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P40187

- PIG2_YEAST

UniProt

P40187 - PIG2_YEAST

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Protein

GSY2-interacting protein PIG2

Gene
PIG2, YIL045W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with glycogen synthase 2 (GSY2); possibly also interacts with phosphatase 1 (GLC7).

GO - Molecular functioni

  1. protein phosphatase type 1 regulator activity Source: SGD

GO - Biological processi

  1. regulation of catalytic activity Source: GOC
  2. regulation of glycogen biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31316-MONOMER.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
GSY2-interacting protein PIG2
Gene namesi
Name:PIG2
Ordered Locus Names:YIL045W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL045w.
SGDiS000001307. PIG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538GSY2-interacting protein PIG2PRO_0000071522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621Phosphoserine2 Publications
Modified residuei196 – 1961Phosphoserine1 Publication
Modified residuei296 – 2961Phosphoserine1 Publication
Modified residuei304 – 3041Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40187.
PaxDbiP40187.

Expressioni

Gene expression databases

GenevestigatoriP40187.

Interactioni

Protein-protein interaction databases

BioGridi34945. 27 interactions.
DIPiDIP-5191N.
IntActiP40187. 12 interactions.
MINTiMINT-537691.
STRINGi4932.YIL045W.

Structurei

3D structure databases

ProteinModelPortaliP40187.
SMRiP40187. Positions 408-507.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini384 – 508125CBM21Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3986.
GeneTreeiENSGT00530000067694.
OrthoDBiEOG7XWPXD.

Family and domain databases

InterProiIPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF018234. PPase_interacting. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40187-1 [UniParc]FASTAAdd to Basket

« Hide

MATTTQPQNI LMDEPLNLPN NSAHNNNYGN INANIRTFAG MSMHMHPARL    50
NSLEFLHKPR RLSNVKLHRL PQDELQRNTD MNKGMYFNGK QVHAHHPFIN 100
SGANFNAHHQ DVSKLGEEED EISPLSHDNF QYESEENGNP SPPIYKKSGE 150
LVKSSLKRRS KSLPITPKSI FNKTGSKSKH VNLDHVDTRL LQRSKSVHFD 200
RVLPIKLFNE NEKPIDVGKQ MVQQDVLNFK HKPLTRLSAL NGGSDSVPIE 250
DLLSENNQNE YGDTWLQNPK GVFLFGTNSN NRRNKKKKFK LSDDDSDIEN 300
DNDSDDAINR LVRQQDKDQA HLAHGLKNLL INDDDDYLET RTNSAKSGAN 350
LFIGNSKRIV GLYNKNFPIL SDRNRKSLKL NIFLNLSRGR PVFLQEITLL 400
TGFHNMVIIG KVFVKNIYFD KKIIVRYTWD AWRTFHESEC VYFSNANGIL 450
PGSNMDIFKF SIDDIHNPND KDSNISQLEF CIQYLTWGVD RSRKEYWDNN 500
DSANYKIDVV TNETRTGPTT DVNDNYEMKH SLFRNPFH 538
Length:538
Mass (Da):61,938
Last modified:February 1, 1995 - v1
Checksum:i73ED8F5CC6692172
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371F → L in AAU09747. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46861 Genomic DNA. Translation: CAA86906.1.
AY723830 Genomic DNA. Translation: AAU09747.1.
BK006942 Genomic DNA. Translation: DAA08503.1.
PIRiS49933.
RefSeqiNP_012219.3. NM_001179395.3.

Genome annotation databases

EnsemblFungiiYIL045W; YIL045W; YIL045W.
GeneIDi854766.
KEGGisce:YIL045W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46861 Genomic DNA. Translation: CAA86906.1 .
AY723830 Genomic DNA. Translation: AAU09747.1 .
BK006942 Genomic DNA. Translation: DAA08503.1 .
PIRi S49933.
RefSeqi NP_012219.3. NM_001179395.3.

3D structure databases

ProteinModelPortali P40187.
SMRi P40187. Positions 408-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34945. 27 interactions.
DIPi DIP-5191N.
IntActi P40187. 12 interactions.
MINTi MINT-537691.
STRINGi 4932.YIL045W.

Protein family/group databases

CAZyi CBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

MaxQBi P40187.
PaxDbi P40187.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL045W ; YIL045W ; YIL045W .
GeneIDi 854766.
KEGGi sce:YIL045W.

Organism-specific databases

CYGDi YIL045w.
SGDi S000001307. PIG2.

Phylogenomic databases

eggNOGi KOG3986.
GeneTreei ENSGT00530000067694.
OrthoDBi EOG7XWPXD.

Enzyme and pathway databases

BioCyci YEAST:G3O-31316-MONOMER.

Miscellaneous databases

NextBioi 977520.

Gene expression databases

Genevestigatori P40187.

Family and domain databases

InterProi IPR005036. CBM_21.
IPR016717. Pase-1_int.
[Graphical view ]
Pfami PF03370. CBM_21. 1 hit.
[Graphical view ]
PIRSFi PIRSF018234. PPase_interacting. 1 hit.
PROSITEi PS51159. CBM21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p."
    Cheng C., Huang D., Roach P.J.
    Yeast 13:1-8(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE, CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162 AND SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296 AND SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPIG2_YEAST
AccessioniPrimary (citable) accession number: P40187
Secondary accession number(s): D6VVN7, E9P960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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