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P40178 (PUR5_STRFR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative phosphoribosylformylglycinamidine cyclo-ligase

Short name=AIRS
EC=6.3.3.1
Alternative name(s):
AIR synthase
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
OrganismStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifier1906 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length182 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 182›182Putative phosphoribosylformylglycinamidine cyclo-ligase
PRO_0000148257

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P40178 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: EACE0DB622167CAB

FASTA18218,971
        10         20         30         40         50         60 
IRAGDAVIAM ASSGLHSNGY SLVRHVLFDG AGYALDREIP EFGRTLGEEL LEPTRIYSLD 

        70         80         90        100        110        120 
CLALTRTTEV HAFSHITGGG LANNLARVIP DGLHATVDRA TWTPAPVFGL VGSAGSVERT 

       130        140        150        160        170        180 
ELEKTLNMGV GMIAVVAPEG ADAALATLAD RGVDAWICGE ITDRGESGEH AEAVALTGDY 


AV 

« Hide

References

[1]"Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae."
Tang L., Zhang Y.X., Hutchinson C.R.
J. Bacteriol. 176:6107-6119(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C373.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L33872 Genomic DNA. Translation: AAA62389.1.

3D structure databases

ProteinModelPortalP40178.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.90.650.10. 1 hit.
InterProIPR010918. AIR_synth_C_dom.
[Graphical view]
PfamPF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. SSF56042. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_STRFR
AccessionPrimary (citable) accession number: P40178
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways