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Protein

DNA-dependent ATPase MGS1

Gene

MGS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance of proper DNA topology and chromosome integrity via annealing of single-stranded DNA breaks. Modulates DNA polymerase delta during replication or replication-associated repair. May function as a modulator for SGS1 when DNA is damaged.3 Publications

Cofactori

Mg2+1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 3424UBZ-typeAdd
BLAST
Nucleotide bindingi177 – 1848ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • enzyme activator activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • single-stranded DNA-dependent ATPase activity Source: SGD

GO - Biological processi

  • DNA repair Source: InterPro
  • DNA replication, Okazaki fragment processing Source: SGD
  • DNA strand renaturation Source: SGD
  • regulation of DNA repair Source: SGD
Complete GO annotation...

Keywords - Ligandi

ATP-binding, DNA-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33224-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-dependent ATPase MGS1
Alternative name(s):
Maintenance of genome stability protein 1
Gene namesi
Name:MGS1
Ordered Locus Names:YNL218W
ORF Names:N1302
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL218W.
SGDiS000005162. MGS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587DNA-dependent ATPase MGS1PRO_0000084788Add
BLAST

Proteomic databases

MaxQBiP40151.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PCM1P386282EBI-29152,EBI-2351

Protein-protein interaction databases

BioGridi35618. 56 interactions.
DIPiDIP-1638N.
IntActiP40151. 9 interactions.
MINTiMINT-392746.

Structurei

3D structure databases

ProteinModelPortaliP40151.
SMRiP40151. Positions 134-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 UBZ-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 3424UBZ-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000008538.
HOGENOMiHOG000017623.
InParanoidiP40151.
KOiK07478.
OMAiPGHWDAD.
OrthoDBiEOG092C1X6E.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P40151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKRTSVEQ LISCPICSRK VFFSLINSHL DICGKEKSKP SSRPQTVSSL
60 70 80 90 100
LAGPKKRKQA NSEKFIDLEN KDHEIKPGLK SESDDIEIVE NESKRFKAAP
110 120 130 140 150
STDFAKSIVE PASSRDQLHN DYESRWLQKI SHLPLSEKLR PKELRDYVGQ
160 170 180 190 200
QHILSQDNGT LFKYIKQGTI PSMILWGPPG VGKTSLARLL TKTATTSSNE
210 220 230 240 250
SNVGSRYFMI ETSATKANTQ ELRGIFEKSK KEYQLTKRRT VLFIDEIHRF
260 270 280 290 300
NKVQQDLLLP HVENGDIILI GATTENPSFQ LNNALISRCL IFVLEKLNVN
310 320 330 340 350
ELCIVLSRGI ALLNKCRKQV WNIENPLKLS RSILEYVVDL SVGDTRRALN
360 370 380 390 400
MLEMIEVSTR ERKADEEELS IDDVRDIIKN NSSNGLNTYY DPKGDNHYDT
410 420 430 440 450
ISAFHKSIRG GDENASLYYL ARMLQGGEDP LYVARRMIRI ASEDIGLRDS
460 470 480 490 500
SLLPLAVAAH DAVMKVGLPE ADLALAQCCV ALARAPKSVE LYRAWKKLRA
510 520 530 540 550
MMSENMYSLA SSEIPMHIRN APTKLMEELG YHKGYKYNPD YIEGKVQQDY
560 570 580
FPKEVLEKCP NKTDLKFLDG KHLGDKEDPD LRQSYQG
Length:587
Mass (Da):66,544
Last modified:October 1, 1996 - v2
Checksum:iA7464BF94FCC23EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71493 Genomic DNA. Translation: CAA96120.1.
Z71494 Genomic DNA. Translation: CAA96121.1.
AY693190 Genomic DNA. Translation: AAT93209.1.
X78898 Genomic DNA. Translation: CAA55489.1.
BK006947 Genomic DNA. Translation: DAA10338.1.
PIRiS63176.
RefSeqiNP_014181.1. NM_001183056.1.

Genome annotation databases

EnsemblFungiiYNL218W; YNL218W; YNL218W.
GeneIDi855503.
KEGGisce:YNL218W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71493 Genomic DNA. Translation: CAA96120.1.
Z71494 Genomic DNA. Translation: CAA96121.1.
AY693190 Genomic DNA. Translation: AAT93209.1.
X78898 Genomic DNA. Translation: CAA55489.1.
BK006947 Genomic DNA. Translation: DAA10338.1.
PIRiS63176.
RefSeqiNP_014181.1. NM_001183056.1.

3D structure databases

ProteinModelPortaliP40151.
SMRiP40151. Positions 134-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35618. 56 interactions.
DIPiDIP-1638N.
IntActiP40151. 9 interactions.
MINTiMINT-392746.

Proteomic databases

MaxQBiP40151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL218W; YNL218W; YNL218W.
GeneIDi855503.
KEGGisce:YNL218W.

Organism-specific databases

EuPathDBiFungiDB:YNL218W.
SGDiS000005162. MGS1.

Phylogenomic databases

GeneTreeiENSGT00390000008538.
HOGENOMiHOG000017623.
InParanoidiP40151.
KOiK07478.
OMAiPGHWDAD.
OrthoDBiEOG092C1X6E.

Enzyme and pathway databases

BioCyciYEAST:G3O-33224-MONOMER.

Miscellaneous databases

PROiP40151.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWRIP1_YEAST
AccessioniPrimary (citable) accession number: P40151
Secondary accession number(s): D6W0X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1180 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.