P40156 (RRG9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Required for respiratory growth protein 9, mitochondrial

Gene names

Name:	RRG9
Ordered Locus Names:	YNL213C
ORF Names:	N1323

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for respiratory activity and maintenance and expression of the mitochondrial genome. Ref.6
Subcellular location	Mitochondrion Ref.5.
Miscellaneous	Present with 1160 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the RRG9 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial genome maintenance Inferred from mutant phenotype Ref.6. Source: SGD
Cellular_component	mitochondrion Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GCN2	P15442	1	EBI-29140,EBI-330

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 18	18	Mitochondrion Probable
	Chain	19 – 214	196	Required for respiratory growth protein 9, mitochondrial		PRO_0000203389

Sequences

	Sequence		Length	Mass (Da)
	P40156 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: D1564C8905C3A985	FASTA	214	25,274
	10 20 30 40 50 60 MNILRIACRS FHCLRCGPLL NENRGWSSKK IIKLVNKSSL SNKEFTEKVR DGTKDIPEWK 70 80 90 100 110 120 KQKMAVRKKL QGQRWNPPKK ISQEQMEALR LLKFNFPELT ASDLADRFKI SPEAVRRILK 130 140 150 160 170 180 SNWKRTDEEN NNTYERWKRR GERIKEMYQR KEDADFVSNQ IVTSRKIILG SNSNSPELIA 190 200 210 RNVRTFKPFK PNNSTPEKKN TNKLYILKHL GSKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene." Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A. Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae." Merz S., Westermann B. Genome Biol. 10:R95.1-R95.18(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78898 Genomic DNA. Translation: CAA55495.1. Z71489 Genomic DNA. Translation: CAA96115.1. BK006947 Genomic DNA. Translation: DAA10343.1.
PIR	S50718.
RefSeq	NP_014186.1. NM_001183051.1.
3D structure databases
ProteinModelPortal	P40156.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6462N.
IntAct	P40156. 2 interactions.
MINT	MINT-704429.
STRING	4932.YNL213C.
Proteomic databases
PaxDb	P40156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL213C; YNL213C; YNL213C.
GeneID	855508.
KEGG	sce:YNL213C.
Organism-specific databases
CYGD	YNL213c.
SGD	S000005157. RRG9.
Phylogenomic databases
eggNOG	NOG44510.
OMA	NITNTEL.
OrthoDB	EOG466ZWC.
Gene expression databases
Genevestigator	P40156.
GermOnline	YNL213C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR010487. Neugrin-related. [Graphical view]
Pfam	PF06413. Neugrin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	979520.

Entry information

Entry name

RRG9_YEAST

Accession

Primary (citable) accession number: P40156
Secondary accession number(s): D6W0X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program