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Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.1 Publication

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Zinc ABy similarity1
Metal bindingi211Zinc ABy similarity1
Metal bindingi220Zinc ABy similarity1
Metal bindingi369Zinc BBy similarity1
Metal bindingi373Zinc BBy similarity1
Metal bindingi396Zinc BBy similarity1

GO - Molecular functioni

  • copper ion binding Source: ProtInc
  • dopachrome isomerase activity Source: UniProtKB
  • oxidoreductase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processMelanin biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5662702 Melanin biosynthesis
SIGNORiP40126
UniPathwayiUPA00785

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000080166.15
HGNCiHGNC:2709 DCT
MIMi191275 gene
neXtProtiNX_P40126

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 472Lumenal, melanosomeSequence analysisAdd BLAST449
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 519CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1638
OpenTargetsiENSG00000080166
PharmGKBiPA27179

Polymorphism and mutation databases

BioMutaiDCT
DMDMi731026

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003589224 – 519L-dopachrome tautomeraseAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP40126
PeptideAtlasiP40126
PRIDEiP40126

PTM databases

iPTMnetiP40126
PhosphoSitePlusiP40126

Expressioni

Gene expression databases

BgeeiENSG00000080166
CleanExiHS_DCT
ExpressionAtlasiP40126 baseline and differential
GenevisibleiP40126 HS

Organism-specific databases

HPAiCAB017634
HPA010743
HPA010800

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

BioGridi108006, 8 interactors

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HX1X-ray1.80C180-188[»]
ProteinModelPortaliP40126
SMRiP40126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00500000044790
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP40126
KOiK01827
OMAiFVVLHSF
OrthoDBiEOG091G03YR
PhylomeDBiP40126
TreeFamiTF315865

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P40126-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN
60 70 80 90 100
VCGSQQGRGQ CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN
110 120 130 140 150
FAGYNCGDCK FGWTGPNCER KKPPVIRQNI HSLSPQEREQ FLGALDLAKK
160 170 180 190 200
RVHPDYVITT QHWLGLLGPN GTQPQFANCS VYDFFVWLHY YSVRDTLLGP
210 220 230 240 250
GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF ALPYWNFATG
260 270 280 290 300
RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN
310 320 330 340 350
GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA
360 370 380 390 400
LEGFDKADGT LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVLHSFTD
410 420 430 440 450
AIFDEWMKRF NPPADAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ
460 470 480 490 500
LGYSYAIDLP VSVEETPGWP TTLLVVMGTL VALVGLFVLL AFLQYRRLRK
510
GYTPLMETHL SSKRYTEEA
Length:519
Mass (Da):59,145
Last modified:February 1, 1995 - v1
Checksum:iAFDDF21768002A89
GO
Isoform 2 (identifier: P40126-2) [UniParc]FASTAAdd to basket
Also known as: TRP-2-6b

The sequence of this isoform differs from the canonical sequence as follows:
     393-393: V → VVISNRLLYNATTNILEHVRKEKATKELPSLHVL

Show »
Length:552
Mass (Da):62,929
Checksum:iF2B047A524167DD3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043581393V → VVISNRLLYNATTNILEHVR KEKATKELPSLHVL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17547 mRNA Translation: BAA04484.1
L18967 mRNA Translation: AAA20870.1
S69231 mRNA Translation: AAC60627.1
DQ902581 mRNA Translation: ABI73976.1
AL139318 Genomic DNA No translation available.
BC028311 mRNA Translation: AAH28311.1
L38953 Genomic DNA Translation: AAC41925.1
D28767 Genomic DNA Translation: BAA05956.1
CCDSiCCDS45060.1 [P40126-2]
CCDS9470.1 [P40126-1]
PIRiS43510 YRHUR2
RefSeqiNP_001123361.1, NM_001129889.2 [P40126-2]
NP_001913.2, NM_001922.4 [P40126-1]
UniGeneiHs.301865

Genome annotation databases

EnsembliENST00000377028; ENSP00000366227; ENSG00000080166 [P40126-1]
ENST00000446125; ENSP00000392762; ENSG00000080166 [P40126-2]
GeneIDi1638
KEGGihsa:1638
UCSCiuc001vlv.6 human [P40126-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTYRP2_HUMAN
AccessioniPrimary (citable) accession number: P40126
Secondary accession number(s): Q09GT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 31, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health