P40188 (RGI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Respiratory growth induced protein 2

Gene names

Name:	RGI2
Ordered Locus Names:	YIL057C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. Ref.9
Subcellular location	Cytoplasm Ref.5.
Induction	Up-regulated under carbon limitation and repressed under high glucose. Ref.4 Ref.7
Miscellaneous	Present with 5530 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the RGI1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	energy reserve metabolic process Inferred from expression pattern Ref.9. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Respiratory growth induced protein 2		PRO_0000202987
Amino acid modifications
	Modified residue	74	1	Phosphothreonine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P40188 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: FE106D9EE90D28EA	FASTA	164	19,229
	10 20 30 40 50 60 MTKKDKKAKG PKMSTITTKS GESLKVFEDL HDFETYLKGE TEDQEFDHVH CQLKYYPPFV 70 80 90 100 110 120 LHDAHDDPEK IKETANSHSK KFVRHLHQHV EKHLLKDIKT AINKPELKFH DKKKQESFDR 130 140 150 160 IVWNYGEETE LNAKKFKVSV EVVCKHDGAM VDVDYKTEPL QPLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur." Boer V.M., de Winde J.H., Pronk J.T., Piper M.D.W. J. Biol. Chem. 278:3265-3274(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation." Kresnowati M.T., van Winden W.A., Almering M.J., ten Pierick A., Ras C., Knijnenburg T.A., Daran-Lapujade P., Pronk J.T., Heijnen J.J., Daran J.M. Mol. Syst. Biol. 2:49-49(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, MASS SPECTROMETRY.
[9]	"Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance." Domitrovic T., Kozlov G., Freire J.C., Masuda C.A., da Silva Almeida M., Montero-Lomeli M., Atella G.C., Matta-Camacho E., Gehring K., Kurtenbach E. PLoS ONE 5:E11163-E11163(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z38060 Genomic DNA. Translation: CAA86166.1. AY558086 Genomic DNA. Translation: AAS56412.1. BK006942 Genomic DNA. Translation: DAA08491.1.
PIR	S48422.
RefSeq	NP_012207.3. NM_001179407.3.
3D structure databases
ProteinModelPortal	P40188.
SMR	P40188. Positions 18-160.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5500N.
MINT	MINT-563253.
STRING	4932.YIL057C.
Proteomic databases
PaxDb	P40188.
PeptideAtlas	P40188.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL057C; YIL057C; YIL057C.
GeneID	854753.
KEGG	sce:YIL050W. sce:YIL057C.
Organism-specific databases
CYGD	YIL057c.
SGD	S000001319. RGI2.
Phylogenomic databases
eggNOG	NOG41208.
GeneTree	ENSGT00390000011508.
OMA	DETWDND.
OrthoDB	EOG47DDRC.
Gene expression databases
Genevestigator	P40188.
GermOnline	YIL057C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR022554. DUF2578. [Graphical view]
Pfam	PF10843. DUF2578. 1 hit. [Graphical view]
ProDom	PD034538. DUF2578. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	977485.

Entry information

Entry name

RGI2_YEAST

Accession

Primary (citable) accession number: P40188
Secondary accession number(s): D6VVM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program