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P40127 (CYAA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cya
Synonyms:cyaA
Ordered Locus Names:YPO3848, y0382, YP_3199
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length850 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulation

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 850850Adenylate cyclase
PRO_0000195680

Regions

Region1 – 535535Catalytic Potential
Region541 – 850310Regulatory Potential

Experimental info

Sequence conflict220 – 2212AQ → RE in AAC44324. Ref.1
Sequence conflict2771N → K in AAC44324. Ref.1
Sequence conflict3341C → R in AAS63367. Ref.4
Sequence conflict5501R → C in AAC44324. Ref.1
Sequence conflict5721H → D in AAC44324. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P40127 [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: 7B228C81D690B11F

FASTA85096,907
        10         20         30         40         50         60 
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP GYLDGNVPHG 

        70         80         90        100        110        120 
VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS MGSTSSIGQC HTSDLDIWVC 

       130        140        150        160        170        180 
HQAWLDTEER NQLQQKCSLL EKWAASMGVE VSFFLVDENR FRHNASGSLG GEDCGSTQHI 

       190        200        210        220        230        240 
LLLDEFYRSA VRLAGKRILW NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA 

       250        260        270        280        290        300 
EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD 

       310        320        330        340        350        360 
AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV LSQLVSEWGW 

       370        380        390        400        410        420 
SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 

       430        440        450        460        470        480 
KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ 

       490        500        510        520        530        540 
PLEYNRYLNK LVSWAYFNGL LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP 

       550        560        570        580        590        600 
KALYSPCEIR HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN 

       610        620        630        640        650        660 
SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE 

       670        680        690        700        710        720 
CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSV 

       730        740        750        760        770        780 
QVETNQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DEANRVEVYH HCEGSKEELV 

       790        800        810        820        830        840 
RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA 

       850 
SLPTKQCQLH 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: EV 40.
[2]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[3]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[4]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.
[5]"Phylogeny of adenylyl cyclases."
Danchin A.
Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22968 Genomic DNA. Translation: AAC44324.1.
AL590842 Genomic DNA. Translation: CAL22435.1.
AE009952 Genomic DNA. Translation: AAM83971.1.
AE017042 Genomic DNA. Translation: AAS63367.1.
PIRAH0468.
RefSeqNP_667720.1. NC_004088.1.
NP_994490.1. NC_005810.1.
YP_002348726.1. NC_003143.1.

3D structure databases

ProteinModelPortalP40127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP40127. 9 interactions.
STRING214092.YPO3848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM83971; AAM83971; y0382.
AAS63367; AAS63367; YP_3199.
GeneID1145329.
1176683.
2766773.
KEGGype:YPO3848.
ypk:y0382.
ypm:YP_3199.

Phylogenomic databases

eggNOGCOG3072.
HOGENOMHOG000270910.
KOK05851.
OMASEGFLQF.
OrthoDBEOG63JR9H.
ProtClustDBPRK09450.

Enzyme and pathway databases

BioCycYPES214092:GKDD-3819-MONOMER.

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_YERPE
AccessionPrimary (citable) accession number: P40127
Secondary accession number(s): Q0WAG2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: November 13, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families