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P40127

- CYAA_YERPE

UniProt

P40127 - CYAA_YERPE

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Protein

Adenylate cyclase

Gene
cya, cyaA, YPO3848, y0382, YP_3199
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulationi

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cya
Synonyms:cyaA
Ordered Locus Names:YPO3848, y0382, YP_3199
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 850850Adenylate cyclasePRO_0000195680Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP40127. 9 interactions.
STRINGi214092.YPO3848.

Structurei

3D structure databases

ProteinModelPortaliP40127.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 535535Catalytic Reviewed predictionAdd
BLAST
Regioni541 – 850310Regulatory Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiSEGFLQF.
OrthoDBiEOG63JR9H.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P40127-1 [UniParc]FASTAAdd to Basket

« Hide

MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP    50
GYLDGNVPHG VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS 100
MGSTSSIGQC HTSDLDIWVC HQAWLDTEER NQLQQKCSLL EKWAASMGVE 150
VSFFLVDENR FRHNASGSLG GEDCGSTQHI LLLDEFYRSA VRLAGKRILW 200
NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA EEYFGASLWQ 250
LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD 300
AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV 350
LSQLVSEWGW SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF 400
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEEHLT 450
FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ PLEYNRYLNK LVSWAYFNGL 500
LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP KALYSPCEIR 550
HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN 600
SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI 650
RTRIQQLVSE CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL 700
ENAVEFYGAI SNNKLHGLSV QVETNQIHLP PVVDGFASEG IIQFFFEGTA 750
DEKGFNIYIL DEANRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA SLPTKQCQLH 850
Length:850
Mass (Da):96,907
Last modified:November 16, 2001 - v2
Checksum:i7B228C81D690B11F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2212AQ → RE in AAC44324. 1 Publication
Sequence conflicti277 – 2771N → K in AAC44324. 1 Publication
Sequence conflicti334 – 3341C → R in AAS63367. 1 Publication
Sequence conflicti550 – 5501R → C in AAC44324. 1 Publication
Sequence conflicti572 – 5721H → D in AAC44324. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22968 Genomic DNA. Translation: AAC44324.1.
AL590842 Genomic DNA. Translation: CAL22435.1.
AE009952 Genomic DNA. Translation: AAM83971.1.
AE017042 Genomic DNA. Translation: AAS63367.1.
PIRiAH0468.
RefSeqiNP_667720.1. NC_004088.1.
NP_994490.1. NC_005810.1.
YP_002348726.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83971; AAM83971; y0382.
AAS63367; AAS63367; YP_3199.
GeneIDi1145329.
1176683.
2766773.
KEGGiype:YPO3848.
ypk:y0382.
ypm:YP_3199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22968 Genomic DNA. Translation: AAC44324.1 .
AL590842 Genomic DNA. Translation: CAL22435.1 .
AE009952 Genomic DNA. Translation: AAM83971.1 .
AE017042 Genomic DNA. Translation: AAS63367.1 .
PIRi AH0468.
RefSeqi NP_667720.1. NC_004088.1.
NP_994490.1. NC_005810.1.
YP_002348726.1. NC_003143.1.

3D structure databases

ProteinModelPortali P40127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P40127. 9 interactions.
STRINGi 214092.YPO3848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM83971 ; AAM83971 ; y0382 .
AAS63367 ; AAS63367 ; YP_3199 .
GeneIDi 1145329.
1176683.
2766773.
KEGGi ype:YPO3848.
ypk:y0382.
ypm:YP_3199.

Phylogenomic databases

eggNOGi COG3072.
HOGENOMi HOG000270910.
KOi K05851.
OMAi SEGFLQF.
OrthoDBi EOG63JR9H.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-3819-MONOMER.

Family and domain databases

InterProi IPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view ]
Pfami PF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view ]
PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EV 40.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.
  5. "Phylogeny of adenylyl cyclases."
    Danchin A.
    Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiCYAA_YERPE
AccessioniPrimary (citable) accession number: P40127
Secondary accession number(s): Q0WAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 16, 2001
Last modified: May 14, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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