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Protein

Adenylate cyclase

Gene

cya

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961MagnesiumBy similarity
Metal bindingi240 – 2401MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cya
Ordered Locus Names:SCO4928
ORF Names:SCK13.20
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Adenylate cyclasePRO_0000195749Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4928.

Structurei

3D structure databases

ProteinModelPortaliP40135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 300110Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108QER. Bacteria.
COG2114. LUCA.
HOGENOMiHOG000241813.
InParanoidiP40135.
KOiK01768.
OMAiFGTTVNL.
OrthoDBiEOG62K1XZ.
PhylomeDBiP40135.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR032026. Ad_Cy_reg.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16701. Ad_Cy_reg. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVDDTGSGA DGDGRVDPEP APDSADPGED PLALRLEGLI LGAERRYTPF
60 70 80 90 100
QAARSAGVSM ELASRFWRAM GFADIGQAKA LTEADVLALR RLAGLVEAGL
110 120 130 140 150
LSEAMAVQVA RSTGQTTARL AEWQIDSFLE GLTEPPEPGM TRTEVTYPIV
160 170 180 190 200
ELLLPELQEF LVYVWRRQLA ASAGRVIQAG DDEEMVDRRL AVGFADLVGF
210 220 230 240 250
TRLTRRMEEE ELGELVEAFE TTSADLVAAR GGRLVKTLGD EVLYAADDAG
260 270 280 290 300
TAAEIALLLV ETMAHDETMP ELRVGIAFGT VTTRMGDVFG TTVNLASRLT
310 320 330 340 350
SIAPKDAVLV DTAFAEELIR TRDAPASEAA AAEEAAAAEK EGEEPPVYRF
360 370 380
ALQPMWQRPV RGLGVVEPWL LTRRDGGGGE A
Length:381
Mass (Da):40,903
Last modified:February 1, 1995 - v1
Checksum:iF9356425011A6D02
GO

Sequence cautioni

The sequence CAA52780.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74768 Genomic DNA. Translation: CAA52780.2. Different initiation.
AL939121 Genomic DNA. Translation: CAD30918.1.
PIRiS42625.
RefSeqiNP_629081.1. NC_003888.3.
WP_011029954.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD30918; CAD30918; CAD30918.
GeneIDi1100369.
KEGGisco:SCO4928.
PATRICi23739694. VBIStrCoe124346_5007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74768 Genomic DNA. Translation: CAA52780.2. Different initiation.
AL939121 Genomic DNA. Translation: CAD30918.1.
PIRiS42625.
RefSeqiNP_629081.1. NC_003888.3.
WP_011029954.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP40135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD30918; CAD30918; CAD30918.
GeneIDi1100369.
KEGGisco:SCO4928.
PATRICi23739694. VBIStrCoe124346_5007.

Phylogenomic databases

eggNOGiENOG4108QER. Bacteria.
COG2114. LUCA.
HOGENOMiHOG000241813.
InParanoidiP40135.
KOiK01768.
OMAiFGTTVNL.
OrthoDBiEOG62K1XZ.
PhylomeDBiP40135.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR032026. Ad_Cy_reg.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16701. Ad_Cy_reg. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The adenylate cyclase catalytic domain of Streptomyces coelicolor is carboxy-terminal."
    Danchin A., Pidoux J., Krin E., Thompson C.J., Ullmann A.
    FEMS Microbiol. Lett. 114:145-152(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCYAA_STRCO
AccessioniPrimary (citable) accession number: P40135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 11, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.