ID   CYAA_YERPE              Reviewed;         850 AA.
AC   P40127; Q0WAG2;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   24-JAN-2024, entry version 135.
DE   RecName: Full=Adenylate cyclase;
DE            EC=4.6.1.1;
DE   AltName: Full=ATP pyrophosphate-lyase;
DE   AltName: Full=Adenylyl cyclase;
GN   Name=cya; Synonyms=cyaA; OrderedLocusNames=YPO3848, y0382, YP_3199;
OS   Yersinia pestis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EV 40;
RX   PubMed=8874804; DOI=10.1016/0300-9084(96)82192-4;
RA   Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.;
RT   "Comparative analysis of the cya locus in enterobacteria and related Gram-
RT   negative facultative anaerobes.";
RL   Biochimie 78:277-287(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [5]
RP   REVIEW.
RX   PubMed=8418825;
RA   Danchin A.;
RT   "Phylogeny of adenylyl cyclases.";
RL   Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC   -!- ACTIVITY REGULATION: The regulatory domain is involved in the
CC       regulation of cyclase activity by the carbon source.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000305}.
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DR   EMBL; U22968; AAC44324.1; -; Genomic_DNA.
DR   EMBL; AL590842; CAL22435.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM83971.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS63367.1; -; Genomic_DNA.
DR   PIR; AH0468; AH0468.
DR   RefSeq; WP_002211468.1; NZ_WUCM01000033.1.
DR   RefSeq; YP_002348726.1; NC_003143.1.
DR   AlphaFoldDB; P40127; -.
DR   IntAct; P40127; 9.
DR   STRING; 214092.YPO3848; -.
DR   PaxDb; 214092-YPO3848; -.
DR   EnsemblBacteria; AAS63367; AAS63367; YP_3199.
DR   GeneID; 57974861; -.
DR   KEGG; ype:YPO3848; -.
DR   KEGG; ypj:CH55_3167; -.
DR   KEGG; ypk:y0382; -.
DR   KEGG; ypl:CH46_1218; -.
DR   KEGG; ypm:YP_3199; -.
DR   KEGG; ypv:BZ15_3865; -.
DR   KEGG; ypw:CH59_1783; -.
DR   PATRIC; fig|214092.21.peg.4372; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OMA; YDDYVMS; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; cAMP biosynthesis; Cytoplasm; Lyase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..850
FT                   /note="Adenylate cyclase"
FT                   /id="PRO_0000195680"
FT   REGION          1..535
FT                   /note="Catalytic"
FT                   /evidence="ECO:0000255"
FT   REGION          541..850
FT                   /note="Regulatory"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        220..221
FT                   /note="AQ -> RE (in Ref. 1; AAC44324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        277
FT                   /note="N -> K (in Ref. 1; AAC44324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        334
FT                   /note="C -> R (in Ref. 4; AAS63367)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        550
FT                   /note="R -> C (in Ref. 1; AAC44324)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        572
FT                   /note="H -> D (in Ref. 1; AAC44324)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   850 AA;  96907 MW;  7B228C81D690B11F CRC64;
     MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP GYLDGNVPHG
     VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS MGSTSSIGQC HTSDLDIWVC
     HQAWLDTEER NQLQQKCSLL EKWAASMGVE VSFFLVDENR FRHNASGSLG GEDCGSTQHI
     LLLDEFYRSA VRLAGKRILW NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA
     EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD
     AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV LSQLVSEWGW
     SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR
     KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ
     PLEYNRYLNK LVSWAYFNGL LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP
     KALYSPCEIR HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN
     SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE
     CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSV
     QVETNQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DEANRVEVYH HCEGSKEELV
     RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA
     SLPTKQCQLH
//