ID   RRG9_YEAST              Reviewed;         214 AA.
AC   P40156; D6W0X7;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Required for respiratory growth protein 9, mitochondrial;
DE   Flags: Precursor;
GN   Name=RRG9; OrderedLocusNames=YNL213C; ORFNames=N1323;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=7762305; DOI=10.1002/yea.320110111;
RA   Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.;
RT   "The sequence of a 13.5 kb DNA segment from the left arm of yeast
RT   chromosome XIV reveals MER1; RAP1; a new putative member of the DNA
RT   replication complex and a new putative serine/threonine phosphatase gene.";
RL   Yeast 11:85-91(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169873;
RA   Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA   Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA   Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA   Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA   Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA   Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA   Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA   Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA   Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA   Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA   Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA   Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA   Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA   Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA   Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA   Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA   Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT   evolutionary implications.";
RL   Nature 387:93-98(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=16823961; DOI=10.1021/pr050477f;
RA   Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT   "Toward the complete yeast mitochondrial proteome: multidimensional
RT   separation techniques for mitochondrial proteomics.";
RL   J. Proteome Res. 5:1543-1554(2006).
RN   [6]
RP   FUNCTION.
RX   PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA   Merz S., Westermann B.;
RT   "Genome-wide deletion mutant analysis reveals genes required for
RT   respiratory growth, mitochondrial genome maintenance and mitochondrial
RT   protein synthesis in Saccharomyces cerevisiae.";
RL   Genome Biol. 10:R95.1-R95.18(2009).
CC   -!- FUNCTION: Required for respiratory activity and maintenance and
CC       expression of the mitochondrial genome. {ECO:0000269|PubMed:19751518}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823961}.
CC   -!- MISCELLANEOUS: Present with 1160 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the RRG9 family. {ECO:0000305}.
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DR   EMBL; X78898; CAA55495.1; -; Genomic_DNA.
DR   EMBL; Z71489; CAA96115.1; -; Genomic_DNA.
DR   EMBL; BK006947; DAA10343.1; -; Genomic_DNA.
DR   PIR; S50718; S50718.
DR   RefSeq; NP_014186.1; NM_001183051.1.
DR   AlphaFoldDB; P40156; -.
DR   SMR; P40156; -.
DR   BioGRID; 35623; 175.
DR   DIP; DIP-6462N; -.
DR   IntAct; P40156; 2.
DR   STRING; 4932.YNL213C; -.
DR   PaxDb; 4932-YNL213C; -.
DR   PeptideAtlas; P40156; -.
DR   EnsemblFungi; YNL213C_mRNA; YNL213C; YNL213C.
DR   GeneID; 855508; -.
DR   KEGG; sce:YNL213C; -.
DR   AGR; SGD:S000005157; -.
DR   SGD; S000005157; RRG9.
DR   VEuPathDB; FungiDB:YNL213C; -.
DR   eggNOG; ENOG502S7IA; Eukaryota.
DR   GeneTree; ENSGT00390000014472; -.
DR   HOGENOM; CLU_100293_0_0_1; -.
DR   InParanoid; P40156; -.
DR   OMA; KRSFANI; -.
DR   OrthoDB; 1387399at2759; -.
DR   BioCyc; YEAST:G3O-33219-MONOMER; -.
DR   BioGRID-ORCS; 855508; 1 hit in 10 CRISPR screens.
DR   PRO; PR:P40156; -.
DR   Proteomes; UP000002311; Chromosome XIV.
DR   RNAct; P40156; Protein.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IMP:SGD.
DR   GO; GO:0007005; P:mitochondrion organization; IMP:SGD.
DR   InterPro; IPR010487; NGRN/Rrg9.
DR   PANTHER; PTHR13475; NEUGRIN; 1.
DR   PANTHER; PTHR13475:SF3; NEUGRIN; 1.
DR   Pfam; PF06413; Neugrin; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..18
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           19..214
FT                   /note="Required for respiratory growth protein 9,
FT                   mitochondrial"
FT                   /id="PRO_0000203389"
SQ   SEQUENCE   214 AA;  25274 MW;  D1564C8905C3A985 CRC64;
     MNILRIACRS FHCLRCGPLL NENRGWSSKK IIKLVNKSSL SNKEFTEKVR DGTKDIPEWK
     KQKMAVRKKL QGQRWNPPKK ISQEQMEALR LLKFNFPELT ASDLADRFKI SPEAVRRILK
     SNWKRTDEEN NNTYERWKRR GERIKEMYQR KEDADFVSNQ IVTSRKIILG SNSNSPELIA
     RNVRTFKPFK PNNSTPEKKN TNKLYILKHL GSKQ
//