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P40134

- CYAA_HAEIN

UniProt

P40134 - CYAA_HAEIN

Protein

Adenylate cyclase

Gene

cyaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Plays an essential role in competence development.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. establishment of competence for transformation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis, Competence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cyaA
    Synonyms:cya
    Ordered Locus Names:HI_0604
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Loss of competence, the ability to bind, take-up and integrate exogenous DNA. Loss of the ability to ferment ribose or xylose.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 843843Adenylate cyclasePRO_0000195676Add
    BLAST

    Expressioni

    Inductioni

    Expressed during exponential growth; expression decreases 10-fold on shifting to starvation media.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0604.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 542542CatalyticSequence AnalysisAdd
    BLAST
    Regioni549 – 843295RegulatorySequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-1 family.Curated

    Phylogenomic databases

    eggNOGiCOG3072.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.
    PhylomeDBiP40134.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40134-1 [UniParc]FASTAAdd to Basket

    « Hide

    MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP    50
    GYVIHAPSGI ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP 100
    PILGVYVMGS FGSISQTSSS DLDTWICVRD GLSLDEYTLL TQKAKRISEW 150
    AMQFNVEINF YLMDQQRFRN EHYADPLTIE NSGSAQYMLL LDEFYRSAVR 200
    LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF GGLGQFSANE 250
    YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG 300
    NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ 350
    ANNWRIRYME ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML 400
    SYRNLVEFAR KHHIHSSVVP QDINILSRKL YTAFEELPGK VSLLNTQISH 450
    NLSEAHLTFV EVRGNKHFKD GWYLINQPIH HIMFSKERVI EYGESLNKLV 500
    SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS TIAKQPKNSD 550
    LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI 600
    DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE 650
    RYRQDLRQLV MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI 700
    SLQEIGNESV CNEAESAVDF DEVLQTPIED GETNQESRRY PPEMDAFASE 750
    GFLQFFFEDN SDHSFNVYIL DESNHLEIYR HCDGEKDEKV REINQLYQNA 800
    KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ MNK 843
    Length:843
    Mass (Da):97,927
    Last modified:February 1, 1995 - v1
    Checksum:iB8C7BDFDFB07EEE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23824 Unassigned DNA. Translation: AAC36855.1.
    L42023 Genomic DNA. Translation: AAC22262.1.
    PIRiA49922.
    RefSeqiNP_438762.1. NC_000907.1.
    WP_005694539.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22262; AAC22262; HI_0604.
    GeneIDi950010.
    KEGGihin:HI0604.
    PATRICi20189787. VBIHaeInf48452_0628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23824 Unassigned DNA. Translation: AAC36855.1 .
    L42023 Genomic DNA. Translation: AAC22262.1 .
    PIRi A49922.
    RefSeqi NP_438762.1. NC_000907.1.
    WP_005694539.1. NC_000907.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22262 ; AAC22262 ; HI_0604 .
    GeneIDi 950010.
    KEGGi hin:HI0604.
    PATRICi 20189787. VBIHaeInf48452_0628.

    Phylogenomic databases

    eggNOGi COG3072.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.
    PhylomeDBi P40134.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, and essential role in competence."
      Dorocicz I.R., Williams P.M., Redfield R.J.
      J. Bacteriol. 175:7142-7149(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    3. "A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae."
      Redfield R.J., Cameron A.D., Qian Q., Hinds J., Ali T.R., Kroll J.S., Langford P.R.
      J. Mol. Biol. 347:735-747(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiCYAA_HAEIN
    AccessioniPrimary (citable) accession number: P40134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3