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P40185

- MMF1_YEAST

UniProt

P40185 - MMF1_YEAST

Protein

Protein MMF1, mitochondrial

Gene

MMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Plays a role in the maintenance of mitochondrial DNA.

    GO - Molecular functioni

    1. deaminase activity Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: SGD
    2. mitochondrial translation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31322-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MMF1, mitochondrial
    Alternative name(s):
    Isoleucine biosynthesis and maintenance of intact mitochondria 1
    Maintenance of mitochondrial function 1
    Gene namesi
    Name:MMF1
    Synonyms:IBM1
    Ordered Locus Names:YIL051C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL051c.
    SGDiS000001313. MMF1.

    Subcellular locationi

    Mitochondrion matrix 2 Publications

    GO - Cellular componenti

    1. mitochondrial matrix Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1717Mitochondrion2 PublicationsAdd
    BLAST
    Chaini18 – 145128Protein MMF1, mitochondrialPRO_0000036209Add
    BLAST

    Proteomic databases

    MaxQBiP40185.
    PaxDbiP40185.
    PeptideAtlasiP40185.

    2D gel databases

    SWISS-2DPAGEP40185.

    Expressioni

    Gene expression databases

    GenevestigatoriP40185.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ECM4P361561EBI-11022,EBI-2042717
    HAL5P389701EBI-11022,EBI-8142

    Protein-protein interaction databases

    BioGridi34939. 85 interactions.
    DIPiDIP-4714N.
    IntActiP40185. 5 interactions.
    MINTiMINT-487056.
    STRINGi4932.YIL051C.

    Structurei

    Secondary structure

    1
    145
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 244
    Beta strandi38 – 425
    Beta strandi45 – 517
    Helixi65 – 8218
    Helixi87 – 893
    Beta strandi90 – 989
    Helixi100 – 1023
    Helixi103 – 11311
    Beta strandi114 – 1163
    Beta strandi120 – 1256
    Helixi130 – 1323
    Beta strandi134 – 1429

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3QUWX-ray1.75A1-145[»]
    ProteinModelPortaliP40185.
    SMRiP40185. Positions 20-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RutC family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0251.
    GeneTreeiENSGT00420000029792.
    HOGENOMiHOG000267215.
    OMAiIIPQPFP.
    OrthoDBiEOG7N640Z.

    Family and domain databases

    Gene3Di3.30.1330.40. 1 hit.
    InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
    IPR006056. YjgF-like.
    IPR019897. YjgF-like_CS.
    IPR006175. YjgF/Yer057p/UK114.
    [Graphical view]
    PANTHERiPTHR11803. PTHR11803. 1 hit.
    PfamiPF01042. Ribonuc_L-PSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55298. SSF55298. 1 hit.
    TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
    PROSITEiPS01094. UPF0076. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P40185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLRNSVLRT APVLRRGITT LTPVSTKLAP PAAASYSQAM KANNFVYVSG    50
    QIPYTPDNKP VQGSISEKAE QVFQNVKNIL AESNSSLDNI VKVNVFLADM 100
    KNFAEFNSVY AKHFHTHKPA RSCVGVASLP LNVDLEMEVI AVEKN 145
    Length:145
    Mass (Da):15,908
    Last modified:February 1, 1995 - v1
    Checksum:iF2DC4E32C04CED45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050474 Genomic DNA. Translation: BAB20814.1.
    Z38060 Genomic DNA. Translation: CAA86171.1.
    AY558301 Genomic DNA. Translation: AAS56627.1.
    BK006942 Genomic DNA. Translation: DAA08496.1.
    PIRiS48428.
    RefSeqiNP_012213.3. NM_001179401.3.

    Genome annotation databases

    EnsemblFungiiYIL051C; YIL051C; YIL051C.
    GeneIDi854760.
    KEGGisce:YIL051C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050474 Genomic DNA. Translation: BAB20814.1 .
    Z38060 Genomic DNA. Translation: CAA86171.1 .
    AY558301 Genomic DNA. Translation: AAS56627.1 .
    BK006942 Genomic DNA. Translation: DAA08496.1 .
    PIRi S48428.
    RefSeqi NP_012213.3. NM_001179401.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3QUW X-ray 1.75 A 1-145 [» ]
    ProteinModelPortali P40185.
    SMRi P40185. Positions 20-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34939. 85 interactions.
    DIPi DIP-4714N.
    IntActi P40185. 5 interactions.
    MINTi MINT-487056.
    STRINGi 4932.YIL051C.

    2D gel databases

    SWISS-2DPAGE P40185.

    Proteomic databases

    MaxQBi P40185.
    PaxDbi P40185.
    PeptideAtlasi P40185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL051C ; YIL051C ; YIL051C .
    GeneIDi 854760.
    KEGGi sce:YIL051C.

    Organism-specific databases

    CYGDi YIL051c.
    SGDi S000001313. MMF1.

    Phylogenomic databases

    eggNOGi COG0251.
    GeneTreei ENSGT00420000029792.
    HOGENOMi HOG000267215.
    OMAi IIPQPFP.
    OrthoDBi EOG7N640Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31322-MONOMER.

    Miscellaneous databases

    NextBioi 977502.

    Gene expression databases

    Genevestigatori P40185.

    Family and domain databases

    Gene3Di 3.30.1330.40. 1 hit.
    InterProi IPR013813. Endoribo_LPSP/chorism_mut-like.
    IPR006056. YjgF-like.
    IPR019897. YjgF-like_CS.
    IPR006175. YjgF/Yer057p/UK114.
    [Graphical view ]
    PANTHERi PTHR11803. PTHR11803. 1 hit.
    Pfami PF01042. Ribonuc_L-PSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55298. SSF55298. 1 hit.
    TIGRFAMsi TIGR00004. TIGR00004. 1 hit.
    PROSITEi PS01094. UPF0076. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
      Kim J.-M., Yoshikawa H., Shirahige K.
      Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, CHARACTERIZATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: PROTEIN SEQUENCE OF 18-28.
      Strain: ATCC 26786 / X2180-1A.
    6. "Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
      Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
      Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, CHARACTERIZATION.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMMF1_YEAST
    AccessioniPrimary (citable) accession number: P40185
    Secondary accession number(s): D6VVN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 168000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3