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Protein

Adenylate cyclase

Gene

cya

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulationi

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cya
Synonyms:cyaA
Ordered Locus Names:YPO3848, y0382, YP_3199
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 850850Adenylate cyclasePRO_0000195680Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP40127. 9 interactions.
STRINGi214092.YPO3848.

Structurei

3D structure databases

ProteinModelPortaliP40127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 535535CatalyticSequence AnalysisAdd
BLAST
Regioni541 – 850310RegulatorySequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.Curated

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiPIHGLFL.
OrthoDBiEOG63JR9H.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP
60 70 80 90 100
GYLDGNVPHG VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS
110 120 130 140 150
MGSTSSIGQC HTSDLDIWVC HQAWLDTEER NQLQQKCSLL EKWAASMGVE
160 170 180 190 200
VSFFLVDENR FRHNASGSLG GEDCGSTQHI LLLDEFYRSA VRLAGKRILW
210 220 230 240 250
NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA EEYFGASLWQ
260 270 280 290 300
LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD
310 320 330 340 350
AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV
360 370 380 390 400
LSQLVSEWGW SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF
410 420 430 440 450
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEEHLT
460 470 480 490 500
FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ PLEYNRYLNK LVSWAYFNGL
510 520 530 540 550
LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP KALYSPCEIR
560 570 580 590 600
HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN
610 620 630 640 650
SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI
660 670 680 690 700
RTRIQQLVSE CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL
710 720 730 740 750
ENAVEFYGAI SNNKLHGLSV QVETNQIHLP PVVDGFASEG IIQFFFEGTA
760 770 780 790 800
DEKGFNIYIL DEANRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF
810 820 830 840 850
INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA SLPTKQCQLH
Length:850
Mass (Da):96,907
Last modified:November 16, 2001 - v2
Checksum:i7B228C81D690B11F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2212AQ → RE in AAC44324 (PubMed:8874804).Curated
Sequence conflicti277 – 2771N → K in AAC44324 (PubMed:8874804).Curated
Sequence conflicti334 – 3341C → R in AAS63367 (PubMed:15368893).Curated
Sequence conflicti550 – 5501R → C in AAC44324 (PubMed:8874804).Curated
Sequence conflicti572 – 5721H → D in AAC44324 (PubMed:8874804).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22968 Genomic DNA. Translation: AAC44324.1.
AL590842 Genomic DNA. Translation: CAL22435.1.
AE009952 Genomic DNA. Translation: AAM83971.1.
AE017042 Genomic DNA. Translation: AAS63367.1.
PIRiAH0468.
RefSeqiNP_667720.1. NC_004088.1.
NP_994490.1. NC_005810.1.
WP_002211468.1. NZ_KN150726.1.
YP_002348726.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83971; AAM83971; y0382.
AAS63367; AAS63367; YP_3199.
GeneIDi1176683.
KEGGiype:YPO3848.
ypk:y0382.
ypm:YP_3199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22968 Genomic DNA. Translation: AAC44324.1.
AL590842 Genomic DNA. Translation: CAL22435.1.
AE009952 Genomic DNA. Translation: AAM83971.1.
AE017042 Genomic DNA. Translation: AAS63367.1.
PIRiAH0468.
RefSeqiNP_667720.1. NC_004088.1.
NP_994490.1. NC_005810.1.
WP_002211468.1. NZ_KN150726.1.
YP_002348726.1. NC_003143.1.

3D structure databases

ProteinModelPortaliP40127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP40127. 9 interactions.
STRINGi214092.YPO3848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM83971; AAM83971; y0382.
AAS63367; AAS63367; YP_3199.
GeneIDi1176683.
KEGGiype:YPO3848.
ypk:y0382.
ypm:YP_3199.

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiPIHGLFL.
OrthoDBiEOG63JR9H.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3819-MONOMER.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EV 40.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.
  5. "Phylogeny of adenylyl cyclases."
    Danchin A.
    Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiCYAA_YERPE
AccessioniPrimary (citable) accession number: P40127
Secondary accession number(s): Q0WAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: June 24, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.