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P40178

- PUR5_STRFR

UniProt

P40178 - PUR5_STRFR

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Protein

Putative phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM
Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Short name:
AIRS
Alternative name(s):
AIR synthase
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 182›182Putative phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148257Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP40178.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Family and domain databases

Gene3Di3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
[Graphical view]
PfamiPF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.

Sequencei

Sequence statusi: Fragment.

P40178-1 [UniParc]FASTAAdd to Basket

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IRAGDAVIAM ASSGLHSNGY SLVRHVLFDG AGYALDREIP EFGRTLGEEL    50
LEPTRIYSLD CLALTRTTEV HAFSHITGGG LANNLARVIP DGLHATVDRA 100
TWTPAPVFGL VGSAGSVERT ELEKTLNMGV GMIAVVAPEG ADAALATLAD 150
RGVDAWICGE ITDRGESGEH AEAVALTGDY AV 182
Length:182
Mass (Da):18,971
Last modified:February 1, 1995 - v1
Checksum:iEACE0DB622167CAB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33872 Genomic DNA. Translation: AAA62389.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33872 Genomic DNA. Translation: AAA62389.1 .

3D structure databases

ProteinModelPortali P40178.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.90.650.10. 1 hit.
InterProi IPR010918. AIR_synth_C_dom.
[Graphical view ]
Pfami PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56042. SSF56042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae."
    Tang L., Zhang Y.X., Hutchinson C.R.
    J. Bacteriol. 176:6107-6119(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C373.1.

Entry informationi

Entry nameiPUR5_STRFR
AccessioniPrimary (citable) accession number: P40178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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