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Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.1 Publication

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Zinc ABy similarity1
Metal bindingi211Zinc ABy similarity1
Metal bindingi220Zinc ABy similarity1
Metal bindingi369Zinc BBy similarity1
Metal bindingi373Zinc BBy similarity1
Metal bindingi396Zinc BBy similarity1

GO - Molecular functioni

  • copper ion binding Source: ProtInc
  • dopachrome isomerase activity Source: UniProtKB
  • oxidoreductase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processMelanin biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5662702. Melanin biosynthesis.
SIGNORiP40126.
UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000080166.15.
HGNCiHGNC:2709. DCT.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 472Lumenal, melanosomeSequence analysisAdd BLAST449
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 519CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1638.
OpenTargetsiENSG00000080166.
PharmGKBiPA27179.

Polymorphism and mutation databases

BioMutaiDCT.
DMDMi731026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003589224 – 519L-dopachrome tautomeraseAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP40126.
PRIDEiP40126.

PTM databases

iPTMnetiP40126.
PhosphoSitePlusiP40126.

Expressioni

Gene expression databases

BgeeiENSG00000080166.
CleanExiHS_DCT.
ExpressionAtlasiP40126. baseline and differential.
GenevisibleiP40126. HS.

Organism-specific databases

HPAiCAB017634.
HPA010743.
HPA010800.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

BioGridi108006. 8 interactors.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HX1X-ray1.80C180-188[»]
ProteinModelPortaliP40126.
SMRiP40126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00500000044790.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP40126.
KOiK01827.
OMAiFVVLHSF.
OrthoDBiEOG091G03YR.
PhylomeDBiP40126.
TreeFamiTF315865.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiView protein in InterPro
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
PfamiView protein in Pfam
PF00264. Tyrosinase. 1 hit.
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiView protein in PROSITE
PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40126-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN
60 70 80 90 100
VCGSQQGRGQ CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN
110 120 130 140 150
FAGYNCGDCK FGWTGPNCER KKPPVIRQNI HSLSPQEREQ FLGALDLAKK
160 170 180 190 200
RVHPDYVITT QHWLGLLGPN GTQPQFANCS VYDFFVWLHY YSVRDTLLGP
210 220 230 240 250
GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF ALPYWNFATG
260 270 280 290 300
RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN
310 320 330 340 350
GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA
360 370 380 390 400
LEGFDKADGT LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVLHSFTD
410 420 430 440 450
AIFDEWMKRF NPPADAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ
460 470 480 490 500
LGYSYAIDLP VSVEETPGWP TTLLVVMGTL VALVGLFVLL AFLQYRRLRK
510
GYTPLMETHL SSKRYTEEA
Length:519
Mass (Da):59,145
Last modified:February 1, 1995 - v1
Checksum:iAFDDF21768002A89
GO
Isoform 2 (identifier: P40126-2) [UniParc]FASTAAdd to basket
Also known as: TRP-2-6b

The sequence of this isoform differs from the canonical sequence as follows:
     393-393: V → VVISNRLLYNATTNILEHVRKEKATKELPSLHVL

Show »
Length:552
Mass (Da):62,929
Checksum:iF2B047A524167DD3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043581393V → VVISNRLLYNATTNILEHVR KEKATKELPSLHVL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17547 mRNA. Translation: BAA04484.1.
L18967 mRNA. Translation: AAA20870.1.
S69231 mRNA. Translation: AAC60627.1.
DQ902581 mRNA. Translation: ABI73976.1.
AL139318 Genomic DNA. No translation available.
BC028311 mRNA. Translation: AAH28311.1.
L38953 Genomic DNA. Translation: AAC41925.1.
D28767 Genomic DNA. Translation: BAA05956.1.
CCDSiCCDS45060.1. [P40126-2]
CCDS9470.1. [P40126-1]
PIRiS43510. YRHUR2.
RefSeqiNP_001123361.1. NM_001129889.2. [P40126-2]
NP_001913.2. NM_001922.4. [P40126-1]
UniGeneiHs.301865.

Genome annotation databases

EnsembliENST00000377028; ENSP00000366227; ENSG00000080166. [P40126-1]
ENST00000446125; ENSP00000392762; ENSG00000080166. [P40126-2]
GeneIDi1638.
KEGGihsa:1638.
UCSCiuc001vlv.6. human. [P40126-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTYRP2_HUMAN
AccessioniPrimary (citable) accession number: P40126
Secondary accession number(s): Q09GT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families