00000134352. [P40189-1]
ENST00000381287; ENSP00000370687; ENSG00000134352. [P40189-2]
ENST00000381294; ENSP00000370694; ENSG00000134352. [P40189-3]
ENST00000381298; ENSP00000370698; ENSG00000134352. [P40189-1]
ENST00000502326; ENSP00000462158; ENSG00000134352. [P40189-1]
ENST00000522633; ENSP00000435399; ENSG00000134352. [P40189-2]
GeneIDi3572.
KEGGihsa:3572.
UCSCiuc003jqq.3. human. [P40189-1]
uc003jqr.3. human. [P40189-2]
uc010iwb.3. human. [P40189-3]

Polymorphism databases

DMDMi215273999.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57230 mRNA. Translation: AAA59155.1 .
AB015706 mRNA. Translation: BAA78112.1 .
AB102802 mRNA. Translation: BAD89393.1 .
EF064722 Genomic DNA. Translation: ABK41905.1 .
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54936.1 .
CCDSi CCDS3971.1. [P40189-1 ]
CCDS47209.1. [P40189-2 ]
CCDS54856.1. [P40189-3 ]
PIRi A36337.
RefSeqi NP_001177910.1. NM_001190981.1. [P40189-3 ]
NP_002175.2. NM_002184.3. [P40189-1 ]
NP_786943.1. NM_175767.2. [P40189-2 ]
UniGenei Hs.532082.
Hs.706627.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BJ8 NMR - A 219-325 [» ]
1BQU X-ray 2.00 A/B 122-333 [» ]
1I1R X-ray 2.40 A 23-325 [» ]
1N2Q model - A/B 23-324 [» ]
1P9M X-ray 3.65 A 23-321 [» ]
1PVH X-ray 2.50 A/C 123-323 [» ]
3L5H X-ray 3.60 A 24-612 [» ]
3L5I X-ray 1.90 A 323-612 [» ]
3L5J X-ray 3.04 A/B 323-610 [» ]
ProteinModelPortali P40189.
SMRi P40189. Positions 24-612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109786. 24 interactions.
DIPi DIP-95N.
IntActi P40189. 9 interactions.
MINTi MINT-130473.
STRINGi 9606.ENSP00000338799.

Chemistry

ChEMBLi CHEMBL3124734.

PTM databases

PhosphoSitei P40189.

Polymorphism databases

DMDMi 215273999.

Proteomic databases

MaxQBi P40189.
PaxDbi P40189.
PRIDEi P40189.

Protocols and materials databases

DNASUi 3572.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336909 ; ENSP00000338799 ; ENSG00000134352 . [P40189-1 ]
ENST00000381287 ; ENSP00000370687 ; ENSG00000134352 . [P40189-2 ]
ENST00000381294 ; ENSP00000370694 ; ENSG00000134352 . [P40189-3 ]
ENST00000381298 ; ENSP00000370698 ; ENSG00000134352 . [P40189-1 ]
ENST00000502326 ; ENSP00000462158 ; ENSG00000134352 . [P40189-1 ]
ENST00000522633 ; ENSP00000435399 ; ENSG00000134352 . [P40189-2 ]
GeneIDi 3572.
KEGGi hsa:3572.
UCSCi uc003jqq.3. human. [P40189-1 ]
uc003jqr.3. human. [P40189-2 ]
uc010iwb.3. human. [P40189-3 ]

Organism-specific databases

CTDi 3572.
GeneCardsi GC05M055230.
HGNCi HGNC:6021. IL6ST.
HPAi CAB025784.
HPA010558.
MIMi 600694. gene.
neXtProti NX_P40189.
PharmGKBi PA29837.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145009.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000015771.
HOVERGENi HBG052119.
InParanoidi P40189.
KOi K05060.
OMAi FKQNCSQ.
OrthoDBi EOG7FXZXN.
PhylomeDBi P40189.
TreeFami TF338122.

Enzyme and pathway databases

Reactomei REACT_27307. Interleukin-6 signaling.
SignaLinki P40189.

Miscellaneous databases

ChiTaRSi IL6ST. human.
EvolutionaryTracei P40189.
GeneWikii Glycoprotein_130.
GenomeRNAii 3572.
NextBioi 13960.
PROi P40189.
SOURCEi Search...

Gene expression databases

Bgeei P40189.
CleanExi HS_IL6ST.
ExpressionAtlasi P40189. baseline and differential.
Genevestigatori P40189.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
PROSITEi PS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of an IL-6 signal transducer, gp130."
    Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T.
    Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-8.
    Tissue: Myeloma and Placenta.
  2. "Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis."
    Tanaka M., Kishimura M., Ozaki S., Osakada F., Hashimoto H., Okubo M., Murakami M., Nakao K.
    J. Clin. Invest. 106:137-144(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-8.
    Tissue: Synovium.
  3. "IL6ST mRNA, nirs splice variant 4."
    Hayashi A., Sameshima E., Tabata Y., Iida K., Mitsuyama M., Kanai S., Furuya T., Saito T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130."
    Moritz R.L., Hall N.E., Connolly L.M., Simpson R.J.
    J. Biol. Chem. 276:8244-8253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS, GLYCOSYLATION AT ASN-43; ASN-83; ASN-131; ASN-157; ASN-227; ASN-379; ASN-383; ASN-553 AND ASN-564.
  8. "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
    Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.
    J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INDUCTION.
  9. "Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."
    Hallek M., Neumann C., Schaffer M., Danhauser-Riedl S., von Bubnoff N., de Vos G., Druker B.J., Yasukawa K., Griffin J.D., Emmerich B.
    Exp. Hematol. 25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCK.
  10. "Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling."
    Gibson R.M., Schiemann W.P., Prichard L.B., Reno J.M., Ericsson L.H., Nathanson N.M.
    J. Biol. Chem. 275:22574-22582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-782, MUTAGENESIS OF SER-782, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling."
    Li H., Wang H., Nicholas J.
    J. Virol. 75:3325-3334(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-8 PROTEIN VIL6.
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-379 AND ASN-383.
    Tissue: Plasma.
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227 AND ASN-390.
    Tissue: Liver.
  17. Cited for: GLYCOSYLATION AT ASN-390.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Crystal structure of a cytokine-binding region of gp130."
    Bravo J., Staunton D., Heath J.K., Jones E.Y.
    EMBO J. 17:1665-1674(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 122-325.
  20. "Structure of an extracellular gp130 cytokine receptor signaling complex."
    Chow D.-C., He X.-L., Snow A.L., Rose-John S., Garcia K.C.
    Science 291:2150-2155(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 23-325 IN COMPLEX WITH HERPES VIRUS IL6, SUBUNIT, GLYCOSYLATION.
  21. "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."
    Boulanger M.J., Bankovich A.J., Kortemme T., Baker D., Garcia K.C.
    Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 123-323 IN COMPLEX WITH LIF.
  22. "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
    Boulanger M.J., Chow D.-C., Brevnova E.E., Garcia K.C.
    Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 23-321 IN COMPLEX WITH IL6 AND IL6R, SUBUNIT.
  23. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-415.

Entry informationi

Entry nameiIL6RB_HUMAN
AccessioniPrimary (citable) accession number: P40189
Secondary accession number(s): A0N0L4, Q5FC04, Q9UQ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 173 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3