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P40134 (CYAA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cyaA
Synonyms:cya
Ordered Locus Names:HI_0604
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length843 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an essential role in competence development.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Subcellular location

Cytoplasm.

Induction

Expressed during exponential growth; expression decreases 10-fold on shifting to starvation media. Ref.3

Disruption phenotype

Loss of competence, the ability to bind, take-up and integrate exogenous DNA. Loss of the ability to ferment ribose or xylose. Ref.1

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
Competence
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processestablishment of competence for transformation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 843843Adenylate cyclase
PRO_0000195676

Regions

Region1 – 542542Catalytic Potential
Region549 – 843295Regulatory Potential

Sequences

Sequence LengthMass (Da)Tools
P40134 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B8C7BDFDFB07EEE7

FASTA84397,927
        10         20         30         40         50         60 
MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP GYVIHAPSGI 

        70         80         90        100        110        120 
ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP PILGVYVMGS FGSISQTSSS 

       130        140        150        160        170        180 
DLDTWICVRD GLSLDEYTLL TQKAKRISEW AMQFNVEINF YLMDQQRFRN EHYADPLTIE 

       190        200        210        220        230        240 
NSGSAQYMLL LDEFYRSAVR LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF 

       250        260        270        280        290        300 
GGLGQFSANE YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG 

       310        320        330        340        350        360 
NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ ANNWRIRYME 

       370        380        390        400        410        420 
ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML SYRNLVEFAR KHHIHSSVVP 

       430        440        450        460        470        480 
QDINILSRKL YTAFEELPGK VSLLNTQISH NLSEAHLTFV EVRGNKHFKD GWYLINQPIH 

       490        500        510        520        530        540 
HIMFSKERVI EYGESLNKLV SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS 

       550        560        570        580        590        600 
TIAKQPKNSD LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI 

       610        620        630        640        650        660 
DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE RYRQDLRQLV 

       670        680        690        700        710        720 
MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI SLQEIGNESV CNEAESAVDF 

       730        740        750        760        770        780 
DEVLQTPIED GETNQESRRY PPEMDAFASE GFLQFFFEDN SDHSFNVYIL DESNHLEIYR 

       790        800        810        820        830        840 
HCDGEKDEKV REINQLYQNA KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ 


MNK 

« Hide

References

« Hide 'large scale' references
[1]"The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, and essential role in competence."
Dorocicz I.R., Williams P.M., Redfield R.J.
J. Bacteriol. 175:7142-7149(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd."
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. expand/collapse author list , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.
Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[3]"A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae."
Redfield R.J., Cameron A.D., Qian Q., Hinds J., Ali T.R., Kroll J.S., Langford P.R.
J. Mol. Biol. 347:735-747(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23824 Unassigned DNA. Translation: AAC36855.1.
L42023 Genomic DNA. Translation: AAC22262.1.
PIRA49922.
RefSeqNP_438762.1. NC_000907.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0604.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22262; AAC22262; HI_0604.
GeneID950010.
KEGGhin:HI0604.
PATRIC20189787. VBIHaeInf48452_0628.

Phylogenomic databases

eggNOGCOG3072.
KOK05851.
OMASEGFLQF.
OrthoDBEOG63JR9H.
PhylomeDBP40134.

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_HAEIN
AccessionPrimary (citable) accession number: P40134
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names