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Protein

Adenylate cyclase

Gene

cya

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulationi

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cya
Synonyms:cyaA
Ordered Locus Names:YPO3848, y0382, YP_3199
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956801 – 850Adenylate cyclaseAdd BLAST850

Proteomic databases

PaxDbiP40127

Interactioni

Protein-protein interaction databases

IntActiP40127, 9 interactors
STRINGi187410.y0382

Structurei

3D structure databases

ProteinModelPortaliP40127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 535CatalyticSequence analysisAdd BLAST535
Regioni541 – 850RegulatorySequence analysisAdd BLAST310

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.Curated

Phylogenomic databases

eggNOGiENOG4107T0K Bacteria
COG3072 LUCA
HOGENOMiHOG000270910
KOiK05851
OMAiHPLLPGY

Family and domain databases

InterProiView protein in InterPro
IPR000274 Adenylate_cyclase_1
IPR024686 Adenylate_cyclase_1_CS
IPR024685 Adenylate_cyclase_1_N
PANTHERiPTHR38760 PTHR38760, 1 hit
PfamiView protein in Pfam
PF12633 Adenyl_cycl_N, 1 hit
PF01295 Adenylate_cycl, 1 hit
PIRSFiPIRSF001444 Adenylate_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01092 ADENYLATE_CYCLASE_1_1, 1 hit
PS01093 ADENYLATE_CYCLASE_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P40127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP
60 70 80 90 100
GYLDGNVPHG VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS
110 120 130 140 150
MGSTSSIGQC HTSDLDIWVC HQAWLDTEER NQLQQKCSLL EKWAASMGVE
160 170 180 190 200
VSFFLVDENR FRHNASGSLG GEDCGSTQHI LLLDEFYRSA VRLAGKRILW
210 220 230 240 250
NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA EEYFGASLWQ
260 270 280 290 300
LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD
310 320 330 340 350
AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV
360 370 380 390 400
LSQLVSEWGW SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF
410 420 430 440 450
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEEHLT
460 470 480 490 500
FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ PLEYNRYLNK LVSWAYFNGL
510 520 530 540 550
LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP KALYSPCEIR
560 570 580 590 600
HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN
610 620 630 640 650
SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI
660 670 680 690 700
RTRIQQLVSE CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL
710 720 730 740 750
ENAVEFYGAI SNNKLHGLSV QVETNQIHLP PVVDGFASEG IIQFFFEGTA
760 770 780 790 800
DEKGFNIYIL DEANRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF
810 820 830 840 850
INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA SLPTKQCQLH
Length:850
Mass (Da):96,907
Last modified:November 16, 2001 - v2
Checksum:i7B228C81D690B11F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220 – 221AQ → RE in AAC44324 (PubMed:8874804).Curated2
Sequence conflicti277N → K in AAC44324 (PubMed:8874804).Curated1
Sequence conflicti334C → R in AAS63367 (PubMed:15368893).Curated1
Sequence conflicti550R → C in AAC44324 (PubMed:8874804).Curated1
Sequence conflicti572H → D in AAC44324 (PubMed:8874804).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22968 Genomic DNA Translation: AAC44324.1
AL590842 Genomic DNA Translation: CAL22435.1
AE009952 Genomic DNA Translation: AAM83971.1
AE017042 Genomic DNA Translation: AAS63367.1
PIRiAH0468
RefSeqiWP_002211468.1, NZ_PDBR01000036.1
YP_002348726.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM83971; AAM83971; y0382
AAS63367; AAS63367; YP_3199
GeneIDi1176683
KEGGiype:YPO3848
ypk:y0382
ypm:YP_3199
PATRICifig|214092.21.peg.4372

Similar proteinsi

Entry informationi

Entry nameiCYAA_YERPE
AccessioniPrimary (citable) accession number: P40127
Secondary accession number(s): Q0WAG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health