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Protein

60 kDa chaperonin 1

Gene

groL1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 1UniRule annotation
Alternative name(s):
HSP58
Protein Cpn60 1UniRule annotation
groEL1 protein
Gene namesi
Name:groL1UniRule annotation
Synonyms:groEL1UniRule annotation
Ordered Locus Names:SCO4762
ORF Names:SC6G4.40
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 54154060 kDa chaperonin 1PRO_0000063549Add
BLAST

Proteomic databases

PRIDEiP40171.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO4762.

Structurei

3D structure databases

ProteinModelPortaliP40171.
SMRiP40171. Positions 2-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
InParanoidiP40171.
KOiK04077.
OMAiIHQGKIS.
OrthoDBiEOG6JDWBZ.
PhylomeDBiP40171.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILKFDED ARRALERGVN KLADTVKVTI GPKGRNVVID KKFGAPTITN
60 70 80 90 100
DGVTIAREVE VEDPYENLGA QLVKEVATKT NDIAGDGTTT ATVLAQALVR
110 120 130 140 150
EGLKNVAAGA SPALLKKGID AAVAAVSEDL LATARPIDEK SDIAAVAALS
160 170 180 190 200
AQDQQVGELI AEAMDKVGKD GVITVEESNT FGLELDFTEG MAFDKGYLSP
210 220 230 240 250
YFVTDQERME AVLDDPYILI NQGKISSIAD LLPLLEKVIQ ANASKPLLII
260 270 280 290 300
AEDLEGEALS TLVVNKIRGT FNAVAVKAPG FGDRRKAMLQ DMAVLTGATV
310 320 330 340 350
ISEEVGLKLD QVGLEVLGTA RRITVTKDDT TIVDGAGKRD EVQGRIAQIK
360 370 380 390 400
AEIENTDSDW DREKLQERLA KLAGGVCVIK VGAATEVELK ERKHRLEDAI
410 420 430 440 450
SATRAAVEEG IVSGGGSALV HAVKVLEGNL GKTGDEATGV AVVRRAAVEP
460 470 480 490 500
LRWIAENAGL EGYVITSKVA DLDKGQGFNA ATGEYGDLVK AGVIDPVKVT
510 520 530 540
RSALENAASI ASLLLTTETL VVEKKEEEEP AAGGHSHGHS H
Length:541
Mass (Da):57,119
Last modified:January 23, 2007 - v3
Checksum:iC2EFED580B33FFD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 352GR → A in CAA53019 (PubMed:7913076).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75206 Genomic DNA. Translation: CAA53019.1.
AL939121 Genomic DNA. Translation: CAA20418.1.
PIRiS37566.
T35591.
RefSeqiNP_628920.1. NC_003888.3.
WP_003974210.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA20418; CAA20418; CAA20418.
GeneIDi1100203.
KEGGisco:SCO4762.
PATRICi23739348. VBIStrCoe124346_4834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75206 Genomic DNA. Translation: CAA53019.1.
AL939121 Genomic DNA. Translation: CAA20418.1.
PIRiS37566.
T35591.
RefSeqiNP_628920.1. NC_003888.3.
WP_003974210.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP40171.
SMRiP40171. Positions 2-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4762.

Proteomic databases

PRIDEiP40171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA20418; CAA20418; CAA20418.
GeneIDi1100203.
KEGGisco:SCO4762.
PATRICi23739348. VBIStrCoe124346_4834.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
InParanoidiP40171.
KOiK04077.
OMAiIHQGKIS.
OrthoDBiEOG6JDWBZ.
PhylomeDBiP40171.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two groEL genes in Streptomyces coelicolor A3(2)."
    Duchene A.M., Kieser H.M., Hopwood D.A., Thompson C.J., Mazodier P.
    Gene 144:97-101(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / J1501.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCH601_STRCO
AccessioniPrimary (citable) accession number: P40171
Secondary accession number(s): O86801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.