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P40178

- PUR5_STRFR

UniProt

P40178 - PUR5_STRFR

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Protein

Putative phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Short name:
AIRS
Alternative name(s):
AIR synthase
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 182›182Putative phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148257Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP40178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.Curated

Family and domain databases

Gene3Di3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
[Graphical view]
PfamiPF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.

Sequencei

Sequence statusi: Fragment.

P40178-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IRAGDAVIAM ASSGLHSNGY SLVRHVLFDG AGYALDREIP EFGRTLGEEL
60 70 80 90 100
LEPTRIYSLD CLALTRTTEV HAFSHITGGG LANNLARVIP DGLHATVDRA
110 120 130 140 150
TWTPAPVFGL VGSAGSVERT ELEKTLNMGV GMIAVVAPEG ADAALATLAD
160 170 180
RGVDAWICGE ITDRGESGEH AEAVALTGDY AV
Length:182
Mass (Da):18,971
Last modified:February 1, 1995 - v1
Checksum:iEACE0DB622167CAB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33872 Genomic DNA. Translation: AAA62389.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33872 Genomic DNA. Translation: AAA62389.1 .

3D structure databases

ProteinModelPortali P40178.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.90.650.10. 1 hit.
InterProi IPR010918. AIR_synth_C_dom.
[Graphical view ]
Pfami PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56042. SSF56042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae."
    Tang L., Zhang Y.X., Hutchinson C.R.
    J. Bacteriol. 176:6107-6119(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C373.1.

Entry informationi

Entry nameiPUR5_STRFR
AccessioniPrimary (citable) accession number: P40178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3