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P40185 (MMF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MMF1, mitochondrial
Alternative name(s):
Isoleucine biosynthesis and maintenance of intact mitochondria 1
Maintenance of mitochondrial function 1
Gene names
Name:MMF1
Synonyms:IBM1
Ordered Locus Names:YIL051C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the maintenance of mitochondrial DNA.

Subcellular location

Mitochondrion matrix Ref.1 Ref.6.

Miscellaneous

Present with 168000 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RutC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ECM4P361561EBI-11022,EBI-2042717
HAL5P389701EBI-11022,EBI-8142

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1717Mitochondrion Ref.5 Ref.6
Chain18 – 145128Protein MMF1, mitochondrial
PRO_0000036209

Secondary structure

...................... 145
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P40185 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F2DC4E32C04CED45

FASTA14515,908
        10         20         30         40         50         60 
MFLRNSVLRT APVLRRGITT LTPVSTKLAP PAAASYSQAM KANNFVYVSG QIPYTPDNKP 

        70         80         90        100        110        120 
VQGSISEKAE QVFQNVKNIL AESNSSLDNI VKVNVFLADM KNFAEFNSVY AKHFHTHKPA 

       130        140 
RSCVGVASLP LNVDLEMEVI AVEKN 

« Hide

References

« Hide 'large scale' references
[1]"A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae."
Kim J.-M., Yoshikawa H., Shirahige K.
Genes Cells 6:507-517(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, CHARACTERIZATION.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Frutiger S., Paquet N., Pasquali C., Ravier F., Sanchez J.-C., Hughes G.J., Hochstrasser D.F.
Submitted (JUN-1995) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-28.
Strain: ATCC 26786 / X2180-1A.
[6]"Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome."
Oxelmark E., Marchini A., Malanchi I., Magherini F., Jaquet L., Hajibagheri M.A., Blight K.J., Jauniaux J.-C., Tommasino M.
Mol. Cell. Biol. 20:7784-7797(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF N-TERMINUS, SUBCELLULAR LOCATION, CHARACTERIZATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB050474 Genomic DNA. Translation: BAB20814.1.
Z38060 Genomic DNA. Translation: CAA86171.1.
AY558301 Genomic DNA. Translation: AAS56627.1.
BK006942 Genomic DNA. Translation: DAA08496.1.
PIRS48428.
RefSeqNP_012213.3. NM_001179401.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3QUWX-ray1.75A1-145[»]
ProteinModelPortalP40185.
SMRP40185. Positions 20-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34939. 85 interactions.
DIPDIP-4714N.
IntActP40185. 5 interactions.
MINTMINT-487056.
STRING4932.YIL051C.

2D gel databases

SWISS-2DPAGEP40185.

Proteomic databases

PaxDbP40185.
PeptideAtlasP40185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL051C; YIL051C; YIL051C.
GeneID854760.
KEGGsce:YIL051C.

Organism-specific databases

CYGDYIL051c.
SGDS000001313. MMF1.

Phylogenomic databases

eggNOGCOG0251.
GeneTreeENSGT00420000029792.
HOGENOMHOG000267215.
OMARTTLEIN.
OrthoDBEOG7N640Z.

Enzyme and pathway databases

BioCycYEAST:G3O-31322-MONOMER.

Gene expression databases

GenevestigatorP40185.

Family and domain databases

Gene3D3.30.1330.40. 1 hit.
InterProIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. YjgF-like.
IPR019897. YjgF-like_CS.
IPR006175. YjgF/Yer057p/UK114.
[Graphical view]
PANTHERPTHR11803. PTHR11803. 1 hit.
PfamPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMSSF55298. SSF55298. 1 hit.
TIGRFAMsTIGR00004. TIGR00004. 1 hit.
PROSITEPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977502.

Entry information

Entry nameMMF1_YEAST
AccessionPrimary (citable) accession number: P40185
Secondary accession number(s): D6VVN0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references