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P40154

- IES2_YEAST

UniProt

P40154 - IES2_YEAST

Protein

Ino eighty subunit 2

Gene

IES2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33221-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ino eighty subunit 2
    Gene namesi
    Name:IES2
    Ordered Locus Names:YNL215W
    ORF Names:N1315
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL215w.
    SGDiS000005159. IES2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Ino80 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Ino eighty subunit 2PRO_0000084154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671Phosphoserine1 Publication
    Modified residuei129 – 1291Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP40154.
    PaxDbiP40154.

    Expressioni

    Gene expression databases

    GenevestigatoriP40154.

    Interactioni

    Subunit structurei

    Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

    Protein-protein interaction databases

    BioGridi35621. 240 interactions.
    DIPiDIP-5062N.
    IntActiP40154. 6 interactions.
    MINTiMINT-560359.
    STRINGi4932.YNL215W.

    Structurei

    3D structure databases

    ProteinModelPortaliP40154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IES2 family.Curated

    Phylogenomic databases

    eggNOGiNOG75630.
    KOiK11676.
    OMAiDYTEDID.
    OrthoDBiEOG769ZW5.

    Family and domain databases

    InterProiIPR029523. INO80B/Ies2.
    IPR006880. INO80B_C.
    [Graphical view]
    PANTHERiPTHR21561:SF12. PTHR21561:SF12. 1 hit.
    PfamiPF04795. PAPA-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40154-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSEASDIEA ELSDSVSAGG EEYIDDDDYT EDIDDQIVTA KSSRRTARRS    50
    VPKGVRTSKR IRDKELSVEV DEDYDEEEDV LSPSKKRHLH TRSMDKRQVA 100
    ATASEKSDIG DSKGNDGEIE DGILEEEESL EKELNRGGGK EVEKSEESYY 150
    AQNDVGQKGE EEQDGESGGY EDNEPSISKE SDELVSVVNG NGNEEDDEVE 200
    ATKENTTDST RSTTTRSKML LDLLEDGGSK KKLTDEEIQL RRAENARKRK 250
    NLSEKRLEEE KQDTINKLLK KRAGKSRSHL PNDDEKNDGS SSFVKPRRPY 300
    NSEGMTRILR RYEEDLFCTF 320
    Length:320
    Mass (Da):36,154
    Last modified:February 1, 1995 - v1
    Checksum:i6F0AA04387A3B3E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78898 Genomic DNA. Translation: CAA55493.1.
    Z71491 Genomic DNA. Translation: CAA96117.1.
    BK006947 Genomic DNA. Translation: DAA10341.1.
    PIRiS50716.
    RefSeqiNP_014184.1. NM_001183053.1.

    Genome annotation databases

    EnsemblFungiiYNL215W; YNL215W; YNL215W.
    GeneIDi855506.
    KEGGisce:YNL215W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78898 Genomic DNA. Translation: CAA55493.1 .
    Z71491 Genomic DNA. Translation: CAA96117.1 .
    BK006947 Genomic DNA. Translation: DAA10341.1 .
    PIRi S50716.
    RefSeqi NP_014184.1. NM_001183053.1.

    3D structure databases

    ProteinModelPortali P40154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35621. 240 interactions.
    DIPi DIP-5062N.
    IntActi P40154. 6 interactions.
    MINTi MINT-560359.
    STRINGi 4932.YNL215W.

    Proteomic databases

    MaxQBi P40154.
    PaxDbi P40154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL215W ; YNL215W ; YNL215W .
    GeneIDi 855506.
    KEGGi sce:YNL215W.

    Organism-specific databases

    CYGDi YNL215w.
    SGDi S000005159. IES2.

    Phylogenomic databases

    eggNOGi NOG75630.
    KOi K11676.
    OMAi DYTEDID.
    OrthoDBi EOG769ZW5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33221-MONOMER.

    Miscellaneous databases

    NextBioi 979514.

    Gene expression databases

    Genevestigatori P40154.

    Family and domain databases

    InterProi IPR029523. INO80B/Ies2.
    IPR006880. INO80B_C.
    [Graphical view ]
    PANTHERi PTHR21561:SF12. PTHR21561:SF12. 1 hit.
    Pfami PF04795. PAPA-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene."
      Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.
      Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
      Shen X., Ranallo R., Choi E., Wu C.
      Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIES2_YEAST
    AccessioniPrimary (citable) accession number: P40154
    Secondary accession number(s): D6W0X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1470 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3