Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P40164 (PP4R3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3

Short name=PP4R3
Gene names
Name:PSY2
Ordered Locus Names:YNL201C
ORF Names:N1366
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint. Ref.7

Subunit structure

Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4, SPT5 and TIP41. Ref.6 Ref.7

Subcellular location

Nucleus Ref.4.

Miscellaneous

Present with 7010 molecules/cell in log phase SD medium.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Serine/threonine-protein phosphatase 4 regulatory subunit 3
PRO_0000203395

Sequences

Sequence LengthMass (Da)Tools
P40164 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9AB94C259FF7A55B

FASTA85898,053
        10         20         30         40         50         60 
MSLPGTPTTS PTPMDEDTEQ AVSVNTEPKR VKVYILENNE WKDTGTGFCI GEVDEGKFAY 

        70         80         90        100        110        120 
LVVSDEDSPT ETLLKSKLEG NIEYQRQEET LIVWKDLGGK DIALSFEESM GCDTLCEFIV 

       130        140        150        160        170        180 
HVQRNIESNI SLVTVKSSDN GLGSVHDIIT GPVTLPSNDQ QQNSQTLLEA LKILNENTSF 

       190        200        210        220        230        240 
DFLKNETIEF ILQSNYIDTL ISHFHKAEEE KIPKDLFLLS NIIKTLILYN KRDILESMVE 

       250        260        270        280        290        300 
DDRIMGIVGI LEYDTEYPTS KANHRKYLGS KGPNFKEVIP LENEDLKIIM KKCFRLQFLK 

       310        320        330        340        350        360 
DVVLVRFLDD HNFNLISEIV MDLETCIIDF LQVGTFLDRL IELYDTKTLP ESSSEKEKFV 

       370        380        390        400        410        420 
QKRKDGIRLL QQCVQMSINL DAVDRSKFYK TLVRKGLFKV LDYAFHMETD SNVRILATDT 

       430        440        450        460        470        480 
IITIIEHDIL LIHNVQNEDS FKRQHKSAPD DKSSHRKYPQ DYSSSTDSKL LLILSTILLS 

       490        500        510        520        530        540 
DRSPGLREQV VQALNTLLHP EGCVGNGEGS YDLMGRSNYE AKNTSEDFPS FSYGLNSDSI 

       550        560        570        580        590        600 
NLNNYHYSSD EMNNLEPESE SEFQVMEYFA NFYNKIAPIL FGPLIKKDIT TEMAEIDGQI 

       610        620        630        640        650        660 
EKVTKDDLLL IHLVKLVSFV CTEHDRVLSR RFILENGILD SVSKLIGGNH MMQLRLTAVR 

       670        680        690        700        710        720 
CIKNLMCLDD KYYHRYMISK NLYAPVFKLF QENIDKNNLA NSCIQDFFRI IITECRAYQS 

       730        740        750        760        770        780 
DGHNRKEKTN GSYDGNGNDV KTNVNNNRTN FTILNKYLVQ TYGDVLRKAT DIPFIQDMLE 

       790        800        810        820        830        840 
TGEENQPDHS SFENSIEGGN DISVNMSTDG FASNHLEDID IKNVKRLHSE IEHFENDPHY 

       850 
SGDQLAFKKS VDQMNAST 

« Hide

References

« Hide 'large scale' references
[1]"A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."
Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R.
Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RAD53; SPT4; SPT5 AND TIP41.
[7]"A phosphatase complex that dephosphorylates gamma-H2AX regulates DNA damage checkpoint recovery."
Keogh M.-C., Kim J.-A., Downey M., Fillingham J., Chowdhury D., Harrison J.C., Onishi M., Datta N., Galicia S., Emili A., Lieberman J., Shen X., Buratowski S., Haber J.E., Durocher D., Greenblatt J.F., Krogan N.J.
Nature 439:497-501(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78898 Genomic DNA. Translation: CAA55507.1.
Z71477 Genomic DNA. Translation: CAA96100.1.
BK006947 Genomic DNA. Translation: DAA10353.1.
PIRS50730.
RefSeqNP_014198.1. NM_001183039.1.

3D structure databases

ProteinModelPortalP40164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35633. 117 interactions.
DIPDIP-1513N.
IntActP40164. 20 interactions.
MINTMINT-384732.
STRING4932.YNL201C.

Proteomic databases

MaxQBP40164.
PaxDbP40164.
PeptideAtlasP40164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL201C; YNL201C; YNL201C.
GeneID855520.
KEGGsce:YNL201C.

Organism-specific databases

CYGDYNL201c.
SGDS000005145. PSY2.

Phylogenomic databases

eggNOGNOG314899.
GeneTreeENSGT00390000018199.
HOGENOMHOG000115652.
KOK17491.
OMATSKANHR.
OrthoDBEOG72VHFD.

Enzyme and pathway databases

BioCycYEAST:G3O-33210-MONOMER.

Gene expression databases

GenevestigatorP40164.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR006887. DUF625.
[Graphical view]
PfamPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 3 hits.
ProtoNetSearch...

Other

NextBio979550.
PROP40164.

Entry information

Entry namePP4R3_YEAST
AccessionPrimary (citable) accession number: P40164
Secondary accession number(s): D6W0Y7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD