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Protein

GSY2-interacting protein PIG2

Gene

PIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).

GO - Molecular functioni

  1. protein phosphatase type 1 regulator activity Source: SGD

GO - Biological processi

  1. regulation of catalytic activity Source: GOC
  2. regulation of glycogen biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31316-MONOMER.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
GSY2-interacting protein PIG2
Gene namesi
Name:PIG2
Ordered Locus Names:YIL045W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IX

Organism-specific databases

CYGDiYIL045w.
EuPathDBiFungiDB:YIL045W.
SGDiS000001307. PIG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538GSY2-interacting protein PIG2PRO_0000071522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621Phosphoserine2 Publications
Modified residuei196 – 1961Phosphoserine1 Publication
Modified residuei296 – 2961Phosphoserine1 Publication
Modified residuei304 – 3041Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40187.
PaxDbiP40187.

Expressioni

Gene expression databases

GenevestigatoriP40187.

Interactioni

Protein-protein interaction databases

BioGridi34945. 27 interactions.
DIPiDIP-5191N.
IntActiP40187. 12 interactions.
MINTiMINT-537691.
STRINGi4932.YIL045W.

Structurei

3D structure databases

ProteinModelPortaliP40187.
SMRiP40187. Positions 410-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini384 – 508125CBM21PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3986.
GeneTreeiENSGT00530000067694.
InParanoidiP40187.
OrthoDBiEOG7XWPXD.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTTQPQNI LMDEPLNLPN NSAHNNNYGN INANIRTFAG MSMHMHPARL
60 70 80 90 100
NSLEFLHKPR RLSNVKLHRL PQDELQRNTD MNKGMYFNGK QVHAHHPFIN
110 120 130 140 150
SGANFNAHHQ DVSKLGEEED EISPLSHDNF QYESEENGNP SPPIYKKSGE
160 170 180 190 200
LVKSSLKRRS KSLPITPKSI FNKTGSKSKH VNLDHVDTRL LQRSKSVHFD
210 220 230 240 250
RVLPIKLFNE NEKPIDVGKQ MVQQDVLNFK HKPLTRLSAL NGGSDSVPIE
260 270 280 290 300
DLLSENNQNE YGDTWLQNPK GVFLFGTNSN NRRNKKKKFK LSDDDSDIEN
310 320 330 340 350
DNDSDDAINR LVRQQDKDQA HLAHGLKNLL INDDDDYLET RTNSAKSGAN
360 370 380 390 400
LFIGNSKRIV GLYNKNFPIL SDRNRKSLKL NIFLNLSRGR PVFLQEITLL
410 420 430 440 450
TGFHNMVIIG KVFVKNIYFD KKIIVRYTWD AWRTFHESEC VYFSNANGIL
460 470 480 490 500
PGSNMDIFKF SIDDIHNPND KDSNISQLEF CIQYLTWGVD RSRKEYWDNN
510 520 530
DSANYKIDVV TNETRTGPTT DVNDNYEMKH SLFRNPFH
Length:538
Mass (Da):61,938
Last modified:February 1, 1995 - v1
Checksum:i73ED8F5CC6692172
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371F → L in AAU09747 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86906.1.
AY723830 Genomic DNA. Translation: AAU09747.1.
BK006942 Genomic DNA. Translation: DAA08503.1.
PIRiS49933.
RefSeqiNP_012219.3. NM_001179395.3.

Genome annotation databases

EnsemblFungiiYIL045W; YIL045W; YIL045W.
GeneIDi854766.
KEGGisce:YIL045W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46861 Genomic DNA. Translation: CAA86906.1.
AY723830 Genomic DNA. Translation: AAU09747.1.
BK006942 Genomic DNA. Translation: DAA08503.1.
PIRiS49933.
RefSeqiNP_012219.3. NM_001179395.3.

3D structure databases

ProteinModelPortaliP40187.
SMRiP40187. Positions 410-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34945. 27 interactions.
DIPiDIP-5191N.
IntActiP40187. 12 interactions.
MINTiMINT-537691.
STRINGi4932.YIL045W.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

MaxQBiP40187.
PaxDbiP40187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL045W; YIL045W; YIL045W.
GeneIDi854766.
KEGGisce:YIL045W.

Organism-specific databases

CYGDiYIL045w.
EuPathDBiFungiDB:YIL045W.
SGDiS000001307. PIG2.

Phylogenomic databases

eggNOGiKOG3986.
GeneTreeiENSGT00530000067694.
InParanoidiP40187.
OrthoDBiEOG7XWPXD.

Enzyme and pathway databases

BioCyciYEAST:G3O-31316-MONOMER.

Miscellaneous databases

NextBioi977520.
PROiP40187.

Gene expression databases

GenevestigatoriP40187.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p."
    Cheng C., Huang D., Roach P.J.
    Yeast 13:1-8(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE, CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162 AND SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296 AND SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPIG2_YEAST
AccessioniPrimary (citable) accession number: P40187
Secondary accession number(s): D6VVN7, E9P960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.