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P40134

- CYAA_HAEIN

UniProt

P40134 - CYAA_HAEIN

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Protein

Adenylate cyclase

Gene

cyaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an essential role in competence development.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis, Competence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cyaA
Synonyms:cya
Ordered Locus Names:HI_0604
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Loss of competence, the ability to bind, take-up and integrate exogenous DNA. Loss of the ability to ferment ribose or xylose.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843Adenylate cyclasePRO_0000195676Add
BLAST

Expressioni

Inductioni

Expressed during exponential growth; expression decreases 10-fold on shifting to starvation media.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0604.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 542542CatalyticSequence AnalysisAdd
BLAST
Regioni549 – 843295RegulatorySequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.Curated

Phylogenomic databases

eggNOGiCOG3072.
KOiK05851.
OMAiSEGFLQF.
OrthoDBiEOG63JR9H.
PhylomeDBiP40134.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP
60 70 80 90 100
GYVIHAPSGI ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP
110 120 130 140 150
PILGVYVMGS FGSISQTSSS DLDTWICVRD GLSLDEYTLL TQKAKRISEW
160 170 180 190 200
AMQFNVEINF YLMDQQRFRN EHYADPLTIE NSGSAQYMLL LDEFYRSAVR
210 220 230 240 250
LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF GGLGQFSANE
260 270 280 290 300
YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG
310 320 330 340 350
NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ
360 370 380 390 400
ANNWRIRYME ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML
410 420 430 440 450
SYRNLVEFAR KHHIHSSVVP QDINILSRKL YTAFEELPGK VSLLNTQISH
460 470 480 490 500
NLSEAHLTFV EVRGNKHFKD GWYLINQPIH HIMFSKERVI EYGESLNKLV
510 520 530 540 550
SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS TIAKQPKNSD
560 570 580 590 600
LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI
610 620 630 640 650
DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE
660 670 680 690 700
RYRQDLRQLV MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI
710 720 730 740 750
SLQEIGNESV CNEAESAVDF DEVLQTPIED GETNQESRRY PPEMDAFASE
760 770 780 790 800
GFLQFFFEDN SDHSFNVYIL DESNHLEIYR HCDGEKDEKV REINQLYQNA
810 820 830 840
KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ MNK
Length:843
Mass (Da):97,927
Last modified:February 1, 1995 - v1
Checksum:iB8C7BDFDFB07EEE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23824 Unassigned DNA. Translation: AAC36855.1.
L42023 Genomic DNA. Translation: AAC22262.1.
PIRiA49922.
RefSeqiNP_438762.1. NC_000907.1.
WP_005694539.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22262; AAC22262; HI_0604.
GeneIDi950010.
KEGGihin:HI0604.
PATRICi20189787. VBIHaeInf48452_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23824 Unassigned DNA. Translation: AAC36855.1 .
L42023 Genomic DNA. Translation: AAC22262.1 .
PIRi A49922.
RefSeqi NP_438762.1. NC_000907.1.
WP_005694539.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22262 ; AAC22262 ; HI_0604 .
GeneIDi 950010.
KEGGi hin:HI0604.
PATRICi 20189787. VBIHaeInf48452_0628.

Phylogenomic databases

eggNOGi COG3072.
KOi K05851.
OMAi SEGFLQF.
OrthoDBi EOG63JR9H.
PhylomeDBi P40134.

Family and domain databases

InterProi IPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view ]
Pfami PF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view ]
PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, and essential role in competence."
    Dorocicz I.R., Williams P.M., Redfield R.J.
    J. Bacteriol. 175:7142-7149(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  3. "A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae."
    Redfield R.J., Cameron A.D., Qian Q., Hinds J., Ali T.R., Kroll J.S., Langford P.R.
    J. Mol. Biol. 347:735-747(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCYAA_HAEIN
AccessioniPrimary (citable) accession number: P40134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3