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P40164

- PP4R3_YEAST

UniProt

P40164 - PP4R3_YEAST

Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3

Gene

PSY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein phosphatase type 2A regulator activity Source: SGD

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: SGD
    2. negative regulation of DNA damage checkpoint Source: SGD
    3. negative regulation of glucose mediated signaling pathway Source: SGD
    4. protein dephosphorylation Source: SGD
    5. regulation of catalytic activity Source: GOC
    6. signal transduction involved in meiotic recombination checkpoint Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3
    Short name:
    PP4R3
    Gene namesi
    Name:PSY2
    Ordered Locus Names:YNL201C
    ORF Names:N1366
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL201c.
    SGDiS000005145. PSY2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein phosphatase 4 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Serine/threonine-protein phosphatase 4 regulatory subunit 3PRO_0000203395Add
    BLAST

    Proteomic databases

    MaxQBiP40164.
    PaxDbiP40164.
    PeptideAtlasiP40164.

    Expressioni

    Gene expression databases

    GenevestigatoriP40164.

    Interactioni

    Subunit structurei

    Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4, SPT5 and TIP41.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PSY4P381938EBI-29107,EBI-21239
    RRD1P404543EBI-29107,EBI-25278
    SPT5P276926EBI-29107,EBI-17937

    Protein-protein interaction databases

    BioGridi35633. 117 interactions.
    DIPiDIP-1513N.
    IntActiP40164. 20 interactions.
    MINTiMINT-384732.
    STRINGi4932.YNL201C.

    Structurei

    3D structure databases

    ProteinModelPortaliP40164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG314899.
    GeneTreeiENSGT00390000018199.
    HOGENOMiHOG000115652.
    KOiK17491.
    OMAiTSKANHR.
    OrthoDBiEOG72VHFD.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR006887. DUF625.
    [Graphical view]
    PfamiPF04802. SMK-1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P40164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPGTPTTS PTPMDEDTEQ AVSVNTEPKR VKVYILENNE WKDTGTGFCI    50
    GEVDEGKFAY LVVSDEDSPT ETLLKSKLEG NIEYQRQEET LIVWKDLGGK 100
    DIALSFEESM GCDTLCEFIV HVQRNIESNI SLVTVKSSDN GLGSVHDIIT 150
    GPVTLPSNDQ QQNSQTLLEA LKILNENTSF DFLKNETIEF ILQSNYIDTL 200
    ISHFHKAEEE KIPKDLFLLS NIIKTLILYN KRDILESMVE DDRIMGIVGI 250
    LEYDTEYPTS KANHRKYLGS KGPNFKEVIP LENEDLKIIM KKCFRLQFLK 300
    DVVLVRFLDD HNFNLISEIV MDLETCIIDF LQVGTFLDRL IELYDTKTLP 350
    ESSSEKEKFV QKRKDGIRLL QQCVQMSINL DAVDRSKFYK TLVRKGLFKV 400
    LDYAFHMETD SNVRILATDT IITIIEHDIL LIHNVQNEDS FKRQHKSAPD 450
    DKSSHRKYPQ DYSSSTDSKL LLILSTILLS DRSPGLREQV VQALNTLLHP 500
    EGCVGNGEGS YDLMGRSNYE AKNTSEDFPS FSYGLNSDSI NLNNYHYSSD 550
    EMNNLEPESE SEFQVMEYFA NFYNKIAPIL FGPLIKKDIT TEMAEIDGQI 600
    EKVTKDDLLL IHLVKLVSFV CTEHDRVLSR RFILENGILD SVSKLIGGNH 650
    MMQLRLTAVR CIKNLMCLDD KYYHRYMISK NLYAPVFKLF QENIDKNNLA 700
    NSCIQDFFRI IITECRAYQS DGHNRKEKTN GSYDGNGNDV KTNVNNNRTN 750
    FTILNKYLVQ TYGDVLRKAT DIPFIQDMLE TGEENQPDHS SFENSIEGGN 800
    DISVNMSTDG FASNHLEDID IKNVKRLHSE IEHFENDPHY SGDQLAFKKS 850
    VDQMNAST 858
    Length:858
    Mass (Da):98,053
    Last modified:February 1, 1995 - v1
    Checksum:i9AB94C259FF7A55B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78898 Genomic DNA. Translation: CAA55507.1.
    Z71477 Genomic DNA. Translation: CAA96100.1.
    BK006947 Genomic DNA. Translation: DAA10353.1.
    PIRiS50730.
    RefSeqiNP_014198.1. NM_001183039.1.

    Genome annotation databases

    EnsemblFungiiYNL201C; YNL201C; YNL201C.
    GeneIDi855520.
    KEGGisce:YNL201C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78898 Genomic DNA. Translation: CAA55507.1 .
    Z71477 Genomic DNA. Translation: CAA96100.1 .
    BK006947 Genomic DNA. Translation: DAA10353.1 .
    PIRi S50730.
    RefSeqi NP_014198.1. NM_001183039.1.

    3D structure databases

    ProteinModelPortali P40164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35633. 117 interactions.
    DIPi DIP-1513N.
    IntActi P40164. 20 interactions.
    MINTi MINT-384732.
    STRINGi 4932.YNL201C.

    Proteomic databases

    MaxQBi P40164.
    PaxDbi P40164.
    PeptideAtlasi P40164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL201C ; YNL201C ; YNL201C .
    GeneIDi 855520.
    KEGGi sce:YNL201C.

    Organism-specific databases

    CYGDi YNL201c.
    SGDi S000005145. PSY2.

    Phylogenomic databases

    eggNOGi NOG314899.
    GeneTreei ENSGT00390000018199.
    HOGENOMi HOG000115652.
    KOi K17491.
    OMAi TSKANHR.
    OrthoDBi EOG72VHFD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33210-MONOMER.

    Miscellaneous databases

    NextBioi 979550.
    PROi P40164.

    Gene expression databases

    Genevestigatori P40164.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR006887. DUF625.
    [Graphical view ]
    Pfami PF04802. SMK-1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function."
      Jonniaux J.-L., Coster F., Purnelle B., Goffeau A.
      Yeast 10:1639-1645(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."
      Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R.
      Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RAD53; SPT4; SPT5 AND TIP41.
    7. Cited for: FUNCTION, IDENTIFICATION IN HTP-C COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPP4R3_YEAST
    AccessioniPrimary (citable) accession number: P40164
    Secondary accession number(s): D6W0Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7010 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3