P40127 (CYAA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:	cya
Synonyms:	cyaA
Ordered Locus Names:	YPO3848, y0382, YP_3199

Organism

Yersinia pestis [Reference proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	850 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Enzyme regulation	The regulatory domain is involved in the regulation of cyclase activity by the carbon source.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 850	850	Adenylate cyclase		PRO_0000195680
Regions
	Region	1 – 535	535	Catalytic Potential
	Region	541 – 850	310	Regulatory Potential
Experimental info
	Sequence conflict	220 – 221	2	AQ → RE in AAC44324. Ref.1
	Sequence conflict	277	1	N → K in AAC44324. Ref.1
	Sequence conflict	334	1	C → R in AAS63367. Ref.4
	Sequence conflict	550	1	R → C in AAC44324. Ref.1
	Sequence conflict	572	1	H → D in AAC44324. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P40127 [UniParc]. Last modified November 16, 2001. Version 2. Checksum: 7B228C81D690B11F	FASTA	850	96,907
	10 20 30 40 50 60 MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP GYLDGNVPHG 70 80 90 100 110 120 VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS MGSTSSIGQC HTSDLDIWVC 130 140 150 160 170 180 HQAWLDTEER NQLQQKCSLL EKWAASMGVE VSFFLVDENR FRHNASGSLG GEDCGSTQHI 190 200 210 220 230 240 LLLDEFYRSA VRLAGKRILW NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA 250 260 270 280 290 300 EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD 310 320 330 340 350 360 AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV LSQLVSEWGW 370 380 390 400 410 420 SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 430 440 450 460 470 480 KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ 490 500 510 520 530 540 PLEYNRYLNK LVSWAYFNGL LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP 550 560 570 580 590 600 KALYSPCEIR HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN 610 620 630 640 650 660 SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE 670 680 690 700 710 720 CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSV 730 740 750 760 770 780 QVETNQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DEANRVEVYH HCEGSKEELV 790 800 810 820 830 840 RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA 850 SLPTKQCQLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes." Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A. Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: EV 40.
[2]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[3]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM10+ / Biovar Mediaevalis.
[4]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.
[5]	"Phylogeny of adenylyl cyclases." Danchin A. Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U22968 Genomic DNA. Translation: AAC44324.1. AL590842 Genomic DNA. Translation: CAL22435.1. AE009952 Genomic DNA. Translation: AAM83971.1. AE017042 Genomic DNA. Translation: AAS63367.1.
PIR	AH0468.
RefSeq	NP_667720.1. NC_004088.1. NP_994490.1. NC_005810.1. YP_002348726.1. NC_003143.1.
3D structure databases
ProteinModelPortal	P40127.
ModBase	Search...
Protein-protein interaction databases
IntAct	P40127. 9 interactions.
STRING	214092.YPO3848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM83971; AAM83971; y0382. AAS63367; AAS63367; YP_3199.
GeneID	1145329. 1176683. 2766773.
KEGG	ype:YPO3848. ypk:y0382. ypm:YP_3199.
Phylogenomic databases
eggNOG	COG3072.
HOGENOM	HOG000270910.
KO	K05851.
OMA	LWQLYKG.
ProtClustDB	PRK09450.
Family and domain databases
InterPro	IPR000274. Adenylate_cyclase_1. IPR024686. Adenylate_cyclase_1_CS. IPR024685. Adenylate_cyclase_1_N. [Graphical view]
Pfam	PF12633. Adenyl_cycl_N. 1 hit. PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_YERPE

Accession

Primary (citable) accession number: P40127
Secondary accession number(s): Q0WAG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 16, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program