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P40187 (PIG2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GSY2-interacting protein PIG2
Gene names
Name:PIG2
Ordered Locus Names:YIL045W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 CBM21 (carbohydrate binding type-21) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538GSY2-interacting protein PIG2
PRO_0000071522

Regions

Domain384 – 508125CBM21

Amino acid modifications

Modified residue1621Phosphoserine Ref.6 Ref.7
Modified residue1961Phosphoserine Ref.7
Modified residue2961Phosphoserine Ref.9
Modified residue3041Phosphoserine Ref.9

Experimental info

Sequence conflict5371F → L in AAU09747. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P40187 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 73ED8F5CC6692172

FASTA53861,938
        10         20         30         40         50         60 
MATTTQPQNI LMDEPLNLPN NSAHNNNYGN INANIRTFAG MSMHMHPARL NSLEFLHKPR 

        70         80         90        100        110        120 
RLSNVKLHRL PQDELQRNTD MNKGMYFNGK QVHAHHPFIN SGANFNAHHQ DVSKLGEEED 

       130        140        150        160        170        180 
EISPLSHDNF QYESEENGNP SPPIYKKSGE LVKSSLKRRS KSLPITPKSI FNKTGSKSKH 

       190        200        210        220        230        240 
VNLDHVDTRL LQRSKSVHFD RVLPIKLFNE NEKPIDVGKQ MVQQDVLNFK HKPLTRLSAL 

       250        260        270        280        290        300 
NGGSDSVPIE DLLSENNQNE YGDTWLQNPK GVFLFGTNSN NRRNKKKKFK LSDDDSDIEN 

       310        320        330        340        350        360 
DNDSDDAINR LVRQQDKDQA HLAHGLKNLL INDDDDYLET RTNSAKSGAN LFIGNSKRIV 

       370        380        390        400        410        420 
GLYNKNFPIL SDRNRKSLKL NIFLNLSRGR PVFLQEITLL TGFHNMVIIG KVFVKNIYFD 

       430        440        450        460        470        480 
KKIIVRYTWD AWRTFHESEC VYFSNANGIL PGSNMDIFKF SIDDIHNPND KDSNISQLEF 

       490        500        510        520        530 
CIQYLTWGVD RSRKEYWDNN DSANYKIDVV TNETRTGPTT DVNDNYEMKH SLFRNPFH 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p."
Cheng C., Huang D., Roach P.J.
Yeast 13:1-8(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE, CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162 AND SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296 AND SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46861 Genomic DNA. Translation: CAA86906.1.
AY723830 Genomic DNA. Translation: AAU09747.1.
BK006942 Genomic DNA. Translation: DAA08503.1.
PIRS49933.
RefSeqNP_012219.3. NM_001179395.3.

3D structure databases

ProteinModelPortalP40187.
SMRP40187. Positions 366-520.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34945. 27 interactions.
DIPDIP-5191N.
IntActP40187. 12 interactions.
MINTMINT-537691.
STRING4932.YIL045W.

Protein family/group databases

CAZyCBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

PaxDbP40187.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL045W; YIL045W; YIL045W.
GeneID854766.
KEGGsce:YIL045W.

Organism-specific databases

CYGDYIL045w.
SGDS000001307. PIG2.

Phylogenomic databases

eggNOGKOG3986.
GeneTreeENSGT00530000067694.
OMANANIRTF.
OrthoDBEOG7XWPXD.

Enzyme and pathway databases

BioCycYEAST:G3O-31316-MONOMER.

Gene expression databases

GenevestigatorP40187.

Family and domain databases

InterProIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFPIRSF018234. PPase_interacting. 1 hit.
PROSITEPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977520.

Entry information

Entry namePIG2_YEAST
AccessionPrimary (citable) accession number: P40187
Secondary accession number(s): D6VVN7, E9P960
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families