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Protein

Ino eighty subunit 2

Gene

IES2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33221-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ino eighty subunit 2
Gene namesi
Name:IES2
Ordered Locus Names:YNL215W
ORF Names:N1315
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL215W
SGDiS000005159 IES2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841541 – 320Ino eighty subunit 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP40154
PaxDbiP40154
PRIDEiP40154

PTM databases

iPTMnetiP40154

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35621, 347 interactors
DIPiDIP-5062N
IntActiP40154, 22 interactors
MINTiP40154
STRINGi4932.YNL215W

Structurei

3D structure databases

ProteinModelPortaliP40154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IES2 family.Curated

Phylogenomic databases

InParanoidiP40154
KOiK11676
OrthoDBiEOG092C4OC7

Family and domain databases

InterProiView protein in InterPro
IPR029523 INO80B/Ies2
IPR006880 INO80B_C
PANTHERiPTHR21561 PTHR21561, 1 hit
PfamiView protein in Pfam
PF04795 PAPA-1, 1 hit
SMARTiView protein in SMART
SM01406 PAPA-1, 1 hit

Sequencei

Sequence statusi: Complete.

P40154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEASDIEA ELSDSVSAGG EEYIDDDDYT EDIDDQIVTA KSSRRTARRS
60 70 80 90 100
VPKGVRTSKR IRDKELSVEV DEDYDEEEDV LSPSKKRHLH TRSMDKRQVA
110 120 130 140 150
ATASEKSDIG DSKGNDGEIE DGILEEEESL EKELNRGGGK EVEKSEESYY
160 170 180 190 200
AQNDVGQKGE EEQDGESGGY EDNEPSISKE SDELVSVVNG NGNEEDDEVE
210 220 230 240 250
ATKENTTDST RSTTTRSKML LDLLEDGGSK KKLTDEEIQL RRAENARKRK
260 270 280 290 300
NLSEKRLEEE KQDTINKLLK KRAGKSRSHL PNDDEKNDGS SSFVKPRRPY
310 320
NSEGMTRILR RYEEDLFCTF
Length:320
Mass (Da):36,154
Last modified:February 1, 1995 - v1
Checksum:i6F0AA04387A3B3E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78898 Genomic DNA Translation: CAA55493.1
Z71491 Genomic DNA Translation: CAA96117.1
BK006947 Genomic DNA Translation: DAA10341.1
PIRiS50716
RefSeqiNP_014184.1, NM_001183053.1

Genome annotation databases

EnsemblFungiiYNL215W; YNL215W; YNL215W
GeneIDi855506
KEGGisce:YNL215W

Similar proteinsi

Entry informationi

Entry nameiIES2_YEAST
AccessioniPrimary (citable) accession number: P40154
Secondary accession number(s): D6W0X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health