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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3

Gene

PSY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.1 Publication

Miscellaneous

Present with 7010 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein phosphatase regulator activity Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • negative regulation of DNA damage checkpoint Source: SGD
  • negative regulation of glucose mediated signaling pathway Source: SGD
  • positive regulation of double-strand break repair via nonhomologous end joining Source: SGD
  • protein dephosphorylation Source: SGD
  • signal transduction involved in meiotic recombination checkpoint Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Short name:
PP4R3
Gene namesi
Name:PSY2
Ordered Locus Names:YNL201C
ORF Names:N1366
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL201C.
SGDiS000005145. PSY2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033951 – 858Serine/threonine-protein phosphatase 4 regulatory subunit 3Add BLAST858

Proteomic databases

MaxQBiP40164.
PRIDEiP40164.

Interactioni

Subunit structurei

Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4, SPT5 and TIP41.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35633. 140 interactors.
DIPiDIP-1513N.
IntActiP40164. 47 interactors.
MINTiMINT-384732.
STRINGi4932.YNL201C.

Structurei

3D structure databases

ProteinModelPortaliP40164.
SMRiP40164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018199.
HOGENOMiHOG000115652.
InParanoidiP40164.
KOiK17491.
OMAiKNGPQTQ.
OrthoDBiEOG092C2EGO.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_dom-like.
PfamiView protein in Pfam
PF04802. SMK-1. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

P40164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPGTPTTS PTPMDEDTEQ AVSVNTEPKR VKVYILENNE WKDTGTGFCI
60 70 80 90 100
GEVDEGKFAY LVVSDEDSPT ETLLKSKLEG NIEYQRQEET LIVWKDLGGK
110 120 130 140 150
DIALSFEESM GCDTLCEFIV HVQRNIESNI SLVTVKSSDN GLGSVHDIIT
160 170 180 190 200
GPVTLPSNDQ QQNSQTLLEA LKILNENTSF DFLKNETIEF ILQSNYIDTL
210 220 230 240 250
ISHFHKAEEE KIPKDLFLLS NIIKTLILYN KRDILESMVE DDRIMGIVGI
260 270 280 290 300
LEYDTEYPTS KANHRKYLGS KGPNFKEVIP LENEDLKIIM KKCFRLQFLK
310 320 330 340 350
DVVLVRFLDD HNFNLISEIV MDLETCIIDF LQVGTFLDRL IELYDTKTLP
360 370 380 390 400
ESSSEKEKFV QKRKDGIRLL QQCVQMSINL DAVDRSKFYK TLVRKGLFKV
410 420 430 440 450
LDYAFHMETD SNVRILATDT IITIIEHDIL LIHNVQNEDS FKRQHKSAPD
460 470 480 490 500
DKSSHRKYPQ DYSSSTDSKL LLILSTILLS DRSPGLREQV VQALNTLLHP
510 520 530 540 550
EGCVGNGEGS YDLMGRSNYE AKNTSEDFPS FSYGLNSDSI NLNNYHYSSD
560 570 580 590 600
EMNNLEPESE SEFQVMEYFA NFYNKIAPIL FGPLIKKDIT TEMAEIDGQI
610 620 630 640 650
EKVTKDDLLL IHLVKLVSFV CTEHDRVLSR RFILENGILD SVSKLIGGNH
660 670 680 690 700
MMQLRLTAVR CIKNLMCLDD KYYHRYMISK NLYAPVFKLF QENIDKNNLA
710 720 730 740 750
NSCIQDFFRI IITECRAYQS DGHNRKEKTN GSYDGNGNDV KTNVNNNRTN
760 770 780 790 800
FTILNKYLVQ TYGDVLRKAT DIPFIQDMLE TGEENQPDHS SFENSIEGGN
810 820 830 840 850
DISVNMSTDG FASNHLEDID IKNVKRLHSE IEHFENDPHY SGDQLAFKKS

VDQMNAST
Length:858
Mass (Da):98,053
Last modified:February 1, 1995 - v1
Checksum:i9AB94C259FF7A55B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78898 Genomic DNA. Translation: CAA55507.1.
Z71477 Genomic DNA. Translation: CAA96100.1.
BK006947 Genomic DNA. Translation: DAA10353.1.
PIRiS50730.
RefSeqiNP_014198.1. NM_001183039.1.

Genome annotation databases

EnsemblFungiiYNL201C; YNL201C; YNL201C.
GeneIDi855520.
KEGGisce:YNL201C.

Similar proteinsi

Entry informationi

Entry nameiPP4R3_YEAST
AccessioniPrimary (citable) accession number: P40164
Secondary accession number(s): D6W0Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names