Reviewed, UniProtKB/Swiss-Prot P40137 (CYAA_STIAU)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase 1
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase 1
    Adenylyl cyclase 1
      Short name=AC 1

Gene names

Name:

cyaA

Organism

Stigmatella aurantiaca

Taxonomic identifier

41 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Cystobacteraceae › Stigmatella

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Enzyme regulation	Inhibited by adenosine. Activated by GTP.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.
Caution	It is uncertain whether Met-1 or Met-2 is the initiator.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Adenylate cyclase 1		PRO_0000195747
Regions
	Transmembrane	26 – 46	21	Potential
	Transmembrane	57 – 77	21	Potential
	Transmembrane	88 – 108	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	163 – 183	21	Potential
	Domain	230 – 363	134	Guanylate cyclase
	Region	1 – 223	223	Ion channel Potential
Sites
	Metal binding	235	1	Magnesium By similarity
	Metal binding	279	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P40137-1 [UniParc]. Last modified July 15, 1999. Version 3. Checksum: C41C6841D7237EE3	FASTA	424	46,048
	10 20 30 40 50 60 MMDAAGRTTQ ETLARTLESE QGHNALNLSW VRLLATSAVL IVSLYFGRVR GMTDWDVYTP 70 80 90 100 110 120 PFAAYWSVTA LTLVALYRFE RLRRWAGLSL ALVDVPAIYW LQHIALPLSP SPGGVAGFTL 130 140 150 160 170 180 GLYATLILLS ALSLRRTMTL VVTACAAVGE VALQREAHIS LGAQLTAVVV LGACAAGACH 190 200 210 220 230 240 LLLRIRTLLT TATQQELKRA RLGRYFSPAV AERLQDLDRS ETSPELREVT LLFADIRDFT 250 260 270 280 290 300 SLSERLRPEQ VVTLLNEYYG RMVEVVFRHG GTLDKFIGDA LMVYFGAPIA DPAHARRGVQ 310 320 330 340 350 360 CALDMVQELE TVNALRSARG EPCLRIGVGV HTGPAVLGNI GSATRRLEYT AIGDTVNLAS 370 380 390 400 410 420 RIESLTKTRD VPILASRATR EQAGDTFLWN EMAPASVPGK SQPVAIFTPR NRTPAQQAGA PAAA

References

[1]	"Bifunctional structure of two adenylyl cyclases from the myxobacterium Stigmatella aurantiaca." Coudart-Cavalli M.-P., Sismeiro O., Danchin A. Biochimie 79:757-767(1997) [PubMed: 9523018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: B17R20.
[2]	"Phylogeny of adenylyl cyclases." Danchin A. Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed: 8418825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 213-424.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ223796 Genomic DNA. Translation: CAA11549.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.6.1.1. 119283.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_STIAU

Accession

Primary (citable) accession number: P40137

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	July 15, 1999
Last modified:	November 24, 2009
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)