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P40127

- CYAA_YERPE

UniProt

P40127 - CYAA_YERPE

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Protein
Adenylate cyclase
Gene
cya, cyaA, YPO3848, y0382, YP_3199
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulationi

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3819-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cya
    Synonyms:cyaA
    Ordered Locus Names:YPO3848, y0382, YP_3199
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 850850Adenylate cyclase
    PRO_0000195680Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP40127. 9 interactions.
    STRINGi214092.YPO3848.

    Structurei

    3D structure databases

    ProteinModelPortaliP40127.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 535535Catalytic Reviewed prediction
    Add
    BLAST
    Regioni541 – 850310Regulatory Reviewed prediction
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3072.
    HOGENOMiHOG000270910.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P40127-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPI LLHCHHPQMP    50
    GYLDGNVPHG VCLFTPNEIQ QDYLADVEAR WGEPLAPSAG GELPITGVYS 100
    MGSTSSIGQC HTSDLDIWVC HQAWLDTEER NQLQQKCSLL EKWAASMGVE 150
    VSFFLVDENR FRHNASGSLG GEDCGSTQHI LLLDEFYRSA VRLAGKRILW 200
    NMVPVKEEEH YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA EEYFGASLWQ 250
    LYKSIDSPYK AVLKTLLLEA YSWEYPNSQL LAMEIKQHLH AGEIVSFGLD 300
    AYCMMLDRVT RYLIQINDTT RLNLVRRCFY LKVCEKLSRT PASTGWRREV 350
    LSQLVSEWGW SNEKLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF 400
    ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEEHLT 450
    FIHVPAGRAN RPGWYLYNQA PSMDAIVSHQ PLEYNRYLNK LVSWAYFNGL 500
    LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLAAPTP KALYSPCEIR 550
    HLAIIVNLEH DPTTTFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN 600
    SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI 650
    RTRIQQLVSE CIDLRLSSTR QEPGRFKAVR VSGQTWGLFF ERLSVSVQKL 700
    ENAVEFYGAI SNNKLHGLSV QVETNQIHLP PVVDGFASEG IIQFFFEGTA 750
    DEKGFNIYIL DEANRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
    INFNLPQFYQ IVQLDGRTQV IPFRSNTLSQ LCANIAEKEA SLPTKQCQLH 850
    Length:850
    Mass (Da):96,907
    Last modified:November 16, 2001 - v2
    Checksum:i7B228C81D690B11F
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2212AQ → RE in AAC44324. 1 Publication
    Sequence conflicti277 – 2771N → K in AAC44324. 1 Publication
    Sequence conflicti334 – 3341C → R in AAS63367. 1 Publication
    Sequence conflicti550 – 5501R → C in AAC44324. 1 Publication
    Sequence conflicti572 – 5721H → D in AAC44324. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22968 Genomic DNA. Translation: AAC44324.1.
    AL590842 Genomic DNA. Translation: CAL22435.1.
    AE009952 Genomic DNA. Translation: AAM83971.1.
    AE017042 Genomic DNA. Translation: AAS63367.1.
    PIRiAH0468.
    RefSeqiNP_667720.1. NC_004088.1.
    NP_994490.1. NC_005810.1.
    YP_002348726.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM83971; AAM83971; y0382.
    AAS63367; AAS63367; YP_3199.
    GeneIDi1145329.
    1176683.
    2766773.
    KEGGiype:YPO3848.
    ypk:y0382.
    ypm:YP_3199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22968 Genomic DNA. Translation: AAC44324.1 .
    AL590842 Genomic DNA. Translation: CAL22435.1 .
    AE009952 Genomic DNA. Translation: AAM83971.1 .
    AE017042 Genomic DNA. Translation: AAS63367.1 .
    PIRi AH0468.
    RefSeqi NP_667720.1. NC_004088.1.
    NP_994490.1. NC_005810.1.
    YP_002348726.1. NC_003143.1.

    3D structure databases

    ProteinModelPortali P40127.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi P40127. 9 interactions.
    STRINGi 214092.YPO3848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM83971 ; AAM83971 ; y0382 .
    AAS63367 ; AAS63367 ; YP_3199 .
    GeneIDi 1145329.
    1176683.
    2766773.
    KEGGi ype:YPO3848.
    ypk:y0382.
    ypm:YP_3199.

    Phylogenomic databases

    eggNOGi COG3072.
    HOGENOMi HOG000270910.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-3819-MONOMER.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
      Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
      Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: EV 40.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.
    5. "Phylogeny of adenylyl cyclases."
      Danchin A.
      Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCYAA_YERPE
    AccessioniPrimary (citable) accession number: P40127
    Secondary accession number(s): Q0WAG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 16, 2001
    Last modified: May 14, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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