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P40130 (CYAA_ERWCH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase
EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cya
OrganismErwinia chrysanthemi
Taxonomic identifier556 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length851 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 851851Adenylate cyclase
PRO_0000195675

Regions

Region1 – 534534Catalytic Potential
Region540 – 851312Regulatory Potential

Sequences

Sequence LengthMass (Da)Tools
P40130 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 0EA8AE944F302AD2

FASTA85197,560
        10         20         30         40         50         60 
MYFYIETLKQ RLDAINQLRV DRALEAMKPA FQQVYSLLPV LLHHHHPLMP GYLEGKVPHG 

        70         80         90        100        110        120 
ICLFSPDEKQ QHYLDSVELR WGELSAPDRK GELPITGVYS MGSTSSIGQS CSSDLDIWVC 

       130        140        150        160        170        180 
HQSWLDNEER QLQQKCSLLE KWAAGQGVDV SFFLMDENRF RHNESGSLGG EDCGSTQHIL 

       190        200        210        220        230        240 
LLDEFYRTAV RMAGKRILWN MVPVEEEAHY DEFVLSLYAR GALAPNEWLD LGGLSALSAE 

       250        260        270        280        290        300 
EYFGASLWQL YKSIDSPYKA VLKTLLLEAY SWEYPNTRLL SSEIKARLHK GEIVSFGLDP 

       310        320        330        340        350        360 
YCMMLERVTQ YLDAINDQTR LDLVRRCFYL KVCEKLSRER ACTAWRRQIL TQMVQAWGWS 

       370        380        390        400        410        420 
DERLVMLDNR ANWKIGQVRE AHNELLDAMM QSYRNLIRFA RRNNLSVSAS PQDIGVLTRK 

       430        440        450        460        470        480 
LYAAFEALPG KVTLVNPQIS PDLSETNLTF IYVPAGRANR SGWYLYNQAP SMDAIISHQP 

       490        500        510        520        530        540 
LEYNRYLNKL VAWAYFNGLL TSSTRLHIKG HELCDIARLQ ELVSDVSSHF PLRVAAPTPK 

       550        560        570        580        590        600 
ALYSPCEIRH LAIIVNLEHD PTAAFRNQVV HFDFRQLDVF SFGQQQQCLV GSIDLLYRNS 

       610        620        630        640        650        660 
WNEVRTLHFS GEQAMLEALK TILGKMHQDA ALPESLEVFC YSQHLRGLIR TRVQQLVSEC 

       670        680        690        700        710        720 
IELRLSSTRQ EPGRFKAVKV AGETWGLFFE RLSVSAQKLE NAVEFYGAIS NNKLQGLPVQ 

       730        740        750        760        770        780 
VETNHIHLPP VVDGVASEGI IQFFFEDQHD NQGFNIYILD ESNRVEVYHH CEGSKEELVR 

       790        800        810        820        830        840 
DVSRFYSSSH DRFTYGSSFI NFNLPQFYQI VQLDGRTQVI PFRSSALSHL CVTPSSEDKK 

       850 
NLVLSQRLQM L

« Hide

References

[1]"Structure and evolution of bacterial adenylate cyclase: comparison between Escherichia coli and Erwinia chrysanthemi."
Danchin A., Lenzen G.
Second Messengers Phosphoproteins 12:7-28(1988) [PubMed: 3057176] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: B374.
[2]"Phylogeny of adenylyl cyclases."
Danchin A.
Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed: 8418825] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X63207 Genomic DNA. Translation: CAA44891.1.
PIRS23699.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_ERWCH
AccessionPrimary (citable) accession number: P40130
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 19, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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