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P40178

- PUR5_STRFR

UniProt

P40178 - PUR5_STRFR

Protein

Putative phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
    Short name:
    AIRS
    Alternative name(s):
    AIR synthase
    Phosphoribosyl-aminoimidazole synthetase
    Gene namesi
    Name:purM
    OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
    Taxonomic identifieri1906 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 182›182Putative phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148257Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP40178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.Curated

    Family and domain databases

    Gene3Di3.90.650.10. 1 hit.
    InterProiIPR010918. AIR_synth_C_dom.
    [Graphical view]
    PfamiPF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56042. SSF56042. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P40178-1 [UniParc]FASTAAdd to Basket

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    IRAGDAVIAM ASSGLHSNGY SLVRHVLFDG AGYALDREIP EFGRTLGEEL    50
    LEPTRIYSLD CLALTRTTEV HAFSHITGGG LANNLARVIP DGLHATVDRA 100
    TWTPAPVFGL VGSAGSVERT ELEKTLNMGV GMIAVVAPEG ADAALATLAD 150
    RGVDAWICGE ITDRGESGEH AEAVALTGDY AV 182
    Length:182
    Mass (Da):18,971
    Last modified:February 1, 1995 - v1
    Checksum:iEACE0DB622167CAB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33872 Genomic DNA. Translation: AAA62389.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33872 Genomic DNA. Translation: AAA62389.1 .

    3D structure databases

    ProteinModelPortali P40178.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .

    Family and domain databases

    Gene3Di 3.90.650.10. 1 hit.
    InterProi IPR010918. AIR_synth_C_dom.
    [Graphical view ]
    Pfami PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56042. SSF56042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae."
      Tang L., Zhang Y.X., Hutchinson C.R.
      J. Bacteriol. 176:6107-6119(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C373.1.

    Entry informationi

    Entry nameiPUR5_STRFR
    AccessioniPrimary (citable) accession number: P40178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3