Adenylate cyclase type 5 - Oryctolagus cuniculus (Rabbit)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Adenylate cyclase type 5
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase 5
Adenylate cyclase type V
Adenylyl cyclase 5

Gene names

Name:

ADCY5

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	1264 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation By similarity.
Subunit structure	Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 By similarity. Interacts with RAF1 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein. Cell projection › cilium By similarity.
Tissue specificity	Myocardial tissue.
Post-translational modification	The N-terminus is blocked. Phosphorylated by RAF1 By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell projection Cilium Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW primary cilium Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1264

1264

Adenylate cyclase type 5

PRO_0000195696

Regions

Topological domain

1 – 244

244

Cytoplasmic Potential

Transmembrane

245 – 265

21

Helical; Potential

Transmembrane

271 – 290

20

Helical; Potential

Transmembrane

301 – 322

22

Helical; Potential

Transmembrane

331 – 348

18

Helical; Potential

Transmembrane

351 – 369

19

Helical; Potential

Transmembrane

377 – 398

22

Helical; Potential

Topological domain

399 – 765

367

Cytoplasmic Potential

Transmembrane

766 – 786

21

Helical; Potential

Transmembrane

797 – 816

20

Helical; Potential

Transmembrane

839 – 859

21

Helical; Potential

Topological domain

860 – 912

53

Extracellular Potential

Transmembrane

913 – 933

21

Helical; Potential

Transmembrane

938 – 958

21

Helical; Potential

Transmembrane

987 – 1006

20

Helical; Potential

Topological domain

1007 – 1264

258

Cytoplasmic Potential

Domain

472 – 599

128

Guanylate cyclase 1

Domain

1074 – 1213

140

Guanylate cyclase 2

Compositional bias

64 – 70

7

Poly-Gln

Compositional bias

79 – 82

4

Poly-Asp

Compositional bias

145 – 151

7

Poly-Ala

Sites

Metal binding

477

1

Magnesium 1 By similarity

Metal binding

477

1

Magnesium 2 By similarity

Metal binding

478

1

Magnesium 2; via carbonyl oxygen By similarity

Metal binding

521

1

Magnesium 1 By similarity

Metal binding

521

1

Magnesium 2 By similarity

Amino acid modifications

Modified residue

8

1

Phosphoserine By similarity

Glycosylation

873

1

N-linked (GlcNAc...) Potential

Glycosylation

890

1

N-linked (GlcNAc...) Potential

Glycosylation

975

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P40144 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 1787EB42A0C2FDF6
Show »

FASTA

1,264

139,624

        10         20         30         40         50         60 
MSGSKGVSPP GYAAQTAAAP ASRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA 

        70         80         90        100        110        120 
VTPQQQQQQQ RLASRWRGDD DDEPPLSGDD PLAGGFGFSF RSKSAWQERG GDDCGRGSRR 

       130        140        150        160        170        180 
QRRGAAGGGS TRAPPAGGGC GGGSAAAAAA AGGTEVRPRS VELGLEERRG KGRAVDELEA 

       190        200        210        220        230        240 
GAVEGGEGAE DGGSSADSSN GPGAVLSLGA CCLALLQIFR SKKFPSDKLE RLYQRYFFRL 

       250        260        270        280        290        300 
NQSSLTMLMA VLVLVCLVML AFHAARPPLQ LPYLAVLAAA VGVILVMAVL CNRAAFHQDH 

       310        320        330        340        350        360 
MGLACYALIA VVLAVQVVGL LLPQPRSASE GIWWTVFFIY TIYTLLPVRM RAAVLSGVLL 

       370        380        390        400        410        420 
STLHLAIALR TNAQDRFLLK QLVSNVLIFS CTNIVGVCTH YPAEVSQRQA FQETRECIQA 

       430        440        450        460        470        480 
RLHSQRENQQ QERLLLSVLP RHVAMEMKAD INAKQEDMMF HKIYIQKHDN VSILFADIEG 

       490        500        510        520        530        540 
FTSLASQCTA QELVMTLNEL FARFDKLAAE NHCLRIKILG DCYYCVSGLP EARADHAHCC 

       550        560        570        580        590        600 
VEMGMDMIEA ISLVREVTGV NVNMRVGIHS GRVHCGVLGL RKWQFDVWSN DVTLANHMEA 

       610        620        630        640        650        660 
GGKAGRIHIT KATLNYLNGD YEVEPGCGGE RNAYLKEHSI ETFLILRCTQ KRKEEKAMIA 

       670        680        690        700        710        720 
KMNRQRTNSI GHNPPHWGAE RPFYNHLGGN QVSKEMKRMG FEDPKDKNAQ ESTNPEDEVD 

       730        740        750        760        770        780 
EFLGRAIDAR SIDRLRSEHV RRFLLTFREP DLEKKYSKQV DDRFGAYVAC ASLVFLFICC 

       790        800        810        820        830        840 
VQITIVPHSM FMLSFYLACF LLLTLVVFVS MIYSCVKLFP RPLQSLSRKI VRSKMNSTLV 

       850        860        870        880        890        900 
GVFTITLVFL SAFVNMFMCN SKDLLDCLAA EHNISVIHVN ACHVVESAFN YSLGNEQGFC 

       910        920        930        940        950        960 
GNSRPNCNFP EYFTYSVLLS LLACSVFLQI SCIGKLVLML AIELTYVLIV EVPRVTLFDN 

       970        980        990       1000       1010       1020 
ADLLVTANAI DISSNGTSQC PEHATKVALK VVTPIIISVF VLALYLHAQQ VESTARLDFL 

      1030       1040       1050       1060       1070       1080 
WKLQATEEKE EMEELQAYNR RLLHNILPKD VAAHFLARER RNDELYYQSC ECVAVMFASI 

      1090       1100       1110       1120       1130       1140 
ANFSEFYVEL EANNEGVECL RLLNEIIADF DEIISEDRFR QLEKIKTIGS TYMAASGLND 

      1150       1160       1170       1180       1190       1200 
STYDKVGKTH IKALADFAMK LMDQMKYINE HSFNNFQMKI GLNIGPVVAG VIGARKPQYD 

      1210       1220       1230       1240       1250       1260 
IWGNTVNVAS RMDSTGVPDR IQVTTDMYQV LAANTYQLEC RGVVKVKGKG EMMTYFLNGG 


PPLS

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References

[1]	"Molecular cloning and expression of a novel type V adenylyl cyclase from rabbit myocardium." Wallach J., Droste M., Kluxen F.-W., Pfeuffer T., Frank R. FEBS Lett. 338:257-263(1994) [PubMed: 8307190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Myocardium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z29371 mRNA. Translation: CAA82562.1.
PIR	S41603.
RefSeq	NP_001076097.1. NM_001082628.1.
UniGene	Ocu.3285.
3D structure databases
ProteinModelPortal	P40144.
SMR	P40144. Positions 457-646, 1065-1240.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009315.
Organism-specific databases
CTD	111.
Phylogenomic databases
eggNOG	maNOG12560.
GeneTree	ENSGT00590000082802.
HOVERGEN	HBG050458.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADCY5_RABIT

Accession

Primary (citable) accession number: P40144

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents