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Protein

Sporulation-specific with a leucine zipper motif protein 1

Gene

SLZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. In the complex, mediates the entry of the MIS complex in nucleolus, where methylation takes place.2 Publications

GO - Biological processi

  1. meiotic nuclear division Source: SGD
  2. mRNA methylation Source: SGD
  3. negative regulation of pseudohyphal growth Source: SGD
  4. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Meiosis, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33206-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific with a leucine zipper motif protein 1
Gene namesi
Name:SLZ1
Ordered Locus Names:YNL196C
ORF Names:N1386
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL196c.
SGDiS000005140. SLZ1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleusnucleolus 1 Publication
Note: Mediates localization of the MIS complex to the nucleolus during the period of m6A mRNA accumulation.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. MIS complex Source: UniProtKB
  3. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Impairs sporulation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Sporulation-specific with a leucine zipper motif protein 1PRO_0000203397Add
BLAST

Expressioni

Inductioni

During sporulation. Expression is activated by IME1 during meiosis.2 Publications

Gene expression databases

GenevestigatoriP40167.

Interactioni

Subunit structurei

Component of the MIS complex, composed of SLZ1, MUM2 and IME4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IME4P418332EBI-29095,EBI-9210

Protein-protein interaction databases

BioGridi35637. 9 interactions.
DIPiDIP-2978N.
IntActiP40167. 1 interaction.
MINTiMINT-546880.
STRINGi4932.YNL196C.

Structurei

3D structure databases

ProteinModelPortaliP40167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP40167.
OrthoDBiEOG72G1JH.

Sequencei

Sequence statusi: Complete.

P40167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKVDQIIG YKKYEVKLPK DRQVKKNKSK GGNVDQIDTK REKDKMRAFG
60 70 80 90 100
EERKKFLDKM AKNKKKNTSR KDREKPKEVE KENYKREDKR LKEQKKLSLA
110 120 130 140 150
KEFRFKEPNS EAINQNTAAE NGKPKPQTGL DFDIDHQTVS KIMIDQAIQT
160 170 180 190 200
SSPLNVQLTE LFNDNVLDVS KDSQFVLQDM EFTSWERRWS NCSTTSNATT
210 220 230 240 250
VSSVPDPKYN INYNDITSFN SVALITEDLN ISASSNGLHE RGKKLLQQEM
260 270 280 290
EYSNKVKNVT IGLERLCMDE KPVPDAGITM QQASRWSEFP TCCDQAAI
Length:298
Mass (Da):34,318
Last modified:February 1, 1995 - v1
Checksum:i72B8AE0DB8D8F1E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78898 Genomic DNA. Translation: CAA55512.1.
Z71472 Genomic DNA. Translation: CAA96091.1.
BK006947 Genomic DNA. Translation: DAA10357.1.
PIRiS50735.
RefSeqiNP_014203.1. NM_001183034.1.

Genome annotation databases

EnsemblFungiiYNL196C; YNL196C; YNL196C.
GeneIDi855525.
KEGGisce:YNL196C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78898 Genomic DNA. Translation: CAA55512.1.
Z71472 Genomic DNA. Translation: CAA96091.1.
BK006947 Genomic DNA. Translation: DAA10357.1.
PIRiS50735.
RefSeqiNP_014203.1. NM_001183034.1.

3D structure databases

ProteinModelPortaliP40167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35637. 9 interactions.
DIPiDIP-2978N.
IntActiP40167. 1 interaction.
MINTiMINT-546880.
STRINGi4932.YNL196C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL196C; YNL196C; YNL196C.
GeneIDi855525.
KEGGisce:YNL196C.

Organism-specific databases

CYGDiYNL196c.
SGDiS000005140. SLZ1.

Phylogenomic databases

InParanoidiP40167.
OrthoDBiEOG72G1JH.

Enzyme and pathway databases

BioCyciYEAST:G3O-33206-MONOMER.

Miscellaneous databases

NextBioi979562.

Gene expression databases

GenevestigatoriP40167.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
    Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
    Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae."
    Briza P., Bogengruber E., Thuer A., Ruetzler M., Muensterkoetter M., Dawes I.W., Breitenbach M.
    Yeast 19:403-422(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, INDUCTION.
  5. "RNA methylation by the MIS complex regulates a cell fate decision in yeast."
    Agarwala S.D., Blitzblau H.G., Hochwagen A., Fink G.R.
    PLoS Genet. 8:E1002732-E1002732(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MIS COMPLEX, FUNCTION.
  6. "High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis."
    Schwartz S., Agarwala S.D., Mumbach M.R., Jovanovic M., Mertins P., Shishkin A., Tabach Y., Mikkelsen T.S., Satija R., Ruvkun G., Carr S.A., Lander E.S., Fink G.R., Regev A.
    Cell 155:1409-1421(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MIS COMPLEX, INDUCTION BY IME1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSLZ1_YEAST
AccessioniPrimary (citable) accession number: P40167
Secondary accession number(s): D6W0Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.