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P40185

- MMF1_YEAST

UniProt

P40185 - MMF1_YEAST

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Protein
Protein MMF1, mitochondrial
Gene
MMF1, IBM1, YIL051C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the maintenance of mitochondrial DNA.

GO - Molecular functioni

  1. deaminase activity Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: SGD
  2. mitochondrial translation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MMF1, mitochondrial
Alternative name(s):
Isoleucine biosynthesis and maintenance of intact mitochondria 1
Maintenance of mitochondrial function 1
Gene namesi
Name:MMF1
Synonyms:IBM1
Ordered Locus Names:YIL051C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL051c.
SGDiS000001313. MMF1.

Subcellular locationi

Mitochondrion matrix 2 Publications

GO - Cellular componenti

  1. mitochondrial matrix Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717Mitochondrion2 Publications
Add
BLAST
Chaini18 – 145128Protein MMF1, mitochondrial
PRO_0000036209Add
BLAST

Proteomic databases

MaxQBiP40185.
PaxDbiP40185.
PeptideAtlasiP40185.

2D gel databases

SWISS-2DPAGEP40185.

Expressioni

Gene expression databases

GenevestigatoriP40185.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ECM4P361561EBI-11022,EBI-2042717
HAL5P389701EBI-11022,EBI-8142

Protein-protein interaction databases

BioGridi34939. 85 interactions.
DIPiDIP-4714N.
IntActiP40185. 5 interactions.
MINTiMINT-487056.
STRINGi4932.YIL051C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 244
Beta strandi38 – 425
Beta strandi45 – 517
Helixi65 – 8218
Helixi87 – 893
Beta strandi90 – 989
Helixi100 – 1023
Helixi103 – 11311
Beta strandi114 – 1163
Beta strandi120 – 1256
Helixi130 – 1323
Beta strandi134 – 1429

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QUWX-ray1.75A1-145[»]
ProteinModelPortaliP40185.
SMRiP40185. Positions 20-144.

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0251.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
OMAiIIPQPFP.
OrthoDBiEOG7N640Z.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40185-1 [UniParc]FASTAAdd to Basket

« Hide

MFLRNSVLRT APVLRRGITT LTPVSTKLAP PAAASYSQAM KANNFVYVSG    50
QIPYTPDNKP VQGSISEKAE QVFQNVKNIL AESNSSLDNI VKVNVFLADM 100
KNFAEFNSVY AKHFHTHKPA RSCVGVASLP LNVDLEMEVI AVEKN 145
Length:145
Mass (Da):15,908
Last modified:February 1, 1995 - v1
Checksum:iF2DC4E32C04CED45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050474 Genomic DNA. Translation: BAB20814.1.
Z38060 Genomic DNA. Translation: CAA86171.1.
AY558301 Genomic DNA. Translation: AAS56627.1.
BK006942 Genomic DNA. Translation: DAA08496.1.
PIRiS48428.
RefSeqiNP_012213.3. NM_001179401.3.

Genome annotation databases

EnsemblFungiiYIL051C; YIL051C; YIL051C.
GeneIDi854760.
KEGGisce:YIL051C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050474 Genomic DNA. Translation: BAB20814.1 .
Z38060 Genomic DNA. Translation: CAA86171.1 .
AY558301 Genomic DNA. Translation: AAS56627.1 .
BK006942 Genomic DNA. Translation: DAA08496.1 .
PIRi S48428.
RefSeqi NP_012213.3. NM_001179401.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QUW X-ray 1.75 A 1-145 [» ]
ProteinModelPortali P40185.
SMRi P40185. Positions 20-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34939. 85 interactions.
DIPi DIP-4714N.
IntActi P40185. 5 interactions.
MINTi MINT-487056.
STRINGi 4932.YIL051C.

2D gel databases

SWISS-2DPAGE P40185.

Proteomic databases

MaxQBi P40185.
PaxDbi P40185.
PeptideAtlasi P40185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL051C ; YIL051C ; YIL051C .
GeneIDi 854760.
KEGGi sce:YIL051C.

Organism-specific databases

CYGDi YIL051c.
SGDi S000001313. MMF1.

Phylogenomic databases

eggNOGi COG0251.
GeneTreei ENSGT00420000029792.
HOGENOMi HOG000267215.
OMAi IIPQPFP.
OrthoDBi EOG7N640Z.

Enzyme and pathway databases

BioCyci YEAST:G3O-31322-MONOMER.

Miscellaneous databases

NextBioi 977502.

Gene expression databases

Genevestigatori P40185.

Family and domain databases

Gene3Di 3.30.1330.40. 1 hit.
InterProi IPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view ]
PANTHERi PTHR11803. PTHR11803. 1 hit.
Pfami PF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view ]
SUPFAMi SSF55298. SSF55298. 1 hit.
TIGRFAMsi TIGR00004. TIGR00004. 1 hit.
PROSITEi PS01094. UPF0076. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
    Kim J.-M., Yoshikawa H., Shirahige K.
    Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: PROTEIN SEQUENCE OF 18-28.
    Strain: ATCC 26786 / X2180-1A.
  6. "Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
    Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
    Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, CHARACTERIZATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMMF1_YEAST
AccessioniPrimary (citable) accession number: P40185
Secondary accession number(s): D6VVN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 168000 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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