ID   CYAA_HAEIN              Reviewed;         843 AA.
AC   P40134;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=Adenylate cyclase;
DE            EC=4.6.1.1;
DE   AltName: Full=ATP pyrophosphate-lyase;
DE   AltName: Full=Adenylyl cyclase;
GN   Name=cyaA; Synonyms=cya; OrderedLocusNames=HI_0604;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=8226661; DOI=10.1128/jb.175.22.7142-7149.1993;
RA   Dorocicz I.R., Williams P.M., Redfield R.J.;
RT   "The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, and
RT   essential role in competence.";
RL   J. Bacteriol. 175:7142-7149(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=15769466; DOI=10.1016/j.jmb.2005.01.012;
RA   Redfield R.J., Cameron A.D., Qian Q., Hinds J., Ali T.R., Kroll J.S.,
RA   Langford P.R.;
RT   "A novel CRP-dependent regulon controls expression of competence genes in
RT   Haemophilus influenzae.";
RL   J. Mol. Biol. 347:735-747(2005).
CC   -!- FUNCTION: Plays an essential role in competence development.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: Expressed during exponential growth; expression decreases
CC       10-fold on shifting to starvation media. {ECO:0000269|PubMed:15769466}.
CC   -!- DISRUPTION PHENOTYPE: Loss of competence, the ability to bind, take-up
CC       and integrate exogenous DNA. Loss of the ability to ferment ribose or
CC       xylose. {ECO:0000269|PubMed:8226661}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L23824; AAC36855.1; -; Unassigned_DNA.
DR   EMBL; L42023; AAC22262.1; -; Genomic_DNA.
DR   PIR; A49922; A49922.
DR   RefSeq; NP_438762.1; NC_000907.1.
DR   AlphaFoldDB; P40134; -.
DR   STRING; 71421.HI_0604; -.
DR   EnsemblBacteria; AAC22262; AAC22262; HI_0604.
DR   KEGG; hin:HI_0604; -.
DR   PATRIC; fig|71421.8.peg.628; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   PhylomeDB; P40134; -.
DR   BioCyc; HINF71421:G1GJ1-623-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; cAMP biosynthesis; Competence; Cytoplasm; Lyase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..843
FT                   /note="Adenylate cyclase"
FT                   /id="PRO_0000195676"
FT   REGION          1..542
FT                   /note="Catalytic"
FT                   /evidence="ECO:0000255"
FT   REGION          549..843
FT                   /note="Regulatory"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   843 AA;  97927 MW;  B8C7BDFDFB07EEE7 CRC64;
     MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP GYVIHAPSGI
     ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP PILGVYVMGS FGSISQTSSS
     DLDTWICVRD GLSLDEYTLL TQKAKRISEW AMQFNVEINF YLMDQQRFRN EHYADPLTIE
     NSGSAQYMLL LDEFYRSAVR LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF
     GGLGQFSANE YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG
     NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ ANNWRIRYME
     ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML SYRNLVEFAR KHHIHSSVVP
     QDINILSRKL YTAFEELPGK VSLLNTQISH NLSEAHLTFV EVRGNKHFKD GWYLINQPIH
     HIMFSKERVI EYGESLNKLV SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS
     TIAKQPKNSD LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI
     DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE RYRQDLRQLV
     MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI SLQEIGNESV CNEAESAVDF
     DEVLQTPIED GETNQESRRY PPEMDAFASE GFLQFFFEDN SDHSFNVYIL DESNHLEIYR
     HCDGEKDEKV REINQLYQNA KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ
     MNK
//