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P40164

- PP4R3_YEAST

UniProt

P40164 - PP4R3_YEAST

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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3

Gene

PSY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.1 Publication

GO - Molecular functioni

  1. protein phosphatase type 2A regulator activity Source: SGD

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: SGD
  2. negative regulation of DNA damage checkpoint Source: SGD
  3. negative regulation of glucose mediated signaling pathway Source: SGD
  4. positive regulation of double-strand break repair via nonhomologous end joining Source: SGD
  5. protein dephosphorylation Source: SGD
  6. regulation of catalytic activity Source: GOC
  7. signal transduction involved in meiotic recombination checkpoint Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Short name:
PP4R3
Gene namesi
Name:PSY2
Ordered Locus Names:YNL201C
ORF Names:N1366
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL201c.
SGDiS000005145. PSY2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. protein phosphatase 4 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Serine/threonine-protein phosphatase 4 regulatory subunit 3PRO_0000203395Add
BLAST

Proteomic databases

MaxQBiP40164.
PaxDbiP40164.
PeptideAtlasiP40164.

Expressioni

Gene expression databases

GenevestigatoriP40164.

Interactioni

Subunit structurei

Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4, SPT5 and TIP41.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PSY4P381938EBI-29107,EBI-21239
RRD1P404543EBI-29107,EBI-25278
SPT5P276926EBI-29107,EBI-17937

Protein-protein interaction databases

BioGridi35633. 117 interactions.
DIPiDIP-1513N.
IntActiP40164. 20 interactions.
MINTiMINT-384732.
STRINGi4932.YNL201C.

Structurei

3D structure databases

ProteinModelPortaliP40164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG314899.
GeneTreeiENSGT00390000018199.
HOGENOMiHOG000115652.
InParanoidiP40164.
KOiK17491.
OMAiTSKANHR.
OrthoDBiEOG72VHFD.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR006887. DUF625.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

P40164-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPGTPTTS PTPMDEDTEQ AVSVNTEPKR VKVYILENNE WKDTGTGFCI
60 70 80 90 100
GEVDEGKFAY LVVSDEDSPT ETLLKSKLEG NIEYQRQEET LIVWKDLGGK
110 120 130 140 150
DIALSFEESM GCDTLCEFIV HVQRNIESNI SLVTVKSSDN GLGSVHDIIT
160 170 180 190 200
GPVTLPSNDQ QQNSQTLLEA LKILNENTSF DFLKNETIEF ILQSNYIDTL
210 220 230 240 250
ISHFHKAEEE KIPKDLFLLS NIIKTLILYN KRDILESMVE DDRIMGIVGI
260 270 280 290 300
LEYDTEYPTS KANHRKYLGS KGPNFKEVIP LENEDLKIIM KKCFRLQFLK
310 320 330 340 350
DVVLVRFLDD HNFNLISEIV MDLETCIIDF LQVGTFLDRL IELYDTKTLP
360 370 380 390 400
ESSSEKEKFV QKRKDGIRLL QQCVQMSINL DAVDRSKFYK TLVRKGLFKV
410 420 430 440 450
LDYAFHMETD SNVRILATDT IITIIEHDIL LIHNVQNEDS FKRQHKSAPD
460 470 480 490 500
DKSSHRKYPQ DYSSSTDSKL LLILSTILLS DRSPGLREQV VQALNTLLHP
510 520 530 540 550
EGCVGNGEGS YDLMGRSNYE AKNTSEDFPS FSYGLNSDSI NLNNYHYSSD
560 570 580 590 600
EMNNLEPESE SEFQVMEYFA NFYNKIAPIL FGPLIKKDIT TEMAEIDGQI
610 620 630 640 650
EKVTKDDLLL IHLVKLVSFV CTEHDRVLSR RFILENGILD SVSKLIGGNH
660 670 680 690 700
MMQLRLTAVR CIKNLMCLDD KYYHRYMISK NLYAPVFKLF QENIDKNNLA
710 720 730 740 750
NSCIQDFFRI IITECRAYQS DGHNRKEKTN GSYDGNGNDV KTNVNNNRTN
760 770 780 790 800
FTILNKYLVQ TYGDVLRKAT DIPFIQDMLE TGEENQPDHS SFENSIEGGN
810 820 830 840 850
DISVNMSTDG FASNHLEDID IKNVKRLHSE IEHFENDPHY SGDQLAFKKS

VDQMNAST
Length:858
Mass (Da):98,053
Last modified:February 1, 1995 - v1
Checksum:i9AB94C259FF7A55B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78898 Genomic DNA. Translation: CAA55507.1.
Z71477 Genomic DNA. Translation: CAA96100.1.
BK006947 Genomic DNA. Translation: DAA10353.1.
PIRiS50730.
RefSeqiNP_014198.1. NM_001183039.1.

Genome annotation databases

EnsemblFungiiYNL201C; YNL201C; YNL201C.
GeneIDi855520.
KEGGisce:YNL201C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78898 Genomic DNA. Translation: CAA55507.1 .
Z71477 Genomic DNA. Translation: CAA96100.1 .
BK006947 Genomic DNA. Translation: DAA10353.1 .
PIRi S50730.
RefSeqi NP_014198.1. NM_001183039.1.

3D structure databases

ProteinModelPortali P40164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35633. 117 interactions.
DIPi DIP-1513N.
IntActi P40164. 20 interactions.
MINTi MINT-384732.
STRINGi 4932.YNL201C.

Proteomic databases

MaxQBi P40164.
PaxDbi P40164.
PeptideAtlasi P40164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL201C ; YNL201C ; YNL201C .
GeneIDi 855520.
KEGGi sce:YNL201C.

Organism-specific databases

CYGDi YNL201c.
SGDi S000005145. PSY2.

Phylogenomic databases

eggNOGi NOG314899.
GeneTreei ENSGT00390000018199.
HOGENOMi HOG000115652.
InParanoidi P40164.
KOi K17491.
OMAi TSKANHR.
OrthoDBi EOG72VHFD.

Enzyme and pathway databases

BioCyci YEAST:G3O-33210-MONOMER.

Miscellaneous databases

NextBioi 979550.
PROi P40164.

Gene expression databases

Genevestigatori P40164.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR006887. DUF625.
[Graphical view ]
Pfami PF04802. SMK-1. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
    Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
    Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."
    Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R.
    Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RAD53; SPT4; SPT5 AND TIP41.
  7. Cited for: FUNCTION, IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPP4R3_YEAST
AccessioniPrimary (citable) accession number: P40164
Secondary accession number(s): D6W0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3