Reviewed, UniProtKB/Swiss-Prot P40135 (CYAA_STRCO)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:	cya
Ordered Locus Names:	SCO4928
ORF Names:	SCK13.20

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Adenylate cyclase		PRO_0000195749
Regions
	Domain	191 – 300	110	Guanylate cyclase
Sites
	Metal binding	196	1	Magnesium By similarity
	Metal binding	240	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P40135-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: F9356425011A6D02	FASTA	381	40,903
	10 20 30 40 50 60 MTVDDTGSGA DGDGRVDPEP APDSADPGED PLALRLEGLI LGAERRYTPF QAARSAGVSM 70 80 90 100 110 120 ELASRFWRAM GFADIGQAKA LTEADVLALR RLAGLVEAGL LSEAMAVQVA RSTGQTTARL 130 140 150 160 170 180 AEWQIDSFLE GLTEPPEPGM TRTEVTYPIV ELLLPELQEF LVYVWRRQLA ASAGRVIQAG 190 200 210 220 230 240 DDEEMVDRRL AVGFADLVGF TRLTRRMEEE ELGELVEAFE TTSADLVAAR GGRLVKTLGD 250 260 270 280 290 300 EVLYAADDAG TAAEIALLLV ETMAHDETMP ELRVGIAFGT VTTRMGDVFG TTVNLASRLT 310 320 330 340 350 360 SIAPKDAVLV DTAFAEELIR TRDAPASEAA AAEEAAAAEK EGEEPPVYRF ALQPMWQRPV 370 380 RGLGVVEPWL LTRRDGGGGE A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The adenylate cyclase catalytic domain of Streptomyces coelicolor is carboxy-terminal." Danchin A., Pidoux J., Krin E., Thompson C.J., Ullmann A. FEMS Microbiol. Lett. 114:145-152(1993) [PubMed: 8282183] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X74768 Genomic DNA. Translation: CAA52780.2. Different initiation. AL939121 Genomic DNA. Translation: CAD30918.1.
PIR	S42625.
RefSeq	NP_629081.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1100369.
GenomeReviews	Gene locus SCO4928 in contig AL645882_GR.
KEGG	sco:SCO4928.
NMPDR	fig|100226.1.peg.4883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P40135.
OMA	IWRALGF.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO4928-MON.
BRENDA	4.6.1.1. 1084.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_STRCO

Accession

Primary (citable) accession number: P40135

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)