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Protein

DNA-dependent ATPase MGS1

Gene

MGS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance of proper DNA topology and chromosome integrity via annealing of single-stranded DNA breaks. Modulates DNA polymerase delta during replication or replication-associated repair. May function as a modulator for SGS1 when DNA is damaged.3 Publications

Miscellaneous

Present with 1180 molecules/cell in log phase SD medium.1 Publication

Cofactori

Mg2+1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34UBZ-typeSequence analysisAdd BLAST24
Nucleotide bindingi177 – 184ATPSequence analysis8
Nucleotide bindingi179 – 185ATPBy similarity7

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • enzyme activator activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • single-stranded DNA-dependent ATPase activity Source: SGD

GO - Biological processi

  • DNA repair Source: InterPro
  • DNA replication, Okazaki fragment processing Source: SGD
  • DNA strand renaturation Source: SGD
  • regulation of DNA repair Source: SGD

Keywordsi

Molecular functionDNA-binding
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33224-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-dependent ATPase MGS1
Alternative name(s):
Maintenance of genome stability protein 1
Gene namesi
Name:MGS1
Ordered Locus Names:YNL218W
ORF Names:N1302
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL218W
SGDiS000005162 MGS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847881 – 587DNA-dependent ATPase MGS1Add BLAST587

Proteomic databases

MaxQBiP40151
PaxDbiP40151
PRIDEiP40151

Interactioni

Protein-protein interaction databases

BioGridi35618, 75 interactors
DIPiDIP-1638N
IntActiP40151, 9 interactors
MINTiP40151
STRINGi4932.YNL218W

Structurei

3D structure databases

ProteinModelPortaliP40151
SMRiP40151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34UBZ-typeSequence analysisAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000008538
HOGENOMiHOG000017623
InParanoidiP40151
KOiK07478
OMAiRIILSQC
OrthoDBiEOG092C1X6E

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032423 AAA_assoc_2
IPR003959 ATPase_AAA_core
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR021886 MgsA_C
IPR027417 P-loop_NTPase
IPR006642 Znf_Rad18_put
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF16193 AAA_assoc_2, 1 hit
PF12002 MgsA_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00734 ZnF_Rad18, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P40151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKRTSVEQ LISCPICSRK VFFSLINSHL DICGKEKSKP SSRPQTVSSL
60 70 80 90 100
LAGPKKRKQA NSEKFIDLEN KDHEIKPGLK SESDDIEIVE NESKRFKAAP
110 120 130 140 150
STDFAKSIVE PASSRDQLHN DYESRWLQKI SHLPLSEKLR PKELRDYVGQ
160 170 180 190 200
QHILSQDNGT LFKYIKQGTI PSMILWGPPG VGKTSLARLL TKTATTSSNE
210 220 230 240 250
SNVGSRYFMI ETSATKANTQ ELRGIFEKSK KEYQLTKRRT VLFIDEIHRF
260 270 280 290 300
NKVQQDLLLP HVENGDIILI GATTENPSFQ LNNALISRCL IFVLEKLNVN
310 320 330 340 350
ELCIVLSRGI ALLNKCRKQV WNIENPLKLS RSILEYVVDL SVGDTRRALN
360 370 380 390 400
MLEMIEVSTR ERKADEEELS IDDVRDIIKN NSSNGLNTYY DPKGDNHYDT
410 420 430 440 450
ISAFHKSIRG GDENASLYYL ARMLQGGEDP LYVARRMIRI ASEDIGLRDS
460 470 480 490 500
SLLPLAVAAH DAVMKVGLPE ADLALAQCCV ALARAPKSVE LYRAWKKLRA
510 520 530 540 550
MMSENMYSLA SSEIPMHIRN APTKLMEELG YHKGYKYNPD YIEGKVQQDY
560 570 580
FPKEVLEKCP NKTDLKFLDG KHLGDKEDPD LRQSYQG
Length:587
Mass (Da):66,544
Last modified:October 1, 1996 - v2
Checksum:iA7464BF94FCC23EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71493 Genomic DNA Translation: CAA96120.1
Z71494 Genomic DNA Translation: CAA96121.1
AY693190 Genomic DNA Translation: AAT93209.1
X78898 Genomic DNA Translation: CAA55489.1
BK006947 Genomic DNA Translation: DAA10338.1
PIRiS63176
RefSeqiNP_014181.1, NM_001183056.1

Genome annotation databases

EnsemblFungiiYNL218W; YNL218W; YNL218W
GeneIDi855503
KEGGisce:YNL218W

Similar proteinsi

Entry informationi

Entry nameiWRIP1_YEAST
AccessioniPrimary (citable) accession number: P40151
Secondary accession number(s): D6W0X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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