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P40187

- PIG2_YEAST

UniProt

P40187 - PIG2_YEAST

Protein

GSY2-interacting protein PIG2

Gene

PIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).

    GO - Molecular functioni

    1. protein phosphatase type 1 regulator activity Source: SGD

    GO - Biological processi

    1. regulation of catalytic activity Source: GOC
    2. regulation of glycogen biosynthetic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31316-MONOMER.

    Protein family/group databases

    CAZyiCBM21. Carbohydrate-Binding Module Family 21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GSY2-interacting protein PIG2
    Gene namesi
    Name:PIG2
    Ordered Locus Names:YIL045W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL045w.
    SGDiS000001307. PIG2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538GSY2-interacting protein PIG2PRO_0000071522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei162 – 1621Phosphoserine2 Publications
    Modified residuei196 – 1961Phosphoserine1 Publication
    Modified residuei296 – 2961Phosphoserine1 Publication
    Modified residuei304 – 3041Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40187.
    PaxDbiP40187.

    Expressioni

    Gene expression databases

    GenevestigatoriP40187.

    Interactioni

    Protein-protein interaction databases

    BioGridi34945. 27 interactions.
    DIPiDIP-5191N.
    IntActiP40187. 12 interactions.
    MINTiMINT-537691.
    STRINGi4932.YIL045W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40187.
    SMRiP40187. Positions 408-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini384 – 508125CBM21PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiKOG3986.
    GeneTreeiENSGT00530000067694.
    OrthoDBiEOG7XWPXD.

    Family and domain databases

    InterProiIPR005036. CBM_21.
    IPR016717. Pase-1_int.
    [Graphical view]
    PfamiPF03370. CBM_21. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018234. PPase_interacting. 1 hit.
    PROSITEiPS51159. CBM21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40187-1 [UniParc]FASTAAdd to Basket

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    MATTTQPQNI LMDEPLNLPN NSAHNNNYGN INANIRTFAG MSMHMHPARL    50
    NSLEFLHKPR RLSNVKLHRL PQDELQRNTD MNKGMYFNGK QVHAHHPFIN 100
    SGANFNAHHQ DVSKLGEEED EISPLSHDNF QYESEENGNP SPPIYKKSGE 150
    LVKSSLKRRS KSLPITPKSI FNKTGSKSKH VNLDHVDTRL LQRSKSVHFD 200
    RVLPIKLFNE NEKPIDVGKQ MVQQDVLNFK HKPLTRLSAL NGGSDSVPIE 250
    DLLSENNQNE YGDTWLQNPK GVFLFGTNSN NRRNKKKKFK LSDDDSDIEN 300
    DNDSDDAINR LVRQQDKDQA HLAHGLKNLL INDDDDYLET RTNSAKSGAN 350
    LFIGNSKRIV GLYNKNFPIL SDRNRKSLKL NIFLNLSRGR PVFLQEITLL 400
    TGFHNMVIIG KVFVKNIYFD KKIIVRYTWD AWRTFHESEC VYFSNANGIL 450
    PGSNMDIFKF SIDDIHNPND KDSNISQLEF CIQYLTWGVD RSRKEYWDNN 500
    DSANYKIDVV TNETRTGPTT DVNDNYEMKH SLFRNPFH 538
    Length:538
    Mass (Da):61,938
    Last modified:February 1, 1995 - v1
    Checksum:i73ED8F5CC6692172
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti537 – 5371F → L in AAU09747. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46861 Genomic DNA. Translation: CAA86906.1.
    AY723830 Genomic DNA. Translation: AAU09747.1.
    BK006942 Genomic DNA. Translation: DAA08503.1.
    PIRiS49933.
    RefSeqiNP_012219.3. NM_001179395.3.

    Genome annotation databases

    EnsemblFungiiYIL045W; YIL045W; YIL045W.
    GeneIDi854766.
    KEGGisce:YIL045W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46861 Genomic DNA. Translation: CAA86906.1 .
    AY723830 Genomic DNA. Translation: AAU09747.1 .
    BK006942 Genomic DNA. Translation: DAA08503.1 .
    PIRi S49933.
    RefSeqi NP_012219.3. NM_001179395.3.

    3D structure databases

    ProteinModelPortali P40187.
    SMRi P40187. Positions 408-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34945. 27 interactions.
    DIPi DIP-5191N.
    IntActi P40187. 12 interactions.
    MINTi MINT-537691.
    STRINGi 4932.YIL045W.

    Protein family/group databases

    CAZyi CBM21. Carbohydrate-Binding Module Family 21.

    Proteomic databases

    MaxQBi P40187.
    PaxDbi P40187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL045W ; YIL045W ; YIL045W .
    GeneIDi 854766.
    KEGGi sce:YIL045W.

    Organism-specific databases

    CYGDi YIL045w.
    SGDi S000001307. PIG2.

    Phylogenomic databases

    eggNOGi KOG3986.
    GeneTreei ENSGT00530000067694.
    OrthoDBi EOG7XWPXD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31316-MONOMER.

    Miscellaneous databases

    NextBioi 977520.

    Gene expression databases

    Genevestigatori P40187.

    Family and domain databases

    InterProi IPR005036. CBM_21.
    IPR016717. Pase-1_int.
    [Graphical view ]
    Pfami PF03370. CBM_21. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018234. PPase_interacting. 1 hit.
    PROSITEi PS51159. CBM21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p."
      Cheng C., Huang D., Roach P.J.
      Yeast 13:1-8(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE, CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162 AND SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296 AND SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPIG2_YEAST
    AccessioniPrimary (citable) accession number: P40187
    Secondary accession number(s): D6VVN7, E9P960
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 996 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3